WO1999019515A1 - Precision fluorescently dyed particles and methods of making and using same - Google Patents
Precision fluorescently dyed particles and methods of making and using same Download PDFInfo
- Publication number
- WO1999019515A1 WO1999019515A1 PCT/US1998/021562 US9821562W WO9919515A1 WO 1999019515 A1 WO1999019515 A1 WO 1999019515A1 US 9821562 W US9821562 W US 9821562W WO 9919515 A1 WO9919515 A1 WO 9919515A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microspheres
- population
- fluorescent dyes
- dyes
- fluorescent
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06P—DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM
- D06P1/00—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed
- D06P1/0004—General aspects of dyeing
- D06P1/0012—Effecting dyeing to obtain luminescent or phosphorescent dyeings
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06P—DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM
- D06P1/00—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed
- D06P1/90—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof
- D06P1/92—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof in organic solvents
- D06P1/922—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof in organic solvents hydrocarbons
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06P—DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM
- D06P1/00—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed
- D06P1/90—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof
- D06P1/92—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof in organic solvents
- D06P1/922—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof in organic solvents hydrocarbons
- D06P1/924—Halogenated hydrocarbons
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06P—DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM
- D06P1/00—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed
- D06P1/90—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof
- D06P1/92—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof in organic solvents
- D06P1/922—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof in organic solvents hydrocarbons
- D06P1/926—Non-halogenated hydrocarbons
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06P—DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM
- D06P1/00—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed
- D06P1/90—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof
- D06P1/92—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof in organic solvents
- D06P1/928—Solvents other than hydrocarbons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
- Y10T428/2998—Coated including synthetic resin or polymer
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2306501A CA2306501C (en) | 1997-10-14 | 1998-10-14 | Precision fluorescently dyed particles and methods of making and using same |
JP2000516066A JP4357112B2 (en) | 1997-10-14 | 1998-10-14 | Precise fluorescent dyed particles and methods for making and using the same |
IL13559398A IL135593A (en) | 1997-10-14 | 1998-10-14 | Precision fluorescently dyed polymeric microspheres and methods of making and using same |
AU10809/99A AU1080999A (en) | 1997-10-14 | 1998-10-14 | Precision fluorescently dyed particles and methods of making and using same |
EP98953430.0A EP1023464B1 (en) | 1997-10-14 | 1998-10-14 | Precision fluorescently dyed particles and methods of making and using same |
KR1020007004042A KR20010031140A (en) | 1997-10-14 | 1998-10-14 | Precision fluorescently dyed particles and methods of making and using same |
HU0003986A HUP0003986A3 (en) | 1997-10-14 | 1998-10-14 | Precision fluorescently dyed particles and methods of making and using same |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6193897P | 1997-10-14 | 1997-10-14 | |
US60/061,938 | 1997-10-14 | ||
US8558498P | 1998-05-15 | 1998-05-15 | |
US60/085,584 | 1998-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999019515A1 true WO1999019515A1 (en) | 1999-04-22 |
Family
ID=26741675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/021562 WO1999019515A1 (en) | 1997-10-14 | 1998-10-14 | Precision fluorescently dyed particles and methods of making and using same |
Country Status (9)
Country | Link |
---|---|
US (5) | US6632526B1 (en) |
EP (1) | EP1023464B1 (en) |
JP (1) | JP4357112B2 (en) |
KR (1) | KR20010031140A (en) |
AU (1) | AU1080999A (en) |
CA (1) | CA2306501C (en) |
HU (1) | HUP0003986A3 (en) |
IL (1) | IL135593A (en) |
WO (1) | WO1999019515A1 (en) |
Cited By (70)
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---|---|---|---|---|
WO2000014545A1 (en) * | 1998-09-03 | 2000-03-16 | Trellis Bioinformatics, Inc. | Multihued labels |
WO2000055363A2 (en) * | 1999-03-12 | 2000-09-21 | Amersham Pharmacia Biotech Uk Ltd | Analysis of differential gene expression |
EP1049807A1 (en) * | 1998-01-22 | 2000-11-08 | Luminex Corporation | Microparticles with multiple fluorescent signals |
WO2001013119A1 (en) * | 1999-08-17 | 2001-02-22 | Luminex Corporation | Encapsulation of fluorescent particles |
WO2001014589A2 (en) * | 1999-08-20 | 2001-03-01 | Luminex Corporation | Liquid array technology |
EP1079967A1 (en) * | 1998-04-13 | 2001-03-07 | Luminex Corporation | Liquid labeling with fluorescent microparticles |
WO2001020533A2 (en) * | 1999-09-15 | 2001-03-22 | Luminex Corporation | Creation of a database of biochemical data and methods of use |
US6207392B1 (en) | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US6261782B1 (en) | 1999-04-06 | 2001-07-17 | Yale University | Fixed address analysis of sequence tags |
WO2001073117A1 (en) * | 2000-03-31 | 2001-10-04 | MEMOREC STOFFEL GmbH - MEDIZINISCH-MOLEKULARE ENTWICKLUNG, KÖLN | Use of particles which have signal-emitting characteristics and at least one group with an affinity for marked nucleic acids |
US6306610B1 (en) | 1998-09-18 | 2001-10-23 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
US6319426B1 (en) | 1998-09-18 | 2001-11-20 | Massachusetts Institute Of Technology | Water-soluble fluorescent semiconductor nanocrystals |
WO2002016948A2 (en) * | 2000-08-18 | 2002-02-28 | Syngenta Participations Ag | High throughput method and kit |
US6383754B1 (en) | 1999-08-13 | 2002-05-07 | Yale University | Binary encoded sequence tags |
US6383740B2 (en) | 1999-07-30 | 2002-05-07 | Bioergonomics, Inc. | Methods for simultaneously detecting both members of a binding pair |
US6387707B1 (en) | 1996-04-25 | 2002-05-14 | Bioarray Solutions | Array Cytometry |
US6423551B1 (en) | 1997-11-25 | 2002-07-23 | The Regents Of The University Of California | Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US6468811B1 (en) | 1996-04-25 | 2002-10-22 | Bioarray Solutions | Light-controlled electrokinetic assembly of particles near surfaces |
US6492125B2 (en) | 1998-09-03 | 2002-12-10 | Trellis Bioscience, Inc. | Method to assess library X library interactions |
WO2003003810A2 (en) * | 2001-07-03 | 2003-01-16 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
US6602671B1 (en) | 1998-09-18 | 2003-08-05 | Massachusetts Institute Of Technology | Semiconductor nanocrystals for inventory control |
US6696304B1 (en) | 1999-02-24 | 2004-02-24 | Luminex Corporation | Particulate solid phase immobilized protein quantitation |
