WO1999016475A3 - Process for preparing biologically compatible polymers and their use in medical devices - Google Patents
Process for preparing biologically compatible polymers and their use in medical devices Download PDFInfo
- Publication number
- WO1999016475A3 WO1999016475A3 PCT/IB1998/001622 IB9801622W WO9916475A3 WO 1999016475 A3 WO1999016475 A3 WO 1999016475A3 IB 9801622 W IB9801622 W IB 9801622W WO 9916475 A3 WO9916475 A3 WO 9916475A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pharmacologic
- polymer
- chemically bonded
- materials
- medical devices
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0047—Enzymes, e.g. urokinase, streptokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S524/916—Hydrogel compositions
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU92788/98A AU9278898A (en) | 1997-10-01 | 1998-10-01 | Process for preparing biologically compatible polymers and their use in medical devices |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/942,571 | 1997-10-01 | ||
US08/942,571 US5945457A (en) | 1997-10-01 | 1997-10-01 | Process for preparing biologically compatible polymers and their use in medical devices |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999016475A2 WO1999016475A2 (en) | 1999-04-08 |
WO1999016475A3 true WO1999016475A3 (en) | 1999-09-02 |
Family
ID=25478292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB1998/001622 WO1999016475A2 (en) | 1997-10-01 | 1998-10-01 | Process for preparing biologically compatible polymers and their use in medical devices |
Country Status (3)
Country | Link |
---|---|
US (1) | US5945457A (en) |
AU (1) | AU9278898A (en) |
WO (1) | WO1999016475A2 (en) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6562781B1 (en) | 1995-11-30 | 2003-05-13 | Hamilton Civic Hospitals Research Development Inc. | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
US7045585B2 (en) * | 1995-11-30 | 2006-05-16 | Hamilton Civic Hospital Research Development Inc. | Methods of coating a device using anti-thrombin heparin |
US6491965B1 (en) | 1995-11-30 | 2002-12-10 | Hamilton Civic Hospitals Research Development, Inc. | Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
US7034061B1 (en) * | 1996-04-30 | 2006-04-25 | Ajay Kumar Luthra | Non-thrombogenic and anti-thrombogenic polymers |
US7060469B2 (en) * | 1998-04-02 | 2006-06-13 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
KR19990085365A (en) * | 1998-05-16 | 1999-12-06 | 허영섭 | Biodegradable polymer microspheres capable of continuously controlled controlled release and preparation method thereof |
US6596401B1 (en) * | 1998-11-10 | 2003-07-22 | C. R. Bard Inc. | Silane copolymer compositions containing active agents |
JP2002529064A (en) | 1998-11-11 | 2002-09-10 | ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ オクラホマ | Polymer grafting with polysaccharide synthase |
US20060105431A1 (en) * | 1998-11-11 | 2006-05-18 | Deangelis Paul L | Polymer grafting by polysaccharide synthases using artificial sugar acceptors |
US6958212B1 (en) * | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
US6143354A (en) * | 1999-02-08 | 2000-11-07 | Medtronic Inc. | One-step method for attachment of biomolecules to substrate surfaces |
US7642071B2 (en) | 1999-04-01 | 2010-01-05 | The Board Of Regents Of The University Of Oklahoma | Methods of expressing gram-negative glycosaminoglycan synthase genes in gram-positive hosts |
WO2000062630A1 (en) | 1999-04-16 | 2000-10-26 | Wm. Marsh Rice University | Functionalized poly(propylene fumarate) and poly(propylene fumarate-co-ethylene glycol) |
US7534589B2 (en) * | 1999-11-10 | 2009-05-19 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
