WO1999015539A3 - Pentopyranosyl-nucleosid, seine herstellung und verwendung - Google Patents

Pentopyranosyl-nucleosid, seine herstellung und verwendung Download PDF

Info

Publication number
WO1999015539A3
WO1999015539A3 PCT/EP1998/005997 EP9805997W WO9915539A3 WO 1999015539 A3 WO1999015539 A3 WO 1999015539A3 EP 9805997 W EP9805997 W EP 9805997W WO 9915539 A3 WO9915539 A3 WO 9915539A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
same
pentopyranosyl nucleoside
pentopyranosyl
nucleoside
Prior art date
Application number
PCT/EP1998/005997
Other languages
English (en)
French (fr)
Other versions
WO1999015539A2 (de
Inventor
Christian Miculka
Norbert Windhab
Tilmann Brandstetter
Gerhard Burdinski
Original Assignee
Aventis Res & Tech Gmbh & Co
Christian Miculka
Norbert Windhab
Tilmann Brandstetter
Gerhard Burdinski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Res & Tech Gmbh & Co, Christian Miculka, Norbert Windhab, Tilmann Brandstetter, Gerhard Burdinski filed Critical Aventis Res & Tech Gmbh & Co
Priority to AU10245/99A priority Critical patent/AU757983B2/en
Priority to DE59811296T priority patent/DE59811296D1/de
Priority to US09/509,058 priority patent/US6608186B1/en
Priority to AT98952610T priority patent/ATE265462T1/de
Priority to KR1020007003010A priority patent/KR100571299B1/ko
Priority to BR9812381-5A priority patent/BR9812381A/pt
Priority to CA002303229A priority patent/CA2303229C/en
Priority to JP2000512844A priority patent/JP4674964B2/ja
Priority to EP98952610A priority patent/EP1017703B1/de
Publication of WO1999015539A2 publication Critical patent/WO1999015539A2/de
Publication of WO1999015539A3 publication Critical patent/WO1999015539A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/724—Devices having flexible or movable element
    • Y10S977/727—Devices having flexible or movable element formed from biological material
    • Y10S977/728—Nucleic acids, e.g. DNA or RNA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/797—Lipid particle
    • Y10S977/798—Lipid particle having internalized material
    • Y10S977/799—Containing biological material
    • Y10S977/80—Nucleic acid, e.g. DNA or RNA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/832—Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
    • Y10S977/835—Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial
    • Y10S977/836—Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial having biological reactive capability
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/894—Manufacture, treatment, or detection of nanostructure having step or means utilizing biological growth
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/895—Manufacture, treatment, or detection of nanostructure having step or means utilizing chemical property
    • Y10S977/896—Chemical synthesis, e.g. chemical bonding or breaking
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/914—Protein engineering
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/925—Bioelectrical

Abstract

Die Erfindung betrifft ein Pentopyranosyl-Nucleosid der Formel (I) oder der Formel (II), deren Herstellung und Verwendung zur Herstellung eines Therapeutikums, Diagnostikums und/oder elektronischen Bauteils.
PCT/EP1998/005997 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung WO1999015539A2 (de)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU10245/99A AU757983B2 (en) 1997-09-22 1998-09-21 Pentopyranosyl nucleoside, and production and use of the same
DE59811296T DE59811296D1 (de) 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung
US09/509,058 US6608186B1 (en) 1997-09-22 1998-09-21 Pyranosyl nucleic acid conjugates
AT98952610T ATE265462T1 (de) 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung
KR1020007003010A KR100571299B1 (ko) 1997-09-22 1998-09-21 펜토피라노실 뉴클레오시드 및 이의 제조방법
BR9812381-5A BR9812381A (pt) 1997-09-22 1998-09-21 Peptopiranosilnucleosìdeo, seu preparo e uso
CA002303229A CA2303229C (en) 1997-09-22 1998-09-21 Pentopyranosylnucleoside, its preparation and use
JP2000512844A JP4674964B2 (ja) 1997-09-22 1998-09-21 ペントピラノシルヌクレオシド、その製造および使用
EP98952610A EP1017703B1 (de) 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19741715.9 1997-09-22
DE19741715A DE19741715A1 (de) 1997-09-22 1997-09-22 Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung

Publications (2)

