WO1999020327A2 - Spring-actuated infusion syringe - Google Patents
Spring-actuated infusion syringe Download PDFInfo
- Publication number
- WO1999020327A2 WO1999020327A2 PCT/US1998/022083 US9822083W WO9920327A2 WO 1999020327 A2 WO1999020327 A2 WO 1999020327A2 US 9822083 W US9822083 W US 9822083W WO 9920327 A2 WO9920327 A2 WO 9920327A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- barrel
- housing
- proximal end
- syringe
- piston
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M5/1454—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons spring-actuated, e.g. by a clockwork
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3114—Filling or refilling
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
A spring-actuated infusion syringe includes a housing having an open distal end, with a spring-loaded piston disposed for axial translation in the housing. The piston is biased toward the distal end of the housing. The syringe also includes a barrel for containing a liquid medicament, the barrel having a distal end having a fluid passage therethrough and an open proximal end. A plunger is disposed in the barrel for axial translation therein. The proximal end of the barrel is axially insertable into the distal end of the housing, whereby the piston enters the proximal end of the barrel and engages the plunger. In use, the barrel is filled with a medicament through the fluid flow passage, and the flow of medicament from the syringe is obstructed. The proximal end of the barrel is inserted into the distal end of the housing, whereby the piston enters the proximal end of the barrel. The plunger, immobilized by the hydrostatic pressure of the liquid in the barrel, pushes the piston proximally against its biasing force. An engagement between an annular barrel flange and an internal housing thread retains the barrel at the desired axial position within the housing. To deliver the liquid from the syringe, the obstruction is removed. The hydrostatic pressure in the barrel being relieved, the biasing force of the piston pushes the plunger distally into the barrel, displacing the liquid therefrom through the fluid flow passage.
Description
ι SPRING-ACTUATED INFUSION SYRINGE
2
3 CROSS-REFERENCE TO RELATED APPLICATION
4 Not Applicable
5
6 FEDERALLY FUNDED RESEARCH OR DEVELOPMENT
7 Not Applicable
8
9 BACKGROUND OF THE INVENTION ιo This invention relates generally to the field of liquid infusion ιι devices for medical applications. More specifically, it relates to
12 mechanically-driven infusion devices used for the administration of a
13 liquid medicament to a patient from a filled syringe into an intravenous
14 (IV) administration system.
15 Various devices have been developed for the intravenous (IV)
16 infusion of liquid medicaments into a patient at a controlled flow rate
17 over an extended period of time. For example, gravity flow IV
18 administration sets have been employed for many years, and more
19 recently, IV administration sets with electrically powered pumps have
20 been developed.
21 There are applications in which a more compact and inexpensive
22 type of infusion device is desired or required. For example, in addition
23 to direct infusion from a syringe, it is frequently necessary to infuse a
24 secondary fluid into a primary IV flow from a gravity flow or
25 electrically-pumped IV administration set. Also, infusion into an
26 ambulatory patient frequently requires an infusion device that is less
27 bulky, less complex, and easier to use than gravity flow or
28 pump-powered devices. For such applications, relatively complex
29 self-powered infusion devices are frequently used.
ι With a typical, manually actuated IV administration syringe,
2 infusion over an extended period of time is usually impractical or
3 inconvenient. Furthermore, even among syringes of the same size from
4 the same manufacturer, the actuation forces required to provide a given
5 fluid flow-versus-time profile vary greatly from syringe to syringe.
6 Consequently, it is necessary to provide a sufficiently high actuation
7 force to achieve a substantial degree of uniformity in fluid delivery from s syringe to syringe. It has proven difficult consistently to achieve such
9 sufficiently high syringe actuation forces with manually actuated ιo syringes. ιι To overcome these problems, the prior art has devised a variety
12 of mechanisms for increasing the actuation force on the syringe
13 throughout the infusion process. One type of syringe actuation
14 mechanism is that which utilizes either internal or external springs to is displace the plunger of the syringe. Examples of such mechanisms are
16 shown in the following U.S. Patents: 2,472,116 - Maynes; 2,565,081 -
17 Maynes; 2,591,457 - Maynes; 3,880,163 - Ritterskamp; 3,882,863 - is Sarnoff et al.; 4,381,006 - Genese; 4,530,695 - Phillips et al.; 4,597,754 -
19 Thill et al.; 4,623,330 - Laby et al.; 4,755,172 - Baldwin; 4,966,585 -
20 Gangemi; 4,997,420 - LeFevre; 5,078,679 - Reese; 5,100,389 -
21 Vaillancourt; 5,178,609 - Ishikawa; 5,318,539 - O'Neil; 5,320,609 - Haber
22 et al.; 5,330,430 - Sullivan; 5,383,858 - Reilly et al.; and 5,599,315 -
23 McPhee. Another example is shown in European Patent Application
24 Publication No. 584 569 A2.
25 The known prior art devices suffer from one or more
26 shortcomings, however. For example, several of the above-listed patents
27 show the use of "constant force" springs, which are elongated flat leaf
28 springs coiled on a drum. Such springs, however, add expense, bulk,
29 and mechanical complexity to the device.
ι Another drawback of some prior art devices is that a relatively
2 great physical effort is required to compress the plunger actuation
3 spring, because these devices lack a sufficient mechanical advantage to
4 reduce the "loading effort" any appreciable degree. Other syringe
5 actuation devices of the prior art require the syringe to be disconnected
6 from any downstream fluid conduits (such as an IV administration set)
7 before being loaded into the actuation device. This limitation makes s such devices disadvantageous for use in those clinical applications, such
9 as IV administration procedures, in which it is advantageous to load a ιo pre-filled syringe into the syringe actuation device while the syringe is ιι connected to the IV conduit.
12 It would therefore be a significant advancement over the prior art
13 to provide a spring-actuated infusion syringe that overcomes the
14 aforementioned limitations. Specifically, it would be advantageous to
15 provide such a device that yields improved uniformity in
16 syringe-to-syringe fluid flow rates without a mechanism of undue
17 complexity. Furthermore, it would be advantageous to provide such a is syringe that may be filled and spring-loaded without undue physical
19 effort, and without disconnecting it from a downstream conduit.
20 21 SUMMARY OF THE INVENTION
22 Broadly, the present invention is a spring-actuated infusion
23 syringe comprising a tubular barrel for holding a liquid medicament.
