WO1999015092A9 - Method and apparatus for heating during cryosurgery - Google Patents
Method and apparatus for heating during cryosurgeryInfo
- Publication number
- WO1999015092A9 WO1999015092A9 PCT/US1998/020023 US9820023W WO9915092A9 WO 1999015092 A9 WO1999015092 A9 WO 1999015092A9 US 9820023 W US9820023 W US 9820023W WO 9915092 A9 WO9915092 A9 WO 9915092A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cryoheater
- shell
- patient
- tissue
- cryoprobe
- Prior art date
Links
- 238000010438 heat treatment Methods 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims abstract description 40
- 238000002681 cryosurgery Methods 0.000 title claims abstract description 28
- 230000007246 mechanism Effects 0.000 claims abstract description 63
- 238000007710 freezing Methods 0.000 claims abstract description 56
- 230000008014 freezing Effects 0.000 claims abstract description 56
- 230000003213 activating effect Effects 0.000 claims abstract description 11
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- 239000012772 electrical insulation material Substances 0.000 claims description 4
- 210000001519 tissue Anatomy 0.000 description 61
- 238000010257 thawing Methods 0.000 description 28
- 238000001816 cooling Methods 0.000 description 10
- 230000002265 prevention Effects 0.000 description 8
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- 230000004913 activation Effects 0.000 description 3
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- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 229910001006 Constantan Inorganic materials 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 206010020843 Hyperthermia Diseases 0.000 description 1
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- 238000001574 biopsy Methods 0.000 description 1
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- 230000036760 body temperature Effects 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00041—Heating, e.g. defrosting
Definitions
- the present invention relates generally to cryosurgical devices and procedures. More particularly, the invention concerns a cryosurgical apparatus that has the abilities to either control the thawing stage of a cryosurgical procedure; prevent the freezing front from propagation into undesired directions; or, protect tissues from freezing within the cryotreated region or nearby.
- the mainstay of the new invention is a temperature controlled electrical heater which will be termed cryoheater from hereon.
- Cryosurgery or the destruction of undesired biological tissues by freezing, has long been accepted as an important alternative technique of surgery (Orpwood, 1981; Rubinsky and Onik, 1991; Gage, 1992) .
- visceral cryosurgery especially minimally invasive cryosurgery offers the following potential advantages: simplicity of the procedure, minimal bleeding, anaesthetic effect of low temperatures, short period of patient recovery, low cost, minimal scarring, and possible stimulation of the body's immune system.
- Cryosurgical success, or maximal destruction of undesired biological tissues by freezing is influenced by many factors: the cooling rate (Smith and Fraser, 1974; Gage, 1985; Fahy, 1990), the thawing rate (Miller and Mazur, 1976), the minimal temperature achieved (Gage, 1982) , and the number of repeated freezing ⁇ thawing cycles (Rand et al . , 1985).
- Many controlled cryodevices and cryoprotocols have been suggested to improve the cryodestruction, where the controlled variable is the cryoprobe temperature.
- Additional thermocouples, which are distributed in the cryotreated region are used in some cases as an external feedback for the control system. In some other cases the electrical impedance of the cryotreated tissue is used as an additional indicator of cryodestruction.
- cryoprotocols deal with the cooling stage of the cryoprocedure and therefore extensive efforts have been made to develop cryoprobes that can be accurately controlled within this stage. Some cryoprobes have a further ability of controlled heating at the thawing stage of the cryoprocedure
- the controlled thawing process is performed either by forcing hot working fluids through the cryoprobe' s passageways or by activating an electrical heater which is an integral part of the cryoprobe.
- Cryosurgery of internal organs, and especially minimally invasive cryosurgery is monitored by one of the following imaging techniques: ultrasound, CT or NMR.
- ultrasound is the most accepted imaging technique among cryosurgeons.
- the cryosurgeon inserts the cryoprobe (s) into the expected cryotreated region.
- the cryosurgeon activates the cryoprobe (s) according to some cooling protocol and monitors the frozen region growth (which is also termed "ice-ball") .
- the cryosurgeon terminates the cooling process and the thawing stage follows. In some cases the cooling ⁇ thawing stages are repeated in order to increase the cryodestruction. What is desired is a way to provide more affirmative control to the thawing process to more accurately control the overall cooling and heating of the undesired tissues.
- a further objective of the invention is to provide a method and apparatus for increasing of cryodestruction by means of control of the thawing rate.
- the present invention pertains to a cryoheater for insertion into a patient.
- the cryoheater comprises a shell.