Publication Number Publication Date
WO1999015539A2 WO1999015539A2 (de) 1999-04-01
WO1999015539A3 true WO1999015539A3 (de) 1999-06-17

Family

ID=7843183

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/EP1998/005998 WO1999015540A2 (de) 1997-09-22 1998-09-21 Verfahren zur herstellung eines pentopyranosyl-nucleosids
PCT/EP1998/005997 WO1999015539A2 (de) 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung
PCT/EP1998/005999 WO1999015541A2 (de) 1997-09-22 1998-09-21 Verwendung eines pentopyranosyl-nucleosids zur herstellung eines elektronischen bauteils sowie konjugate davon

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/005998 WO1999015540A2 (de) 1997-09-22 1998-09-21 Verfahren zur herstellung eines pentopyranosyl-nucleosids

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/005999 WO1999015541A2 (de) 1997-09-22 1998-09-21 Verwendung eines pentopyranosyl-nucleosids zur herstellung eines elektronischen bauteils sowie konjugate davon

Country Status (10)

Country Link
US (8) US6613894B1 (de)
EP (3) EP1019423B1 (de)
JP (3) JP4674964B2 (de)
KR (3) KR20010030656A (de)
AT (3) ATE233272T1 (de)
AU (3) AU1024699A (de)
BR (3) BR9812381A (de)
CA (3) CA2302414A1 (de)
DE (4) DE19741715A1 (de)
WO (3) WO1999015540A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19741739B4 (de) * 1997-09-22 2006-04-27 Nanogen Recognomics Gmbh Supramolekulares Paarungssystem, dessen Herstellung und Verwendung
DE19741738A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Linker-Nucleosid, seine Herstellung und Verwendung
DE19741715A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE19815901A1 (de) * 1998-04-08 1999-10-14 Aventis Res & Tech Gmbh & Co Verfahren zur Herstellung von Pentopyranosyl-Nucleosiden
DE19837387A1 (de) 1998-08-18 2000-02-24 Aventis Res & Tech Gmbh & Co 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung
US20010049111A1 (en) * 1999-08-13 2001-12-06 Norbert Windhab Methods, procedures, and formats for using microelectronic array devices to perform multiplex immunoassay analyses
DE10010118A1 (de) * 2000-03-03 2001-09-20 Henkel Kgaa Beschichtungssystem auf der Basis von Pyranosyl-Nukleinsäuren
DE10111681A1 (de) * 2001-03-09 2002-10-02 Nanogen Recognomics Gmbh Verbessertes Verfahren zur Herstellung von Pentopyranosyl-Nucleosiden
US6893822B2 (en) 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
AU2003219576A1 (en) * 2003-04-03 2004-10-25 Korea Advanced Institute Of Science And Technology Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof
CA2463719A1 (en) * 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Nucleotide analogs with six membered rings
US20070286863A1 (en) * 2006-05-17 2007-12-13 Christopher Sinal CMKLR regulation of adipogenesis and adipocyte metabolic function
JP5126706B2 (ja) * 2007-02-16 2013-01-23 独立行政法人農業・食品産業技術総合研究機構 ２以上の水酸基を有する化合物のライブラリー合成方法
SG171914A1 (en) 2008-12-02 2011-07-28 Chiralgen Ltd Method for the synthesis of phosphorus atom modified nucleic acids
KR101885383B1 (ko) 2009-07-06 2018-08-03 웨이브 라이프 사이언시스 리미티드 신규한 핵산 프로드러그 및 그의 사용 방법
EP2593892A1 (de) * 2010-07-16 2013-05-22 Elitech Holding B.V. Orthogonale nukleinsäureaffinitätspaare
JP5868324B2 (ja) 2010-09-24 2016-02-24 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ 不斉補助基
DK2734208T3 (en) 2011-07-19 2017-06-19 Wave Life Sciences Ltd PROCEDURES FOR SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS
CN104684923B (zh) 2012-07-13 2018-09-28 株式会社新日本科学 手性核酸佐剂
KR101850319B1 (ko) 2012-07-13 2018-04-20 웨이브 라이프 사이언시스 리미티드 비대칭 보조 그룹
CN104661664B (zh) 2012-07-13 2020-07-03 波涛生命科学有限公司 手性控制
WO2014175974A2 (en) 2013-03-13 2014-10-30 Elitech Holding B.V. Artificial nucleic acids
EP3095460A4 (de) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chirales nukleinsäureadjuvans mit antiallergischer wirkung und antiallergikum
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
SG10201912897UA (en) 2014-01-16 2020-02-27 Wave Life Sciences Ltd Chiral design
US10870845B2 (en) 2014-07-01 2020-12-22 Global Life Sciences Solutions Operations UK Ltd Methods for capturing nucleic acids
US10472620B2 (en) 2014-07-01 2019-11-12 General Electric Company Method, substrate and device for separating nucleic acids
US9593368B2 (en) 2014-07-01 2017-03-14 General Electric Company Methods for amplifying nucleic acids on substrates
CN107556355B (zh) * 2016-06-30 2021-10-22 上海兆维科技发展有限公司 一种核苷双亚磷酰胺及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57146796A (en) * 1981-03-09 1982-09-10 Haruo Ogura Glycoside derivative
WO1998025943A1 (de) * 1996-12-11 1998-06-18 Aventis Research & Technologies Gmbh & Co Kg Nicht-helikale supramolekulare nanosysteme