24 The barrel has an open proximal end and a distal end portion that
25 defines a fluid flow passage communicating with the interior of the
26 barrel. A plunger disposed for axial translation in the barrel is engaged
27 by a spring-loaded piston that drives the plunger distally into the barrel
28 to express the contents of the barrel from the syringe.
29 More specifically, in accordance with a preferred embodiment of
ι the invention, the syringe further comprises an internally-threaded
2 hollow housing with an open distal end and a coil spring disposed
3 longitudinally therein. The spring has a proximal end that is seated
4 against an end cap forming a closed proximal end for the housing. The
5 piston includes a hollow, tubular portion that receives the distal end of
6 the spring, the latter seating against a spring seat at the distal end of the
7 piston. The proximal end of the syringe barrel has an annular flange β that functions as an external thread for engagement with the internal 9 thread of the housing. The spring provides a distally-directed biasing ιo force against the piston. ιι In use, the barrel of the syringe is filled with a medicament
12 through the fluid flow passage in the distal end portion, and then the
13 flow of medicament from the syringe is obstructed (for example, by a
14 valve or a clamp or the like). The proximal end of the syringe barrel is is inserted into the open distal end of the housing, and it is installed in the
16 housing by threading the flange along the internal housing thread.
17 When the barrel is inserted into the housing, the piston enters the is proximal end of the barrel and seats against the plunger. As the barrel
19 is threaded into the housing, the piston compresses the spring against
20 the biasing force of the spring. The threading is stopped when the
21 spring is compressed to the desired degree. Decompression of the
22 spring is prevented by the hydrostatic pressure of the liquid within the
23 barrel, which cannot be relieved due to the obstruction of the outflow of
24 liquid from the barrel. The engagement between the annular barrel
25 flange and the internal housing thread retains the barrel at the desired
26 axial position within the housing.
27 When it is desired to deliver the liquid from the syringe into the
28 infusion system, the obstruction is removed. The hydrostatic pressure
29 on the liquid in the barrel being thereby relieved, the spring
ι decompresses, its biasing force pushing the piston, and with it the
2 plunger, distally into the syringe barrel. The movement of the plunger
3 distally within the barrel displaces the liquid therefrom through the fluid
4 flow passage in the distal tip portion of the barrel, and expresses the
5 liquid as an outflow into the system.
6 The plunger is advantageously configured to facilitate the filling
7 of the barrel with a liquid medicament provided from an external source
8 or container. Specifically, a filling implement is provided, which
9 comprises a rod with a handle at its proximal end and a hook at its ιo distal end. The interior of the plunger is provided with a fitting that ιι may be engaged by the hook. When the barrel is empty, with the
12 plunger at its distal extreme of travel, the filling implement is inserted
13 into the open proximal end of the barrel, and the hook is engaged with
14 the fitting. With the barrel in fluid communication with a source of is liquid medicament, the plunger is pulled proximally by means of the
16 filling implement, thereby filling the barrel. When the barrel is filled,
17 the hook is disengaged from the fitting, and the filling implement is is removed from the barrel. The barrel is now ready for installation in the
19 housing, as described above.
20 As will be seen from the foregoing summary, a spring-actuated
21 syringe in accordance with the present invention provides sufficient
22 syringe actuation force substantially to overcome non-uniformity in
23 syringe-to-syringe operational characteristics, with a more nearly
24 constant fluid flow rate as the syringe is emptied without the use of
25 "constant force" springs and their attendant complexities. Furthermore,
26 the syringe does not have to be disconnected from an infusion system in
27 order to be loaded into a separate actuation device. In addition, the
28 syringe can be filled without having to overcome the force of the spring,
29 since the spring is removed from the barrel during the filling process.
ι Moreover, the spring-actuated syringe is compact in size and simple to
2 operate. Still further, it can be manufactured at sufficiently low cost so
3 as to be disposable. These and other advantages will be more fully
4 appreciated from the detailed description that follows.
BRIEF DESCRIPTION OF THE DRAWINGS
Figure 1 is an axial cross-sectional view of a spring-actuated β infusion syringe in accordance with a preferred embodiment of the
9 invention, showing a filled syringe at the beginning of the spring-loading ιo process; ιι Figure 2 is an axial cross-sectional view, similar to that of Figure
12 1, showing a filled syringe at the conclusion of the spring-loading
13 process;
14 Figure 3 is an axial cross-sectional view, similar to that of Figures is 1 and 2, showing the syringe after its contents have been discharged;
16 Figure 4 is a cross-sectional view taken along line 4 - 4 of Figure
17 1;
18 Figure 5 is an exploded perspective view of the plunger assembly
19 and the piston of the syringe;
20 Figure 6 is an axial cross-sectional view of the syringe barrel and
21 plunger, with a filling attachment attached to the plunger prior to filling
22 the barrel; and
23 Figure 7 is an axial cross-sectional view, similar to that of Figure
24 6, showing the position of the plunger and the filling attachment after
25 the barrel has been filled.
26
27 DETAILED DESCRIPTION OF THE
28 PREFERRED EMBODIMENT
29 Referring now to the drawings, and specifically to Figures 1
ι through 5, a spring-actuated syringe 10, in accordance with a preferred
2 embodiment of the invention, is shown. The syringe 10 comprises a
3 hollow, tubular barrel 12 having a tapered, conical distal tip portion 14
4 that defines a fluid flow passage 15 (Figure 3) that communicates with
5 the interior of the barrel 12. The distal tip portion terminates in a
6 fitting 16 that is adapted for connection to a fluid conduit 17 (Figure 6),
7 of the type commonly used in infusion systems. The barrel 12 has an
8 open proximal end surrounded by an annular flange 18.
9 Disposed within the barrel 12 for longitudinal (axial) translation ιo therein is a plunger assembly, comprising a conical plunger tip 20, ιι formed of an elastomeric material, attached to a more rigid plunger
12 core 22. The attachment of the plunger tip 20 to the plunger core 22
13 may be by means of an annular lip 24 on the tip 20 that is received by,
14 and frictionally crimped into, a mating annular groove 26 in the core 22, is as best shown in Figure 5. The plunger core 22 includes proximally-
16 extending central projection 28 that has a transverse bore 30. A
1 peripheral rim 32 coaxially surrounds the projection 28, thereby defining is an annular surface 34 between the projection 24 and the rim 32, as best
19 shown in Figures 6 and 7.
