WO1999020328A2 - Dispenser for an adhesive tissue sealant - Google Patents
Dispenser for an adhesive tissue sealant Download PDFInfo
- Publication number
- WO1999020328A2 WO1999020328A2 PCT/US1998/022380 US9822380W WO9920328A2 WO 1999020328 A2 WO1999020328 A2 WO 1999020328A2 US 9822380 W US9822380 W US 9822380W WO 9920328 A2 WO9920328 A2 WO 9920328A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- septum
- dispenser
- component
- carpule
- container
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00491—Surgical glue applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00491—Surgical glue applicators
- A61B2017/00495—Surgical glue applicators for two-component glue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
Definitions
- the invention relates generally to the dispensing of adhesive tissue sealants and other liquid preparations, including those requiring mixing immediately prior to use.
- an absorbable adhesive sealant composition to bond and/or seal tissue.
- the adhesive composition is readily formed from a two component mixture which includes a first part of a crosslinking agent and a second part of a protein, preferably a serum protein such as albumin. When the two parts of the mixture are combined, the mixture is initially liquid. The combined mixture then cures a vivo on the surface of tissue to give a substantive composition which securely bonds to the tissue.
- a known approach for dispensing two-part tissue sealants is to supply the user with a kit consisting of two syringes, vials containing the components, a syringe body for receiving and supporting both syringes, and a manifold for connecting the two syringes to a common nozzle.
- the user fills the syringes by piercing the septums on the vials and withdrawing solution into the barrel of the syringe. If a component is in powder form within a vial, the user first injects a solvent and then withdraws the reconstituted solution.
- the needles on the syringes are removed, the syringe barrels and plungers are supported in a syringe body, and the syringe nozzles are received in a manifold.
- the manifold passages connecting the two syringes to the common nozzle are typically narrow conduits of circular cross section.
- Carpules have been used in some syringes, e.g., U.S. Patent No. 3,767,085 to
- Cannon shows a dual carpule syringe for mixing compositions used in dentistry.
- the present invention provides an improved dispenser suitable, e.g., for quickly and easily setting up and dispensing two-part sealants or other two-part compositions requiring separation of the components until just prior to application on the tissue surface.
- the invention features a dispenser in which a dry powder (one component of a two-part adhesive tissue sealant) is stored in a container (e.g., a carpule) having a septum at one end, an open end opposite the septum, and a movable plug.
- a container e.g., a carpule
- the powder is retained at the septum end of the container by the movable plug, which is displaced and pushed back as the solvent used for reconstituting the powder is introduced (e.g., through the septum).
- the second part of the tissue sealant is contained within a second container, also with a movable plug.
- a manifold is fitted which pierces both septums and allows the contents to be dispensed.
- a dual syringe body supports the containers, and has pistons that enter the open ends to advance the movable plugs.
- the first component may be a dry powder of a water-compatible or water- soluble crosslinking agent.
- the aqueous solution for dissolving the powder may be introduced through the first septum (e.g., either via the piercer or via a second injection through the septum by a syringe).
- the movable plug may be positioned in a position in which the space between the plug and the septum is substantially the minimum necessary to contain the dry powder, thereby reducing the amount of air in that space and consequently the amount of pressure rise associated with injecting liquid through the septum.
- the movable plug can move away from the septum as liquid is injected to reduce any pressure rise.
- the second component stored in the second carpule may be a solution.
- the second component may be a protein dissolved in an aqueous buffer and capable of reacting with the solution of the first component to provide the adhesive tissue sealant.
- the invention features an improved manifold for a two-part dispenser.
- Two containers e.g., carpules
- a dual syringe body which has pistons configured to enter the open ends of the containers to advance the movable plugs.
- a manifold has cavities that receive the septum ends of the containers, and a disk supporting a piercer (e.g., hollow needle) is mounted in the base of each cavity so that the septum of a container is pierced when it is installed in a cavity.