Family Cites Families (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2644817A (en) * 1949-10-28 1953-07-07 Merck & Co Inc 1-glycosido-5, 6 dimethyl benzimidazoles and process therefor
GB690119A (en) * 1950-07-13 1953-04-15 British Drug Houses Ltd Improvements in or relating to the manufacture of heterocyclic compounds
US2719843A (en) * 1951-10-24 1955-10-04 Davoll John Method of synthesizing nucleosides and analogous compounds and compounds prepared thereby
GB866815A (en) * 1957-06-14 1961-05-03 Pfizer & Co C Piperazine salts
US2993039A (en) * 1959-11-06 1961-07-18 Upjohn Co Preparing nu-glycosides of aldose and ketose sugars
US3658788A (en) * 1969-06-06 1972-04-25 Salk Inst For Biological Studi Aminooxazolines and products thereof and processes for synthesizing same
US3752804A (en) 1969-06-14 1973-08-14 Takeda Chemical Industries Ltd 2-allyloxyinosine-5'-phosphate and physiologically acceptable salts thereof
JPS5036087A (de) * 1973-07-13 1975-04-04
JPS5821005B2 (ja) * 1974-08-26 1983-04-26 株式会社クボタ 球状黒鉛鋳鉄製造における黒鉛球状化剤
US3995190A (en) * 1974-09-19 1976-11-30 Butler, Binion, Rice, Cook & Knapp Mobile ion film memory
US4283773A (en) * 1977-08-30 1981-08-11 Xerox Corporation Programmable master controller communicating with plural controllers
US4225410A (en) * 1978-12-04 1980-09-30 Technicon Instruments Corporation Integrated array of electrochemical sensors
JPS55153796A (en) * 1979-05-21 1980-11-29 Meiji Seika Kaisha Ltd 5-fluorouracil nucleoside and its preparation
US4352795A (en) 1981-01-29 1982-10-05 Warner-Lambert Company 7-β-D-Arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine compounds and methods for their production
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4476301A (en) * 1982-04-29 1984-10-09 Centre National De La Recherche Scientifique Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon
CA1223831A (en) * 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4580895A (en) * 1983-10-28 1986-04-08 Dynatech Laboratories, Incorporated Sample-scanning photometer
EP0143623A3 (de) * 1983-11-25 1987-09-23 Mars Incorporated Automatisches Prüfgerät
US4661451A (en) * 1984-02-06 1987-04-28 Ortho Diagnostic Systems, Inc. Methods for immobilizing and translocating biological cells
FI71768C (fi) 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
DE3434039A1 (de) * 1984-09-17 1986-03-27 Behringwerke Ag, 3550 Marburg Glycopeptide, verfahren zu ihrer herstellung und ihre verwendung
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
US4584075A (en) * 1984-11-26 1986-04-22 Ionics Incorporated Process and apparatus for electrically desorbing components selectively sorbed on an electrolytically conducting barrier
GB8432118D0 (en) 1984-12-19 1985-01-30 Malcolm A D B Sandwich hybridisation technique
US4594135A (en) * 1985-02-20 1986-06-10 Ionics Incorporated Process and apparatus for electrically desorbing components selectively sorbed on granules
US5096807A (en) * 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
JPH0337770Y2 (de) 1985-03-30 1991-08-09
DE3513168A1 (de) 1985-04-12 1986-10-16 Thomas 8000 München Dandekar Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren)
US4751177A (en) * 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays
US4816418A (en) * 1985-07-22 1989-03-28 Sequoia-Turner Corporation Method and apparatus for performing automated, multi-sequential immunoassays
EP0213825A3 (de) * 1985-08-22 1989-04-26 Molecular Devices Corporation Chemisch-modulierte Mehrfachkapazitanz
US4822566A (en) * 1985-11-19 1989-04-18 The Johns Hopkins University Optimized capacitive sensor for chemical analysis and measurement
EP0228075B1 (en) 1986-01-03 1991-04-03 Molecular Diagnostics, Inc. Eucaryotic genomic dna dot-blot hybridization method
US5242797A (en) * 1986-03-21 1993-09-07 Myron J. Block Nucleic acid assay method
