WO1999021558A3 - Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction - Google Patents

Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction Download PDF

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Publication number
WO1999021558A3
WO1999021558A3 PCT/US1998/022928 US9822928W WO9921558A3 WO 1999021558 A3 WO1999021558 A3 WO 1999021558A3 US 9822928 W US9822928 W US 9822928W WO 9921558 A3 WO9921558 A3 WO 9921558A3
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WO
WIPO (PCT)
Prior art keywords
erectile dysfunction
local administration
treatment
phosphodiesterase inhibitors
administration
Prior art date
Application number
PCT/US1998/022928
Other languages
French (fr)
Other versions
WO1999021558A2 (en
Inventor
Paul C Doherty Jr
Virgil A Place
William L Smith
Original Assignee
Vivus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/181,070 external-priority patent/US6037346A/en
Application filed by Vivus Inc filed Critical Vivus Inc
Priority to JP2000517716A priority Critical patent/JP2003525845A/en
Priority to CA002305394A priority patent/CA2305394C/en
Priority to EP19980954032 priority patent/EP1027054A4/en
Priority to AU11254/99A priority patent/AU734734B2/en
Publication of WO1999021558A2 publication Critical patent/WO1999021558A2/en
Publication of WO1999021558A3 publication Critical patent/WO1999021558A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

A method is provided for treating erectile dysfunction in a mammalian male individual. The method involves the local administration of a phosphodiesterase inhibitor or a pharmaceutically acceptable salt, ester, amide or derivative thereof, within the context of an effective dosing regimen. A preferred mode of administration is transurethral. Pharmaceutical formulations and kits are provided as well.
PCT/US1998/022928 1997-10-28 1998-10-28 Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction WO1999021558A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000517716A JP2003525845A (en) 1997-10-28 1998-10-28 Topical administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
CA002305394A CA2305394C (en) 1997-10-28 1998-10-28 Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
EP19980954032 EP1027054A4 (en) 1997-10-28 1998-10-28 Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
AU11254/99A AU734734B2 (en) 1997-10-28 1998-10-28 Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US95881697A 1997-10-28 1997-10-28
US08/958,816 1997-10-28
US09/181,070 1998-10-27
US09/181,070 US6037346A (en) 1997-10-28 1998-10-27 Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction

Publications (2)

Publication Number Publication Date
WO1999021558A2 WO1999021558A2 (en) 1999-05-06
WO1999021558A3 true WO1999021558A3 (en) 2000-10-26

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PCT/US1998/022928 WO1999021558A2 (en) 1997-10-28 1998-10-28 Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction

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EP (1) EP1027054A4 (en)
JP (1) JP2003525845A (en)
AU (1) AU734734B2 (en)
CA (1) CA2305394C (en)
WO (1) WO1999021558A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125816B2 (en) 2000-08-30 2015-09-08 Besins Healthcare Inc. Pharmaceutical composition and method for treating hypogonadism
US9480733B2 (en) 2002-06-07 2016-11-01 Dyax Corp. Prevention and reduction of blood loss

Families Citing this family (28)

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CA2305394A1 (en) 1999-05-06
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AU734734B2 (en) 2001-06-21

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