WO1999013862A3 - A pharmaceutical composition for treating dysmenorrhea and premature labor - Google Patents

A pharmaceutical composition for treating dysmenorrhea and premature labor Download PDF

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Publication number
WO1999013862A3
WO1999013862A3 PCT/US1998/018538 US9818538W WO9913862A3 WO 1999013862 A3 WO1999013862 A3 WO 1999013862A3 US 9818538 W US9818538 W US 9818538W WO 9913862 A3 WO9913862 A3 WO 9913862A3
Authority
WO
WIPO (PCT)
Prior art keywords
premature labor
pharmaceutical composition
composition
treating dysmenorrhea
present
Prior art date
Application number
PCT/US1998/018538
Other languages
French (fr)
Other versions
WO1999013862A2 (en
Inventor
Howard L Levine
William J Bologna
Ziegler Dominique De
Original Assignee
Columbia Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26738031&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999013862(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to DE69819748T priority Critical patent/DE69819748T2/en
Priority to UA2000042000A priority patent/UA62983C2/en
Priority to CA002303339A priority patent/CA2303339C/en
Priority to AT98943548T priority patent/ATE253892T1/en
Priority to IL13456498A priority patent/IL134564A0/en
Priority to JP2000511486A priority patent/JP2002503637A/en
Priority to EP98943548A priority patent/EP1011632B1/en
Priority to DK98943548T priority patent/DK1011632T3/en
Priority to NZ502926A priority patent/NZ502926A/en
Application filed by Columbia Lab Inc filed Critical Columbia Lab Inc
Priority to AU91311/98A priority patent/AU738460B2/en
Priority to KR1020007002610A priority patent/KR100575386B1/en
Priority to ROA200000269A priority patent/RO120814B1/en
Priority to HU0003784A priority patent/HUP0003784A3/en
Priority to BR9812134-0A priority patent/BR9812134A/en
Publication of WO1999013862A2 publication Critical patent/WO1999013862A2/en
Publication of WO1999013862A3 publication Critical patent/WO1999013862A3/en
Priority to NO20001287A priority patent/NO329203B1/en
Priority to HK00104419A priority patent/HK1025055A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants

Abstract

The present invention teaches a composition comprising a β-adrenergic agonist in a bioadhesive carrier. Preferably, the composition comprises terbutaline in polycarbophil. The present invention additionally teaches the local administration of a β-adrenergic agonist for the purpose of treating or preventing dysmenorrhea or premature labor. Using this composition and the method of treatment provides sufficient local levels of the drug to provide therapeutic efficacy, but avoids many untoward adverse events.
PCT/US1998/018538 1997-09-12 1998-09-08 A pharmaceutical composition for treating dysmenorrhea and premature labor WO1999013862A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DE69819748T DE69819748T2 (en) 1997-09-12 1988-09-08 MEDICINES FOR TREATING DYSMENORRHEA AND PREVIOUS BLIES
UA2000042000A UA62983C2 (en) 1997-09-12 1998-08-09 Pharmaceutical composition for treating or preventing dysmenorrhea or premature labor
BR9812134-0A BR9812134A (en) 1997-09-12 1998-09-08 Pharmaceutical composition for the treatment of dysmenorrhea and premature birth
KR1020007002610A KR100575386B1 (en) 1997-09-12 1998-09-08 A pharmaceutical composition for the prevention or treatment of dysmenorrhea and premature labor
IL13456498A IL134564A0 (en) 1997-09-12 1998-09-08 A pharmaceutical composition for treating dysmenorrhea and premature labor
JP2000511486A JP2002503637A (en) 1997-09-12 1998-09-08 Pharmaceutical compositions for the treatment of dysmenorrhea and preterm labor
EP98943548A EP1011632B1 (en) 1997-09-12 1998-09-08 A pharmaceutical composition for treating dysmenorrhea and premature labor
DK98943548T DK1011632T3 (en) 1997-09-12 1998-09-08 Pharmaceutical preparation for the treatment of dysmenorrhea and preterm birth
NZ502926A NZ502926A (en) 1997-09-12 1998-09-08 A pharmaceutical composition containing a therapeutically effective amount of a beta-adrenergic agonist together with a pharmaceutically acceptable bioadhesive for treating dysmenorrhea and premature labour
CA002303339A CA2303339C (en) 1997-09-12 1998-09-08 A pharmaceutical composition for treating dysmenorrhea and premature labor
AU91311/98A AU738460B2 (en) 1997-09-12 1998-09-08 A pharmaceutical composition for treating dysmenorrhea and premature labor
AT98943548T ATE253892T1 (en) 1997-09-12 1998-09-08 MEDICINAL PRODUCTS FOR THE TREATMENT OF DYSMENORRHEA AND PREMATURE LABOR
ROA200000269A RO120814B1 (en) 1997-09-12 1998-09-08 Pharmaceutical composition for treating dysmenorrhea and premature labour and use thereof
HU0003784A HUP0003784A3 (en) 1997-09-12 1998-09-08 A pharmaceutical composition for treating dysmenorrhea and premature labor
NO20001287A NO329203B1 (en) 1997-09-12 2000-03-10 Pharmaceutical compositions and applications thereof
HK00104419A HK1025055A1 (en) 1997-09-12 2000-07-19 A pharmaceutical composition for treating dysmenorrhea and premature labor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5878997P 1997-09-12 1997-09-12
US09/145,172 US6126959A (en) 1997-09-12 1998-09-01 Pharmaceutical composition for treating dysmenorrhea and premature labor
US60/058,789 1998-09-01
US09/145,172 1998-09-01