US5125748A (en) * 1986-03-26 1992-06-30 Beckman Instruments, Inc. Optical detection module for use in an automated laboratory work station
FR2604438B1 (fr) * 1986-09-26 1988-12-23 Centre Nat Rech Scient Nouveaux conjugues de couplage entre des sequences d'arn ou d'adn et une proteine, leur procede de preparation et leur application biologique
US4918056A (en) * 1986-10-14 1990-04-17 Health Research, Inc. (Roswell Park Division) 2-substituted arabinopyranosyl nucleosides and nucleotides
ATE111083T1 (de) * 1986-10-22 1994-09-15 Abbott Lab Chemilumineszierende acridinium- und phenantridiniumsalze.
US4859538A (en) * 1986-11-20 1989-08-22 Ribi Hans O Novel lipid-protein compositions and articles and methods for their preparation
US4885211A (en) * 1987-02-11 1989-12-05 Eastman Kodak Company Electroluminescent device with improved cathode
YU57087A (en) 1987-04-01 1990-08-31 Centar Za Genticko Inzenjerstv Process for obtaining genome by hebridization and oligonucleotidic tests
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5114674A (en) 1987-05-01 1992-05-19 Biotronic Systems Corporation Added array of molecular chains for interfering with electrical fields
US4787963A (en) * 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
US5074977A (en) * 1987-05-05 1991-12-24 The Washington Technology Center Digital biosensors and method of using same
JP2682859B2 (ja) 1987-07-27 1997-11-26 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション レセプター膜
JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
KR970005898B1 (ko) 1987-09-21 1997-04-21 젠- 프로우브 인코퍼레이티드 뉴클레오티드 프로브에 대한 비-뉴클레오티드 연결시약
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5075077A (en) * 1988-08-02 1991-12-24 Abbott Laboratories Test card for performing assays
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
WO1990001564A1 (en) 1988-08-09 1990-02-22 Microprobe Corporation Methods for multiple target analyses through nucleic acid hybridization
WO1990002327A1 (en) * 1988-08-18 1990-03-08 AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE LTD., Commonwealth Scientific and Industrial Research Organization Improvements in sensitivity and selectivity of ion channel membrane biosensors
US5096669A (en) * 1988-09-15 1992-03-17 I-Stat Corporation Disposable sensing device for real time fluid analysis
US5849482A (en) * 1988-09-28 1998-12-15 Epoch Pharmaceuticals, Inc. Crosslinking oligonucleotides
US5063081A (en) * 1988-11-14 1991-11-05 I-Stat Corporation Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5391723A (en) * 1989-05-31 1995-02-21 Neorx Corporation Oligonucleotide conjugates
US5219726A (en) * 1989-06-02 1993-06-15 The Salk Institute For Biological Studies Physical mapping of complex genomes
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
DE3924454A1 (de) * 1989-07-24 1991-02-07 Cornelis P Prof Dr Hollenberg Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips)
US5681941A (en) * 1990-01-11 1997-10-28 Isis Pharmaceuticals, Inc. Substituted purines and oligonucleotide cross-linking
US5126022A (en) * 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5750015A (en) * 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
CA2079005A1 (en) * 1990-04-11 1991-10-12 Geoffrey Stephen Begg Methods and apparatus allowing sequential chemical reactions
US5166063A (en) * 1990-06-29 1992-11-24 Eli Lilly And Company Immobolization of biomolecules by enhanced electrophoretic precipitation
US5527670A (en) * 1990-09-12 1996-06-18 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
GB2247889A (en) 1990-09-12 1992-03-18 Scient Generics Ltd DNA denaturation by an electric potential
WO1992004470A1 (en) 1990-09-12 1992-03-19 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
US5227265A (en) * 1990-11-30 1993-07-13 Eastman Kodak Company Migration imaging system