- a piercer e.g., hollow needle
- Each disk is supported a distance above the base of a cavity to form a plenum defined by the disk and adjacent walls of the base of the cavity. Liquid exiting a container travels through the lumen of the piercer, then into the adjacent plenum, and then out of the plenum along a conduit extending to the nozzle.
- This arrangement of disks each supporting a piercer and forming a plenum provides an effective, relatively low-cost way of constructing a manifold for connecting carpule piercers to a common nozzle.
- Preferred implementations of the second aspect may include one or more of the following features.
- Each disk may be sealed to the surrounding wall of the cavity (e.g., by an elastomeric sealing member on the disk) so that the adjacent plenum is defined by the disk and the base of the cavity.
- the conduit and piercer lumen may each communicate with the plenum at laterally spaced apart locations so that flow from the piercer lumen to the conduit changes direction from a generally longitudinal flow path through the piercer lumen, to a generally lateral direction in the plenum, and then to a generally longitudinal flow path in the conduit.
- the disk may be supported from the base of the cavity by standoffs.
- the first container may contain a quantity of the first component in the form of a dry powder so that the first component must be dissolved prior to use by introduction of an aqueous solvent.
- the second container may contain a quantity of protein in an aqueous buffer that is capable of reacting with a dissolved first component to provide an adhesive tissue sealant.
- the invention features a method for dispensing a component stored in a dispenser in dry powder form and reconstituted by introduction of a solvent.
- a carpule is provided with a septum at one end, an open end opposite the septum end, and a movable plug disposed therebetween.
- the dry powder is stored between the septum and the movable plug.
- Solvent is introduced into the interior of the container by piercing the septum with a syringe and injecting the solvent into the carpule.
- the carpule is installed in a syringe body and manifold, the latter providing a flow path from the piercer to an outlet nozzle.
- Preferred implementations of the third aspect may include one or more of the following features.
- Installing the carpule in the syringe body and manifold may occur before or after the solvent is injected through the septum.
- the first movable plug may be positioned in a position in which the space between the plug and the septum is substantially the minimum necessary to contain the dry powder, thereby reducing the amount of air in that space and reducing the pressure increase within the carpule when the solvent is introduced by piercing the first septum.
- the movable plug can move away from the septum as liquid is injected to reduce any pressure rise.
- the dispenser may comprise a second carpule comprising a second septum at one end, an open end opposite the second septum and a second movable plug disposed therein, the second carpule containing a second component, and the syringe body and manifold may be sized and configured to accept the first and second carpule.
- the second component may be a protein in an aqueous buffer and capable of reacting with the first component to provide an adhesive tissue sealant.
- the dry powder of the first component may be water-compatible or water- soluble crosslinking agent capable of reacting with the second component to provide the adhesive tissue sealant.
- the invention provides a significantly simpler and easier to use dispenser, one particularly well suited to handling adhesive tissue sealants. It is also simple and relatively inexpensive to manufacture. It delivers excellent performance, and is particularly good at mixing solutions reconstituted from dry powder. Other features and advantages of the invention will be apparent from the following description and drawings, and from the claims.
- Installing the carpule in the syringe body and manifold may occur before or after the solvent is injected through the septum.
- the first movable plug may be positioned in a position in which the space between the plug and the septum is substantially the minimum necessary to contain the dry powder, thereby reducing the amount of air in that space and reducing the pressure increase within the carpule when the solvent is introduced by piercing the first septum.
- the movable plug can move away from the septum as liquid is injected to reduce any pressure rise.
- the dispenser may comprise a second carpule comprising a second septum at one end, an open end opposite the second septum, and a second movable plug disposed therein, the second carpule containing a second component, and the syringe body and manifold may be sized and configured to accept the first and second carpule.
- the second component may be a protein in an aqueous buffer and capable of reacting with the first component to provide an adhesive tissue sealant.