- the cryoheater also comprises a heating mechanism within the shell.
- the cryoheater includes a sensor which determines the temperature of the shell. The sensor is adjacent to the shell.
- the present invention pertains to a system for performing cryosurgery on a patient.
- the system comprises a mechanism for freezing tissue in a patient. Additionally, the system comprises a mechanism for heating other tissue near the tissue being frozen by the freezing mechanism such that essentially only desired tissue is frozen by the freezing mechanism and heat from the heating mechanism prevents the other tissue from being frozen.
- the heating mechanism is disposed adjacent the freezing mechanism.
- the present invention pertains to a system for performing cryosurgery on a patient.
- the system comprises a mechanism for freezing tissue in a patient.
- the system comprises a mechanism for heating the tissue frozen by the freezing mechanism.
- the heating mechanism is disposed adjacent the freezing mechanism.
- the present invention pertains to a method for performing cryosurgery on a patient.
- the method comprises the steps of inserting a cryoprobe into a patient.
- Next there is the step of placing a cryoheater into contact with the patient adjacent the cryoprobe.
- the present invention pertains to a method for performing cryosurgery on a patient.
- the method comprises the steps of inserting a cryoprobe into a patient. Then, there is the step of placing a cryoheater into contact with the patient adjacent the cryoprobe. Next, there is the step of activating the cryoprobe so the cryoprobe freezes desired tissue in the patient. Then, there is the step of activating the cryoheater after the cryoprobe has frozen the desired tissue to heat the frozen tissue.
- Figure 1 is a side view of cryoheater 21A.
- FIG. 2 is a side view of cryoheater 2IB.
- FIG. 3 is a side view of cryoheater 21C.
- Figure 4 is a schematic view illustrating one form of control mechanism of the cryoheater of the invention.
- FIG. 5 is diagrammatic representation showing examples of cryoprobe (s) and cryoheater (s) configurations for different operations: (a) single cryoprobe for superficial cryotreatment in combination with cryoheaters (side view) ;
- cryoprobes' center lines (viewed in a direction parallel to the cryoprobes' center lines) ; (d) preventing the freezing process from propagation into undesired direction, which in this case is perpendicular to the cryoheaters line (viewed in a direction parallel to the cryoprobe' s center lines); (e) protecting blood vessel from freezing (side view) ; (f) protecting the urethra during cryosurgery of the prostate (viewed in a direction parallel to the cryoprobes' center lines) .
- the control cryoheater 21 comprises a shell 13.
- the cryoheater 21 also comprises a heating mechanism 23 within the shell 13.
- the cryoheater 21 includes a sensor 8 which determines the temperature of the shell 13. The sensor 8 is adjacent to the shell 13.
- the heating mechanism 23 includes an electrical resistor 1 disposed in the shell 13.
- the heating mechanism 23 preferably includes a control mechanism 24 which provides a desired electrical power, such as current, to the resistor 1.
- the control mechanism 24 includes a controller 25 which controls the amount of electrical power provided to the resistor 1.
- the heating mechanism 23 includes a "+" terminal in connection with the electrical resistor 1 and a "0" terminal in connection with the electrical resistor 1 so electrical current flows only in or through the shell 13 but not in a patient.
- the heating mechanism 23 preferably also includes electrical isolator material disposed in the shell 13 between the resistor 1 and the shell 13.
- the controller 25 preferably controls the temperature of the shell 13 by controlling the amount of electrical power provided to the electrical resistor 1 in accordance with the desired temperature forcing function.
- the control mechanism 24 includes a temperature unit 27 connected to the sensor 8 for reading temperature signals from the sensor 8 and producing a temperature control signal.
- a controller 25 provides electrical signals which are amplified to provide electrical power to the electrical resistor 1 corresponding to the difference between the forcing function and the temperature control signal.
- the shell 13 has a tip which is pointed.
- the shell 13 is made of metal and has a connector extending from an end opposite the tip, which is the "0" terminal.
- the electrical resistor 1 in this embodiment is connected to the tip so electrical current flows through the resistor 1, along the shell 13 and to the connector.
- the electrical resistor 1 has a first connector which is the " +" terminal and a second connector which is a "0" terminal and the resistor 1 forms a loop which is disposed in the shell 13.
- the shell 13 is made of metal, and has a rounded tip.
- the heating mechanism 23 in this embodiment includes a flexible tube connected to the shell 13 and a flexible electrical conductor 15 disposed in the flexible tube in which electrical current carrying wires are disposed and connected to the resistor 1.