US5679757A (en) 1990-12-12 1997-10-21 The Regents Of The University Of California Highly organic solvent soluble, water insoluble electroluminescent polyphenylene vinylenes having pendant steroid groups and products and uses thereof
WO1992019960A1 (en) * 1991-05-09 1992-11-12 Nanophore, Inc. Methods for the electrophoretic separation of nucleic acids and other linear macromolecules in gel media with restrictive pore diameters
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6048690A (en) 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5349203A (en) * 1991-12-09 1994-09-20 Mitsubishi Denki Kabushiki Kaisha Organic electric-field switching device
JPH05236997A (ja) * 1992-02-28 1993-09-17 Hitachi Ltd ポリヌクレオチド捕捉用チップ
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
GB9207086D0 (en) * 1992-03-31 1992-05-13 Sharp Kk Improvements relating to information technology
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
ATE256143T1 (de) * 1992-07-23 2003-12-15 Isis Pharmaceuticals Inc 2'-0-alkyl-nukleoside und-phosphoramidite, verfahren zu ihrer herstellung und ihre verwendungen
US5312527A (en) * 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
US5433819A (en) * 1993-05-26 1995-07-18 Pressac, Inc. Method of making circuit boards
CA2170264A1 (en) 1993-09-10 1995-03-16 Michael W. Konrad Optical detection of position of oligonucleotides on large dna molecules
US5965452A (en) 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US5445525A (en) * 1994-05-12 1995-08-29 Intel Corporation Interconnection scheme for integrated circuit card with auxiliary contacts
JPH10507763A (ja) * 1994-10-24 1998-07-28 ジェネンコア インターナショナル インコーポレーテッド Ｌ−ピラノシルヌクレオシド
US5718915A (en) * 1994-10-31 1998-02-17 Burstein Laboratories, Inc. Antiviral liposome having coupled target-binding moiety and hydrolytic enzyme
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5464517A (en) * 1995-01-30 1995-11-07 Bio-Rad Laboratories Electrophoresis in low conductivity buffers
US5559222A (en) * 1995-02-03 1996-09-24 Eli Lilly And Company Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
US5602262A (en) * 1995-02-03 1997-02-11 Eli Lilly And Company Process for the preparation of 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
PT739898E (pt) * 1995-03-13 2002-03-28 Aventis Pharma Gmbh Mono-esteres de acidos fosfonucleicos processo para a sua preparacao e sua utilizacao
WO1996039414A1 (en) * 1995-06-01 1996-12-12 Hybridon, Inc. Novel base protecting groups for oligonucleotide synthesis
KR19990028344A (ko) * 1995-06-23 1999-04-15 로버터 에이.커리 치료 화합물
AU6514096A (en) 1995-07-27 1997-02-26 Carsten Behrens A new achiral linker reagent for the incorporation of multiple amino groups into oligonucleotides
US5912340A (en) 1995-10-04 1999-06-15 Epoch Pharmaceuticals, Inc. Selective binding complementary oligonucleotides
AU7286696A (en) * 1995-10-13 1997-05-07 F. Hoffmann-La Roche Ag Antisense oligomers
JP2002515738A (ja) * 1996-01-23 2002-05-28 アフィメトリックス，インコーポレイティド 核酸分析法
GB9602028D0 (en) 1996-02-01 1996-04-03 Amersham Int Plc Nucleoside analogues
US5660701A (en) * 1996-02-29 1997-08-26 Bio-Rad Laboratories, Inc. Protein separations by capillary electrophoresis using amino acid-containing buffers
JPH10306907A (ja) * 1997-05-06 1998-11-17 Kobe Steel Ltd 流動層熱分解方法及び熱分解炉並びに被燃焼物処理装置
ID24054A (id) * 1997-06-10 2000-07-06 Glaxo Group Ltd Glaxo Turunan turunan benzimidazol
DE19741715A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE19741738A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Linker-Nucleosid, seine Herstellung und Verwendung
CA2381750A1 (en) * 1999-08-13 2001-02-22 Nanogen, Inc. Microelectronic molecular descriptor array devices, methods, procedures, and formats for combinatorial selection of intermolecular ligand binding structures and for drug screening