US6699723B1 (en) | 1997-11-25 | 2004-03-02 | The Regents Of The University Of California | Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US6819692B2 (en) | 2000-03-14 | 2004-11-16 | Massachusetts Institute Of Technology | Optical amplifiers and lasers |
US6838289B2 (en) | 2001-11-14 | 2005-01-04 | Beckman Coulter, Inc. | Analyte detection system |
US6908737B2 (en) | 1999-04-15 | 2005-06-21 | Vitra Bioscience, Inc. | Systems and methods of conducting multiplexed experiments |
US6921496B2 (en) | 2000-03-20 | 2005-07-26 | Massachusetts Institute Of Technology | Inorganic particle conjugates |
WO2005071412A2 (en) | 2004-01-09 | 2005-08-04 | Applera Corporation | Phosphor particle coded beads |
US6964747B2 (en) | 2003-01-21 | 2005-11-15 | Bioarray Solutions, Ltd. | Production of dyed polymer microparticles |
US7041510B2 (en) * | 1996-04-25 | 2006-05-09 | Bioarray Solutions Ltd. | System and method for programmable illumination pattern generation |
US7057704B2 (en) * | 2000-09-17 | 2006-06-06 | Bioarray Solutions Ltd. | System and method for programmable illumination pattern generation |
US7083914B2 (en) | 1997-05-23 | 2006-08-01 | Bioarray Solutions Ltd. | Color-encoding and in-situ interrogation of matrix-coupled chemical compounds |
US7150910B2 (en) | 2001-11-16 | 2006-12-19 | Massachusetts Institute Of Technology | Nanocrystal structures |
US7190870B2 (en) | 2001-09-17 | 2007-03-13 | Massachusetts Institute Of Technology | Semiconductor nanocrystal composite |
US7229690B2 (en) | 2004-07-26 | 2007-06-12 | Massachusetts Institute Of Technology | Microspheres including nanoparticles |
US7253435B2 (en) | 1999-04-15 | 2007-08-07 | Millipore Corporation | Particles with light-polarizing codes |
US7255895B2 (en) | 2003-01-21 | 2007-08-14 | Bioarray Solutions, Ltd. | Method for controlling solute loading of polymer microparticles |
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US7912653B1 (en) | 2003-04-17 | 2011-03-22 | Nanosys, Inc. | Nanocrystal taggants |
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US8525107B2 (en) | 2004-03-25 | 2013-09-03 | Perkinelmer Health Sciences, Inc. | Magnetic sector mass spectrometry based multi-parametric particle analyzer |
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US8735172B2 (en) | 2000-10-19 | 2014-05-27 | Biocartis S.A. | Method and device for the manipulation of microcarriers for an identification purpose |
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US8939376B1 (en) | 1999-04-16 | 2015-01-27 | Mycartis Nv | Encoding of microcarriers |
US9147037B2 (en) | 2004-08-02 | 2015-09-29 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
US9251583B2 (en) | 2002-11-15 | 2016-02-02 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
EP2982963A1 (en) | 2006-11-02 | 2016-02-10 | Fluidigm Canada Inc. | Particles containing detectable elemental code |
US9371563B2 (en) | 2005-12-23 | 2016-06-21 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
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US9436088B2 (en) | 2001-06-21 | 2016-09-06 | Bioarray Solutions, Ltd. | Un-supported polymeric film with embedded microbeads |
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---|---|---|---|---|
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WO2005008219A2 (en) | 2003-07-18 | 2005-01-27 | Bio-Rad Laboratories, Inc. | System and method for multi-analyte detection |
EP1660679B1 (en) * | 2003-08-01 | 2012-11-14 | Dynal Biotech Inc. | Self-hybridizing multiple target nucleic acid probes and methods of use |
AU2003270759A1 (en) | 2003-08-04 | 2005-03-07 | Emory University | Porous materials embedded with nanospecies |
US7692773B2 (en) * | 2003-08-05 | 2010-04-06 | Luminex Corporation | Light emitting diode based measurement systems |
US7069191B1 (en) | 2003-08-06 | 2006-06-27 | Luminex Corporation | Methods for reducing the susceptibility of a peak search to signal noise |
KR101149880B1 (en) * | 2003-08-13 | 2012-05-24 | 루미넥스 코포레이션 | Methods for controlling one or more parameters of a flow cytometer type measurement system |
US20050106712A1 (en) * | 2003-11-14 | 2005-05-19 | Eastman Kodak Company | Yellow low fluorescence dye for coated optical bead random array DNA analysis |
CN1910441A (en) * | 2004-01-14 | 2007-02-07 | 卢米尼克斯股份有限公司 | Methods for altering one or more parameters of a measurement system |
CN1910440A (en) * | 2004-01-14 | 2007-02-07 | 卢米尼克斯股份有限公司 | Method and systems for dynamic range expansion |
US7229778B2 (en) * | 2004-02-26 | 2007-06-12 | The Procter & Gamble Company | Methods for determining the relative benefits and/or evaluating quantitative changes of products on epithelial tissue |
EP1735619A4 (en) * | 2004-04-01 | 2007-09-26 | Rules Based Medicine Inc | Universal shotgun assay |
US7407816B2 (en) * | 2004-05-07 | 2008-08-05 | Gentius, Inc | Isoelectric particles and uses thereof |
US7465543B1 (en) | 2004-05-21 | 2008-12-16 | The United States Of America, As Represented By The Secretary Of Agriculture | Multiplex DNA identification of clinical yeasts using flow cytometry |
US7858323B2 (en) | 2004-06-09 | 2010-12-28 | The Regents Of The University Of Michigan | Phage microarray profiling of the humoral response to disease |
US7635563B2 (en) * | 2004-06-30 | 2009-12-22 | Massachusetts Institute Of Technology | High throughput methods relating to microRNA expression analysis |
US20060045814A1 (en) * | 2004-09-01 | 2006-03-02 | Zhang Yu-Zhong | Microplates containing microsphere fluorescence standards, microsphere standards, and methods for their use |
US8088629B1 (en) | 2004-10-12 | 2012-01-03 | Luminex Corporation | Methods for forming dyed microspheres and populations of microspheres |
CN101044213B (en) * | 2004-10-12 | 2014-04-02 | 卢米尼克斯股份有限公司 | Methods for forming dyed microspheres and populations of dyed microspheres |
JP4988578B2 (en) * | 2004-10-12 | 2012-08-01 | ルミネックス コーポレーション | Method for changing the surface properties of microspheres |
US8927892B2 (en) * | 2004-10-22 | 2015-01-06 | Parallel Synthesis Technologies | Rare earth downconverting phosphor compositions for optically encoding objects and methods and apparatus relating to same |
EP1828748A1 (en) * | 2004-12-17 | 2007-09-05 | Luminex Corporation | Systems, illumination subsystems, and methods for increasing fluorescence emitted by a fluorophore |
JP4452188B2 (en) * | 2005-01-17 | 2010-04-21 | 凸版印刷株式会社 | Color bead manufacturing apparatus, color bead manufacturing method, and bioanalytical apparatus |
US20060157647A1 (en) * | 2005-01-18 | 2006-07-20 | Becton, Dickinson And Company | Multidimensional liquid chromatography/spectrometry |
DE602006015908D1 (en) * | 2005-01-20 | 2010-09-16 | Luminex Corp | MICROBALLS WITH FLUORESCENT AND MAGNETIC CHARACTERISTICS |
CA2495138C (en) * | 2005-01-20 | 2012-10-23 | Alison Jane Basile | Multiplexed analysis for determining a serodiagnosis of viral infection |
BRPI0609302A2 (en) | 2005-04-15 | 2011-10-11 | Becton Dickinson Co | methods for predicting the development of sepsis and for diagnosing sepsis in an individual to be tested, microarray, kit for predicting the development of sepsis in an individual to be tested, computer program product, computer, computer system for determining if an individual is likely to develop sepsis, digital signal embedded in a carrier wave, and, graphical user interface to determine if an individual is likely to develop sepsis |
JP2008538609A (en) * | 2005-04-20 | 2008-10-30 | ベクトン・ディキンソン・アンド・カンパニー | Multiplex microparticle system |