- the dry powder of the first component may be a water-compatible or water- soluble crosslinking agent capable of reacting with the second component to provide the adhesive tissue sealant.
- the invention provides a significantly simpler and easier to use dispenser, one particularly well suited to handling adhesive tissue sealants. It is also simple and relatively inexpensive to manufacture. It delivers excellent performance, and is particularly good at mixing solutions reconstituted from dry powder.
- Figs. 1A, IB, 1C and ID are side views of elements of a preferred embodiment of the invention.
- Fig. 2 is a side view of the base of the dual syringe body;
- Fig. 3 is a bottom view of the base of Fig. 2;
- Fig. 4 is a cross-sectional view taken along section lines 4-4 in Fig. 3;
- Fig. 5 is a cross-sectional view taken along section lines 5-5 in Fig. 3;
- Fig. 6 is a perspective view of the dual piston
- Fig. 7 is a side view of the dual piston of Fig. 6;
- Fig. 8 is a side view of the manifold
- Fig. 9 is a bottom view of the manifold of Fig. 9.
- Fig. 10 is a cross-sectional view taken along section lines 10-10 in Fig. 9.
- the dispenser kit 20 includes a first carpule 22, a second carpule 24, a dual syringe body 26 adapted to receive and support the first and second carpules, a syringe 28, and a manifold (nozzle body) 30.
- First carpule 22 has a first septum 32 at one end of first carpule body 34, the other end of the first carpule body being an open end 36.
- first movable plug 38 disposed within the first carpule 22 so that a quantity of a first component 40 is contained between the first septum 32 and the first movable plug.
- first component 40 is a quantity of dry powder of a water-compatible or water-soluble multi-functional crosslinking agent.
- the first carpule body 32 has a ridge 42 near open end 36 to facilitate the retaining of the first carpule within dual syringe 26.
- First movable plug 38 is positioned so that the space between the plug and the septum is substantially the minimum necessary to contain the dry powder, thereby reducing the amount of air in the space between the plug and septum. Reducing the amount of air entrapped with the powder has the benefit that when solvent is injected into the carpule to dissolve the powder there is less rise in pressure within the carpule, as the plug is able to move away from the septum to reduce any pressure rise. Elevated pressure is undesirable in that it could lead to difficulty when the solvent is injected into the carpule and when the carpule is later pierced on insertion in the manifold 30. An elevated pressure could result, once piercing occurs, in immediate flow of the first component into the manifold and nozzle.
- Second carpule 24 has a second septum 44 at one end of second carpule body 46, the other end of the second carpule body being an open end 48.
- second component 52 is a quantity of protein in an aqueous buffer.
- the second carpule body 46 has a ridge 56 near open end 48 to facilitate the retaining of the second carpule within dual syringe 26.
- Dual syringe body 26 includes a base 57 having two cylinders 58 and 60 adapted to receive and support the first and second carpules 22 and 24.
- Dual piston 62 is provided, adapted to enter the open ends 36 and 48 of the carpules 22 and 24 so as to contact and advance the first and second movable plugs 38 and 50.
- a flange 64 is provided to allow the practitioner to grip the dual syringe body 26 during injection in the conventional manner for syringes.
- a pair of latches 66 (only one being visible in this view) are provided to attach dual syringe body 26 to manifold 30.
- Syringe 28 is conveniently of conventional type, having a body 68, a nozzle or needle 70 at one end, and a piston 72 at the other end.
- a protective cap 74 is provided to preserve the needle 70 in a sterile condition until the kit is to be used.
- the needle 70 is adapted to pierce the first septum 32 for injecting the aqueous solvent 76 contained within syringe 28 into the first carpule 22.
- solvent 76 is pyrogen free sterile water for dissolving the dry powder of a water-compatible or water-soluble multi-functional crosslinking agent.
- Manifold 30 is adapted to fit over and pierce the first and second septums 32 and 44 after the first component 40 has been mixed with the solvent 76.