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57146796A (en) * 1981-03-09 1982-09-10 Haruo Ogura Glycoside derivative
WO1998025943A1 (de) * 1996-12-11 1998-06-18 Aventis Research & Technologies Gmbh & Co Kg Nicht-helikale supramolekulare nanosysteme

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
B.DOBOSZEWSKI ET AL.: "Synthesis of 3'-Deoxy-3'-C-Hydroxymethyl-aldopentopyranosyl Nucleosides and their Incorporation into Oligonucleotides. Part II.", TETRAHEDRON, vol. 51, no. 45, 1995, pages 12319 - 12336, XP002096831 *
CHEMICAL ABSTRACTS, vol. 98, no. 13, 28 March 1983, Columbus, Ohio, US; abstract no. 107682z, H.OGURA: "Glucoside Derivatives." page 636; column 2; XP002097208 *
I.SCHLÖNVOGT ET AL.: "188. Pyranosyl-RNA ('p-RNA'): NMR and Molecular Dynamics Study of the DUplex Formed by Self-Pairing of Ribopyranosyl-(C-G-A-A-T-T-C-G)", HELVETICA CHIMICA ACTA., vol. 79, no. 8, 1996, BASEL CH, pages 2316 - 2345, XP002096829 *
J.A.KELLEY ET AL.: "Furanose-pyranose Isomerization of Reduced Pyrimidine and Cyclic Urea Ribosides.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 29, no. 11, November 1986 (1986-11-01), WASHINGTON US, pages 2351 - 2358, XP002097206 *
M.BÖHRINGER ET AL.: "110. Warum Pentose- und Nicht Hexose-Nucleinsäuren ? Oligonucleotide aus 2',3'-Dideoxy-B-D-glucopyranosyl-Bausteinen ('Homo-DNS'): Hersellung.", HELVETICA CHIMICA ACTA., vol. 75, no. 5, 13 August 1992 (1992-08-13), BASEL CH, pages 1416 - 1477, XP002096856 *
M.BOLLI ET AL.: "131. Pyranosyl-RNA : Further Observations on Replication.", HELVETICA CHIMICA ACTA., vol. 80, no. 6, 22 September 1997 (1997-09-22), BASEL CH, pages 1901 - 1951, XP002096832 *
M.MELGUIZO ET AL.: "A New One-Step Synthesis of 8-Aminopurines Nucleoside Analogs from 6-(glycosylamino)-5-nitrosopyrimidines.", JOURNAL OF ORGANIC CHEMISTRY., vol. 57, no. 2, 1992, EASTON US, pages 559 - 565, XP002097207 *
S.PITSCH ET AL.: "122. Pyranosyl-RNA ('p-RNA'): Base-Pairing Selectivity and Potential to Replicate.", HELVETICA CHIMICA ACTA., vol. 78, no. 7, 1995, BASEL CH, pages 1621 - 1635, XP002096830 *
S.PITSCH ET AL.: "147. Why Pentose- and Not Hexose-Nucleic Acids ? Pyranosyl-RNA ('p-RNA')", HELVETICA CHIMICA ACTA., vol. 76, no. 6, 1993, BASEL CH, pages 2161 - 2183, XP002094190 *