CN100506293C (en) * | 2000-03-15 | 2009-07-01 | 祥丰医疗有限公司 | Coating that promotes endothelial Cell adherence |
US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
US20030229393A1 (en) * | 2001-03-15 | 2003-12-11 | Kutryk Michael J. B. | Medical device with coating that promotes cell adherence and differentiation |
US20070141107A1 (en) * | 2000-03-15 | 2007-06-21 | Orbusneich Medical, Inc. | Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device |
US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
US8460367B2 (en) * | 2000-03-15 | 2013-06-11 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
US20070055367A1 (en) * | 2000-03-15 | 2007-03-08 | Orbus Medical Technologies, Inc. | Medical device with coating that promotes endothelial cell adherence and differentiation |
US6884778B2 (en) * | 2000-04-14 | 2005-04-26 | William Marsh Rice University | Biocompatible macromers |
US7291673B2 (en) * | 2000-06-02 | 2007-11-06 | Eidgenossiche Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
MXPA02011891A (en) * | 2000-06-02 | 2004-04-02 | Eidgenoess Tech Hochschule | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds. |
USRE44145E1 (en) | 2000-07-07 | 2013-04-09 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
AU2002245205B2 (en) * | 2000-10-19 | 2007-07-19 | Ecole Polytechnique Federale De Lausanne | Block copolymers for multifunctional self-assembled systems |
US6433061B1 (en) | 2000-10-24 | 2002-08-13 | Noveon Ip Holdings Corp. | Rheology modifying copolymer composition |
US6630460B2 (en) | 2001-02-09 | 2003-10-07 | Medtronic, Inc. | Heparin compositions and methods of making and using the same |
MXPA03008498A (en) * | 2001-03-20 | 2005-06-30 | Univ Zuerich | Two-phase processing of thermosensitive polymers for use as biomaterials. |
US20030235549A1 (en) * | 2001-05-01 | 2003-12-25 | Parminder Singh | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
RU2276998C2 (en) | 2001-05-01 | 2006-05-27 | Институт Нефтехимического Синтеза Имени А.В. Топчиева Российской Академии Наук | Hydrogel compositions |
RU2286801C2 (en) | 2001-05-01 | 2006-11-10 | Институт Нефтехимического Синтеза Имени А.В. Топчиева Российской Академии Наук | Water-absorbing biphase bioadhesive compositions |
US8206738B2 (en) * | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
US20050113510A1 (en) | 2001-05-01 | 2005-05-26 | Feldstein Mikhail M. | Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components |
US8840918B2 (en) * | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
US8541021B2 (en) * | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
AU2008201268B2 (en) * | 2001-05-01 | 2010-09-16 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel composition |
US8101196B2 (en) * | 2001-06-26 | 2012-01-24 | Biointeractions, Ltd. | Polysaccharide biomaterials and methods of use thereof |
US6852776B2 (en) * | 2001-07-10 | 2005-02-08 | Microban Products Company | Antimicrobial concentrates containing non-yellowing agents |
US7629388B2 (en) * | 2001-11-20 | 2009-12-08 | William Marsh Rice University | Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion |
US20030179692A1 (en) * | 2002-03-19 | 2003-09-25 | Yoshitaka Ohotomo | Storage medium |
US6968234B2 (en) * | 2002-04-25 | 2005-11-22 | Medtronic, Inc. | Implantable medical device having biologically active polymeric casing |
BR0309976A (en) * | 2002-05-13 | 2005-03-01 | Becton Dickinson Co | Protease Inhibitor Sample Collection System |
WO2003104402A2 (en) * | 2002-06-06 | 2003-12-18 | The Brigham And Women's Hospital, Inc. | Non-polymeric hematopoietic cell clots for delivery of active agents |
US7981862B2 (en) | 2003-08-19 | 2011-07-19 | Biosurface Engineering Technologies, Inc. | Composition comprising BMP-2 amplifier/co-activator for enhancement of osteogenesis |
