WO1999016419A1 - Perforated microparticles and methods of use - Google Patents
Perforated microparticles and methods of use Download PDFInfo
- Publication number
- WO1999016419A1 WO1999016419A1 PCT/US1998/020602 US9820602W WO9916419A1 WO 1999016419 A1 WO1999016419 A1 WO 1999016419A1 US 9820602 W US9820602 W US 9820602W WO 9916419 A1 WO9916419 A1 WO 9916419A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- powder
- perforated
- perforated microstructures
- particles
- agents
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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- A—HUMAN NECESSITIES
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- A61P27/16—Otologicals
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nanotechnology (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Anesthesiology (AREA)
- Diabetes (AREA)
- Inorganic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Optics & Photonics (AREA)
Abstract
Description
Claims
Priority Applications (36)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA200000375A EA002562B1 (en) | 1997-09-29 | 1998-09-29 | Perforated microparticles and methods of use |
AU10644/99A AU757337C (en) | 1997-09-29 | 1998-09-29 | Perforated microparticles and methods of use |
KR1020007003367A KR100589926B1 (en) | 1997-09-29 | 1998-09-29 | Perforated microparticles and method of use |
EEP200000194A EE04628B1 (en) | 1997-09-29 | 1998-09-29 | Powder with Perforated Microstructures and Method for Preparing a Microparticle Composition and Powder with Perforated Microstructures |
DE69813853T DE69813853T3 (en) | 1997-09-29 | 1998-09-29 | PERFORATED MICROTEILS AND THEIR USE |
ES98953220T ES2195408T5 (en) | 1997-09-29 | 1998-09-29 | DUST FORMATION PROCEDURE THAT INCLUDES PERFORATED MICROPARTS. |
BR9812693-8A BR9812693A (en) | 1997-09-29 | 1998-09-29 | Use of a bioactive agent, process to form a perforated microstructure, perforated microstructure, process to increase the dispersibility of a powder, perforated microstructure powder, powder having increased dispersibility, inhalation system for the pulmonary administration of a bioactive agent to a patient, and, process for the pulmonary release of one or more bioactive agents |
CA002304819A CA2304819C (en) | 1997-09-29 | 1998-09-29 | Perforated microparticles and methods of use |
SK449-2000A SK285068B6 (en) | 1997-09-29 | 1998-09-29 | Powder composition, microspheres, method for forming a particulate composition comprising perforated microstructures by spray drying and method for forming powder comprising perforated microstructures by spray drying |
MEP-2008-41A ME00003B (en) | 1997-09-29 | 1998-09-29 | Perforated microparticles and methods of use |
IL13512698A IL135126A0 (en) | 1997-09-29 | 1998-09-29 | Perforated microparticles and methods of use and preparation thereof |
JP2000513557A JP5372306B2 (en) | 1997-09-29 | 1998-09-29 | Porous fine particles and method of use |
MEP-41/08A MEP4108A (en) | 1997-09-29 | 1998-09-29 | Perforated microparticles and methods of use |
PL98339732A PL195212B1 (en) | 1997-09-29 | 1998-09-29 | Perforated microparticles and method of using them |
NZ503464A NZ503464A (en) | 1997-09-29 | 1998-09-29 | Perforated microparticles containing a bioactive agent for pulmonary delivery |
DK98953220.5T DK1019022T4 (en) | 1997-09-29 | 1998-09-29 | Perforated microparticles and their method of use |
EP98953220A EP1019022B2 (en) | 1997-09-29 | 1998-09-29 | Method for forming a powder comprising perforated microparticles |
AT98953220T ATE238035T1 (en) | 1997-09-29 | 1998-09-29 | PERFORATED MICROPARTICLES AND USE THEREOF |
US09/219,736 US6565885B1 (en) | 1997-09-29 | 1998-12-22 | Methods of spray drying pharmaceutical compositions |
JP2000556800A JP2003535017A (en) | 1998-06-29 | 1999-03-31 | Particulate delivery systems and methods of use |