- Manifold 30 has a dual nozzle 78, which in the preferred embodiment keeps the first and second components 40 and 52 complete separate until just after the moment of dispensing.
- a pair of receptacles 80 are provided to attach dual syringe body 26 to manifold 30 by receiving latches 66.
- the kit 20 may include a static mixer and/or dispensing tip which is adapted to be fitted onto nozzle 78.
- a side view of the base 57 of the dual syringe body 26 is illustrated in isolation. It will be noted that the latches 66 each have a projection 82 which allows them to interact with the receptacles 80 as discussed above.
- a bottom view of the base 57 of Fig. 2 is illustrated. In this view it can be seen that cylinders 58 and 60 have internal through bores 84 and 86 respectively which are sized to receive first and second carpules 22 and 24 (shown in Figs. 1 A-1D).
- each of the cylinders 58 and 60 projecting inwards from the walls of each of the cylinders 58 and 60 are four tapered ledges 88 which interact with ridges 42 and 56 of first and second carpules 22 and 24 respectively to retain the carpules within the bores 84 and 86.
- FIG. 4 a cross-sectional view of base 57 taken along section lines 4-4 in Fig. 3 is illustrated.
- base 57 taken along section lines 4-4 in Fig. 3 is illustrated.
- FIG. 5 a cross-section view of base 57 taken along section lines 5-5 in Fig. 3 is illustrated so that the features of the base can be more readily seen.
- Figs. 6 and 7 views of dual piston 62 are illustrated.
- a pair of push rods 92 and 94 extend from a thumb plate 96.
- Each of the push rods 92 and 94 has a circumferential ridge 97 and 98 adapted to interact with the tapered retainers 90 discussed in connection with Figs. 4 and 5 to retain dual piston 62 within bores 84 and 86.
- the free ends 100 and 102 are intended to contact movable plugs 38 and 50 (seen in Figs. 1 A- ID) to advance them and pressurize the fluid in carpules 22 and 24 when pressure is exerted by the hand of the practitioner on the thumb plate 96.
- the manifold 30 includes barrels 104 and 106 which are sized and shaped to enclose the ends of the of carpules 22 and 24 having septums 32 and 44 when the carpules have been inserted into the base 57 and the manifold has been attached to the base by interlocking latches 66 with receptacles 80.
- nozzle 78 includes openings 108 and 110 to allow the components in carpules 22 and 24 to be dispensed as separate solutions.
- a further nozzle element (not shown) could be installed over nozzle 78 to contain and promote mixing of the two streams of liquid emerging from openings 108, 110.
- barrels 104 and 106 have cylindrical, hollow interiors (or cavities) 112 and 114 respectively to receive the carpules 22 and 24.
- a pair of piercers 116 and 118 are provided to pierce the septums 32 and 44 when the manifold 30 is mounted on the base 57.
- the piercers are conveniently mounted on mounting disks 120 and 122, the edges of which form a seal with the walls of cylinders 104 and 106.
- This may be conveniently accomplished by solvent bonding, by ultrasonic welding, or by having an elastomeric member (e.g., an o-ring within a groove) along the edge of the mounting disks 120 and 122 which contact the walls 104 and 106 and hold the mounting disks 120 and 122 in place by friction fit.
- Access is available for the contents of carpules 22 and 24 through the hollow central bore of each of the piercers into plenums 124 and 126 and on into passageways (or conduits) 128 and 130 to openings 108 and 110.
- Several standoffs 132 are conveniently molded into the base of cavities 112 and 114 to position the mounting disks 120 and 122 in the right location to provide for plenums 124 and 126.
- the dispenser kit is easily sterilized.
- the carpules can be sterile filled, and the assembled kit undergoes a terminal sterilization (e.g., with ethylene oxide gas).