US7598224B2 (en) | 2002-08-20 | 2009-10-06 | Biosurface Engineering Technologies, Inc. | Dual chain synthetic heparin-binding growth factor analogs |
US8227411B2 (en) * | 2002-08-20 | 2012-07-24 | BioSurface Engineering Technologies, Incle | FGF growth factor analogs |
JP2006502415A (en) * | 2002-10-10 | 2006-01-19 | ベクトン・ディキンソン・アンド・カンパニー | Sample collection system with caspase inhibitor |
US6884829B2 (en) * | 2002-10-18 | 2005-04-26 | Robert L. Albright | Hemocompatible coated polymer and related one-step methods |
US7112620B2 (en) | 2002-10-18 | 2006-09-26 | Albright Robert L | Hemocompatible polymer systems & related methods |
US7629049B2 (en) * | 2002-10-18 | 2009-12-08 | Medasorb, Inc. | Hemocompatible polymer systems and related devices |
US7351430B2 (en) * | 2002-11-06 | 2008-04-01 | Uluru Inc. | Shape-retentive hydrogel particle aggregates and their uses |
US7811605B2 (en) * | 2002-11-06 | 2010-10-12 | Uluru Inc. | Method of formation of shape-retentive aggregates of gel particles and their uses |
US7597903B2 (en) * | 2002-12-02 | 2009-10-06 | Shenkar College Of Engineering And Design | Method and composition for producing catheters with antibacterial property |
US7468210B1 (en) | 2002-12-10 | 2008-12-23 | Biosurface Engineering Technologies, Inc. | Cross-linked heparin coatings and methods |
WO2004056343A1 (en) | 2002-12-19 | 2004-07-08 | Polymorfix, Inc. | Ingestible formulations for transient, noninvasive reduction of gastric volume |
US6818709B1 (en) * | 2003-07-11 | 2004-11-16 | Celanese International Corporation | Production of vinyl alcohol copolymers |
US8466243B2 (en) | 2003-07-11 | 2013-06-18 | Sekisui Specialty Chemicals America, Llc | Vinyl alcohol copolymers for use in aqueous dispersions and melt extruded articles |
US20050124965A1 (en) * | 2003-12-08 | 2005-06-09 | Becton, Dickinson And Company | Phosphatase inhibitor sample collection system |
CN102764247B (en) | 2004-01-30 | 2016-04-20 | 考里安国际公司 | The rapidly dissolving film of active agent delivery |
US20080227696A1 (en) * | 2005-02-22 | 2008-09-18 | Biosurface Engineering Technologies, Inc. | Single branch heparin-binding growth factor analogs |
JP4895826B2 (en) * | 2004-02-20 | 2012-03-14 | バイオサーフェス エンジニアリング テクノロジーズ,インク. | Bone morphogenetic protein-2 positive modulator |
KR20070008714A (en) | 2004-04-30 | 2007-01-17 | 오르버스네이치 메디칼 인코포레이티드 | Medical device with coating for capturing genetically-altered cells and methods of using same |
AU2005271259B2 (en) | 2004-08-05 | 2012-01-19 | A.V. Topchiev Institute Of Petrochemical Synthesis | Adhesive composition |
US20060159650A1 (en) * | 2005-01-14 | 2006-07-20 | Bacterin, Inc. | Composition and method for covalently coupling an antithrombotic substance and a hydrophilic polymer |
WO2007008300A2 (en) * | 2005-05-31 | 2007-01-18 | ECOLE POLYTECHNIQUE FéDéRALE DE LAUSANNE | Triblock copolymers for cytoplasmic delivery of gene-based drugs |
US7812098B2 (en) * | 2006-03-31 | 2010-10-12 | Depuy Products, Inc. | Bearing material of medical implant having reduced wear rate and method for reducing wear rate |
US8092818B2 (en) * | 2006-05-17 | 2012-01-10 | Boston Scientific Scimed, Inc. | Medical devices having bioactive surfaces |
US7820172B1 (en) | 2006-06-01 | 2010-10-26 | Biosurface Engineering Technologies, Inc. | Laminin-derived multi-domain peptides |
ES2350708T3 (en) * | 2006-08-25 | 2011-01-26 | Depuy Products, Inc. | MEDICAL IMPLANT SUPPORT MATERIAL. |
US7910135B2 (en) * | 2006-10-13 | 2011-03-22 | Uluru Inc. | Hydrogel wound dressing and biomaterials formed in situ and their uses |
US9604196B2 (en) | 2006-11-20 | 2017-03-28 | Cytosorbent, Inc. | Size-selective hemocompatible polymer system |