- the flexible electrical conductor 15 is directly connected to the shell 13 and is grounded so any electrical circuit breakdown will not affect the treated tissue.
- the present invention pertains to a system 30 for performing cryosurgery on a patient.
- the system 30 comprises a mechanism 32 for freezing tissue in a patient. Additionally, the system 30 comprises a mechanism 23 for heating other tissue near the tissue being frozen by the freezing mechanism 32 such that essentially only desired region is frozen by the freezing mechanism 32 and heat from the heating mechanism 23 prevents the other tissue from being frozen.
- the heating mechanism 23 is disposed adjacent the freezing mechanism 32.
- the present invention pertains to a system 30 for performing cryosurgery on a patient, as shown in figures 5a-5f .
- the system 30 comprises a mechanism 32 for freezing tissue, such as cryoprobe 22, in a patient.
- the system 30 comprises a mechanism 23 for heating the tissue frozen by the freezing mechanism 32.
- the heating mechanism 23 is disposed adjacent the freezing mechanism 32.
- the heating mechanism 23 can be a cryoheater 21.
- the present invention pertains to a method for performing cryosurgery on a patient.
- the method comprises the steps of placing and preferably inserting a cryoprobe 22 into contact with a patient.
- the present invention pertains to a method for performing cryosurgery on a patient.
- the method comprises the steps of placing and preferably inserting a cryoprobe 22 into contact with a patient. Then, there is the step of placing and preferably inserting a cryoheater 21 into contact with the patient adjacent the cryoprobe 22. Next, there is the step of activating the cryoprobe 22 so the cryoprobe 22 freezes desired tissue in the patient. Then, there is the step of activating the cryoheater 21 after the cryoprobe 22 has frozen the desired tissue to thaw the frozen tissue.
- cryoheater 21A is comprised of a metallic cryoheater shell 13, which has a tube configuration and a sharp pointed tip, for penetration into either the cryotreated tissues or the surrounding tissues.
- Electrical resistor 1 is connected to the tube's tip through the tube's hollow center.
- Current carrying wire 4 is connected to the other end of electrical resistor 1, on its one end, and is connected to electrical connector 5, on its other end.
- Electrical connector 6 is a metallic extension of cryoheater shell 13.
- temperature sensor 8 is attached on the inner surface of cryoheater shell 13, and near the center of electrical resistor 1, temperature sensor 8 is attached. Temperature sensor wires 9 transfer signals from temperature sensor 8 to the control system.
- the gap between tube 13, electrical resistor 1 and current carrying wire 4 is filled with an electrical insulation material.
- the electrical insulation material within cryoheater shell 13 is sealed with cover 11.
- cryoheater A takes place as follows. Electrical power is supplied to the cryoheater through electrical connectors 5 and 6. The electrical power is transferred through current carrying wire 4 and cryoheater shell 13, respectively, to both ends of electrical resistor 1, which serves as a heating element. Connector 6 is connected to the "0" pole of the electric circuit, while connector 5 is connected to the "+” pole of the power source for safety reasons. Therefore, in case of electrical circuit failure no current will be transferred through the tissues to the ground. The electrical resistor transforms the current into heat .
- the cryoheater should be controlled by a controller to maintain a constant and pre-specified temperature.
- the temperature control process of the cryoheater is presented schematically in figure 4 and is described hereon.
- the temperature of the cryoheater surface is sensed by temperature sensor 8, figure 1.
- the signals are transferred through temperature sensor wires 9, figure 1.
- the signals are amplified and read by a temperature unit, and then are converted into signals which are compatible with the controller's input, figure 4.
- the controller output corresponds to the difference between a desired temperature forcing function and the measured cryoheater temperature according to a control law.
- the "forcing function" is the desired temperature of the cryoheater outer surface (this term is taken from the Theory of Control and is a well known term) .
- the temperature forcing function is the temperature function that the operator "asks" the controller to force the system.
- the desired forcing function is designated by r in figure 4. This function is forced as follows: the cryoheater' s surface temperature is measured by the temperature sensor 8 via the temperature unit, figure 4; the controller compares the desired forcing function, r, and the value read by the temperature unit and applies the control law; if the cryoheater temperature is lower than the desired temperature, the control law will send a signal to the controller to activate the power amplifier, however if the cryoheater temperature is higher than the desired temperature, the control law will send a signal to the controller to cause the power amplifier to produce a zero output.
- the forcing function is an arbitrary function that the operator would like to force the system
- the control unit does the job using temperature measurements as a feedback.