EP1907988B1 (en) * | 2005-06-20 | 2013-11-06 | AuthentiForm Technologies, L.L.C. | Systems and methods for product authentication |
US8247018B2 (en) * | 2005-06-20 | 2012-08-21 | Authentiform Technologies, Llc | Methods for quality control |
US7874489B2 (en) * | 2005-06-20 | 2011-01-25 | Authentiform Technologies, Llc | Product authentication |
EP1904846A4 (en) * | 2005-06-29 | 2009-03-18 | Rules Based Medicine Inc | Methods and kits for the diagnosis of acute coronary syndrome |
NO20053373D0 (en) * | 2005-07-11 | 2005-07-11 | Rikshospitalet Radiumhospitale | Multicolored Particles. |
US7781224B2 (en) * | 2005-08-10 | 2010-08-24 | Lawrence Livermore National Security, Llc | Safe biodegradable fluorescent particles |
US20070043510A1 (en) * | 2005-08-19 | 2007-02-22 | Beckman Coulter, Inc. | Assay system |
CN102621053B (en) | 2005-09-21 | 2015-05-06 | 卢米尼克斯股份有限公司 | Methods and systems for image data processing |
JP4847961B2 (en) * | 2005-09-27 | 2011-12-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Method for forming self-assembly on fine particles and method for detecting target analyte |
US8168447B2 (en) * | 2005-10-07 | 2012-05-01 | University Of Florida Research Foundation, Inc. | Multiple component nanoparticles for multiplexed signaling and optical encoding |
US8673107B2 (en) * | 2005-10-28 | 2014-03-18 | Parallel Synthesis Technologies | Methods for fabricating optically encoded particles and methods for optically encoding objects with such particles |
GB2432419A (en) | 2005-11-16 | 2007-05-23 | Agency Science Tech & Res | Influenza A virus detection method |
US20070239483A1 (en) * | 2006-01-09 | 2007-10-11 | Biophysical Corporation | Methods for individualized health assessment service |
US8309025B1 (en) | 2006-01-26 | 2012-11-13 | Luminex Corporation | Methods and systems for determining composition and completion of an experiment |
WO2007090076A2 (en) | 2006-01-27 | 2007-08-09 | Tripath Imaging, Inc. | Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor |
EP1987361A4 (en) * | 2006-01-30 | 2009-03-04 | Invitrogen Corp | Compositions and methods for detecting and quantifying toxic substances in disease states |
WO2007099289A1 (en) * | 2006-02-28 | 2007-09-07 | Medical Research Council | Targeted iron oxide nanoparticles |
US20070207513A1 (en) * | 2006-03-03 | 2007-09-06 | Luminex Corporation | Methods, Products, and Kits for Identifying an Analyte in a Sample |
US8124943B1 (en) | 2006-04-06 | 2012-02-28 | Lugade Ananda G | Methods and systems for altering fluorescent intensities of a plurality of particles |
US7795040B2 (en) * | 2006-04-17 | 2010-09-14 | Luminex Corporation | Methods, particles, and kits for determining activity of a kinase |
WO2007131171A1 (en) * | 2006-05-05 | 2007-11-15 | Rules-Based Medicine, Inc. | Methods and kits for the diagnosis of hypothyroidism |
EP2021766A2 (en) * | 2006-05-17 | 2009-02-11 | Luminex Corporation | Chip-based flow cytometer type systems for analyzing fluorescently tagged particles |
US7846391B2 (en) | 2006-05-22 | 2010-12-07 | Lumencor, Inc. | Bioanalytical instrumentation using a light source subsystem |
US8296088B2 (en) | 2006-06-02 | 2012-10-23 | Luminex Corporation | Systems and methods for performing measurements of one or more materials |
EP2765423B1 (en) | 2006-06-02 | 2016-11-02 | Luminex Corporation | Systems and methods for performing measurements of one or more analytes comprising using magnetic particles and applying a magnetic field |
WO2008061058A2 (en) | 2006-11-10 | 2008-05-22 | Luminex Corporation | Flow cytometer and fluidic line assembly with multiple injection needles |
JP5156944B2 (en) * | 2006-11-20 | 2013-03-06 | 国立大学法人東京工業大学 | Magnetic polymer particles having fluorescent function and production method thereof |
JP2010510528A (en) | 2006-11-22 | 2010-04-02 | ライフ テクノロジーズ コーポレーション | Biomarkers for autoimmune diseases |
SG143090A1 (en) * | 2006-11-27 | 2008-06-27 | Agency Science Tech & Res | Influenza b virus detection method and kit therefor |
EP2857526B1 (en) | 2006-12-13 | 2016-08-17 | Luminex Corporation | Systems and methods for multiplex analysis of PCR in real time |
WO2008089059A1 (en) * | 2007-01-12 | 2008-07-24 | Rules-Based Medicine, Inc. | Methods and kits for the diagnosis of galactosemia |
WO2008100791A1 (en) * | 2007-02-16 | 2008-08-21 | Rules-Based Medicine, Inc. | Methods and kits for the diagnosis of sickle cell |
EP1961825A1 (en) | 2007-02-26 | 2008-08-27 | INSERM (Institut National de la Santé et de la Recherche Medicale) | Method for predicting the occurrence of metastasis in breast cancer patients |
DE102007010860B4 (en) * | 2007-03-01 | 2014-05-15 | PolyAn Gesellschaft zur Herstellung von Polymeren für spezielle Anwendungen und Analytik mbH | Method of identifying a particle with two or more monodisperse embedded fluorophores |
WO2008109176A2 (en) | 2007-03-07 | 2008-09-12 | President And Fellows Of Harvard College | Assays and other reactions involving droplets |
WO2008109797A1 (en) * | 2007-03-08 | 2008-09-12 | Rules-Based Medicine, Inc. | Methods for rapid disease screening |
WO2008153804A2 (en) * | 2007-05-31 | 2008-12-18 | Monsanto Technology Llc | Soybean polymorphisms and methods of genotyping |
US20090047689A1 (en) * | 2007-06-20 | 2009-02-19 | John Kolman | Autoantigen biomarkers for early diagnosis of lung adenocarcinoma |
US7709811B2 (en) * | 2007-07-03 | 2010-05-04 | Conner Arlie R | Light emitting diode illumination system |
US8098375B2 (en) | 2007-08-06 | 2012-01-17 | Lumencor, Inc. | Light emitting diode illumination system |
US8171777B2 (en) * | 2007-09-17 | 2012-05-08 | Adam Richard Schilffarth | Systems, storage mediums, and methods for identifying particles in flow |
JP5286726B2 (en) * | 2007-09-25 | 2013-09-11 | 富士ゼロックス株式会社 | Black color material and toner |
WO2009042423A1 (en) * | 2007-09-27 | 2009-04-02 | Cellatope Corporation | Methods and compositions for improved diagnostic assays |
US8871687B2 (en) * | 2007-09-28 | 2014-10-28 | Quest Diagnostics Investments Incorporated | Nucleic acid sequencing by single-base primer extension |
JP5738597B2 (en) | 2007-12-21 | 2015-06-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Systems and methods for nucleic acid sequencing |
US20090170214A1 (en) * | 2007-12-27 | 2009-07-02 | Luminex Corporation | Luminescent Reporter Modality for Analyzing an Assay |
JP2011509405A (en) * | 2008-01-07 | 2011-03-24 | ルミネックス コーポレーション | Method of immunomagnetic capture and imaging of biological targets |
JP5550182B2 (en) * | 2008-01-07 | 2014-07-16 | ルミネックス コーポレーション | Method for isolation and enumeration of cells from a composite sample matrix |
US20100279272A1 (en) * | 2008-02-13 | 2010-11-04 | Michael Craig Burrell | Multiplexed analysis methods using sers-active nanoparticles |
US8669113B2 (en) | 2008-04-03 | 2014-03-11 | Becton, Dickinson And Company | Advanced detection of sepsis |
US7777176B2 (en) * | 2008-08-14 | 2010-08-17 | Energy Materials Corporation | Composition and method to characterize membranes' defects |
CA2733609C (en) | 2008-08-14 | 2018-03-06 | Nanostring Technologies, Inc. | Stable nanoreporters |
WO2010019125A1 (en) * | 2008-08-15 | 2010-02-18 | Energy Materials Corporation | Composition and method to characterize membranes' defects |
CN102149753B (en) * | 2008-09-11 | 2013-09-25 | 国立大学法人东京工业大学 | Polymer particle containing fluorescent molecule and method for producing the same |