US20090246155A1 (en) * | 2006-12-05 | 2009-10-01 | Landec Corporation | Compositions and methods for personal care |
EP2500015A1 (en) * | 2006-12-05 | 2012-09-19 | Landec Corporation | Delivery of drugs |
US8399007B2 (en) * | 2006-12-05 | 2013-03-19 | Landec Corporation | Method for formulating a controlled-release pharmaceutical formulation |
US20100004124A1 (en) * | 2006-12-05 | 2010-01-07 | David Taft | Systems and methods for delivery of materials for agriculture and aquaculture |
US20090263346A1 (en) * | 2006-12-05 | 2009-10-22 | David Taft | Systems and methods for delivery of drugs |
US20080228268A1 (en) * | 2007-03-15 | 2008-09-18 | Uluru, Inc. | Method of Formation of Viscous, Shape Conforming Gels and Their Uses as Medical Prosthesis |
US8178617B2 (en) * | 2007-07-16 | 2012-05-15 | Allvivo Vascular, Inc. | Antimicrobial constructs |
US8114883B2 (en) * | 2007-12-04 | 2012-02-14 | Landec Corporation | Polymer formulations for delivery of bioactive materials |
US9271929B2 (en) | 2008-11-25 | 2016-03-01 | École Polytechnique Fédérale De Lausanne (Epfl) | Block copolymers and uses thereof |
WO2010083035A2 (en) | 2009-01-14 | 2010-07-22 | Corium International, Inc. | Transdermal administration of tamsulosin |
US20110301299A1 (en) | 2010-06-08 | 2011-12-08 | Medtronic Vascular, Inc. | Medical Devices and Polymers Therefor Having PTFE Surfaces Modified With Nitric Oxide-Releasing Polymers |
US20120100187A1 (en) * | 2010-10-26 | 2012-04-26 | Surmodics, Inc. | Coatings and methods for controlled elution of hydrophilic active agents |
WO2012109068A2 (en) * | 2011-02-11 | 2012-08-16 | Corning Incorporated | Enzyme cleavable cell release polymeric surface |
US9567357B2 (en) | 2011-06-24 | 2017-02-14 | Biointeractions Ltd. | Biocompatible, biomimetic ampholyte materials |
CN103193926B (en) * | 2013-04-18 | 2015-10-28 | 苏州大学 | Side chain contains multipolymer of lysine residue and preparation method thereof and fibrinolytic function material |
USRE49528E1 (en) | 2013-04-26 | 2023-05-16 | Biointeractions Ltd. | Bioactive coatings |
CN114957564A (en) | 2013-04-26 | 2022-08-30 | 生物相互作用有限公司 | Bioactive coating |
US10711106B2 (en) | 2013-07-25 | 2020-07-14 | The University Of Chicago | High aspect ratio nanofibril materials |
WO2018052936A1 (en) * | 2016-09-13 | 2018-03-22 | Carnegie Mellon University | Therapeutic acrylates as enhanced medical adhesives |
US20190125934A1 (en) * | 2017-10-26 | 2019-05-02 | Massachusetts Institute Of Technology | Tough hydrogel coating and method of manufacture |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3826678A (en) * | 1972-06-06 | 1974-07-30 | Atomic Energy Commission | Method for preparation of biocompatible and biofunctional materials and product thereof |
WO1990000343A2 (en) * | 1988-07-05 | 1990-01-25 | Cardiopulmonics, Inc. | Multifunctional thrombo-resistant coatings and methods of manufacture |
US5001062A (en) * | 1986-05-27 | 1991-03-19 | Camurus Ab | Antithrombogenic article containing lysozyme and heparin adsorbed on a substrate |
EP0426486A2 (en) * | 1989-11-02 | 1991-05-08 | STS Biopolymers, Inc. | Anti-thromobogenic, and/or anti-microbial composition |
US5308641A (en) * | 1993-01-19 | 1994-05-03 | Medtronic, Inc. | Biocompatibility of solid surfaces |
EP0596615A1 (en) * | 1992-10-30 | 1994-05-11 | Medtronic, Inc. | Articles having bioactive surfaces |
Family Cites Families (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE295178C (en) * | 1918-05-03 | |||
US3980772A (en) * | 1969-12-02 | 1976-09-14 | Baxter Laboratories, Inc. | Methods of dissolving blood clots and the like with streptokinase chemically bonded to a carbohydrate matrix |
US3673612A (en) * | 1970-08-28 | 1972-07-04 | Massachusetts Inst Technology | Non-thrombogenic materials and methods for their preparation |