- the control law can be formulated in many ways as is well established in the theory of process control. For the application of cryoheaters it seems that even the simplest, on-off controller should be satisfactory.
- the controller output is amplified to obtain a desired heating power in the cryoheater.
- the electric power is transferred from the power amplifier to electrical resistor 1 through connectors 5 and 6 of the cryoheater, figure 1. It is preferred (but not necessary) to materialize the control unit by a microcomputer, which can very easily control many cryoheaters simultaneously.
- control unit can be assembled from off-the-shelf components.
- off-the-shelf Omega ® temperature amplifiers, controllers, and switching devices can be assembled to create the control unit (Omega, The Temperature HandbookTM, Vol. 29, 1995).
- control unit can be microcomputer based, with a similar temperature unit and a power amplifier used for controlling the temperature of an electrical heated cryoprobe, as is described in detail by Rabin and Shitzer ("A New Cryosurgical Device for Controlled Freezing, Part I: Setup and Validation Test, Cryobiology, Vol. 33, pp. 82-92, 1996, incorporated by reference herein) .
- Rabin and Shitzer A New Cryosurgical Device for Controlled Freezing, Part I: Setup and Validation Test, Cryobiology, Vol. 33, pp. 82-92, 1996, incorporated by reference herein
- Cryoheater 21B is similar to cryoheater A with the only exception that tube 13 is electrically isolated from the electrical circuit. Therefore, cryoheater shell 13 can be made of non-metallic materials in this case.
- Electrical resistor 1 in this configuration has a U shape. Two identical current carrying wires 4 are connected to both electrical resistor 1 ends, and two identical electrical connectors 5 are connected to the other ends, respectively.
- the control loop and the heating process, which dominates and activates cryoheater 21B, respectively, are identical to those described above for cryoheater 21A.
- Cryoheater 21C figure 3, comprised of a metallic cryoheater shell 13 has a rounded or half a spherical tip for its insertion through blood vessels, urethra, or other anatomical passageways.
- Leading tube 16 is flexible and is connected onto cryoheater shell 13 and carries all current carrying wires.
- a hollow and flexible electrical conductor 15 is placed inside tube 16, and carries all the rest of current carrying wires .
- Electrical conductors 12 connect the flexible conductor 15 to metallic tube 13.
- Electrical resistor 1 is located inside cryoheater shell 13 and is powered through the current carrying wires 7.
- Temperature sensor 8 is attached to the inner surface of cryoheater shell 13.
- the temperature sensor signals are transferred through temperature sensors wires 9, which are located inside cryoheater shell 13 and thereafter inside flexible conductor 15.
- the gap between electrical resistor 1 and cryoheater shell 13 is filled with an electrical insulation material.
- electrical conductor 15 is grounded at all times.
- Cryoheater shell 13 and conductor 15 and connectors 12 serve as a grounded shell for the electrical circuit for safety reasons.
- cryoheater 21C The heating process and the control process of cryoheater 21C are very similar to those of cryoheaters 21A and 2IB.
- the internal structure of cryoheater 21C is different. The main reason for this difference is that cryoheater 21C has to have the capacity to be inserted through curved anatomical passageways. Therefore, only the active part of cryoheater 21C is rigid, while the leading tube and its internal electrical conductors are flexible.
- the cryoheater shell should preferably be made of stainless steel.
- the diameter of the cryoheater can be reduced down to an 18-gage needle size.
- the power supply can be either 12V electrical batteries or 110V/12V convertor, which in both cases are designed for high power. From heat transfer consideration the cryoheater should have a power of at least 12W.
- cryosurgeon Before commencing the cryosurgery, the cryosurgeon will typically study the location, depth and configuration of the undesired tissues. The cryosurgeon will evaluate the surrounding healthy tissues as well, and especially the vital tissues. This evaluation can be performed via ultrasound, CT or NMR imaging techniques. Based on this study, one or more appropriately configured cryoprobes, in combination with one or more appropriately configured cryoheaters, will be chosen. In general, cryoheaters can be used in one of two modes: thawing or freezing prevention.
- the thawing mode is addressed first. Based on a thorough study as presented above, one or more appropriately configured cryoprobes will be chosen. The frozen region size and configuration will be estimated. Based on the expected frozen region size and configuration, one or more appropriately configured cryoheaters will be chosen to perform thawing as efficiently as possible. The cryoprobe (s) and the cryoheater (s) will be placed in the cryotreated region at the very beginning of the procedure, prior of any cryoprobe activation. The freezing stage will then be started. The cryoprobe (s) will be operated, according to a cooling protocol to ensure maximal cryodestruction, until a complete freezing of the desired region is achieved. The thawing stage will then be started.
