WO1999015539A3 - Pentopyranosyl-nucleosid, seine herstellung und verwendung - Google Patents

Pentopyranosyl-nucleosid, seine herstellung und verwendung Download PDF

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Publication number
WO1999015539A3
WO1999015539A3 PCT/EP1998/005997 EP9805997W WO9915539A3 WO 1999015539 A3 WO1999015539 A3 WO 1999015539A3 EP 9805997 W EP9805997 W EP 9805997W WO 9915539 A3 WO9915539 A3 WO 9915539A3
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WO
WIPO (PCT)
Prior art keywords
production
same
pentopyranosyl nucleoside
pentopyranosyl
nucleoside
Prior art date
Application number
PCT/EP1998/005997
Other languages
English (en)
French (fr)
Other versions
WO1999015539A2 (de
Inventor
Christian Miculka
Norbert Windhab
Tilmann Brandstetter
Gerhard Burdinski
Original Assignee
Aventis Res & Tech Gmbh & Co
Christian Miculka
Norbert Windhab
Tilmann Brandstetter
Gerhard Burdinski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Res & Tech Gmbh & Co, Christian Miculka, Norbert Windhab, Tilmann Brandstetter, Gerhard Burdinski filed Critical Aventis Res & Tech Gmbh & Co
Priority to US09/509,058 priority Critical patent/US6608186B1/en
Priority to DE59811296T priority patent/DE59811296D1/de
Priority to KR1020007003010A priority patent/KR100571299B1/ko
Priority to AT98952610T priority patent/ATE265462T1/de
Priority to JP2000512844A priority patent/JP4674964B2/ja
Priority to CA002303229A priority patent/CA2303229C/en
Priority to BR9812381-5A priority patent/BR9812381A/pt
Priority to EP98952610A priority patent/EP1017703B1/de
Priority to AU10245/99A priority patent/AU757983B2/en
Publication of WO1999015539A2 publication Critical patent/WO1999015539A2/de
Publication of WO1999015539A3 publication Critical patent/WO1999015539A3/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/724—Devices having flexible or movable element
    • Y10S977/727—Devices having flexible or movable element formed from biological material
    • Y10S977/728—Nucleic acids, e.g. DNA or RNA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/797—Lipid particle
    • Y10S977/798—Lipid particle having internalized material
    • Y10S977/799—Containing biological material
    • Y10S977/80—Nucleic acid, e.g. DNA or RNA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10S977/832—Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
    • Y10S977/835—Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial
    • Y10S977/836—Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial having biological reactive capability
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/894—Manufacture, treatment, or detection of nanostructure having step or means utilizing biological growth
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/895—Manufacture, treatment, or detection of nanostructure having step or means utilizing chemical property
    • Y10S977/896—Chemical synthesis, e.g. chemical bonding or breaking
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S977/915—Therapeutic or pharmaceutical composition
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    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
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Abstract

Die Erfindung betrifft ein Pentopyranosyl-Nucleosid der Formel (I) oder der Formel (II), deren Herstellung und Verwendung zur Herstellung eines Therapeutikums, Diagnostikums und/oder elektronischen Bauteils.
PCT/EP1998/005997 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung WO1999015539A2 (de)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US09/509,058 US6608186B1 (en) 1997-09-22 1998-09-21 Pyranosyl nucleic acid conjugates
DE59811296T DE59811296D1 (de) 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung
KR1020007003010A KR100571299B1 (ko) 1997-09-22 1998-09-21 펜토피라노실 뉴클레오시드 및 이의 제조방법
AT98952610T ATE265462T1 (de) 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung
JP2000512844A JP4674964B2 (ja) 1997-09-22 1998-09-21 ペントピラノシルヌクレオシド、その製造および使用
CA002303229A CA2303229C (en) 1997-09-22 1998-09-21 Pentopyranosylnucleoside, its preparation and use
BR9812381-5A BR9812381A (pt) 1997-09-22 1998-09-21 Peptopiranosilnucleosìdeo, seu preparo e uso
EP98952610A EP1017703B1 (de) 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung
AU10245/99A AU757983B2 (en) 1997-09-22 1998-09-21 Pentopyranosyl nucleoside, and production and use of the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19741715A DE19741715A1 (de) 1997-09-22 1997-09-22 Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE19741715.9 1997-09-22

Publications (2)

Publication Number Publication Date
WO1999015539A2 WO1999015539A2 (de) 1999-04-01
WO1999015539A3 true WO1999015539A3 (de) 1999-06-17

Family

ID=7843183

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/EP1998/005997 WO1999015539A2 (de) 1997-09-22 1998-09-21 Pentopyranosyl-nucleosid, seine herstellung und verwendung
PCT/EP1998/005998 WO1999015540A2 (de) 1997-09-22 1998-09-21 Verfahren zur herstellung eines pentopyranosyl-nucleosids
PCT/EP1998/005999 WO1999015541A2 (de) 1997-09-22 1998-09-21 Verwendung eines pentopyranosyl-nucleosids zur herstellung eines elektronischen bauteils sowie konjugate davon

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/EP1998/005998 WO1999015540A2 (de) 1997-09-22 1998-09-21 Verfahren zur herstellung eines pentopyranosyl-nucleosids
PCT/EP1998/005999 WO1999015541A2 (de) 1997-09-22 1998-09-21 Verwendung eines pentopyranosyl-nucleosids zur herstellung eines elektronischen bauteils sowie konjugate davon

Country Status (10)

Country Link
US (8) US6506896B1 (de)
EP (3) EP1019423B1 (de)
JP (3) JP4674964B2 (de)
KR (3) KR20010024202A (de)
AT (3) ATE265462T1 (de)
AU (3) AU757983B2 (de)
BR (3) BR9812501A (de)
CA (3) CA2302414A1 (de)
DE (4) DE19741715A1 (de)
WO (3) WO1999015539A2 (de)

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