US3932656A (en) * | 1970-09-10 | 1976-01-13 | Alza Corporation | Article of manufacture for instant release of anti-aggregation and non-thrombogenic agents to biological media |
US4048064A (en) * | 1976-04-23 | 1977-09-13 | Clark Iii William T | Biocompatible hemoperfusion system |
FR2478646A2 (en) * | 1980-03-20 | 1981-09-25 | Choay Sa | MUCOPOLYSACCHARIDIC COMPOSITION HAVING A COAGULATION REGULATING ACTIVITY, MEDICAMENT CONTAINING THE SAME, AND METHOD FOR OBTAINING THE SAME |
US4331697A (en) * | 1980-09-02 | 1982-05-25 | Teijin Limited | Novel heparin derivative, method for production thereof, and method for rendering biomedical materials antithrombotic by use of the novel heparin derivative |
FR2503714B1 (en) * | 1981-04-10 | 1986-11-21 | Choay Sa | PROCESS FOR OBTAINING BIOLOGICALLY ACTIVE MUCOPOLYSACCHARIDES, OF HIGH PURITY, BY DEPOLYMERIZATION OF HEPARIN |
JPS6040861A (en) * | 1983-08-15 | 1985-03-04 | Fanuc Ltd | Mechanism for making positions coincident with each other in torque transmission device |
JPS6040860A (en) * | 1983-08-15 | 1985-03-04 | Nissan Motor Co Ltd | Device for controlling oil pressure of automatic transmission |
US4795436A (en) * | 1983-11-14 | 1989-01-03 | Bio-Mimetics, Inc. | Bioadhesive composition and method of treatment therewith |
US4983392A (en) * | 1983-11-14 | 1991-01-08 | Bio-Mimetics, Inc. | Bioadhesive compositions and methods of treatment therewith |
AU565354B2 (en) * | 1983-11-14 | 1987-09-10 | Bio-Mimetics Inc. | Bioadhesive compositions and methods of treatment therewith |
JPS60229933A (en) * | 1984-04-28 | 1985-11-15 | Yoshito Ikada | Method for modifying surface of high polymer material |
JPS6145765A (en) * | 1984-08-07 | 1986-03-05 | 宇部興産株式会社 | Blood vessel prosthesis and its production |
US4582865A (en) * | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
CH665954A5 (en) * | 1985-07-08 | 1988-06-30 | Battelle Memorial Institute | SUBSTRATE WITH A SURFACE OF ANTITHROMBOGENIC ACTIVITY. |
JPS6238174A (en) * | 1985-08-14 | 1987-02-19 | 三菱レイヨン株式会社 | Production of anti-thrombotic organic polymer |
JPS62126107A (en) * | 1985-11-27 | 1987-06-08 | Pola Chem Ind Inc | Film-forming cosmetic |
JPS61168365A (en) * | 1985-12-25 | 1986-07-30 | 東レ株式会社 | Antithrombotic medical material |
US4699141A (en) * | 1986-01-16 | 1987-10-13 | Rhode Island Hospital | Neovascularization |
US4971790A (en) * | 1986-02-07 | 1990-11-20 | Alza Corporation | Dosage form for lessening irritation of mocusa |
US4867969A (en) * | 1986-02-07 | 1989-09-19 | Alza Corporation | Hydrogel formulation for administering non-steroidal drugs |
US4723957A (en) * | 1986-02-07 | 1988-02-09 | Alza Corp. | System for delivering drug with enhanced bioacceptability |
JPH0655222B2 (en) * | 1986-03-18 | 1994-07-27 | 住友ベ−クライト株式会社 | Anticoagulant medical material and method for producing the same |
EP0239062B1 (en) * | 1986-03-27 | 1991-05-29 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | N2-(1-carboxy-3-oxo-3-phenylpropyl)-l-lysine compounds and their derivatives |
US4784736A (en) * | 1986-07-07 | 1988-11-15 | Bend Research, Inc. | Functional, photochemically active, and chemically asymmetric membranes by interfacial polymerization of derivatized multifunctional prepolymers |
JPS63105767A (en) * | 1986-10-24 | 1988-05-11 | 宇部興産株式会社 | Antithrombogenic material and its production |
US4800016A (en) * | 1986-11-24 | 1989-01-24 | The University Of Michigan | Extracorporeal blood de-heparinization system |
JPS63220878A (en) * | 1987-03-09 | 1988-09-14 | 住友ベークライト株式会社 | Production of antithrombogenic medical molded body |
US4861627A (en) * | 1987-05-01 | 1989-08-29 | Massachusetts Institute Of Technology | Preparation of multiwall polymeric microcapsules |