Publications (2)

Publication Number Publication Date
WO1999013862A2 WO1999013862A2 (en) 1999-03-25
WO1999013862A3 true WO1999013862A3 (en) 1999-05-14

Family

ID=26738031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/018538 WO1999013862A2 (en) 1997-09-12 1998-09-08 A pharmaceutical composition for treating dysmenorrhea and premature labor

Country Status (20)

Country Link
US (2) US6126959A (en)
EP (1) EP1011632B1 (en)
JP (1) JP2002503637A (en)
KR (1) KR100575386B1 (en)
CN (1) CN1186009C (en)
AT (1) ATE253892T1 (en)
AU (1) AU738460B2 (en)
BR (1) BR9812134A (en)
CA (1) CA2303339C (en)
DE (1) DE69819748T2 (en)
DK (1) DK1011632T3 (en)
ES (1) ES2210813T3 (en)
HK (1) HK1025055A1 (en)
HU (1) HUP0003784A3 (en)
IL (1) IL134564A0 (en)
NO (1) NO329203B1 (en)
NZ (1) NZ502926A (en)
PT (1) PT1011632E (en)
RO (1) RO120814B1 (en)
WO (1) WO1999013862A2 (en)

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US7341737B2 (en) * 1997-06-11 2008-03-11 Kimberly-Clark Worldwide, Inc. Medicated tampon
DE69819748T2 (en) * 1997-09-12 2004-09-30 Columbia Laboratories (Bermuda) Ltd. MEDICINES FOR TREATING DYSMENORRHEA AND PREVIOUS BLIES
US20040234606A1 (en) * 1997-09-12 2004-11-25 Levine Howard L. Localized vaginal delivery without detrimental blood levels
UA74168C2 (en) * 1999-10-05 2005-11-15 Коламбіа Леборетеріс (Бермуда) Лімітед Use of beta-adrenergic agonist for treating endometriosis and infertility as well as for improving fertility
RU2310474C2 (en) * 1999-10-05 2007-11-20 Колумбия Лабораториз (Бермуда) Лимитед Method for treatment of endometriosis or infertility, or improving of fertility and pharmaceutical composition therefor
US6479045B2 (en) 1999-12-22 2002-11-12 Columbia Laboratories, Inc. Vaginal pH buffering for preventing miscarriage and premature labor, by treating or preventing bacterial vaginosis
DE10141650C1 (en) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Safe transdermal therapeutic system for administration of fentanyl or analogous analgesics, having matrix layer of carboxy group-free polyacrylate adhesive providing high permeation rate
US20080182841A1 (en) * 2001-10-29 2008-07-31 Levine Howard L Vaginally administered anti-dysrhythmic agents for treating pelvic pain
CN101327326A (en) * 2001-10-29 2008-12-24 哥伦比亚实验室(百慕大群岛)有限公司 Vaginally administered anti-dysrhythmic agents for treating pelvic pain and infertility
US20030114394A1 (en) * 2001-10-29 2003-06-19 Levine Howard L. Vaginally administered anti-dysrhythmic agents for treating pelvic pain
US7709026B2 (en) 2001-10-29 2010-05-04 Columbia Laboratories, Inc. Low concentration of peroxide for treating or preventing vaginal infections
US8425892B2 (en) * 2001-10-29 2013-04-23 Columbia Laboratories, Inc. Extended, controlled-release pharmaceutical compositions using charged polymers
FR2841223B1 (en) 2002-06-19 2004-10-15 Sleever Int PACKAGING FOR OBJECTS (S) OF HEAT SHRINKABLE MATERIAL WITH ESSENTIALLY SMOOTH INTERNAL OR EXTERNAL SIDE
US20050226926A1 (en) 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