20 The syringe 10 further comprises a hollow, cylindrical housing 36
21 having a distal end opening 37 and an open proximal end. The interior
22 surface of the housing 36 adjacent the proximal end is provided with an
23 internal thread 38 that mates with an external thread 40 on an end cap
24 42 which closes the proximal end of the housing 36, and which thus
25 defines a proximal end wall. A major portion of the interior surface of
26 the housing 36, extending proximally from its distal end, is formed with
27 a continuous helical land 44 that defines a continuous helical groove 45
28 that functions as a relatively large-pitched internal thread. The inside
29 diameter of the distal opening 37 is sufficiently large to permit the
ι flange 18 at the proximal end of the barrel 12 to be threaded into the
2 housing 36 by cooperation with the helical groove 45. Thus, the barrel
3 12 is retained at a selected axial position within the housing 36 by
4 means of the threaded engagement between the flange 18 and the
5 helical groove 45.
6 Extending distally from the interior surface of the end cap 42 is a
7 first or proximal spring guide 46. The proximal spring guide 46 is a
8 hollow, tubular member that is joined to the interior surface of the end
9 cap 42 by a cylindrical base portion 48. The proximal portion of a coil ιo spring 50 is coaxially carried around the proximal spring guide 46, with ιι the proximal end of the coil spring 50 seating against the proximal end
12 wall defined by the interior surface of the end cap 42, around the base
13 portion 48 of the proximal spring guide 46.
14 The exterior surface of the end cap 42 has a central pocket 52 is that communicates with the hollow interior of the proximal spring guide
16 46 by means of a narrow passage 54 through the base portion 48. The
17 proximal end of a flexible, filamentous tether 56 is passed through the is passage 54 into the pocket 52, where a proximal retention knob 58,
19 preferably a copper stamping or the like, is crimped onto the proximal
20 end of the tether 56. The tether 56 is preferably a length of braided
21 stainless steel wire, although other types of metal wire, and perhaps
22 some types of polymeric filament, may serve.
23 The distal end of the tether 56 is secured to a piston 60 that
24 provides a seat for the distal end of the coil spring 50. The piston 60 is
25 a hollow, tubular member with an open proximal end, and it is disposed
26 coaxially within the housing 36 for axial translation therein. The piston
27 60 has an outside diameter that is slightly smaller than the inside
28 diameter of the barrel 12 so that it is slidably received within the barrel
29 12, through the open proximal end of the barrel 12, for axial translation
ι therein. The piston 60 has an annular distal end wall 62 (best shown in
2 Figure 4) against which the distal end of the coil spring 50 is seated.
3 Extending proximally into the interior of the piston 60 from the distal
4 end wall 62 is a central cylindrical member 64. The cylindrical member
5 64 functions as a distal spring guide that coaxially carries the distal end e of the coil spring 50. The distal spring guide 64 has a hollow interior that defines a chamber 66 that is accessed by a narrow axial passage 68
8 through the proximal wall of the distal spring guide 64.
9 The distal end of the tether 56 passes through the open proximal ιo end of the piston 60. It is then passed though the axial passage 68 and ιι secured within the chamber 66 by a distal retention knob 70, similar to
12 the proximal retention knob 58, that is crimped onto it. The spring 50
13 urges the piston 60 distally toward the open distal end of the housing
14 36. The length of the tether 56 is selected so as to limit the travel of is the piston 60 so that, at its distal limit of travel, no more than about
16 one-third to one-half of the axial length of the piston 60 extends out of
17 the open distal end of the housing 36, as shown in Figure 1.
18 The distal end of the distal spring guide 64 is configured so as to
19 define a central recess 72. This central recess 72 receives the central
20 projection 28 of the plunger core 22. The distal portion of the piston 60
21 is of a slightly smaller outside diameter than the rest of the piston 60,
22 thereby defining a peripheral seat 74 that receives the peripheral rim 32
23 of the plunger core 22. There is thus an intimate engagement between
24 the plunger core 22 and the piston 60.
25 Figures 6 and 7 illustrate the initial steps in the method of using
26 the syringe 10. With the barrel 12 removed from the housing 36, and
27 with the plunger assembly 20, 22 at its distal limit of travel, the distal
28 barrel fitting 16 is connected to one end of the fluid conduit 17, the
29 other end of which is in fluid communication with a medicament source
ι 76. A filling implement 80 is inserted into the open proximal end of the
2 barrel 12, and it is engaged with the plunger assembly 20, 22 to fill the
3 barrel 12 through the conduit 17. The filling implement 80 comprises
4 an elongate rod 82 having an angled or hooked distal end 84 and a
5 proximal end formed into a grip or handle 86. As shown in Figure 6,
6 the hooked distal end 82 of the filling implement is inserted through the
7 transverse bore 30 of the plunger core projection 28. Using the filling s implement 80, a practitioner pulls the plunger assembly 20, 22
9 proximally, thereby drawing the medicament into the barrel 12 through ιo the fluid flow passage 15 in the distal tip portion 16. When the barrel ιι 12 is filled, the plunger is at or near its proximal limit of travel, as
12 shown in Figure 7. At this point, the filling implement 80 is disengaged
13 from the plunger assembly 20, 22, and removed from the barrel 12.
14 Outflow of the contents of the barrel is prevented by obstructing the is conduit 17, by means such as a clamp (not shown) or a valve (not
16 shown).
17 Referring again to Figure 1, the proximal end of the barrel 12 is is inserted into the distal opening 37 of the housing 36. The insertion of
19 the barrel 12 into the housing 36 brings the plunger core 22 into
20 engagement with the piston 60, as described above. The proximal
21 flange 18 of the barrel 12 engages the internal helical groove 45, so that
22 the barrel 12 may be threaded into the housing 36. The fluid in the
23 barrel 12, being obstructed from outflow, is incompressible. Thus, by
24 threading the barrel 12 into the housing 60, the piston 60 is pushed
25 proximally by the plunger assembly 20, 22 against the force of the spring
26 50, thereby compressing the spring 50, as shown in Figure 2. The spring
27 is maintained in a compressed state by the hydrostatic pressure of the
28 fluid contained in the syringe barrel 12.
