WO1999009186A3 - Sequences nucleiques de polypeptides exportes de mycobacteries, vecteurs les comprenant et applications au diagnostic et a la prevention de la tuberculose - Google Patents

Sequences nucleiques de polypeptides exportes de mycobacteries, vecteurs les comprenant et applications au diagnostic et a la prevention de la tuberculose Download PDF

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Publication number
WO1999009186A3
WO1999009186A3 PCT/FR1998/001813 FR9801813W WO9909186A3 WO 1999009186 A3 WO1999009186 A3 WO 1999009186A3 FR 9801813 W FR9801813 W FR 9801813W WO 9909186 A3 WO9909186 A3 WO 9909186A3
Authority
WO
WIPO (PCT)
Prior art keywords
mycobacteria
mycobacterium
exported
belonging
diagnosing
Prior art date
Application number
PCT/FR1998/001813
Other languages
English (en)
Other versions
WO1999009186A2 (fr
Inventor
Brigitte Gicquel
Denis Portnoi
Eng-Mong Lim
Vladimir Pelicic
Agnes Guigueno
Salmoniere Yves De La Goguet
Original Assignee
Pasteur Institut
Brigitte Gicquel
Denis Portnoi
Lim Eng Mong
Vladimir Pelicic
Agnes Guigueno
Salmoniere Yves De La Goguet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9710404A external-priority patent/FR2767336B1/fr
Priority to AU90765/98A priority Critical patent/AU759724B2/en
Priority to CA002301374A priority patent/CA2301374A1/fr
Priority to EP98942748A priority patent/EP1003888B1/fr
Priority to JP2000509849A priority patent/JP2002534956A/ja
Priority to DK98942748T priority patent/DK1003888T3/da
Application filed by Pasteur Institut, Brigitte Gicquel, Denis Portnoi, Lim Eng Mong, Vladimir Pelicic, Agnes Guigueno, Salmoniere Yves De La Goguet filed Critical Pasteur Institut
Priority to NZ503316A priority patent/NZ503316A/xx
Priority to DE69839426T priority patent/DE69839426T2/de
Publication of WO1999009186A2 publication Critical patent/WO1999009186A2/fr
Publication of WO1999009186A3 publication Critical patent/WO1999009186A3/fr
Priority to US09/855,604 priority patent/US7244613B2/en
Priority to US11/329,260 priority patent/US20070015173A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Abstract