PA8578501A1 (en) * 2002-07-25 2005-02-04 Pharmacia Corp DOSAGE FORM ONCE A DAY OF PRAMIPEXOL
PE20040321A1 (en) * 2002-08-22 2004-07-15 Novartis Consumer Health Sa TOPICAL COMPOSITION INCLUDING DICLOFENACO
DE60322103D1 (en) * 2002-12-18 2008-08-21 Ferrer Int PHARMACEUTICAL COMPOSITIONS WITH SERTACONAZOLE FOR VAGINAL USE
ES2237298B1 (en) 2003-07-16 2006-11-01 Italfarmaco, S.A. SEMISOLID MUCOADHESIVE FORMULATIONS.
AU2003265624B2 (en) * 2003-08-21 2011-03-31 Abeona Therapeutics Inc. Liquid formulations for the prevention and treatment of mucosal diseases and disorders
RS51527B2 (en) * 2004-08-13 2018-02-28 Boehringer Ingelheim Int Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
CN101849920A (en) * 2004-08-13 2010-10-06 贝林格尔·英格海姆国际有限公司 The prolongation that comprises pramipexole or its officinal salt discharges pellet formulation, Its Preparation Method And Use
US7481815B2 (en) * 2004-09-23 2009-01-27 Synthes (U.S.A.) Coplanar X-ray guided aiming arm for locking of intramedullary nails
US7919453B2 (en) 2005-03-25 2011-04-05 Kimberly-Clark Worldwide, Inc. Dosage cap assembly for an applicator
US7993667B2 (en) 2005-03-25 2011-08-09 Kimberly-Clark Worldwide, Inc. Methods of manufacturing a medicated tampon assembly
US7744556B2 (en) 2005-03-25 2010-06-29 Kimberly-Clark Worldwide, Inc. Delivery tube assembly for an applicator
US7708726B2 (en) 2005-04-28 2010-05-04 Kimberly-Clark Worldwide, Inc. Dosage form cap for an applicator
WO2007090883A1 (en) * 2006-02-10 2007-08-16 Boehringer Ingelheim International Gmbh Extended release formulation
JP2009526021A (en) * 2006-02-10 2009-07-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Formulation with controlled release
EP2112923A1 (en) 2007-01-22 2009-11-04 Targacept Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
US8828981B2 (en) 2007-02-06 2014-09-09 George Creasy Progesterone for the treatment or prevention of spontaneous preterm birth
WO2009073184A1 (en) * 2007-12-03 2009-06-11 Florida State University Research Foundation, Inc. Compositions for inducing labor and associated methods
US8992589B2 (en) 2007-12-03 2015-03-31 The Florida State University Research Foundation, Inc. Using light to regulate uterine contractions
ES2344673B1 (en) 2008-08-07 2011-05-03 Italfarmaco, S.A. USE OF ESTRIOL IN THE PREPARATION OF A PHARMACEUTICAL FORMULATION FOR THE TREATMENT OF VAGINAL ATROPHY IN WOMEN WITH RISK OF POTOLOGIATUMORAL.
BRPI0803568B8 (en) * 2008-08-14 2021-05-25 Biolab San Us Farm Ltda mucoadhesive composition
ES2344675B1 (en) 2008-12-19 2011-04-28 Italfarmaco, S.A. USE OF ESTRIOL IN THE PREPARATION OF A PHARMACEUTICAL FORMULATION FOR THE TREATMENT OF VAGINAL ATROPHY IN WOMEN WITH RISK OF VARIUM VARCOLOGY.
GB2484977A (en) * 2010-10-29 2012-05-02 Biocopea Ltd Treatment of a Th-1 mediated disease
EP2725904A4 (en) 2011-06-28 2014-12-10 Medicis Pharmaceutical Corp High dosage mucoadhesive metronidazole aqueous-based gel formulations their use to treat bacterial vaginosis
US10407423B2 (en) * 2015-11-16 2019-09-10 Fundación Para La Investigación Médica Aplicada Compounds as inhibitors of DNA methyltransferases