- materials other than an adhesive tissue sealant may be dispensed
- the solvent for dissolving the dry powder could be nonaqueous
- the solvent (whether aqueous or nonaqueous) could be introduced into the carpule by means other than a syringe piercing the septum (e.g., the solvent could be drawn into the carpule by moving the syringe plunger outwardly to create a vacuum).
- More than two barrels and carpules e.g., three
- Individual pistons could be used instead of the dual piston 62.
- the dispenser kit is easily sterilized.
- the carpules can be sterile filled, and the assembled kit undergoes a terminal sterilization (e.g., with ethylene oxide gas).
- materials other than an adhesive tissue sealant may be dispensed
- the solvent for dissolving the dry powder could be nonaqueous
- the solvent (whether aqueous or nonaqueous) could be introduced into the carpule by means other than a syringe piercing the septum (e.g., the solvent could be drawn into the carpule by moving the syringe plunger outwardly to create a vacuum).
- More than two barrels and carpules e.g., three
- Individual pistons could be used instead of the dual piston 62.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98953887A EP1022986A2 (en) | 1997-10-22 | 1998-10-22 | Dispenser for an adhesive tissue sealant |
AU11145/99A AU1114599A (en) | 1997-10-22 | 1998-10-22 | Dispenser for an adhesive tissue sealant |
JP2000516718A JP2001520086A (en) | 1997-10-22 | 1998-10-22 | Dispenser for adhesive tissue sealants |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95630897A | 1997-10-22 | 1997-10-22 | |
US08/956,308 | 1997-10-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999020328A2 true WO1999020328A2 (en) | 1999-04-29 |
WO1999020328A3 WO1999020328A3 (en) | 2000-04-06 |
Family
ID=25498063
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/022380 WO1999020328A2 (en) | 1997-10-22 | 1998-10-22 | Dispenser for an adhesive tissue sealant |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1022986A2 (en) |
JP (1) | JP2001520086A (en) |
AU (1) | AU1114599A (en) |
WO (1) | WO1999020328A2 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1083962A1 (en) * | 1998-06-03 | 2001-03-21 | Baxter International Inc. | Direct dual filling device for sealing agents |
WO2001062162A1 (en) * | 2000-02-22 | 2001-08-30 | Power Medical Interventions, Inc. | A fluid delivery mechanism for use with anastomosing, stapling, and resecting instruments |
WO2001067961A1 (en) * | 2000-03-10 | 2001-09-20 | 3M Innovative Properties Company | Dispenser for an adhesive tissue sealant |
WO2003022457A1 (en) * | 2001-09-12 | 2003-03-20 | 3M Innovative Properties Company | Kit and method for dispensing an adhesive tissue sealant |
US8740932B2 (en) | 2001-11-30 | 2014-06-03 | Covidien Lp | Surgical device |
US8858589B2 (en) | 2002-01-08 | 2014-10-14 | Covidien Lp | Surgical device |
US9017371B2 (en) | 2007-09-21 | 2015-04-28 | Covidien Lp | Surgical device having multiple drivers |
EP2954853A1 (en) * | 2014-06-10 | 2015-12-16 | Ethicon Endo-Surgery, Inc. | Devices for sealing staples in tissue |
US9364200B2 (en) | 1999-06-02 | 2016-06-14 | Covidien Lp | Electro-mechanical surgical device |
US9861362B2 (en) | 2002-06-14 | 2018-01-09 | Covidien Lp | Surgical device |
US10117651B2 (en) | 2007-09-21 | 2018-11-06 | Covidien Lp | Surgical device having a rotatable jaw portion |