JP2723223B2 (en) * | 1987-05-08 | 1998-03-09 | 東レ株式会社 | Manufacturing method of catheter |
US5047020A (en) * | 1987-09-14 | 1991-09-10 | Baxter International Inc. | Ionic heparin coating |
US6174999B1 (en) * | 1987-09-18 | 2001-01-16 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
EP0308235B1 (en) * | 1987-09-18 | 1992-07-22 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Attachment of compounds to polymeric particles using carbamoylonium compounds |
JPS6480368A (en) * | 1987-09-24 | 1989-03-27 | Nippon Oils & Fats Co Ltd | Anti-thrombogenic material |
US4904474A (en) * | 1988-01-25 | 1990-02-27 | Alza Corporation | Delivery of drug to colon by oral disage form |
JPH01230369A (en) * | 1988-03-10 | 1989-09-13 | Ube Ind Ltd | Medical equipment |
JP2640114B2 (en) * | 1988-03-12 | 1997-08-13 | 日本油脂株式会社 | Antithrombotic composite material |
JP2561309B2 (en) * | 1988-03-28 | 1996-12-04 | テルモ株式会社 | Medical material and manufacturing method thereof |
JPH01262869A (en) * | 1988-04-15 | 1989-10-19 | Ube Ind Ltd | Anticoagulant medical treatment implement |
US5061738A (en) * | 1988-04-18 | 1991-10-29 | Becton, Dickinson And Company | Blood compatible, lubricious article and composition and method therefor |
US5160737A (en) * | 1988-05-03 | 1992-11-03 | Perio Products Ltd. | Liquid polymer composition, and method of use |
US5182317A (en) * | 1988-06-08 | 1993-01-26 | Cardiopulmonics, Inc. | Multifunctional thrombo-resistant coatings and methods of manufacture |
US4925677A (en) * | 1988-08-31 | 1990-05-15 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
US4977901A (en) * | 1988-11-23 | 1990-12-18 | Minnesota Mining And Manufacturing Company | Article having non-crosslinked crystallized polymer coatings |
DE69013457T2 (en) * | 1989-04-25 | 1995-02-23 | Toray Industries | ANTITHROMBOTIC BLOOD TREATMENT SYSTEM. |
US5138034A (en) * | 1989-07-12 | 1992-08-11 | The Green Cross Corporation | Method of fractionating plasma proteins |
AT393129B (en) * | 1989-11-10 | 1991-08-26 | Greber Gerd | Tissue-compatible silicone rubbers and process for preparing modified silicas |
JPH07122048B2 (en) * | 1989-11-30 | 1995-12-25 | テルモ株式会社 | Functional group-introduced substrate, method for producing the same, medical material and medical instrument using the same |
US5135516A (en) * | 1989-12-15 | 1992-08-04 | Boston Scientific Corporation | Lubricious antithrombogenic catheters, guidewires and coatings |
US5262404A (en) * | 1990-02-15 | 1993-11-16 | The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation | Cyclodextrin polymers and cyclodextrins immobilized on a solid surface |
EP0524209A1 (en) * | 1990-04-10 | 1993-01-27 | Chembiomed, Ltd. | Nonthrombogenic glycosaminoglycan copolymers |
GB9009570D0 (en) * | 1990-04-27 | 1990-06-20 | Biocompatibles Ltd | Antithrombogenic polymers |
JPH0469331A (en) * | 1990-07-10 | 1992-03-04 | Asahi Chem Ind Co Ltd | Sustained release type pharmaceutical emulsion |
CA2087102C (en) * | 1990-07-12 | 2002-04-23 | Richard James Whitbourne | Anti-thrombogenic and/or anti-microbial composition |
JP2977588B2 (en) * | 1990-08-09 | 1999-11-15 | 旭メディカル株式会社 | Antithrombotic hemofilter |
US5529914A (en) * | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
EP0588895B1 (en) * | 1991-05-31 | 1995-01-11 | Baxter International Inc. | Thromboresistant coating for defoaming applications |
WO1993005825A1 (en) * | 1991-09-20 | 1993-04-01 | Baxter International Inc. | Processes for reducing the thrombogenicity of biomaterials |
SE470006B (en) * | 1991-09-26 | 1993-10-25 | Corline Systems Ab | New conjugate, its preparation and use, and substrates prepared with the conjugate |
