WO1999022670A3 - In-situ radioactive stent - Google Patents

In-situ radioactive stent Download PDF

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Publication number
WO1999022670A3
WO1999022670A3 PCT/US1998/023022 US9823022W WO9922670A3 WO 1999022670 A3 WO1999022670 A3 WO 1999022670A3 US 9823022 W US9823022 W US 9823022W WO 9922670 A3 WO9922670 A3 WO 9922670A3
Authority
WO
WIPO (PCT)
Prior art keywords
substance
radioactive
thrombolytic
placement
situ
Prior art date
Application number
PCT/US1998/023022
Other languages
French (fr)
Other versions
WO1999022670A2 (en
Inventor
Keven S Weadock
Original Assignee
Meadox Medicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meadox Medicals Inc filed Critical Meadox Medicals Inc
Priority to EP98955199A priority Critical patent/EP1045675A4/en
Priority to JP2000518612A priority patent/JP2001521778A/en
Priority to CA002311290A priority patent/CA2311290A1/en
Publication of WO1999022670A2 publication Critical patent/WO1999022670A2/en
Publication of WO1999022670A3 publication Critical patent/WO1999022670A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0495—Pretargeting

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Devices and methods for rendering an intravascular device such as a stent radioactive in-situ, after placement. A device is provided having a surface (20) and a first substance (22) immobilized thereon. The first substance (22) preferably has a high and selective affinity for a second substance (26) which can be radioactive, cytotoxic or thrombolytic. The first substance (22) can also have an affinity for growth factors or thrombolytic, chemolytic or cytotoxic agents. The device can be placed across a stenosed blood vessel region, preferably after dilation by angioplasty or atherectomy. After device placement within the vessel, the second substance (26) can be injected into the blood stream of a patient. With each pass through the device, the second substance (26) is increasingly bound to the first substance (22) on the device surface (20). Suitable complementary substance pairs include avidin and radio-labeled biotin, protamine and radioactive heparin, and protein and anti-protein antibody.
PCT/US1998/023022 1997-11-03 1998-10-29 In-situ radioactive stent WO1999022670A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP98955199A EP1045675A4 (en) 1997-11-03 1998-10-29 In-situ radioactive stent
JP2000518612A JP2001521778A (en) 1997-11-03 1998-10-29 In-situ radioactive stent
CA002311290A CA2311290A1 (en) 1997-11-03 1998-10-29 In-situ radioactive stent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/962,749 US6264596B1 (en) 1997-11-03 1997-11-03 In-situ radioactive medical device
US08/962,749 1997-11-03

Publications (2)

Publication Number Publication Date
WO1999022670A2 WO1999022670A2 (en) 1999-05-14
WO1999022670A3 true WO1999022670A3 (en) 1999-08-19

Family

ID=25506301

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/023022 WO1999022670A2 (en) 1997-11-03 1998-10-29 In-situ radioactive stent

Country Status (5)

Country Link
US (1) US6264596B1 (en)
EP (1) EP1045675A4 (en)
JP (1) JP2001521778A (en)
CA (1) CA2311290A1 (en)
WO (1) WO1999022670A2 (en)

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WO1999022670A2 (en) 1999-05-14
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CA2311290A1 (en) 1999-05-14
JP2001521778A (en) 2001-11-13
EP1045675A2 (en) 2000-10-25

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