US20100068729A1 (en) * | 2008-09-12 | 2010-03-18 | Rules-Based Medicine, Inc. | Method and kits for the diagnosis of diabetes |
WO2010033200A2 (en) * | 2008-09-19 | 2010-03-25 | President And Fellows Of Harvard College | Creation of libraries of droplets and related species |
US20100076302A1 (en) * | 2008-09-25 | 2010-03-25 | Jeff Gray | Invisible Power Port ID Tattoo |
WO2010054385A2 (en) | 2008-11-10 | 2010-05-14 | Luminex Corporation | Method and system for manufacture and use of macroporous beads in a multiplex assay |
US8415161B2 (en) | 2008-11-13 | 2013-04-09 | Becton, Dickinson And Company | Instrument setup system for a fluorescence analyzer |
EP2373812B1 (en) | 2008-12-19 | 2016-11-09 | President and Fellows of Harvard College | Particle-assisted nucleic acid sequencing |
US8242462B2 (en) | 2009-01-23 | 2012-08-14 | Lumencor, Inc. | Lighting design of high quality biomedical devices |
EP2290102A1 (en) | 2009-07-08 | 2011-03-02 | Administración General De La Communidad Autónoma De Euskadi | Methods for the diagnosis of multiple sclerosis based on its microRNA expression profiling |
US20110097723A1 (en) * | 2009-09-19 | 2011-04-28 | Qun Liu | Methods and reagents for analyte detection |
AU2010306862B2 (en) | 2009-10-13 | 2015-08-27 | Nanostring Technologies, Inc. | Protein detection via nanoreporters |
JP5791621B2 (en) | 2009-10-27 | 2015-10-07 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Droplet generation technology |
CA2785529C (en) | 2010-02-11 | 2019-01-08 | Nanostring Technologies, Inc. | Compositions and methods for the detection of small rnas |
US9500644B2 (en) * | 2010-02-23 | 2016-11-22 | Luminex Corporation | Particle populations and assays having varying amounts of magnetic material and particle concentrations among different subsets of particles and methods for processing assays having such particle populations |
US8236574B2 (en) | 2010-03-01 | 2012-08-07 | Quanterix Corporation | Ultra-sensitive detection of molecules or particles using beads or other capture objects |
JP5808349B2 (en) | 2010-03-01 | 2015-11-10 | カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー | Biomarkers for theranosis |
EP2542890B1 (en) | 2010-03-01 | 2015-05-06 | Quanterix Corporation | Methods for extending dynamic range in assays for the detection of molecules or particles |
EP2548025A4 (en) | 2010-03-17 | 2013-09-25 | Univ Michigan | Using phage epitopes to profile the immune response |
WO2011120015A2 (en) * | 2010-03-26 | 2011-09-29 | Armune Biosciences, Inc. | Method and system of particle-coupled phage epitope |
BR112012025593A2 (en) | 2010-04-06 | 2019-06-25 | Caris Life Sciences Luxembourg Holdings | circulating biomarkers for disease |
US8747677B2 (en) | 2010-04-09 | 2014-06-10 | Luminex Corporation | Magnetic separation device |
JP5985140B2 (en) * | 2010-04-28 | 2016-09-06 | ソニー株式会社 | Fluorescence intensity correction method, fluorescence intensity calculation method, and fluorescence intensity calculation apparatus |
US8274656B2 (en) | 2010-06-30 | 2012-09-25 | Luminex Corporation | Apparatus, system, and method for increasing measurement accuracy in a particle imaging device |
US8767069B2 (en) | 2010-06-30 | 2014-07-01 | Luminex Corporation | Apparatus, system, and method for increasing measurement accuracy in a particle imaging device using light distribution |
US20120065092A1 (en) | 2010-09-14 | 2012-03-15 | Wai Hobert | Fusion analyte cytometric bead assay, and systems and kits for performing the same |
US8389957B2 (en) | 2011-01-14 | 2013-03-05 | Lumencor, Inc. | System and method for metered dosage illumination in a bioanalysis or other system |
US8466436B2 (en) | 2011-01-14 | 2013-06-18 | Lumencor, Inc. | System and method for metered dosage illumination in a bioanalysis or other system |
US9758834B2 (en) | 2011-03-28 | 2017-09-12 | Nanostring Technologies, Inc. | Compositions and methods for diagnosing cancer |
US20140302532A1 (en) | 2011-04-12 | 2014-10-09 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury |
EP2546358A1 (en) | 2011-07-15 | 2013-01-16 | Laboratorios Del. Dr. Esteve, S.A. | Methods and reagents for efficient control of HIV progression |
WO2013049613A1 (en) | 2011-09-29 | 2013-04-04 | Luminex Corporation | Hydrolysis probes |
EP2769198B1 (en) | 2011-10-18 | 2016-05-25 | Luminex Corporation | Methods and systems for image data processing |
MX349562B (en) | 2011-12-09 | 2017-08-02 | Pasteur Institut | Multiplex immuno screening assay. |
US9642515B2 (en) | 2012-01-20 | 2017-05-09 | Lumencor, Inc. | Solid state continuous white light source |
EP2812704A4 (en) | 2012-02-07 | 2016-03-23 | Intuitive Biosciences Inc | Mycobacterium tuberculosis specific peptides for detection of infection or immunization in non-human primates |
US9804156B2 (en) | 2012-03-06 | 2017-10-31 | Life Technologies Corporation | Biomarkers for systemic lupus erythematosus |
ES2434853B1 (en) | 2012-06-12 | 2014-09-30 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Molecular marker of therapeutic potency of human mesenchymal stem cells and their uses |
US9217561B2 (en) | 2012-06-15 | 2015-12-22 | Lumencor, Inc. | Solid state light source for photocuring |
CN104541152B (en) | 2012-06-15 | 2017-08-25 | 卢米尼克斯股份有限公司 | Use the image normalization devices, systems, and methods of the Gauss residual error of fitting selection standard |
CA3176706A1 (en) | 2012-07-11 | 2014-01-16 | Imstem Biotechnology, Inc. | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
WO2014028537A1 (en) | 2012-08-14 | 2014-02-20 | 10X Technologies, Inc. | Microcapsule compositions and methods |
US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10584381B2 (en) | 2012-08-14 | 2020-03-10 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
WO2014031902A2 (en) | 2012-08-23 | 2014-02-27 | The Regents Of The University Of California | Spectrally encoded microbeads and methods and devices for making and using same |
US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
ES2912033T3 (en) | 2012-10-23 | 2022-05-24 | Caris Science Inc | Aptamers and uses thereof |
WO2014070958A1 (en) | 2012-10-30 | 2014-05-08 | Certirx Corporation | Product, image, or document authentication, verification, and item identification |
CA2894694C (en) | 2012-12-14 | 2023-04-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
EP2935628B1 (en) | 2012-12-19 | 2018-03-21 | Caris Life Sciences Switzerland Holdings GmbH | Compositions and methods for aptamer screening |
RS58147B1 (en) * | 2012-12-21 | 2019-02-28 | Janssen Biotech Inc | Sensitive multiplex immunoassay for soluble fibroblast growth factor receptors |
EP3862435A1 (en) | 2013-02-08 | 2021-08-11 | 10X Genomics, Inc. | Polynucleotide barcode generation |
WO2014134280A1 (en) | 2013-02-28 | 2014-09-04 | The Terasaki Family Foundation | Methods, compositions and kits to recycle internally dyed particles |
JP6107244B2 (en) * | 2013-03-08 | 2017-04-05 | コニカミノルタ株式会社 | Fluorescent dye labeling resin particles, production method thereof, and tissue immunostaining kit containing the particles |
US9428792B2 (en) | 2013-03-14 | 2016-08-30 | Certirx Corporation | Nucleic acid-based authentication and identification codes |
CA2942831A1 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Princeton University | Methods and devices for high throughput purification |
CN110186835B (en) | 2013-03-15 | 2022-05-31 | Gpb科学有限公司 | On-chip microfluidic processing of particles |