L'invention a pour objet des vecteurs recombinants se réplicant chez les mycobactéries, un ensemble de séquences codant pour des polypeptides exportés détectés par des fusions avec la phosphatase alcaline, notamment un polypeptide, dénommé DP428, d'environ 12kD correspondant à une protéine exportée retrouvée dans les mycobactéries appartenant au complexe de Mycobacterium tuberculosis. L'invention concerne également des procédés et des kits de détection in vitro de la présence d'une mycobactérie et en particulier une mycobactérie appartenant au complexe de Mycobacterium tuberculosis dans un échantillon biologique utilisant lesdits polypeptides, leurs fragments ou des polynucléotides codant pour ces derniers. L'invention vise des compositions immunogènes ou vaccins pour la prévention et/ou le traitement d'infections provoquées par des mycobactéries et en particulier une mycobactérie appartenant audit complexe, en particulier la tuberculose.
PCT/FR1998/001813 1997-08-14 1998-08-14 Sequences nucleiques de polypeptides exportes de mycobacteries, vecteurs les comprenant et applications au diagnostic et a la prevention de la tuberculose WO1999009186A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DE69839426T DE69839426T2 (de) 1997-08-14 1998-08-14 Nukleotidsequenzen, die für sekretierte polypeptide aus mycobacterium kodieren, vektoren, die diese enthalten, und anwendungen zur diagnostik und verhütung von tuberkulose
CA002301374A CA2301374A1 (fr) 1997-08-14 1998-08-14 Sequences nucleiques de polypeptides exportes de mycobacteries, vecteurs les comprenant et applications au diagnostic et a la prevention de la tuberculose
EP98942748A EP1003888B1 (fr) 1997-08-14 1998-08-14 Sequences nucleiques de polypeptides exportes de mycobacteries, vecteurs les comprenant et applications au diagnostic et a la prevention de la tuberculose
JP2000509849A JP2002534956A (ja) 1997-08-14 1998-08-14 マイコバクテリアから輸送されるポリペプチド核酸配列、それを含んでなるベクター、および結核の診断および予防のための使用
DK98942748T DK1003888T3 (da) 1997-08-14 1998-08-14 Nukleinsyresekvenser for polypeptider eksporteret fra mykobakterier, vektorer omfattende disse samt anvendelser til diagnosticering og forebyggelse af tuberkolose
AU90765/98A AU759724B2 (en) 1997-08-14 1998-08-14 Polypeptide nucleic sequences exported from mycobacteria, vectors comprising same and uses for diagnosing and preventing tuberculosis
NZ503316A NZ503316A (en) 1997-08-14 1998-08-14 Polypeptide and nucleic sequences exported from mycobacteria, vectors comprising same and uses for diagnosing and preventing tuberculosis
US09/855,604 US7244613B2 (en) 1997-08-14 2001-05-16 Polypeptide nucleic sequences exported from mycobacteria, vectors comprising same and uses for diagnosing and preventing tuberculosis
US11/329,260 US20070015173A1 (en) 1997-08-14 2006-01-11 Polypeptide nucleic sequences exported from mycobacteria, vectors comprising same and uses for diagnosing and preventing tuberculosis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9710404A FR2767336B1 (fr) 1997-08-14 1997-08-14 Vecteurs recombinants, polynucleotide codant pour un polypeptide pd428 de 12kd de mycobacteries appartenant au complexe de mycobacterium tuberculosis et applications au diagnostic et a la prevention de la tuberculose
FR97/10404 1997-08-14
FR97/11325 1997-09-11
FR9711325A FR2767337B1 (fr) 1997-08-14 1997-09-11 Sequences nucleiques de polypeptides exportes de mycobacteri es, vecteurs les comprenant et applications au diagnostic et a la prevention de la tuberculose

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US48553698A A-371-Of-International 1997-08-14 1998-08-14
US48553698A Continuation-In-Part 1997-08-14 1998-08-14
US09/855,604 Continuation US7244613B2 (en) 1997-08-14 2001-05-16 Polypeptide nucleic sequences exported from mycobacteria, vectors comprising same and uses for diagnosing and preventing tuberculosis

Publications (2)

Publication Number Publication Date
WO1999009186A2 WO1999009186A2 (fr) 1999-02-25
WO1999009186A3 true WO1999009186A3 (fr) 1999-08-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1998/001813 WO1999009186A2 (fr) 1997-08-14 1998-08-14 Sequences nucleiques de polypeptides exportes de mycobacteries, vecteurs les comprenant et applications au diagnostic et a la prevention de la tuberculose

Country Status (13)

Country Link
US (2) US7244613B2 (fr)
EP (2) EP1950221A3 (fr)
JP (1) JP2002534956A (fr)
AT (1) ATE393828T1 (fr)
AU (1) AU759724B2 (fr)
CA (1) CA2301374A1 (fr)
DE (1) DE69839426T2 (fr)
DK (1) DK1003888T3 (fr)
ES (1) ES2306478T3 (fr)
FR (1) FR2767337B1 (fr)
NZ (3) NZ519053A (fr)
PT (1) PT1003888E (fr)
WO (1) WO1999009186A2 (fr)