29 When fluid outflow from the barrel is permitted (i.e., by removing
ι the obstruction from the conduit), the hydrostatic pressure applied by
2 the fluid is relieved, thereby allowing the spring 50 to decompress. The
3 decompressing spring 50 urges the piston 60, and thus the plunger
4 assembly 20, 22, toward the distal end of the barrel, as shown in Figure
5 3, thereby displacing the fluid from the barrel 12 through the fluid flow e passage 15 in the distal tip portion 16.
7 When the barrel 12 is empty, it is merely threaded out of the
8 housing 36. The piston 60 is retained at least partially within the
9 housing 36 by means of the tether 56. ιo The degree of compression of the spring 50, and thus the force it ιι exerts on the piston 60 and the plunger assembly 20, 22, may be
12 adjusted by threading the end cap 42 into or out of the proximal end of
13 the housing. This threading action may be facilitated by means on the
14 exterior surface of the end cap for receiving a tool (not shown) for is turning the end cap. For example, the pocket 52 in the exterior of the
16 end cap 42 may be dimensioned and configured to receive a hex key, or
1 a screwdriver blade, or the like.
18 There has thus been described a novel spring-actuated syringe
19 that provides the benefits of spring-actated syringes with a structure that
20 is simpler and more economical to manufacture than prior art spring-
21 actuated syringes. Thus, a syringe in accordance with the present
22 invention may be made as a disposable assembly. Furthermore, the
23 syringe may filled and spring-loaded without undue physical effort, and
24 without disconnecting it from an infusion system.
25 While a preferred embodiment of the invention has been
26 described herein, it will be appreciated that a number of modifications
27 and variations may suggest themselves to those skilled in the pertinent
28 arts. For example, the configuration of the housing and the spring are
29 exemplary only, as is the structure of the piston, the plunger, and the
filling implement. Such modifications and variations should therefore be considered within the spirit and scope of the present invention, as defined in the claims that follow.
Claims
╬╣ WHAT IS CLAIMED IS:
2 1. A spring-actuated syringe, comprising:
3 a housing having an open distal end and a proximal end
4 terminated by a proximal end wall;
5 a piston disposed in the housing for axial translation e therein;
7 a spring disposed longitudinally in the housing between the
8 piston and the proximal end wall of the housing so as to bias the
9 piston toward the distal end of the housing; ╬╣o a barrel for the containment of a liquid medicament, the ╬╣╬╣ barrel having a distal end portion having a fluid flow passage
12 therethrough and an open proximal end, the proximal end of the
13 barrel being axially insertable in the housing through the open
14 distal end of the housing, whereby the piston is received in the
15 barrel through the proximal end of the barrel when the barrel is
16 inserted into the housing; and
17 a plunger disposed in the barrel for axial translation is therein, the plunger being engaged by the piston when the piston
19 is received in the barrel.
20
21 2. The syringe of Claim 1, further comprising:
22 retention means, operable between the barrel and the housing,
23 for retaining the barrel at a selected axial position in the housing when
24 the barrel is inserted axially into the housing.
25
26 3. The syringe of Claim 1, wherein the piston is connected to the
27 proximal end of the housing by a tether.
28
29 4. The syringe of Claim 3, wherein the tether passes through the ╬╣ length of the spring.
2
3 5. The syringe of Claim 3, wherein the tether is a filamentous
4 element.
5
6 6. The syringe of Claim 2, wherein the retention means
7 comprises:
8 an internal thread in the housing; and
9 a peripheral flange around the proximal end of the barrel ╬╣o that is engageable with the internal thread, whereby the barrel is ╬╣╬╣ threadable into the housing to a selected axial position.
12
13 7. The syringe of Claim 1, further comprising means for adjusting
14 the bias force applied by the spring to the piston.
15
16 8. The syringe of Claim 7, wherein the means for adjusting the
17 bias force comprises: is an end cap in the proximal end of the housing, the end cap
19 including the proximal end wall of the housing; and
20 means for adjusting the axial position of the end cap in the
21 housing.
22
23 9. The syringe of Claim 8, wherein the means for adjusting the
24 axial position of the end cap comprises:
25 an internal thread in the proximal end of the housing; and
26 an external thread on the end cap that is engageable with
27 the internal thread in the proximal end of the housing.
28
29 10. The syringe of Claim 1, wherein the plunger is engageable ╬╣ through the proximal end of the barrel so as to be pulled from the distal
2 end of the barrel toward the proximal end thereof.
3
4 11. A medicament containment device for use in a spring-
5 actuated syringe, comprising:
6 a barrel for the containment of a liquid medicament, the
7 barrel having a distal end with a fluid flow passage therethrough
8 and an open proximal end; and
9 a plunger disposed in the barrel for axial translation ╬╣o therein, wherein the plunger is engageable through the proximal ╬╣╬╣ end of the barrel so as to be pulled from the distal end of the
12 barrel toward the proximal end thereof for filling the barrel with
13 a liquid medicament through the fluid flow passage.
14 is 12. The device of Claim 11, further comprising a filling
16 implement engageable with the plunger through the proximal end of the
17 barrel for pulling the plunger from the distal end of the barrel toward is the proximal end thereof.
19
20 13. The device of Claim 12, wherein the plunger includes a
21 transverse bore, and wherein the filling implement is engageable with
22 the transverse bore.
23
24 14. A method of dispensing a liquid medicament from a syringe,
25 comprising the steps of:
26 providing a syringe barrel having a distal end with a fluid
27 flow passage therethrough and an open proximal end and a
28 plunger disposed for axial translation in the barrel between a
29 distal position and a proximal position; ╬╣ fluidly connecting the distal end of the barrel to a source of
2 liquid medicament;
3 filling the barrel with the liquid medicament through the
4 fluid flow passage by pulling the plunger from the distal position
5 toward the proximal position;
6 obstructing the flow of medicament from the fluid flow
7 passage, whereby a hydrostatic pressure within the barrel
8 substantially prevents the movement of the plunger toward the
9 distal end of the barrel; ╬╣o providing a housing having an open distal end and a piston ╬╣╬╣ disposed for axial translation in the housing, the piston being
12 spring-biased toward the distal end of the housing;
13 inserting the proximal end of the barrel into the distal end
14 of the housing so as to engage plunger against the piston through is the proximal end of the barrel, whereby the piston is displaced
16 against its bias toward the proximal end of the housing by the
17 plunger; and
18 removing the obstruction to the flow of medicament,
19 thereby relieving the hydrostatic pressure, whereby the plunger is
20 displaced toward its distal position by the biasing force of the
21 piston so as to dispense the medicament from the barrel through
22 the fluid flow passage.