US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
ES2523016B1 (en) | 2013-05-20 | 2015-09-09 | 3P Biopharmaceuticals | Alpha-viral vectors and cell lines for the production of recombinant proteins |
EP3957743A1 (en) | 2013-06-19 | 2022-02-23 | Luminex Corporation | Real-time multiplexed hydrolysis probe assay |
EP3461913B1 (en) | 2013-08-09 | 2020-06-24 | Luminex Corporation | Probes for improved melt discrimination and multiplexing in nucleic acid assays |
KR20160080815A (en) | 2013-08-28 | 2016-07-08 | 카리스 라이프 사이언스 스위스 홀딩스 게엠베하 | Oligonucleotide probes and uses thereof |
US10395758B2 (en) | 2013-08-30 | 2019-08-27 | 10X Genomics, Inc. | Sequencing methods |
WO2015069634A1 (en) | 2013-11-08 | 2015-05-14 | President And Fellows Of Harvard College | Microparticles, methods for their preparation and use |
US9824068B2 (en) | 2013-12-16 | 2017-11-21 | 10X Genomics, Inc. | Methods and apparatus for sorting data |
JP6409173B2 (en) * | 2014-02-20 | 2018-10-24 | 国立大学法人東京工業大学 | Fluorescent label set |
AU2015243445B2 (en) | 2014-04-10 | 2020-05-28 | 10X Genomics, Inc. | Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same |
CA2946862A1 (en) | 2014-04-24 | 2015-10-29 | Immusant, Inc. | Use of interleukin-2 for diagnosis of celiac disease |
CN106795553B (en) | 2014-06-26 | 2021-06-04 | 10X基因组学有限公司 | Methods of analyzing nucleic acids from individual cells or cell populations |
KR20170023979A (en) | 2014-06-26 | 2017-03-06 | 10엑스 제노믹스, 인크. | Processes and systems for nucleic acid sequence assembly |
EP3967771B1 (en) | 2014-08-11 | 2023-10-04 | Luminex Corporation | Probes for improved melt discrimination and multiplexing in nucleic acid assays |
CA2964472A1 (en) | 2014-10-29 | 2016-05-06 | 10X Genomics, Inc. | Methods and compositions for targeted nucleic acid sequencing |
US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
US10473647B1 (en) | 2014-11-21 | 2019-11-12 | Immusant, Inc. | Peptides for use in treatment and diagnosis of type 1 diabetes |
EP3244992B1 (en) | 2015-01-12 | 2023-03-08 | 10X Genomics, Inc. | Processes for barcoding nucleic acids |
US20180003703A1 (en) * | 2015-01-13 | 2018-01-04 | Quanterix Corporation | Methods relating to improving accuracy of capture object-based assays |
JP2018508852A (en) | 2015-01-13 | 2018-03-29 | 10エックス ゲノミクス,インコーポレイテッド | System and method for visualizing structural variation and phase information |
MX2017010142A (en) | 2015-02-09 | 2017-12-11 | 10X Genomics Inc | Systems and methods for determining structural variation and phasing using variant call data. |
EP3256855B1 (en) | 2015-02-13 | 2020-10-07 | Quanterix Corporation | Immunoassays for diffrential detection of clostridium difficile |
BR112017018054A2 (en) | 2015-02-24 | 2018-07-24 | 10X Genomics Inc | Methods for Covering Targeted Nucleic Acid Sequences |
EP3262407B1 (en) | 2015-02-24 | 2023-08-30 | 10X Genomics, Inc. | Partition processing methods and systems |
CA2979361A1 (en) | 2015-03-09 | 2016-09-15 | Caris Science, Inc. | Method of preparing oligonucleotide libraries |
WO2017004243A1 (en) | 2015-06-29 | 2017-01-05 | Caris Science, Inc. | Therapeutic oligonucleotides |
SG10202107055SA (en) | 2015-07-17 | 2021-08-30 | Nanostring Technologies Inc | Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue |
SG10202107053QA (en) | 2015-07-17 | 2021-08-30 | Nanostring Technologies Inc | Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue |
WO2017019918A1 (en) | 2015-07-28 | 2017-02-02 | Caris Science, Inc. | Targeted oligonucleotides |
US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
WO2017066231A1 (en) | 2015-10-13 | 2017-04-20 | President And Fellows Of Harvard College | Systems and methods for making and using gel microspheres |
US20170137133A1 (en) * | 2015-11-12 | 2017-05-18 | Goodrich Corporation | System, method, and apparatus for dye in search, rescue, and recovery |
SG10202108763UA (en) | 2015-12-04 | 2021-09-29 | 10X Genomics Inc | Methods and compositions for nucleic acid analysis |
KR102652405B1 (en) * | 2015-12-28 | 2024-03-28 | 삼성디스플레이 주식회사 | Dye beads, photosensitive resin composition comprising the same and color filter |
JP2019503203A (en) | 2016-01-29 | 2019-02-07 | アカオジェン インコーポレイテッド | Screening methods for identifying antibodies that bind to cell surface epitopes |
SG11201806757XA (en) | 2016-02-11 | 2018-09-27 | 10X Genomics Inc | Systems, methods, and media for de novo assembly of whole genome sequence data |
EP4339288A2 (en) | 2016-03-18 | 2024-03-20 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
AU2017271579B2 (en) | 2016-05-25 | 2023-10-19 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
WO2018089764A1 (en) | 2016-11-11 | 2018-05-17 | Ascendant Dx, Llc | Compositions and methods for diagnosing and differentiating systemic juvenile idiopathic arthritis and kawasaki disease |
AU2017361521B2 (en) | 2016-11-21 | 2020-08-27 | Nanostring Technologies, Inc. | Chemical compositions and methods of using same |
US10011872B1 (en) | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
WO2018140827A1 (en) | 2017-01-27 | 2018-08-02 | Achaogen, Inc. | Reporter microorganisms and uses thereof |
WO2018140966A1 (en) | 2017-01-30 | 2018-08-02 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
US11613075B2 (en) | 2017-04-20 | 2023-03-28 | Hewlett-Packard Development Company, L.P. | Build compositions |
WO2018213774A1 (en) | 2017-05-19 | 2018-11-22 | 10X Genomics, Inc. | Systems and methods for analyzing datasets |
US10844372B2 (en) | 2017-05-26 | 2020-11-24 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
SG11201901822QA (en) | 2017-05-26 | 2019-03-28 | 10X Genomics Inc | Single cell analysis of transposase accessible chromatin |
SG11201913654QA (en) | 2017-11-15 | 2020-01-30 | 10X Genomics Inc | Functionalized gel beads |
US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
CN108531550A (en) * | 2018-02-01 | 2018-09-14 | 武汉尚码生物科技有限公司 | Marking and identifying method of particle carrier and application thereof |
WO2019157445A1 (en) | 2018-02-12 | 2019-08-15 | Nanostring Technologies, Inc. | Biomolecular probes and methods of detecting gene and protein expression |
SG11202009889VA (en) | 2018-04-06 | 2020-11-27 | 10X Genomics Inc | Systems and methods for quality control in single cell processing |
SG11202011274YA (en) | 2018-05-14 | 2020-12-30 | Nanostring Technologies Inc | Chemical compositions and methods of using same |
US11929171B2 (en) | 2018-10-18 | 2024-03-12 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for evaluation and treatment of glycemic dysregulation and atherosclerotic cardiovascular disease and applications thereof |
US20220364147A1 (en) | 2019-11-15 | 2022-11-17 | Miltenyi Biotec B.V. & Co. KG | Color and bardcoded beads for single cell indexing |
CN111218498A (en) * | 2019-12-09 | 2020-06-02 | 彩科(苏州)生物科技有限公司 | Nucleic acid molecule detection kit without amplification and use method thereof |
CN111060683B (en) * | 2019-12-09 | 2023-11-21 | 彩科(苏州)生物科技有限公司 | Multiplex immune molecule detection method and kit |
CN113061385B (en) * | 2021-03-31 | 2022-04-12 | 福州大学 | Weather-resistant high-hardness water epoxy amino baking paint and preparation method thereof |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3790492A (en) * | 1971-03-11 | 1974-02-05 | Atomic Energy Commission | Method for production of uniform microspheres |