CN109640834A (en) * | 2016-08-16 | 2019-04-16 | 伊西康公司 | Spray tip for multidirectional delivering different fluid simultaneously |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU759991B2 (en) * | 1998-08-26 | 2003-05-01 | Neo Mend, Inc. | Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers or covering structures |
US9113878B2 (en) | 2002-01-08 | 2015-08-25 | Covidien Lp | Pinion clip for right angle linear cutter |
US6910579B2 (en) | 2002-05-28 | 2005-06-28 | Georgia-Pacific Corporation | Refillable flexible sheet dispenser |
CN108939269A (en) * | 2018-06-12 | 2018-12-07 | 张维娜 | A kind of gynecological clinic drug delivery device |
WO2020005788A2 (en) | 2018-06-29 | 2020-01-02 | The Procter & Gamble Company | Dual phase products |
US11583479B2 (en) | 2018-06-29 | 2023-02-21 | The Procter & Gamble Company | Dual phase products |
CN112334119A (en) | 2018-06-29 | 2021-02-05 | 宝洁公司 | Two-phase product |
Citations (4)
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US3767085A (en) | 1971-08-02 | 1973-10-23 | J Cannon | Mixing syringe |
US4631055A (en) | 1984-03-29 | 1986-12-23 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Apparatus for applying a tissue adhesive |
US4735616A (en) | 1985-06-20 | 1988-04-05 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Arrangement for applying a tissue adhesive |
US5583114A (en) | 1994-07-27 | 1996-12-10 | Minnesota Mining And Manufacturing Company | Adhesive sealant composition |
Family Cites Families (3)
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US1612116A (en) * | 1925-02-02 | 1926-12-28 | Heublein Wilhelm Oskar | Medicament ampulla |
US4886495A (en) * | 1987-07-08 | 1989-12-12 | Duoject Medical Systems Inc. | Vial-based prefilled syringe system for one or two component medicaments |
AT388503B (en) * | 1987-05-21 | 1989-07-25 | Immuno Ag | SET FOR PROVIDING AND APPLICATION OF A TISSUE ADHESIVE |
-
1998
- 1998-10-22 EP EP98953887A patent/EP1022986A2/en not_active Withdrawn
- 1998-10-22 AU AU11145/99A patent/AU1114599A/en not_active Abandoned
- 1998-10-22 WO PCT/US1998/022380 patent/WO1999020328A2/en not_active Application Discontinuation
- 1998-10-22 JP JP2000516718A patent/JP2001520086A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US3767085A (en) | 1971-08-02 | 1973-10-23 | J Cannon | Mixing syringe |
US4631055A (en) | 1984-03-29 | 1986-12-23 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Apparatus for applying a tissue adhesive |
US4735616A (en) | 1985-06-20 | 1988-04-05 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Arrangement for applying a tissue adhesive |
US5583114A (en) | 1994-07-27 | 1996-12-10 | Minnesota Mining And Manufacturing Company | Adhesive sealant composition |
Cited By (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6458095B1 (en) | 1997-10-22 | 2002-10-01 | 3M Innovative Properties Company | Dispenser for an adhesive tissue sealant having a housing with multiple cavities |
US6648852B2 (en) | 1997-10-22 | 2003-11-18 | 3M Innovative Peroperties Company | Dispenser for an adhesive tissue sealant |
US6569113B2 (en) | 1997-10-22 | 2003-05-27 | 3M Innovative Properties Company | Dispenser for an adhesive tissue sealant |
EP1083962A4 (en) * | 1998-06-03 | 2008-11-26 | Baxter Int | Direct dual filling device for sealing agents |
EP1083962A1 (en) * | 1998-06-03 | 2001-03-21 | Baxter International Inc. | Direct dual filling device for sealing agents |
US9078654B2 (en) | 1999-06-02 | 2015-07-14 | Covidien Lp | Surgical device |