Also Published As

Publication number Publication date
AU757983B2 (en) 2003-03-13
ATE265462T1 (de) 2004-05-15
DE59807330D1 (de) 2003-04-03
KR20010030659A (ko) 2001-04-16
EP1017703B1 (de) 2004-04-28
KR20010030656A (ko) 2001-04-16
CA2303229A1 (en) 1999-04-01
JP4674964B2 (ja) 2011-04-20
JP2001517675A (ja) 2001-10-09
US20040198966A1 (en) 2004-10-07
US20050053945A1 (en) 2005-03-10
EP1017703A2 (de) 2000-07-12
US7501506B2 (en) 2009-03-10
US20060270840A1 (en) 2006-11-30
EP1019423B1 (de) 2003-02-26
JP4601817B2 (ja) 2010-12-22
AU751058B2 (en) 2002-08-08
CA2302414A1 (en) 1999-04-01
EP1017704B1 (de) 2004-02-25
KR100571299B1 (ko) 2006-04-17
EP1019423A2 (de) 2000-07-19
BR9812381A (pt) 2002-04-30
BR9812501A (pt) 2000-12-12
ATE260290T1 (de) 2004-03-15
US7153955B2 (en) 2006-12-26
KR20010024202A (ko) 2001-03-26
WO1999015539A2 (de) 1999-04-01
WO1999015541A3 (de) 1999-06-17
AU9627198A (en) 1999-04-12
US7777024B2 (en) 2010-08-17
DE19741715A1 (de) 1999-03-25
DE59810856D1 (de) 2004-04-01
WO1999015540A3 (de) 1999-06-10
WO1999015540A2 (de) 1999-04-01
EP1017704A2 (de) 2000-07-12
US6506896B1 (en) 2003-01-14
JP4674965B2 (ja) 2011-04-20
JP2001517676A (ja) 2001-10-09
WO1999015541A2 (de) 1999-04-01
AU1024599A (en) 1999-04-12
US20090221793A1 (en) 2009-09-03
US20030039997A1 (en) 2003-02-27
JP2001517674A (ja) 2001-10-09
CA2303784A1 (en) 1999-04-01
US6613894B1 (en) 2003-09-02
BR9812376A (pt) 2000-12-12
DE59811296D1 (de) 2004-06-03
US6608186B1 (en) 2003-08-19
ATE233272T1 (de) 2003-03-15
CA2303229C (en) 2009-12-01
AU1024699A (en) 1999-04-12

Similar Documents

Publication Publication Date Title
WO1999015539A3 (de) Pentopyranosyl-nucleosid, seine herstellung und verwendung
EP1145479A3 (de) Bidirektionale, anonyme, elektronische transactionen
CA2352505A1 (en) Epothilone derivatives and their use as antitumor agents
AU5130299A (en) Wrist-mounted i.v. administration set
WO2000015211A3 (en) Compositions of chromium or vanadium with antidiabetics for glucose metabolism disorders
EP1193270A3 (de) Pyrrolobenzodiazepine
AU3553099A (en) Integrated apparatus for interfacing several computers to the internet through asingle connection
MXPA03003870A (es) Terapia de combinacion que comprende agentes antidiabeticos y anticonvulsionantes.
SG116443A1 (en) Wiring and method of manufacturing the same, and wiring board and method of manufacturing the same.
WO2002054321A8 (en) Anonymous electronic transactions
AU1392900A (en) 2,5-diazabicyclo(2.2.1)heptane derivatives, their preparation and therapeutic uses
WO2000064930A3 (en) Tribonectins
CA2388476A1 (en) Bicyclic imidazo-5-yl-amine derivatives
EP0643943A3 (de) Elektronisches Sphygmomanometer.
AU9313198A (en) Gas generant compositions, methods of production of the same and devices made therefrom
AU1749600A (en) Therapeutic and diagnostic tools for impaired glucose tolerance conditions
WO1999054315A3 (de) Triazolone mit neuroprotektiver wirkung
HUP9802634A3 (en) Use of benzimidazoles for the manufacture of pharmaceutical compositions for the treatment of leukemia
AU7504396A (en) Electronic spirometer
AU1497395A (en) Electronic game utilizing bio-signals
AU3896899A (en) Compositions for the treatment of tumors, and uses thereof
GC0000142A (en) An inhibitor of the formation of soluble human cd23.
AU2001277737A1 (en) Novel substance having physiological activity, process for producing the same, and use
CA2445620A1 (en) Tetracyclic compounds as pde5-inhibitors
AU2433100A (en) Methods and compositions for the fixation of trace amounts of radiocaesium

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU BR CA JP KR US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AU BR CA JP KR US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2303229

Country of ref document: CA

Ref country code: CA

Ref document number: 2303229

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 10245/99

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1020007003010

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 1998952610

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1998952610

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 09509058

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1020007003010

Country of ref document: KR

WWG Wipo information: grant in national office

Ref document number: 10245/99

Country of ref document: AU

WWG Wipo information: grant in national office

Ref document number: 1998952610

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1020007003010

Country of ref document: KR