US4267234A (en) | 1978-03-17 | 1981-05-12 | California Institute Of Technology | Polyglutaraldehyde synthesis and protein bonding substrates |
US4267235A (en) | 1979-03-19 | 1981-05-12 | California Institute Of Technology | Polyglutaraldehyde microspheres |
US4552812A (en) | 1981-07-01 | 1985-11-12 | Yeda Research And Development Company | Process for the production of polyacrolein microspheres and grafted microspheres |
US4677138A (en) | 1983-10-19 | 1987-06-30 | Yeda Research And Development Co., Ltd. | High yield process for producing polyaldehyde microspheres |
US4717655A (en) * | 1982-08-30 | 1988-01-05 | Becton, Dickinson And Company | Method and apparatus for distinguishing multiple subpopulations of cells |
US4774189A (en) | 1984-12-24 | 1988-09-27 | Flow Cytometry Standards Corp. | Fluorescent calibration microbeads simulating stained cells |
US5073498A (en) * | 1984-12-24 | 1991-12-17 | Caribbean Microparticles Corporation | Fluorescent alignment microbeads with broad excitation and emission spectra and its use |
US5194300A (en) | 1987-07-15 | 1993-03-16 | Cheung Sau W | Methods of making fluorescent microspheres |
US5326692A (en) * | 1992-05-13 | 1994-07-05 | Molecular Probes, Inc. | Fluorescent microparticles with controllable enhanced stokes shift |
US5723218A (en) * | 1990-04-16 | 1998-03-03 | Molecular Probes, Inc. | Dipyrrometheneboron difluoride labeled flourescent microparticles |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3322373C2 (en) | 1983-05-19 | 1986-12-04 | Ioannis Dr. 3000 Hannover Tripatzis | Test means and methods for the detection of antigens and / or antibodies |
US4677045A (en) | 1984-07-27 | 1987-06-30 | International Business Machines Corporation | Squarylium charge generating dye and electrophotographic photoconductor |
US4667138A (en) * | 1986-03-27 | 1987-05-19 | Rockwell International Corporation | Multiplexed synchro driver |
US5237498A (en) | 1988-07-08 | 1993-08-17 | Hitachi, Ltd. | System and method for computing profits for individual entities of an entity group via use of means to retrieve and process data for specific entities |
US5354873A (en) | 1991-11-20 | 1994-10-11 | Polaroid Corporation | Squarylium dyes, and processes and intermediates for the preparation thereof |
US5227498A (en) * | 1991-11-20 | 1993-07-13 | Polaroid Corporation | Squarylium dyes, and processes and intermediates for the preparation thereof |
FR2707658B1 (en) | 1993-07-12 | 1995-11-24 | Prolabo Sa | Fluorescent latex comprising at least two fluorochromes, process for obtaining and applying said latex as a marker, in particular in biology. |
US5747349A (en) | 1996-03-20 | 1998-05-05 | University Of Washington | Fluorescent reporter beads for fluid analysis |
US5945526A (en) * | 1996-05-03 | 1999-08-31 | Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
US5786219A (en) | 1996-10-28 | 1998-07-28 | Molecular Probes, Inc. | Microspheres with fluorescent spherical zones |
KR20010031140A (en) * | 1997-10-14 | 2001-04-16 | 루미넥스 코포레이션 | Precision fluorescently dyed particles and methods of making and using same |
DE69907630T2 (en) * | 1998-01-22 | 2004-02-26 | Luminex Corp., Austin | MICROPARTICLES WITH MULTIPLE FLUORESCENCE SIGNALS |
US6309701B1 (en) * | 1998-11-10 | 2001-10-30 | Bio-Pixels Ltd. | Fluorescent nanocrystal-labeled microspheres for fluorescence analyses |
AU6779700A (en) * | 1999-08-17 | 2001-03-13 | Luminex Corporation | Microparticles with multiple fluorescent signals and methods of using same |
AU6779200A (en) * | 1999-08-17 | 2001-03-13 | Luminex Corporation | Encapsulation of fluorescent particles |
US6417402B1 (en) * | 2001-09-26 | 2002-07-09 | Council Of Scientific And Industrial Research | Squaraine based dyes and process for preparation thereof |
US6964747B2 (en) * | 2003-01-21 | 2005-11-15 | Bioarray Solutions, Ltd. | Production of dyed polymer microparticles |
-
1998
- 1998-10-14 KR KR1020007004042A patent/KR20010031140A/en not_active Application Discontinuation
- 1998-10-14 IL IL13559398A patent/IL135593A/en not_active IP Right Cessation
- 1998-10-14 US US09/172,174 patent/US6632526B1/en not_active Expired - Lifetime
- 1998-10-14 JP JP2000516066A patent/JP4357112B2/en not_active Expired - Lifetime
- 1998-10-14 EP EP98953430.0A patent/EP1023464B1/en not_active Expired - Lifetime
- 1998-10-14 WO PCT/US1998/021562 patent/WO1999019515A1/en not_active Application Discontinuation
- 1998-10-14 CA CA2306501A patent/CA2306501C/en not_active Expired - Lifetime
- 1998-10-14 HU HU0003986A patent/HUP0003986A3/en unknown
- 1998-10-14 AU AU10809/99A patent/AU1080999A/en not_active Abandoned
-
1999
- 1999-04-13 US US09/290,248 patent/US6514295B1/en not_active Expired - Lifetime
-
2002
- 2002-07-01 US US10/185,869 patent/US6599331B2/en not_active Expired - Lifetime
-
2003
- 2003-07-03 US US10/401,549 patent/US6929859B2/en not_active Expired - Lifetime
-
2005
- 2005-08-02 US US11/195,185 patent/US7445844B2/en not_active Expired - Fee Related
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3790492A (en) * | 1971-03-11 | 1974-02-05 | Atomic Energy Commission | Method for production of uniform microspheres |
US4267234A (en) | 1978-03-17 | 1981-05-12 | California Institute Of Technology | Polyglutaraldehyde synthesis and protein bonding substrates |
US4267235A (en) | 1979-03-19 | 1981-05-12 | California Institute Of Technology | Polyglutaraldehyde microspheres |
US4552812A (en) | 1981-07-01 | 1985-11-12 | Yeda Research And Development Company | Process for the production of polyacrolein microspheres and grafted microspheres |
US4717655A (en) * | 1982-08-30 | 1988-01-05 | Becton, Dickinson And Company | Method and apparatus for distinguishing multiple subpopulations of cells |
US4677138A (en) | 1983-10-19 | 1987-06-30 | Yeda Research And Development Co., Ltd. | High yield process for producing polyaldehyde microspheres |
US4774189A (en) | 1984-12-24 | 1988-09-27 | Flow Cytometry Standards Corp. | Fluorescent calibration microbeads simulating stained cells |
US5073498A (en) * | 1984-12-24 | 1991-12-17 | Caribbean Microparticles Corporation | Fluorescent alignment microbeads with broad excitation and emission spectra and its use |
US5194300A (en) | 1987-07-15 | 1993-03-16 | Cheung Sau W | Methods of making fluorescent microspheres |
US5723218A (en) * | 1990-04-16 | 1998-03-03 | Molecular Probes, Inc. | Dipyrrometheneboron difluoride labeled flourescent microparticles |
US5326692A (en) * | 1992-05-13 | 1994-07-05 | Molecular Probes, Inc. | Fluorescent microparticles with controllable enhanced stokes shift |
US5326692B1 (en) * | 1992-05-13 | 1996-04-30 | Molecular Probes Inc | Fluorescent microparticles with controllable enhanced stokes shift |
US5573909A (en) * | 1992-05-13 | 1996-11-12 | Molecular Probes, Inc. | Fluorescent labeling using microparticles with controllable stokes shift |
Cited By (143)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7749774B2 (en) * | 1996-04-25 | 2010-07-06 | Michael Seul | Arrays formed of encoded beads having ligands attached |
US7615345B2 (en) | 1996-04-25 | 2009-11-10 | Bio Array Solutions Ltd. | Arrays formed of encoded beads having oligonucleotides attached |
US7427512B2 (en) * | 1996-04-25 | 2008-09-23 | Bioarray Solutions Ltd. | Light-controlled electrokinetic assembly of particles near surfaces |
US7056746B2 (en) * | 1996-04-25 | 2006-06-06 | Bioarray Solutions Ltd. | Array cytometry |