23
24 15. The method of Claim 14, wherein the step of inserting the
25 barrel includes the step of retaining the barrel in the housing at a
26 selected axial position in the housing.
27
28 16. The method of Claim 14, wherein the step of filling the
29 barrel includes the steps of: ╬╣ providing a filling implement that is engageable with the
2 plunger;
3 inserting the filling implement into the proximal end of the
4 barrel;
5 attaching the filling implement to the plunger; and
6 pulling the filling implement proximally so as to pull the
7 plunger toward its proximal position.
8
9 17. A spring-actuated syringe, comprising: ╬╣o a housing having an open distal end and a proximal end ╬╣╬╣ terminated by a proximal end wall;
12 a spring-biased piston disposed in the housing for axial
13 translation therein, the piston being biased toward the distal end
14 of the housing; is a filamentous tether connecting the piston to the proximal
16 end wall of the housing;
17 a barrel for the containment of a liquid medicament, the is barrel having a distal end with a fluid flow passage therethrough
19 and an open proximal end, the proximal end of the barrel being
20 axially insertable in the housing through the open distal end of
21 the housing, whereby the piston is received in the barrel through
22 the proximal end of the barrel when the barrel is inserted into the
23 housing; and
24 a plunger disposed in the barrel for axial translation
25 therein, the plunger being engaged by the piston when the piston
26 is received in the barrel.
27
28 18. The syringe of Claim 17, wherein the piston is spring-biased
29 by a bias force applied by a coil spring disposed axially in the housing. ╬╣ 19. The syringe of Claim 17, further comprising:
2 retention means, operable between the barrel and the
3 housing, for retaining the barrel at a selected axial position in the
4 housing when the barrel is inserted axially into the housing.
5
6 20. The syringe of Claim 18, wherein the tether passes through
7 the length of the spring.
8
9 21. The syringe of Claim 19, wherein the retention means ╬╣o comprises: ╬╣╬╣ an internal thread in the housing; and
12 a peripheral flange around the proximal end of the barrel
13 that is engageable with the internal thread, whereby the barrel is
14 threadable into the housing to a selected axial position.
15
16 22. The syringe of Claim 18, further comprising means for
17 adjusting the bias force applied by the spring to the piston.
18
19 23. The syringe of Claim 22, wherein the spring has a proximal
20 end seated against the proximal end wall of the housing, and wherein
21 the means for adjusting the bias force comprises:
22 an end cap in the proximal end of the housing, the end cap
23 including the proximal end wall of the housing; and
24 means for adjusting the axial position of the end cap in the
25 housing.
26
27 24. The syringe of Claim 23, wherein the means for adjusting the
28 axial position of the end cap comprises:
29 an internal thread in the proximal end of the housing; and an external thread on the end cap that is engageable with the internal thread in the proximal end of the housing.
25. The syringe of Claim 17, wherein the plunger is engageable through the proximal end of the barrel so as to be pulled from the distal end of the barrel toward the proximal end thereof.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU98095/98A AU9809598A (en) | 1997-10-21 | 1998-10-19 | Spring-actuated infusion syringe |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/957,970 US6019747A (en) | 1997-10-21 | 1997-10-21 | Spring-actuated infusion syringe |
US08/957,970 | 1997-10-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999020327A2 true WO1999020327A2 (en) | 1999-04-29 |
WO1999020327A3 WO1999020327A3 (en) | 1999-07-01 |
Family
ID=25500426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/022083 WO1999020327A2 (en) | 1997-10-21 | 1998-10-19 | Spring-actuated infusion syringe |
Country Status (3)
Country | Link |
---|---|
US (1) | US6019747A (en) |
AU (1) | AU9809598A (en) |
WO (1) | WO1999020327A2 (en) |
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---|---|---|---|---|
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US6699218B2 (en) | 2000-11-09 | 2004-03-02 | Insulet Corporation | Transcutaneous delivery means |
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US6712794B2 (en) | 2001-08-21 | 2004-03-30 | Spinal Specialties, Inc. | Apparatus for delivering a viscous liquid to a surgical site |
US20040078028A1 (en) * | 2001-11-09 | 2004-04-22 | Flaherty J. Christopher | Plunger assembly for patient infusion device |
US6830558B2 (en) | 2002-03-01 | 2004-12-14 | Insulet Corporation | Flow condition sensor assembly for patient infusion device |
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US6656159B2 (en) | 2002-04-23 | 2003-12-02 | Insulet Corporation | Dispenser for patient infusion device |
US20040153032A1 (en) * | 2002-04-23 | 2004-08-05 | Garribotto John T. | Dispenser for patient infusion device |
US20050238507A1 (en) * | 2002-04-23 | 2005-10-27 | Insulet Corporation | Fluid delivery device |
US6656158B2 (en) | 2002-04-23 | 2003-12-02 | Insulet Corporation | Dispenser for patient infusion device |
JP3854190B2 (en) * | 2002-04-26 | 2006-12-06 | 株式会社ジェイテクト | Motor control device |
US6723072B2 (en) | 2002-06-06 | 2004-04-20 | Insulet Corporation | Plunger assembly for patient infusion device |
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US20040116866A1 (en) * | 2002-12-17 | 2004-06-17 | William Gorman | Skin attachment apparatus and method for patient infusion device |