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JPS5925320A (en) * 1982-08-02 1984-02-09 Watanabe Yakuhin Kogyo Kk Plaster for drug administration
EP0147780A2 (en) * 1984-01-03 1985-07-10 Merck & Co. Inc. Drug delivery device
WO1993000058A1 (en) * 1991-06-27 1993-01-07 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
WO1995007699A1 (en) * 1993-09-15 1995-03-23 Columbia Laboratories, Inc. Novel method of progesterone delivery and affect thereof
FR2720276A1 (en) * 1994-05-24 1995-12-01 Christophe Boyer Use of beta-mimetic agents e.g. salbutamol
WO1996010989A1 (en) * 1994-10-07 1996-04-18 Columbia Laboratories, Inc. Use and composition of an anti-sexually transmitted diseases formulation
WO1998023292A1 (en) * 1996-11-29 1998-06-04 Monsanto Company Lubricious self-standing (intact) gel for oral delivery of biologically-active ingredients
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JPS5925320A (en) * 1982-08-02 1984-02-09 Watanabe Yakuhin Kogyo Kk Plaster for drug administration
EP0147780A2 (en) * 1984-01-03 1985-07-10 Merck & Co. Inc. Drug delivery device
WO1993000058A1 (en) * 1991-06-27 1993-01-07 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
WO1995007699A1 (en) * 1993-09-15 1995-03-23 Columbia Laboratories, Inc. Novel method of progesterone delivery and affect thereof
FR2720276A1 (en) * 1994-05-24 1995-12-01 Christophe Boyer Use of beta-mimetic agents e.g. salbutamol
WO1996010989A1 (en) * 1994-10-07 1996-04-18 Columbia Laboratories, Inc. Use and composition of an anti-sexually transmitted diseases formulation
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DATABASE WPI Week 8412, Derwent World Patents Index; AN 84-071329 [12], XP002096704 *

Also Published As

Publication number Publication date
US6126959A (en) 2000-10-03
IL134564A0 (en) 2001-04-30
NO20001287D0 (en) 2000-03-10
CN1186009C (en) 2005-01-26
DE69819748D1 (en) 2003-12-18
US20020012677A1 (en) 2002-01-31
US6699494B2 (en) 2004-03-02
KR20010030588A (en) 2001-04-16
HK1025055A1 (en) 2000-11-03
CN1270514A (en) 2000-10-18
DK1011632T3 (en) 2004-03-29
PT1011632E (en) 2004-03-31
NO329203B1 (en) 2010-09-13
NO20001287L (en) 2000-03-10
AU9131198A (en) 1999-04-05
CA2303339A1 (en) 1999-03-25
BR9812134A (en) 2000-07-18
HUP0003784A3 (en) 2001-12-28
AU738460B2 (en) 2001-09-20
NZ502926A (en) 2001-10-26
ES2210813T3 (en) 2004-07-01
EP1011632B1 (en) 2003-11-12
RO120814B1 (en) 2006-08-30
HUP0003784A2 (en) 2001-08-28
DE69819748T2 (en) 2004-09-30
CA2303339C (en) 2006-12-12
WO1999013862A2 (en) 1999-03-25
KR100575386B1 (en) 2006-05-03
ATE253892T1 (en) 2003-11-15
JP2002503637A (en) 2002-02-05
EP1011632A2 (en) 2000-06-28

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