US6468811B1 (en) | 1996-04-25 | 2002-10-22 | Bioarray Solutions | Light-controlled electrokinetic assembly of particles near surfaces |
US6514771B1 (en) | 1996-04-25 | 2003-02-04 | Bioarray Solutions | Light-controlled electrokinetic assembly of particles near surfaces |
US6387707B1 (en) | 1996-04-25 | 2002-05-14 | Bioarray Solutions | Array Cytometry |
US8691594B2 (en) | 1996-04-25 | 2014-04-08 | Bioarray Solutions, Ltd. | Method of making a microbead array with attached biomolecules |
US7041510B2 (en) * | 1996-04-25 | 2006-05-09 | Bioarray Solutions Ltd. | System and method for programmable illumination pattern generation |
US9400259B2 (en) | 1996-04-25 | 2016-07-26 | Bioarray Solutions, Ltd. | Method of making a microbead array with attached biomolecules |
US7291504B2 (en) * | 1996-04-25 | 2007-11-06 | Bioarray Solutions Ltd. | Assay involving detection and identification with encoded particles |
US10241026B2 (en) | 1997-03-14 | 2019-03-26 | Trustees Of Tufts College | Target analyte sensors utilizing microspheres |
US9377388B2 (en) | 1997-03-14 | 2016-06-28 | Trustees Of Tufts College | Methods for detecting target analytes and enzymatic reactions |
US9945051B2 (en) | 1997-05-23 | 2018-04-17 | Rutgers, The State University Of New Jersey | Color-encoding and in-situ interrogation of matrix-coupled chemical compounds |
US7083914B2 (en) | 1997-05-23 | 2006-08-01 | Bioarray Solutions Ltd. | Color-encoding and in-situ interrogation of matrix-coupled chemical compounds |
US9441156B2 (en) | 1997-11-13 | 2016-09-13 | Massachusetts Institute Of Technology | Highly luminescent color-selective nanocrystalline materials |
US8481113B2 (en) | 1997-11-13 | 2013-07-09 | Massachusetts Institute Of Technology | Highly luminescent color-selective nanocrystalline materials |
US8481112B2 (en) | 1997-11-13 | 2013-07-09 | Massachusetts Institute Of Technology | Highly luminescent color-selective nanocrystalline materials |
US9790424B2 (en) | 1997-11-13 | 2017-10-17 | Massachusetts Institute Of Technology | Highly luminescent color-selective nanocrystalline materials |
US8101234B2 (en) | 1997-11-13 | 2012-01-24 | Massachusetts Institute Of Technology | Highly luminescent color-selective nanocrystalline materials |
US8158193B2 (en) | 1997-11-13 | 2012-04-17 | Massachusetts Institute Of Technology | Highly luminescent color-selective nanocrystalline materials |
US6207392B1 (en) | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US6423551B1 (en) | 1997-11-25 | 2002-07-23 | The Regents Of The University Of California | Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US6927069B2 (en) | 1997-11-25 | 2005-08-09 | The Regents Of The University Of California | Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US7314764B2 (en) | 1997-11-25 | 2008-01-01 | The Regents Of The University Of California | Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US6699723B1 (en) | 1997-11-25 | 2004-03-02 | The Regents Of The University Of California | Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US7101718B2 (en) | 1997-11-25 | 2006-09-05 | The Regents Of The University Of California | Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US6727065B2 (en) | 1997-11-25 | 2004-04-27 | The Regents Of The University Of California | Methods of use of semiconductor nanocrystal probes for treating a material |
EP1049807A4 (en) * | 1998-01-22 | 2001-08-29 | Luminex Corp | Microparticles with multiple fluorescent signals |
EP1049807A1 (en) * | 1998-01-22 | 2000-11-08 | Luminex Corporation | Microparticles with multiple fluorescent signals |
EP1079967A4 (en) * | 1998-04-13 | 2003-07-23 | Luminex Corp | Liquid labeling with fluorescent microparticles |
EP1079967A1 (en) * | 1998-04-13 | 2001-03-07 | Luminex Corporation | Liquid labeling with fluorescent microparticles |
WO2000014545A1 (en) * | 1998-09-03 | 2000-03-16 | Trellis Bioinformatics, Inc. | Multihued labels |
US6492125B2 (en) | 1998-09-03 | 2002-12-10 | Trellis Bioscience, Inc. | Method to assess library X library interactions |
EP1942346A1 (en) * | 1998-09-03 | 2008-07-09 | Trellis Bioinformatics Inc. | Multihued labels |
US6642062B2 (en) | 1998-09-03 | 2003-11-04 | Trellis Bioinformatics, Inc. | Multihued labels |
US6319426B1 (en) | 1998-09-18 | 2001-11-20 | Massachusetts Institute Of Technology | Water-soluble fluorescent semiconductor nanocrystals |
US6602671B1 (en) | 1998-09-18 | 2003-08-05 | Massachusetts Institute Of Technology | Semiconductor nanocrystals for inventory control |
US7943552B2 (en) | 1998-09-18 | 2011-05-17 | Massachusetts Institute Of Technology | Inventory control |
US6306610B1 (en) | 1998-09-18 | 2001-10-23 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
US6696304B1 (en) | 1999-02-24 | 2004-02-24 | Luminex Corporation | Particulate solid phase immobilized protein quantitation |
WO2000055363A2 (en) * | 1999-03-12 | 2000-09-21 | Amersham Pharmacia Biotech Uk Ltd | Analysis of differential gene expression |
WO2000055363A3 (en) * | 1999-03-12 | 2000-12-21 | Amersham Pharm Biotech Uk Ltd | Analysis of differential gene expression |
US6261782B1 (en) | 1999-04-06 | 2001-07-17 | Yale University | Fixed address analysis of sequence tags |
US6677121B2 (en) | 1999-04-06 | 2004-01-13 | Agilix Corporation | Fixed address analysis of sequence tags |
US6908737B2 (en) | 1999-04-15 | 2005-06-21 | Vitra Bioscience, Inc. | Systems and methods of conducting multiplexed experiments |
US7253435B2 (en) | 1999-04-15 | 2007-08-07 | Millipore Corporation | Particles with light-polarizing codes |
US8939376B1 (en) | 1999-04-16 | 2015-01-27 | Mycartis Nv | Encoding of microcarriers |
US8967483B2 (en) | 1999-04-16 | 2015-03-03 | Mycartis Nv | Encoding of microcarriers |
US7410802B2 (en) | 1999-07-30 | 2008-08-12 | Bioe, Inc. | Methods for simultaneously detecting both members of a binding pair |
US6383740B2 (en) | 1999-07-30 | 2002-05-07 | Bioergonomics, Inc. | Methods for simultaneously detecting both members of a binding pair |
US6773886B2 (en) | 1999-08-13 | 2004-08-10 | Yale University | Binary encoded sequence tags |
US6383754B1 (en) | 1999-08-13 | 2002-05-07 | Yale University | Binary encoded sequence tags |
WO2001013119A1 (en) * | 1999-08-17 | 2001-02-22 | Luminex Corporation | Encapsulation of fluorescent particles |
US6905766B2 (en) | 1999-08-17 | 2005-06-14 | Luminex Corporation | Encapsulation of discrete quanta of fluorescent particles |
WO2001014589A3 (en) * | 1999-08-20 | 2002-08-01 | Luminex Corp | Liquid array technology |
WO2001014589A2 (en) * | 1999-08-20 | 2001-03-01 | Luminex Corporation | Liquid array technology |
WO2001020533A3 (en) * | 1999-09-15 | 2002-08-15 | Luminex Corp | Creation of a database of biochemical data and methods of use |
WO2001020533A2 (en) * | 1999-09-15 | 2001-03-22 | Luminex Corporation | Creation of a database of biochemical data and methods of use |
US6819692B2 (en) | 2000-03-14 | 2004-11-16 | Massachusetts Institute Of Technology | Optical amplifiers and lasers |
US8034259B2 (en) | 2000-03-20 | 2011-10-11 | Massachusetts Institute Of Technology | Inorganic particle conjugates |
US8192646B2 (en) | 2000-03-20 | 2012-06-05 | Massachusetts Institute Of Technology | Inorganic particle conjugates |
US6921496B2 (en) | 2000-03-20 | 2005-07-26 | Massachusetts Institute Of Technology | Inorganic particle conjugates |
US7470379B2 (en) | 2000-03-20 | 2008-12-30 | Massachusetts Institute Of Technology | Inorganic particle conjugates |