US20050182366A1 (en) * | 2003-04-18 | 2005-08-18 | Insulet Corporation | Method For Visual Output Verification |
US20050065760A1 (en) * | 2003-09-23 | 2005-03-24 | Robert Murtfeldt | Method for advising patients concerning doses of insulin |
US20050070847A1 (en) * | 2003-09-29 | 2005-03-31 | Van Erp Wilhelmus Petrus Martinus Maria | Rapid-exchange balloon catheter with hypotube shaft |
US7753879B2 (en) * | 2004-01-29 | 2010-07-13 | M2 Group Holdings, Inc. | Disposable medicine dispensing device |
US20060064101A1 (en) * | 2004-02-12 | 2006-03-23 | Arthrocare Corporation | Bone access system |
US20060164913A1 (en) * | 2005-01-21 | 2006-07-27 | Arthrocare Corporation | Multi-chamber integrated mixing and delivery system |
US20060178633A1 (en) * | 2005-02-03 | 2006-08-10 | Insulet Corporation | Chassis for fluid delivery device |
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US7552240B2 (en) * | 2005-05-23 | 2009-06-23 | International Business Machines Corporation | Method for user space operations for direct I/O between an application instance and an I/O adapter |
US7959598B2 (en) | 2008-08-20 | 2011-06-14 | Asante Solutions, Inc. | Infusion pump systems and methods |
EP2208503A1 (en) * | 2009-01-20 | 2010-07-21 | Sanofi-Aventis Deutschland GmbH | Drive assembly and medication delivery device |
EP2724739B1 (en) | 2009-07-30 | 2015-07-01 | Tandem Diabetes Care, Inc. | Portable infusion pump system |
US8412310B2 (en) * | 2009-09-18 | 2013-04-02 | United Medical Innovations, Inc. | Locking syringe with integrated bias member |
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EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
US9433729B2 (en) * | 2010-09-14 | 2016-09-06 | Neomed, Inc. | Enteral syringe |
US20120237975A1 (en) | 2010-10-01 | 2012-09-20 | Jason Schrum | Engineered nucleic acids and methods of use thereof |
EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
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US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
CA2850624A1 (en) | 2011-10-03 | 2013-04-11 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
KR20140102759A (en) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | Modified nucleoside, nucleotide, and nucleic acid compositions |
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US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US11219719B2 (en) | 2012-08-28 | 2022-01-11 | Osprey Medical, Inc. | Volume monitoring systems |
US9999718B2 (en) | 2012-08-28 | 2018-06-19 | Osprey Medical, Inc. | Volume monitoring device utilizing light-based systems |
US11116892B2 (en) | 2012-08-28 | 2021-09-14 | Osprey Medical, Inc. | Medium injection diversion and measurement |
US10010673B2 (en) | 2012-08-28 | 2018-07-03 | Osprey Medical, Inc. | Adjustable medium diverter |
US9320846B2 (en) | 2012-08-28 | 2016-04-26 | Osprey Medical, Inc. | Devices and methods for modulating medium delivery |
US10022497B2 (en) | 2012-08-28 | 2018-07-17 | Osprey Medical, Inc. | Reservoir for collection and reuse of diverted medium |
US10413677B2 (en) | 2012-08-28 | 2019-09-17 | Osprey Medical, Inc. | Volume monitoring device |
WO2014064534A2 (en) | 2012-10-05 | 2014-05-01 | Chrontech Pharma Ab | Injection needle, device, immunogenic compositions and method of use |
JP6144355B2 (en) | 2012-11-26 | 2017-06-07 | モデルナティエックス インコーポレイテッドModernaTX,Inc. | Chemically modified mRNA |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
JP2016538829A (en) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | Polynucleotide encoding low density lipoprotein receptor |
US9833568B2 (en) * | 2014-01-24 | 2017-12-05 | Freddie Eng Hwee Lee | Compression element driven fluid delivery apparatus |
EP2898910A1 (en) | 2014-01-24 | 2015-07-29 | Freddie Eng Hwee Lee | Elastic band powered fluid delivery apparatus |
EP3380061A4 (en) | 2015-11-24 | 2019-07-24 | Insulet Corporation | Wearable automated medication delivery system |
WO2017091584A1 (en) | 2015-11-25 | 2017-06-01 | Insulet Corporation | Wearable medication delivery device |
EP3374905A1 (en) | 2016-01-13 | 2018-09-19 | Bigfoot Biomedical, Inc. | User interface for diabetes management system |
CN112933333B (en) | 2016-01-14 | 2023-03-28 | 比格福特生物医药公司 | Adjusting insulin delivery rate |
CA3015874A1 (en) | 2016-02-25 | 2017-08-31 | Neomed, Inc. | Syringe plunger with hinged flange |
EP3871708A3 (en) | 2016-05-26 | 2022-01-19 | Insulet Corporation | Wearable drug delivery system comprising a prefilled cartridge |
WO2018031891A1 (en) | 2016-08-12 | 2018-02-15 | Insulet Corporation | Plunger for drug delivery device |
WO2018035032A1 (en) | 2016-08-14 | 2018-02-22 | Insulet Corporation | Automatic drug delivery device with trigger mechanism |
US10751478B2 (en) | 2016-10-07 | 2020-08-25 | Insulet Corporation | Multi-stage delivery system |
WO2018071561A1 (en) * | 2016-10-12 | 2018-04-19 | Repro-Med Systems, Inc. | System and method for a syringe micro pump with wave spring |
US10780217B2 (en) | 2016-11-10 | 2020-09-22 | Insulet Corporation | Ratchet drive for on body delivery system |
US10603440B2 (en) | 2017-01-19 | 2020-03-31 | Insulet Corporation | Cartridge hold-up volume reduction |
US11045603B2 (en) | 2017-02-22 | 2021-06-29 | Insulet Corporation | Needle insertion mechanisms for drug containers |
US10695485B2 (en) | 2017-03-07 | 2020-06-30 | Insulet Corporation | Very high volume user filled drug delivery device |
US10765797B2 (en) | 2017-04-26 | 2020-09-08 | Gil Vardi | Device for controlling fluid delivery |