- the cryoheater (s) will be controlled to ensure complete thawing.
- Some cryoprobes have a capability of heating which can be used in combination with the cryoheaters.
- the freezing ⁇ thawing cycle will be repeated in case of multi-cycle cryosurgery.
- cryoprobe (s) and cryoheaters configurations for thawing mode are presented in figure 5: (a) single cryoprobe for superficial cryotreatment in combination with cryoheaters (side view) ; (b) single cryoprobe for invasive cryotreatment in combination with cryoheaters (side view) ; (c) triple-cryoprobe cryotreatment in combination with 7 cryoheaters (viewed in a direction parallel to the cryoprobes' center lines) .
- Cryoprobes 21A or 2 IB, figures 1 and 2, respectively, will typically be used for the above cases.
- the cryoheater' s temperature is the controlled variable of the apparatus.
- the controller forcing function can be a step function to reduce thawing duration to minimum, on the one hand, but to prevent over heated tissues, on the other hand.
- the temperature of the step can be carefully chosen as the normal body temperature or higher. It is noted that hyperthermia damage due to cryoheaters' over heating can increase the tissues' destruction, but yet needs to be carefully done.
- An alternative forcing function is resulted from the dependency of the cryodestruction in the thawing rate. This alternative forcing function is resulted from an inverse mathematical problem in which its solution gives a constant thawing rate at the thawing front.
- the utilization of the alternative forcing function requires further scientific study.
- freezing prevention can take place either at the edge of the freezing region or in some tissues which are surrounded by other freezing tissues.
- one or more appropriately configured cryoprobe (s) will be chosen.
- the frozen region size and configuration will be estimated.
- One or more appropriately configured cryoheater (s) will be chosen, in order to prevent freezing propagation into undesired direction, or in order to prevent freezing of some tissues which will be surrounded by frozen tissues.
- the cryoprobe (s) and the cryoheater (s) will be placed in the cryotreated region at the very beginning of the procedure, prior of any cryoprobe activation.
- the cryoheater (s) will be activated and set to the range of the undisturbed tissues' temperature. These cryoheaters will be operated all along the cryoprocedure, until complete thawing has been achieved. The freezing stage will then be started. The cryoprobe (s) will be operated, according to a cooling protocol to ensure maximal cryodestruction, until a complete freezing of the target region is achieved. The thawing stage will then take place. The freezing ⁇ thawing cycle will be repeated in case of multicycle cryosurgery.
- cryoprobe (s) and cryoheater (s) configurations for the freezing prevention mode are presented in figure 5: (d) preventing the freezing process from propagation into undesired direction, which in this case is perpendicular to the cryoheaters line (viewed in a direction parallel to the cryoprobe' s center lines); (e) protecting blood vessel freezing (side view) ; (f) protecting the urethra during cryosurgery of the prostate (viewed in a direction parallel to the cryoprobes' center lines) .
- cryoprobes will be inserted in the same common techniques already used today.
- the cryoheater will be inserted through the urethrae similar to the insertion of a catheter.
- the tube 16 and the electrical conductor 15 are flexible in this case.
- a urethral warmer for cryosurgical application in the prostate already exists (Automatic Transperineal Biopsy Guide by Gary Onik and George Reyes) , however, it functions very differently from the new proposed cryoheater.
- the heat sources of the existing urethral warmer is warm and, therefore, the urethral warmer works on the principle of heat exchanger.
- the risk of using the existing urethral warmer is that if, from some reason, the water flow is stopped, even for a shorter period (instantaneous failure of the water pump, for example) , the heat exchanger of the urethral warmer will be blocked by frozen water. In this case, the urethral warmer will be out of function until the end of the operation.
- the new cryoheater is independent of fluid flow, is generating the heat internally, and therefore can be reactivated whenever is necessary.
- cryoheaters are placed at the end of long rigid tubes made from the same material as needles.
- the cryoheater insertion is a minimal invasive procedure since its insertion is similar to the insertion of long needles.
- the cryoheater' s diameter can vary between 1 mm to a few millimeters, depending on the application.
- the cryoheaters should be equally distributed in space for the application of controlled thawing in cryotreated tissue, as shown in figures 5a, 5b and 5c. 2.
- the cryoheater should be placed as close as possible to the cryoprobe, within the protected vessel, in case of freezing prevention of blood vessels, urethrae, or other anatomical passageways, as shown in figures 5e and 5f .