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DE19920712A1 (de) * 1999-05-05 2000-11-09 Rhein Biotech Proz & Prod Gmbh Verfahren zum Herstellen eines rekombinanten Proteines
AU7383500A (en) * 1999-09-17 2001-04-17 United States Government, As Represented By The Department Of Veteran's Affairs Virulence genes of m. marinum and m. tuberculosis
US7009042B1 (en) 1999-10-07 2006-03-07 Corixa Corporation Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins
JP2003527830A (ja) * 1999-10-07 2003-09-24 コリクサ コーポレイション 異種タンパク質の安定かつ高収量の発現を容易にするための、Ｍｙｃｏｂａｃｔｅｒｉｕｍｔｕｂｅｒｃｕｌｏｓｉｓをコードする配列を使用する方法
NZ519667A (en) 2002-06-19 2005-02-25 Univ Massey A putative 23kDa lipoprotein from Mycobacterium paratuberculosis and its use in Johne's disease
WO2004009837A2 (fr) 2002-07-19 2004-01-29 Arizona Board Of Regents Systeme de differenciation du mycobacterium tuberculosum pathogene a haute resolution
US7608277B2 (en) * 2004-12-01 2009-10-27 Gene Therapy Systems, Inc. Tuberculosis nucleic acids, polypeptides and immunogenic compositions
DE102005035586A1 (de) * 2005-06-29 2007-07-12 Grammer Ag Fahrzeugsitz mit einer flexiblen Rückenlehne
WO2007108829A2 (fr) * 2005-10-26 2007-09-27 Gene Therapy Systems, Inc. Acides nucléiques, polypeptides et compositions immunogènes de la tuberculose
WO2007093042A1 (fr) 2006-02-13 2007-08-23 Alethia Biotherapeutics Inc. Séquences polynucléotidiques et polypeptidiques intervenant dans le processus de remodelage osseux
US8168181B2 (en) 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
US7776341B2 (en) * 2006-08-10 2010-08-17 Colorado State University Research Foundation Biomarkers of tuberculosis that distinguish disease categories: use as serodiagnostic antigens
US9297803B2 (en) * 2006-11-01 2016-03-29 Immport Therapeutics, Inc. Compositions and methods for immunodominant antigens
DE102009045951B4 (de) 2009-10-23 2020-07-16 Swg Schraubenwerk Gaisbach Gmbh Bohrschraube
FR2966827B1 (fr) * 2010-10-27 2014-08-22 Kimonella Ventures Ltd Compose peptidique utile pour l'inhibition de la formation de plaques amyloides
WO2012177520A2 (fr) * 2011-06-20 2012-12-27 Matthias Rath Oligopeptides et leur utilisation pour le traitement de maladies infectieuses
EP2875051B1 (fr) 2012-07-19 2019-02-20 Daiichi Sankyo Company, Limited Anticorps anti-siglec-15
US9611297B1 (en) 2016-08-26 2017-04-04 Thrasos Therapeutics Inc. Compositions and methods for the treatment of cast nephropathy and related conditions
CN113549604A (zh) * 2020-04-23 2021-10-26 中国医学科学院病原生物学研究所 结核分枝杆菌毒素抗毒素系统Rv1045-Rv1044及其在制备抗结核药物中的应用

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Also Published As

Publication number Publication date
CA2301374A1 (fr) 1999-02-25
ATE393828T1 (de) 2008-05-15
ES2306478T3 (es) 2008-11-01
US20050158714A9 (en) 2005-07-21
AU759724B2 (en) 2003-04-17
JP2002534956A (ja) 2002-10-22
DE69839426T2 (de) 2009-05-20
EP1003888B1 (fr) 2008-04-30
NZ519053A (en) 2004-02-27
US7244613B2 (en) 2007-07-17
FR2767337B1 (fr) 2002-07-05
DK1003888T3 (da) 2008-07-28
US20040214165A1 (en) 2004-10-28
NZ529503A (en) 2005-12-23
EP1950221A2 (fr) 2008-07-30
WO1999009186A2 (fr) 1999-02-25
DE69839426D1 (de) 2008-06-12
NZ503316A (en) 2003-01-31
EP1003888A2 (fr) 2000-05-31
PT1003888E (pt) 2008-07-01
US20070015173A1 (en) 2007-01-18
AU9076598A (en) 1999-03-08
EP1950221A3 (fr) 2009-07-15
FR2767337A1 (fr) 1999-02-19

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