US11280327B2 (en) | 2017-08-03 | 2022-03-22 | Insulet Corporation | Micro piston pump |
US10973978B2 (en) | 2017-08-03 | 2021-04-13 | Insulet Corporation | Fluid flow regulation arrangements for drug delivery devices |
US11786668B2 (en) | 2017-09-25 | 2023-10-17 | Insulet Corporation | Drug delivery devices, systems, and methods with force transfer elements |
US10898656B2 (en) | 2017-09-26 | 2021-01-26 | Insulet Corporation | Needle mechanism module for drug delivery device |
US11147931B2 (en) | 2017-11-17 | 2021-10-19 | Insulet Corporation | Drug delivery device with air and backflow elimination |
USD928199S1 (en) | 2018-04-02 | 2021-08-17 | Bigfoot Biomedical, Inc. | Medication delivery device with icons |
US10874803B2 (en) | 2018-05-31 | 2020-12-29 | Insulet Corporation | Drug cartridge with drive system |
US11229736B2 (en) | 2018-06-06 | 2022-01-25 | Insulet Corporation | Linear shuttle pump for drug delivery |
US11446435B2 (en) | 2018-11-28 | 2022-09-20 | Insulet Corporation | Drug delivery shuttle pump system and valve assembly |
USD920343S1 (en) | 2019-01-09 | 2021-05-25 | Bigfoot Biomedical, Inc. | Display screen or portion thereof with graphical user interface associated with insulin delivery |
US11499841B2 (en) | 2019-04-12 | 2022-11-15 | Osprey Medical, Inc. | Energy-efficient position determining with multiple sensors |
CN110397567B (en) * | 2019-07-25 | 2020-12-01 | 河海大学常州校区 | Portable precision micropump |
US11369735B2 (en) | 2019-11-05 | 2022-06-28 | Insulet Corporation | Component positioning of a linear shuttle pump |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2472116A (en) | 1945-10-18 | 1949-06-07 | Emma C Maynes | Syringe holder |
US2565081A (en) | 1948-09-15 | 1951-08-21 | Emma C Maynes | Device for operating hypodermic syringes |
US2591457A (en) | 1948-09-15 | 1952-04-01 | Emma C Maynes | Syringe operating device |
US3880163A (en) | 1973-10-26 | 1975-04-29 | Jack H Ritterskamp | Medicinal syringe actuating device |
US3882863A (en) | 1973-08-01 | 1975-05-13 | Survival Technology | Hypodermic injection device having cannula covered with resilient sheath |
US4381006A (en) | 1980-11-10 | 1983-04-26 | Abbott Laboratories | Continuous low flow rate fluid dispenser |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB624958A (en) * | 1947-07-17 | 1949-06-20 | Emanuel Mano Wender | Improvements in syringes |
US4202333A (en) * | 1978-11-08 | 1980-05-13 | Minnesota Mining And Manufacturing Company | Fluid dispensing device |
US4316463A (en) * | 1981-01-26 | 1982-02-23 | Vac-O-Cast, Inc. | Corrosive protected hypodermic module |
NZ203203A (en) * | 1982-02-16 | 1985-09-13 | Commw Scient Ind Res Org | Controlled release device:gas diffusion limited |
US4530695A (en) * | 1982-12-31 | 1985-07-23 | N.J. Phillips Pty. Limited | Injector |
US5318539A (en) * | 1986-10-17 | 1994-06-07 | Alexander G. B. O'Neil | Liquid feeding apparatus utilizing capillary tubing, and syringe driver |
US4755172A (en) * | 1987-06-30 | 1988-07-05 | Baldwin Brian E | Syringe holder/driver and syringe arrangement and syringe/holder driver therefor |
DK579687D0 (en) * | 1987-11-04 | 1987-11-04 | Schubert Seals As | SINGLE SPEED |
US4966585A (en) * | 1988-05-31 | 1990-10-30 | Gangemi Ronald J | Infusion apparatus |
US5100389A (en) * | 1988-06-21 | 1992-03-31 | Vaillancourt Vincent L | Ambulatory infusion pump |
US4911695A (en) * | 1989-04-03 | 1990-03-27 | Coeur Laboratories, Inc. | Plunger for power-driven angiographic syringe, and syringe and power injector system utilizing same |
US4997420A (en) * | 1989-12-28 | 1991-03-05 | Lefevre Robert J | Portable drug delivery device including pump with tapered barrel |
JPH0451966A (en) * | 1990-06-19 | 1992-02-20 | Toichi Ishikawa | Medical fluid continuous injector |
US5078679A (en) * | 1990-11-13 | 1992-01-07 | Reese H William | Post-surgical anesthesia at a continuous and progressively decreasing administration rate |
GB9111600D0 (en) * | 1991-05-30 | 1991-07-24 | Owen Mumford Ltd | Improvements relating to injection devices |
GB9116595D0 (en) * | 1991-08-01 | 1991-09-18 | Univ London | Improvements in or relating to syringes |
JPH07509A (en) * | 1992-07-31 | 1995-01-06 | Nissho Corp | Medicinal liquid injecting device |
US5383858B1 (en) * | 1992-08-17 | 1996-10-29 | Medrad Inc | Front-loading medical injector and syringe for use therewith |
IL107038A (en) * | 1992-10-05 | 1997-04-15 | Senetek Plc | Medicament injectors and methods for injection using same |
US5320609A (en) * | 1992-12-07 | 1994-06-14 | Habley Medical Technology Corporation | Automatic pharmaceutical dispensing syringe |
DE69427226T2 (en) * | 1993-03-24 | 2001-08-30 | Owen Mumford Ltd | DEVICE FOR INJECTION |
US5330435A (en) * | 1993-04-08 | 1994-07-19 | Vaillancourt Vincent L | Valve for a catheter assembly |
SE9302121D0 (en) * | 1993-06-18 | 1993-06-18 | Kabi Pharmacia Ab | APPARATUS FOR CONTROLLED DELIVERY OF LIQUIDS |
US5425715A (en) * | 1993-08-05 | 1995-06-20 | Survival Technology, Inc. | Reloadable injector |
US5599315A (en) * | 1995-12-01 | 1997-02-04 | Charles J. McPhee | Syringe actuation device |
US5800405A (en) * | 1995-12-01 | 1998-09-01 | I-Flow Corporation | Syringe actuation device |
-
1997
- 1997-10-21 US US08/957,970 patent/US6019747A/en not_active Expired - Lifetime
-
1998
- 1998-10-19 AU AU98095/98A patent/AU9809598A/en not_active Abandoned
- 1998-10-19 WO PCT/US1998/022083 patent/WO1999020327A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2472116A (en) | 1945-10-18 | 1949-06-07 | Emma C Maynes | Syringe holder |