AU35469/99A AU760537B2 (en) | 1998-06-29 | 1999-03-31 | Particulate delivery systems and methods of use |
KR1020007015026A KR100796220B1 (en) | 1998-06-29 | 1999-03-31 | Particulate delivery systems and methods of use |
CA002335940A CA2335940A1 (en) | 1998-06-29 | 1999-03-31 | Particulate delivery systems and methods of use |
EP99917320A EP1091755A1 (en) | 1998-06-29 | 1999-03-31 | Particulate delivery systems and methods of use |
IL135126A IL135126A (en) | 1997-09-29 | 2000-03-16 | Perforated microparticles and methods of use and preparation thereof |
IS5415A IS2154B (en) | 1997-09-29 | 2000-03-24 | Perforated cleansers and methods for their use |
NO20001618A NO340149B1 (en) | 1997-09-29 | 2000-03-28 | Perforated microparticles and method of use thereof |
HR20000175A HRP20000175B1 (en) | 1997-09-29 | 2000-03-28 | Perforated microparticles and methods of use |
HK01100524A HK1031680A1 (en) | 1997-09-29 | 2001-01-19 | Perforated microparticles and methods of use |
US09/886,296 US8168223B1 (en) | 1997-09-29 | 2001-06-21 | Engineered particles and methods of use |
US10/096,780 US7306787B2 (en) | 1997-09-29 | 2002-03-12 | Engineered particles and methods of use |
US10/612,393 US20050074498A1 (en) | 1997-09-29 | 2003-07-03 | Engineered particles and methods of use |
US10/616,448 US20040105820A1 (en) | 1997-09-29 | 2003-07-08 | Phospholipid-based powders for inhalation |
US11/317,523 US20060159629A1 (en) | 1997-09-29 | 2005-12-22 | Pulmonary delivery particles with phospholipid structural matrix |
US11/317,839 US20060165606A1 (en) | 1997-09-29 | 2005-12-22 | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US12/774,540 US9554993B2 (en) | 1997-09-29 | 2010-05-05 | Pulmonary delivery particles comprising an active agent |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6033797P | 1997-09-29 | 1997-09-29 | |
US60/060,337 | 1997-09-29 | ||
US10693298A | 1998-06-29 | 1998-06-29 | |
US09/106,932 | 1998-06-29 | ||
US13384898A | 1998-08-14 | 1998-08-14 | |
US09/133,848 | 1998-08-14 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13384898A Continuation-In-Part | 1997-09-29 | 1998-08-14 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/219,736 Continuation US6565885B1 (en) | 1997-09-29 | 1998-12-22 | Methods of spray drying pharmaceutical compositions |
US10/096,780 Continuation US7306787B2 (en) | 1997-09-29 | 2002-03-12 | Engineered particles and methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999016419A1 true WO1999016419A1 (en) | 1999-04-08 |
WO1999016419A9 WO1999016419A9 (en) | 1999-08-19 |
Family
ID=27369827
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/020602 WO1999016419A1 (en) | 1997-09-29 | 1998-09-29 | Perforated microparticles and methods of use |
PCT/US1998/020613 WO1999016421A1 (en) | 1997-09-29 | 1998-09-29 | Stabilized bioactive preparations and methods of use |
PCT/US1998/020615 WO1999016422A1 (en) | 1997-09-29 | 1998-09-29 | Stabilized preparations for use in metered dose inhalers |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/020613 WO1999016421A1 (en) | 1997-09-29 | 1998-09-29 | Stabilized bioactive preparations and methods of use |
PCT/US1998/020615 WO1999016422A1 (en) | 1997-09-29 | 1998-09-29 | Stabilized preparations for use in metered dose inhalers |
Country Status (28)
Country | Link |
---|---|
EP (4) | EP1019021B2 (en) |
JP (9) | JP2001517692A (en) |
KR (4) | KR100589926B1 (en) |
CN (1) | CN1169520C (en) |
AT (3) | ATE248583T1 (en) |
AU (4) | AU750567B2 (en) |
BG (1) | BG64816B1 (en) |
BR (1) | BR9812693A (en) |
CA (4) | CA2304973C (en) |
CZ (1) | CZ300758B6 (en) |
DE (2) | DE69813853T3 (en) |
DK (2) | DK1019021T4 (en) |
EA (2) | EA003665B1 (en) |
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