WO2001073117A1 (en) * | 2000-03-31 | 2001-10-04 | MEMOREC STOFFEL GmbH - MEDIZINISCH-MOLEKULARE ENTWICKLUNG, KÖLN | Use of particles which have signal-emitting characteristics and at least one group with an affinity for marked nucleic acids |
US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
WO2002016948A2 (en) * | 2000-08-18 | 2002-02-28 | Syngenta Participations Ag | High throughput method and kit |
AU2001289811B2 (en) * | 2000-08-18 | 2005-08-25 | Syngenta Participations Ag | High throughput method and kit |
US6586190B2 (en) | 2000-08-18 | 2003-07-01 | Syngenta Participations Ag | Parallel high throughput method and kit |
WO2002016948A3 (en) * | 2000-08-18 | 2003-02-27 | Syngenta Participations Ag | High throughput method and kit |
US7057704B2 (en) * | 2000-09-17 | 2006-06-06 | Bioarray Solutions Ltd. | System and method for programmable illumination pattern generation |
US7465540B2 (en) | 2000-09-21 | 2008-12-16 | Luminex Corporation | Multiple reporter read-out for bioassays |
US8735172B2 (en) | 2000-10-19 | 2014-05-27 | Biocartis S.A. | Method and device for the manipulation of microcarriers for an identification purpose |
US7326365B2 (en) | 2001-02-09 | 2008-02-05 | Massachusetts Institute Of Technology | Composite material including nanocrystals and methods of making |
US7690842B2 (en) | 2001-02-09 | 2010-04-06 | Massachusetts Institute Of Technology | Composite material including nanocrystals and methods of making |
US10107804B2 (en) | 2001-03-23 | 2018-10-23 | Trustees Of Tufts College | Methods for detecting target analytes and enzymatic reactions |
US9436088B2 (en) | 2001-06-21 | 2016-09-06 | Bioarray Solutions, Ltd. | Un-supported polymeric film with embedded microbeads |
US9920380B2 (en) | 2001-07-03 | 2018-03-20 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
US8148512B2 (en) | 2001-07-03 | 2012-04-03 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
US8492094B2 (en) | 2001-07-03 | 2013-07-23 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
WO2003003810A2 (en) * | 2001-07-03 | 2003-01-16 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
US7919237B2 (en) | 2001-07-03 | 2011-04-05 | Nanostring Technologies, Inc. | Methods for detection and quantification of analytes in complex mixtures |
US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
WO2003003810A3 (en) * | 2001-07-03 | 2003-11-27 | Inst Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
US7190870B2 (en) | 2001-09-17 | 2007-03-13 | Massachusetts Institute Of Technology | Semiconductor nanocrystal composite |
CN100399025C (en) * | 2001-09-27 | 2008-07-02 | 北京源德生物医学工程有限公司 | Immununity and gene alaysis system by multiple mark continuous injections |
US10415081B2 (en) | 2001-10-15 | 2019-09-17 | Bioarray Solutions Ltd. | Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection |
US6962820B2 (en) | 2001-11-14 | 2005-11-08 | Beckman Coulter, Inc. | Analyte detection system |
US7300800B2 (en) | 2001-11-14 | 2007-11-27 | Beckman Coulter, Inc. | Analyte detection system |
US6838289B2 (en) | 2001-11-14 | 2005-01-04 | Beckman Coulter, Inc. | Analyte detection system |
US7150910B2 (en) | 2001-11-16 | 2006-12-19 | Massachusetts Institute Of Technology | Nanocrystal structures |
US7470473B2 (en) | 2001-11-16 | 2008-12-30 | Massachusetts Institute Of Technology | Nanocrystal structures |
US8121162B2 (en) | 2001-11-16 | 2012-02-21 | Massachusetts Institute Of Technology | Nanocrystal structures |
EP2196544A1 (en) | 2001-11-21 | 2010-06-16 | Applied Biosystems, LLC | Kit for ligation detection assays using codeable labels |
US7335153B2 (en) | 2001-12-28 | 2008-02-26 | Bio Array Solutions Ltd. | Arrays of microparticles and methods of preparation thereof |
US9611507B2 (en) | 2001-12-28 | 2017-04-04 | Bioarray Solutions, Ltd. | Arrays of microparticles and methods of preparation thereof |
US10138511B2 (en) | 2001-12-28 | 2018-11-27 | Bioarray Solutions Ltd. | Arrays of microparticles and methods of preparation thereof |
US7842649B2 (en) | 2001-12-28 | 2010-11-30 | Bioarray Solutions, Ltd. | Quality control method for making a biochip displaying an encoded bead array |
US7319709B2 (en) | 2002-07-23 | 2008-01-15 | Massachusetts Institute Of Technology | Creating photon atoms |
US9251583B2 (en) | 2002-11-15 | 2016-02-02 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
US7498054B2 (en) | 2003-01-21 | 2009-03-03 | Bioarray Solutions, Ltd. | Method for controlling solute loading of polymer microparticles |
US6964747B2 (en) | 2003-01-21 | 2005-11-15 | Bioarray Solutions, Ltd. | Production of dyed polymer microparticles |
US7255895B2 (en) | 2003-01-21 | 2007-08-14 | Bioarray Solutions, Ltd. | Method for controlling solute loading of polymer microparticles |
US7917298B1 (en) | 2003-04-17 | 2011-03-29 | Nanosys, Inc. | Nanocrystal taggants |
US7912653B1 (en) | 2003-04-17 | 2011-03-22 | Nanosys, Inc. | Nanocrystal taggants |
US8691754B2 (en) | 2003-09-22 | 2014-04-08 | Bioarray Solutions, Ltd. | Microparticles with enhanced covalent binding capacity and their uses |
US9637777B2 (en) | 2003-10-28 | 2017-05-02 | Bioarray Solutions, Ltd. | Optimization of gene expression analysis using immobilized capture probes |
WO2005071412A3 (en) * | 2004-01-09 | 2006-04-06 | Applera Corp | Phosphor particle coded beads |
US7323696B2 (en) | 2004-01-09 | 2008-01-29 | Applera Corporation | Phosphor particle coded beads |
WO2005071412A2 (en) | 2004-01-09 | 2005-08-04 | Applera Corporation | Phosphor particle coded beads |
US8525107B2 (en) | 2004-03-25 | 2013-09-03 | Perkinelmer Health Sciences, Inc. | Magnetic sector mass spectrometry based multi-parametric particle analyzer |
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US7449237B2 (en) | 2004-07-26 | 2008-11-11 | Massachusetts Institute Of Technology | Microspheres including nanoparticles in the peripheral region |
US7229690B2 (en) | 2004-07-26 | 2007-06-12 | Massachusetts Institute Of Technology | Microspheres including nanoparticles |
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US7862892B2 (en) | 2004-07-26 | 2011-01-04 | Massachusetts Institute Of Technology | Microspheres including nanoparticles |
US9147037B2 (en) | 2004-08-02 | 2015-09-29 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
US9890419B2 (en) | 2005-12-23 | 2018-02-13 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
US9371563B2 (en) | 2005-12-23 | 2016-06-21 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
US10871436B2 (en) | 2006-11-02 | 2020-12-22 | Fluidigm Canada Inc. | Particles containing detectable elemental code |
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US6514295B1 (en) | 2003-02-04 |
JP2001520323A (en) | 2001-10-30 |
EP1023464A1 (en) | 2000-08-02 |
KR20010031140A (en) | 2001-04-16 |
CA2306501C (en) | 2011-03-29 |
US20050260676A1 (en) | 2005-11-24 |
US6929859B2 (en) | 2005-08-16 |
US7445844B2 (en) | 2008-11-04 |
US20030028981A1 (en) | 2003-02-13 |
EP1023464B1 (en) | 2017-07-26 |
US6632526B1 (en) | 2003-10-14 |
US6599331B2 (en) | 2003-07-29 |
JP4357112B2 (en) | 2009-11-04 |
US20040053052A1 (en) | 2004-03-18 |
IL135593A (en) | 2004-06-01 |
EP1023464A4 (en) | 2007-01-10 |
HUP0003986A2 (en) | 2001-03-28 |
IL135593A0 (en) | 2001-05-20 |
AU1080999A (en) | 1999-05-03 |
CA2306501A1 (en) | 1999-04-22 |
HUP0003986A3 (en) | 2001-04-28 |
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