JPH05170845A (en) * | 1991-12-20 | 1993-07-09 | Nippon Paint Co Ltd | Fine organic polymer particle and its preparation |
JP2855307B2 (en) * | 1992-02-05 | 1999-02-10 | 生化学工業株式会社 | Photoreactive glycosaminoglycans, cross-linked glycosaminoglycans and methods for producing them |
US5468505A (en) * | 1992-02-28 | 1995-11-21 | Board Of Regents, The University Of Texas System | Local delivery of fibrinolysis enhancing agents |
JPH05279416A (en) * | 1992-03-31 | 1993-10-26 | Ajinomoto Co Inc | Hydrophilic biodegradable polymer |
US5306250A (en) * | 1992-04-02 | 1994-04-26 | Indiana University Foundation | Method and apparatus for intravascular drug delivery |
US5534619A (en) * | 1993-11-12 | 1996-07-09 | The Board Of Regents Acting On Behalf Of University Of Michigan | Peptides for heparin and low molecular weight heparin anticoagulation reversal |
US5342621A (en) * | 1992-09-15 | 1994-08-30 | Advanced Cardiovascular Systems, Inc. | Antithrombogenic surface |
US5278200A (en) * | 1992-10-30 | 1994-01-11 | Medtronic, Inc. | Thromboresistant material and articles |
US5449382A (en) * | 1992-11-04 | 1995-09-12 | Dayton; Michael P. | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5578075B1 (en) * | 1992-11-04 | 2000-02-08 | Daynke Res Inc | Minimally invasive bioactivated endoprosthesis for vessel repair |
GB9226791D0 (en) * | 1992-12-23 | 1993-02-17 | Biocompatibles Ltd | New materials |
US5416198A (en) * | 1993-02-05 | 1995-05-16 | Research Medical, Inc. | Selective sorbent removal system using polycation activated substrates |
US5437861A (en) * | 1993-03-16 | 1995-08-01 | Applied Immune Sciences, Inc. | Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome |
AU680897B2 (en) * | 1993-03-16 | 1997-08-14 | Aventis Pharmaceuticals Inc. | Removal of selected factors from whole blood or its components and prevention and treatment of septic shock symdrome |
JPH0769931A (en) * | 1993-09-03 | 1995-03-14 | Toyobo Co Ltd | Anti-thrombogenic composition and production of tool for anti-thrombogenic medical treatment |
FR2715934B1 (en) * | 1994-02-09 | 1996-05-15 | Serbio | Antithrombogenic glycosaminoglycan polymer material for coating a wall in contact with blood, method of preparation and use. |
JPH07236690A (en) * | 1994-02-25 | 1995-09-12 | Unitika Ltd | Method for fixing fibrinogenolysis active material |
ITPD940054A1 (en) * | 1994-03-23 | 1995-09-23 | Fidia Advanced Biopolymers Srl | SULPHATED POLYSACCHARIDES |
CA2151112A1 (en) * | 1994-06-13 | 1995-12-14 | Michael Bennett Freeman | High temperature polymerization process and products therefrom |
JPH08109142A (en) * | 1994-08-16 | 1996-04-30 | S R L:Kk | System for transferring medicine to platelet |
WO1996010374A1 (en) * | 1994-10-03 | 1996-04-11 | Otogen Corporation | Differentially biodegradable biomedical implants |
JP3341503B2 (en) * | 1994-11-09 | 2002-11-05 | 東レ株式会社 | Antithrombotic medical material and catheter using the same |
US5630978A (en) * | 1995-06-07 | 1997-05-20 | Yissum Research Development Co. Of The Hebrew University Of Jerusalem | Preparation of biologically active molecules by molecular imprinting |
US5840387A (en) * | 1995-07-28 | 1998-11-24 | Aegis Biosciences L.L.C. | Sulfonated multiblock copolymer and uses therefor |
JP3509829B2 (en) * | 1995-11-02 | 2004-03-22 | 東洋紡績株式会社 | Anticoagulant material |
-
1997
- 1997-10-01 US US08/942,571 patent/US5945457A/en not_active Expired - Fee Related
-
1998
- 1998-10-01 AU AU92788/98A patent/AU9278898A/en not_active Abandoned
- 1998-10-01 WO PCT/IB1998/001622 patent/WO1999016475A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3826678A (en) * | 1972-06-06 | 1974-07-30 | Atomic Energy Commission | Method for preparation of biocompatible and biofunctional materials and product thereof |