US2565081A (en) | 1948-09-15 | 1951-08-21 | Emma C Maynes | Device for operating hypodermic syringes |
US2591457A (en) | 1948-09-15 | 1952-04-01 | Emma C Maynes | Syringe operating device |
US3882863A (en) | 1973-08-01 | 1975-05-13 | Survival Technology | Hypodermic injection device having cannula covered with resilient sheath |
US3880163A (en) | 1973-10-26 | 1975-04-29 | Jack H Ritterskamp | Medicinal syringe actuating device |
US4381006A (en) | 1980-11-10 | 1983-04-26 | Abbott Laboratories | Continuous low flow rate fluid dispenser |
Cited By (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US8277412B2 (en) | 2007-07-06 | 2012-10-02 | Shl Group Ab | One shot injector with dual springs |
WO2009007229A1 (en) * | 2007-07-06 | 2009-01-15 | Shl Medical Ab | One shot injector with dual springs |
AU2008274425B2 (en) * | 2007-07-06 | 2011-08-25 | Shl Medical Ab | One shot injector with dual springs |
US10792426B2 (en) | 2008-05-20 | 2020-10-06 | Avant Medical Corp. | Autoinjector system |
US10864324B2 (en) | 2008-05-20 | 2020-12-15 | Avant Medical Corp. | Autoinjector system |
US9974904B2 (en) | 2008-05-20 | 2018-05-22 | Avant Medical Corp. | Autoinjector system |
US11883633B2 (en) | 2008-05-20 | 2024-01-30 | Avant Medical Corp. | Autoinjector system |
US8177749B2 (en) | 2008-05-20 | 2012-05-15 | Avant Medical Corp. | Cassette for a hidden injection needle |
US9925336B2 (en) | 2008-05-20 | 2018-03-27 | Avant Medical Corp. | Cassette for a hidden injection needle |
US11724032B2 (en) | 2008-07-23 | 2023-08-15 | Avant Medical Corp. | System and method for an injection using a syringe needle |
US8052645B2 (en) | 2008-07-23 | 2011-11-08 | Avant Medical Corp. | System and method for an injection using a syringe needle |
US9616173B2 (en) | 2008-07-23 | 2017-04-11 | Avant Medical Corporation | System and method for an injection using a syringe needle |
US10639422B2 (en) | 2008-07-23 | 2020-05-05 | Avant Medical Corp. | System and method for an injection using a syringe needle |
EP2646085B1 (en) | 2010-12-02 | 2019-07-10 | Oval Medical Technologies Limited | A drive assembly for an autoinjector and a method of assembling an autoinjector |
US10918805B2 (en) | 2011-04-20 | 2021-02-16 | Amgen Inc. | Autoinjector apparatus |
US11419990B2 (en) | 2011-04-20 | 2022-08-23 | Amgen Inc. | Autoinjector apparatus |
US10092706B2 (en) | 2011-04-20 | 2018-10-09 | Amgen Inc. | Autoinjector apparatus |
US9814832B2 (en) | 2011-09-02 | 2017-11-14 | Unl Holdings Llc | Drive mechanism for drug delivery pumps with integrated status indication |
US11173244B2 (en) | 2011-09-02 | 2021-11-16 | Unl Holdings Llc | Drive mechanism for drug delivery pumps with integrated status indication |
US10918788B2 (en) | 2011-09-02 | 2021-02-16 | Unl Holdings Llc | Drive mechanism for drug delivery pumps with integrated status indication |
US10322231B2 (en) | 2011-09-02 | 2019-06-18 | UNL Holdings | Drive mechanism for drug delivery pumps with integrated status indication |
US9999727B2 (en) | 2011-09-02 | 2018-06-19 | Unl Holdings Llc | Drive mechanism for drug delivery pumps with integrated status indication |
US9707335B2 (en) | 2011-09-02 | 2017-07-18 | Unitract Syringe Pty Ltd | Drive mechanism for drug delivery pumps with integrated status indication |
US10549029B2 (en) | 2011-09-02 | 2020-02-04 | Unl Holdings Llc | Drive mechanism for drug delivery pumps with integrated status indication |
GB2494682A (en) * | 2011-09-15 | 2013-03-20 | Oxford Nanopore Tech Ltd | Low-profile pump with plunger and sheath |
USD898908S1 (en) | 2012-04-20 | 2020-10-13 | Amgen Inc. | Pharmaceutical product cassette for an injection device |
EP3210636A1 (en) * | 2012-08-29 | 2017-08-30 | Unitract Syringe Pty Ltd | Variable rate controlled delivery drive mechanisms for drug delivery pumps |
US11135356B2 (en) | 2012-08-29 | 2021-10-05 | Unl Holdings Llc | Controlled delivery drive mechanisms for drug delivery pumps |
WO2014036285A3 (en) * | 2012-08-29 | 2014-07-03 | Unitract Syringe Pty Ltd | Variable rate controlled delivery drive mechanisms for drug delivery pumps |
US9987419B2 (en) | 2012-08-29 | 2018-06-05 | Unl Holdings Llc | Controlled delivery drive mechanisms for drug delivery pumps |
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US11020537B2 (en) | 2013-03-15 | 2021-06-01 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
US10786629B2 (en) | 2013-03-15 | 2020-09-29 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
US10092703B2 (en) | 2013-03-15 | 2018-10-09 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
US10492990B2 (en) | 2013-03-15 | 2019-12-03 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
US11944798B2 (en) | 2013-03-15 | 2024-04-02 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
WO2016091877A1 (en) * | 2014-12-08 | 2016-06-16 | Sanofi | Drug delivery device with a drive mechanism |
US10695487B2 (en) | 2016-08-30 | 2020-06-30 | Unl Holdings Llc | Controlled delivery drive mechanisms for drug delivery pumps |
IT201900019460A1 (en) * | 2019-10-21 | 2021-04-21 | Cane Spa | MANUALLY OPERATED MECHANICAL PUMP FOR DRUG INFUSION |
IT202100027785A1 (en) * | 2021-10-29 | 2023-04-29 | Efg S R L | SYRINGE WITH SPRING |
WO2023073636A1 (en) * | 2021-10-29 | 2023-05-04 | BCS S.r.l. | Ic-ecg measurement system |
Also Published As
Publication number | Publication date |
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AU9809598A (en) | 1999-05-10 |
US6019747A (en) | 2000-02-01 |
WO1999020327A3 (en) | 1999-07-01 |
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