US10314659B2 (en) | 1999-06-02 | 2019-06-11 | Covidien Lp | Electro-mechanical surgical device |
US9364200B2 (en) | 1999-06-02 | 2016-06-14 | Covidien Lp | Electro-mechanical surgical device |
JP2003532455A (en) * | 2000-02-22 | 2003-11-05 | パワー メディカル インターベンションズ,インコーポレイテッド | Fluid transport mechanism for anastomosis, staple anastomosis and resection instrument |
WO2001062162A1 (en) * | 2000-02-22 | 2001-08-30 | Power Medical Interventions, Inc. | A fluid delivery mechanism for use with anastomosing, stapling, and resecting instruments |
JP2010042310A (en) * | 2000-02-22 | 2010-02-25 | Power Medical Interventions Llc | Fluid delivery mechanism for use with anastomosing, stapling and resecting instrument |
WO2001067961A1 (en) * | 2000-03-10 | 2001-09-20 | 3M Innovative Properties Company | Dispenser for an adhesive tissue sealant |
EP2275039A1 (en) * | 2000-03-10 | 2011-01-19 | NeoMend, Inc. | Dispenser for an adhesive tissue sealant |
WO2003022457A1 (en) * | 2001-09-12 | 2003-03-20 | 3M Innovative Properties Company | Kit and method for dispensing an adhesive tissue sealant |
US7037289B2 (en) | 2001-09-12 | 2006-05-02 | 3M Innovative Properties Company | Apparatus and methods for dispensing an adhesive tissue sealant |
US8740932B2 (en) | 2001-11-30 | 2014-06-03 | Covidien Lp | Surgical device |
US8858589B2 (en) | 2002-01-08 | 2014-10-14 | Covidien Lp | Surgical device |
US9861362B2 (en) | 2002-06-14 | 2018-01-09 | Covidien Lp | Surgical device |
US9017371B2 (en) | 2007-09-21 | 2015-04-28 | Covidien Lp | Surgical device having multiple drivers |
US11317909B2 (en) | 2007-09-21 | 2022-05-03 | Covidien Lp | Surgical device having multiple drivers |
US9282961B2 (en) | 2007-09-21 | 2016-03-15 | Covidien Lp | Surgical device having multiple drivers |
US10881397B2 (en) | 2007-09-21 | 2021-01-05 | Covidien Lp | Surgical device having a rotatable jaw portion |
US10420548B2 (en) | 2007-09-21 | 2019-09-24 | Covidien Lp | Surgical device having multiple drivers |
US10117651B2 (en) | 2007-09-21 | 2018-11-06 | Covidien Lp | Surgical device having a rotatable jaw portion |
EP2954853A1 (en) * | 2014-06-10 | 2015-12-16 | Ethicon Endo-Surgery, Inc. | Devices for sealing staples in tissue |
US9936954B2 (en) | 2014-06-10 | 2018-04-10 | Ethicon Llc | Devices and methods for sealing staples in tissue |
US9924946B2 (en) | 2014-06-10 | 2018-03-27 | Ethicon Llc | Devices and methods for sealing staples in tissue |
US10390828B2 (en) | 2014-06-10 | 2019-08-27 | Ethicon Llc | Devices and methods for sealing staples in tissue |
US9913646B2 (en) | 2014-06-10 | 2018-03-13 | Ethicon Llc | Devices for sealing staples in tissue |
CN106659500B (en) * | 2014-06-10 | 2020-02-14 | 伊西康内外科有限责任公司 | Device for sealing staples in tissue |
CN106659500A (en) * | 2014-06-10 | 2017-05-10 | 伊西康内外科有限责任公司 | Devices for sealing staples in tissue |
WO2015191187A1 (en) * | 2014-06-10 | 2015-12-17 | Ethicon Endo-Surgery, Inc. | Devices for sealing staples in tissue |
CN109640834A (en) * | 2016-08-16 | 2019-04-16 | 伊西康公司 | Spray tip for multidirectional delivering different fluid simultaneously |
Also Published As
Publication number | Publication date |
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AU1114599A (en) | 1999-05-10 |
WO1999020328A3 (en) | 2000-04-06 |
EP1022986A2 (en) | 2000-08-02 |
JP2001520086A (en) | 2001-10-30 |
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