US5001062A (en) * | 1986-05-27 | 1991-03-19 | Camurus Ab | Antithrombogenic article containing lysozyme and heparin adsorbed on a substrate |
WO1990000343A2 (en) * | 1988-07-05 | 1990-01-25 | Cardiopulmonics, Inc. | Multifunctional thrombo-resistant coatings and methods of manufacture |
EP0426486A2 (en) * | 1989-11-02 | 1991-05-08 | STS Biopolymers, Inc. | Anti-thromobogenic, and/or anti-microbial composition |
EP0596615A1 (en) * | 1992-10-30 | 1994-05-11 | Medtronic, Inc. | Articles having bioactive surfaces |
US5308641A (en) * | 1993-01-19 | 1994-05-03 | Medtronic, Inc. | Biocompatibility of solid surfaces |
Also Published As
Publication number | Publication date |
---|---|
AU9278898A (en) | 1999-04-23 |
US5945457A (en) | 1999-08-31 |
WO1999016475A2 (en) | 1999-04-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1999016475A3 (en) | Process for preparing biologically compatible polymers and their use in medical devices | |
CA2129905A1 (en) | New materials | |
EP0294905B1 (en) | Covalent attachment of anticoagulants and the like onto biomaterials | |
KR100801826B1 (en) | Absorbent, lubricious coating and articles coated therewith | |
AU628674B2 (en) | Polymer complexes of a sugar response type | |
AU6889491A (en) | Aqueous-liquid and blood-absorbing powdery reticulated polymers, process for producing the same and their use as absorbents in sanitary articles | |
NO931809L (en) | hemophilia | |
AU5180999A (en) | Bioadhesive compositions comprising hydrophobic polymers | |
YU185290A (en) | LACTON POLYMERIZATION CATALYZED | |
NO903871D0 (en) | LIQUID POLYMES AND POLYOL COMPOSITIONS, AND PROCEDURES FOR THE PREPARATION OF PHENOL FUNCTIONAL POLYMER. | |
ZA95656B (en) | Films and absorbent articles comprising a biodegradable polyhydroxyalkanoate comprising 3-polyhydroxybutryrate and 3-polyhydroxyhexanoate | |
CA2270599A1 (en) | Chemical modification of biomedical materials with genipin | |
EP0406161A3 (en) | Fluorine and/or silicone containing poly(alkylene-oxide)-block copolymers and contact lenses thereof | |
SE8503486L (en) | CROSS-GELED GELES OF HYALURONIC ACID, METHOD FOR PREPARING SUDAN GELLS AND PRODUCTS CONTAINING SUDAN GEL | |
DE69528454T2 (en) | SURFACE-MODIFIED TERMINALS FOR BIOMEDICAL POLYMERS | |
GB2154469B (en) | Peritoneal dialysis and compositions for use therein | |
CA2044548A1 (en) | Coating process by a ph-sensitive polymer of active ingredients | |
IT1230061B (en) | POLYMERIZATION CATALYST, PROCEDURE FOR ITS PREPARATION AND USE IN THE OMO AND COPOLYMERISATION OF ETHYLENE. | |
AU8105087A (en) | Hemolysis inhibitor and medical resin composition, medical implement, and blood-preserving fluid containing the same | |
DE10330900A1 (en) | Modular coating system for biomaterials | |
KR0175975B1 (en) | Block-copolymers with sulfonic acid for anti-coagulation and medical articles produced therefrom | |
AU625391B2 (en) | Articles exhibiting a blood-compatible surface layer and process for providing articles with such a surface layer | |
JP2009227887A (en) | Nonspecific adsorption preventing agent of biological material | |
SU1407013A1 (en) | Method of heme-compatible polymeric material producing | |
Hilborn | Poly (arylene ether phenylesters) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CZ EE GE HU ID IL IS JP KE KG KR KZ LC LK LR LS LT LV MD MG MK MN MW MX NO NZ PL RO RU SD SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CZ EE GE HU ID IL IS JP KE KG KR KZ LC LK LR LS LT LV MD MG MK MN MW MX NO NZ PL RO RU SD SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
NENP | Non-entry into the national phase |
Ref country code: KR |
|
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: CA |