- cryotreated tissues is done by freezing the tissues, therefore the cryoprobes are the main surgical tools.
- the cryoheaters are used to reduce the duration of the cryoprocedure and to save vital organs or tissues adjunct to the cryotreated tissues, and to assist in shaping the frozen region.
- cryoheaters operating under these two modes can be combined to provide freezing prevention of some tissues and controlled thawing of other tissues in the same cryoprocedure .
- cryoheater 21B has, for example, the following design parameters.
- Cryoheater shell 13 was made of a copper tube having a diameter of 2.4 mm OD (1.7 mm ID) and a length of 50 mm. One end of the tube was soldered and machined into a sharp pointed tip configuration, in an angle of 35° .
- the electrical heating element was constructed as follows. A 22 -gage current carrying wire (0.7 mm OD) , coated by a plastic insulation having a diameter of 1.2 mm, was used as the core of the electrical heater. The length of the wire was cut to fit into the hollow of the cryoheater shell.
- a standard electrical resistor wire having a resistance of 12 ⁇ and a length of 100 mm, was taken out from a power resistor that was rated 20 W.
- the electrical resistor was carefully coiled around the plastic insulation of the current carrying wire, in such a way that no contact was made between one coil ring to another.
- the electrical resistor covered a total length of 20 mm starting at one end of the current carrying wire.
- One end of the electrical resistor was connected to the adjunct end of the current carrying wire, while the other end was lead along the plastic insulation, toward the other current carrying wire end.
- the coiled electrical resistor was coated with glue (Clear Epoxy) , to fix its position and to provide a complete electrical insulation for the electrical resistor wire.
- the outer diameter of the glue was less than the ID of the cryoheater shell, i.e. 1.7 mm.
- the assembly of the current carrying wire and the electrical resistor was inserted into the cryoheater shell, leaving both ends of the current carrying wire and of the electrical resistor outside of the cryoheater shell.
- the electrical heater was connected in series with an on/off switch onto an electrical power source of 12 V and 1 Amp.
- the electrical power source was a simple AC/DC convertor from the 110V electrical network. While the electrical heater is "on” it can give a power of up to 12 W.
- thermocouple was connected to the cryoheater shell, about 10 mm from its sharp pointed tip.
- thermocouple was connected onto the cryoheater shell outer surface. This connection has no affect on the results.
- the cryoheater was inserted in water as a substitute for the biological tissue.
- the cryoheater was placed at the center of a water container having a diameter of 17 cm and a depth of 6.5 cm.
- the cryoheater tip was immersed into a depth of 4 cm from the water level and was held with a supporting device.
- the water container, together with the supporting device and the cryoheater were placed in a freezer (-20°C) for about 24 hours. After a complete freezing, the container with the cryoheater was removed from the freezer and the cryoheater was connected to the electrical circuit and activated.
- the temperature of the cryoheater outer surface was elevated from about -20°C up to 65°C within about 20 seconds.
- the ice which was in contact with the outer surface of the cryoheater, started to melt almost immediately.
- An unfrozen region (thawed ice) developed around the cryoheater, having a larger diameter near the cryoheater tip and narrower diameter near the ice surface.
- the diameter of melted ice near the ice surface reached 8 mm within 70 sec of activation of the cryoheater.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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AU95073/98A AU9507398A (en) | 1997-09-25 | 1998-09-23 | Method and apparatus for heating during cryosurgery |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US08/936,958 US5899897A (en) | 1996-09-26 | 1997-09-25 | Method and apparatus for heating during cryosurgery |
US08/936,958 | 1997-09-25 |
Publications (2)
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WO1999015092A1 WO1999015092A1 (en) | 1999-04-01 |
WO1999015092A9 true WO1999015092A9 (en) | 1999-06-03 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/020023 WO1999015092A1 (en) | 1997-09-25 | 1998-09-23 | Method and apparatus for heating during cryosurgery |
Country Status (3)
Country | Link |
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US (1) | US5899897A (en) |
AU (1) | AU9507398A (en) |
WO (1) | WO1999015092A1 (en) |
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1997
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-
1998
- 1998-09-23 WO PCT/US1998/020023 patent/WO1999015092A1/en active Application Filing
- 1998-09-23 AU AU95073/98A patent/AU9507398A/en not_active Abandoned
Also Published As
Publication number | Publication date |
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WO1999015092A1 (en) | 1999-04-01 |
AU9507398A (en) | 1999-04-12 |
US5899897A (en) | 1999-05-04 |
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