WO1999029732A3 - Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation - Google Patents
Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation Download PDFInfo
- Publication number
- WO1999029732A3 WO1999029732A3 PCT/US1998/025978 US9825978W WO9929732A3 WO 1999029732 A3 WO1999029732 A3 WO 1999029732A3 US 9825978 W US9825978 W US 9825978W WO 9929732 A3 WO9929732 A3 WO 9929732A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fusion proteins
- fused
- subunit
- fusion protein
- proteins useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69824039T DE69824039T2 (en) | 1997-12-08 | 1998-12-08 | HETERODIMARY FUSION PROTEINS FOR THE USE OF TARGETED IMMUNOTHERAPY AND GENERAL IMMUNE REGION |
CA2312188A CA2312188C (en) | 1997-12-08 | 1998-12-08 | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
EP98961978A EP1037927B1 (en) | 1997-12-08 | 1998-12-08 | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
AT98961978T ATE267215T1 (en) | 1997-12-08 | 1998-12-08 | HETERODIMARY FUSION PROTEINS FOR USE FOR TARGETED IMMUNTHERAPY AND GENERAL IMMUNE EXCITATION |
AU17160/99A AU763719B2 (en) | 1997-12-08 | 1998-12-08 | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
JP2000524321A JP4336452B2 (en) | 1997-12-08 | 1998-12-08 | Dimeric fusion proteins useful for targeted immunotherapy and general immune stimulation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98699797A | 1997-12-08 | 1997-12-08 | |
US08/986,997 | 1997-12-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999029732A2 WO1999029732A2 (en) | 1999-06-17 |
WO1999029732A3 true WO1999029732A3 (en) | 1999-08-26 |
Family
ID=25532973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/025978 WO1999029732A2 (en) | 1997-12-08 | 1998-12-08 | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
Country Status (11)
Country | Link |
---|---|
US (4) | US6838260B2 (en) |
EP (2) | EP1037927B1 (en) |
JP (2) | JP4336452B2 (en) |
AT (1) | ATE267215T1 (en) |
AU (1) | AU763719B2 (en) |
CA (2) | CA2693296C (en) |
DE (1) | DE69824039T2 (en) |
DK (1) | DK1037927T3 (en) |
ES (2) | ES2221717T3 (en) |
PT (1) | PT1037927E (en) |
WO (1) | WO1999029732A2 (en) |
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US8691952B2 (en) | 2005-12-30 | 2014-04-08 | Merck Patent Gmbh | Anti-CD19 antibodies with reduced immunogenicity |
US8835606B2 (en) | 2004-01-22 | 2014-09-16 | Merck Patent Gmbh | Anti-cancer antibodies with reduced complement fixation |
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WO1999029732A2 (en) | 1997-12-08 | 1999-06-17 | Lexigen Pharmaceuticals Corporation | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
JP2002511432A (en) * | 1998-04-15 | 2002-04-16 | レキシジェン ファーマシューティカルズ コーポレイション | Enhancement of antibody-cytokine fusion protein-mediated immune response by co-administration of an angiogenesis inhibitor |
PL352332A1 (en) * | 1999-05-19 | 2003-08-11 | Lexigen Pharm Corp | Expression and export of interferon-alpha proteins as fc fusion proteins |
US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
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US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
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Cited By (3)
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US8835606B2 (en) | 2004-01-22 | 2014-09-16 | Merck Patent Gmbh | Anti-cancer antibodies with reduced complement fixation |
US8691952B2 (en) | 2005-12-30 | 2014-04-08 | Merck Patent Gmbh | Anti-CD19 antibodies with reduced immunogenicity |
US8957195B2 (en) | 2005-12-30 | 2015-02-17 | Merck Patent Gmbh | Anti-CD19 antibodies with reduced immunogenicity |
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AU763719B2 (en) | 2003-07-31 |
DE69824039D1 (en) | 2004-06-24 |
US20100015089A1 (en) | 2010-01-21 |
JP4336452B2 (en) | 2009-09-30 |
CA2693296A1 (en) | 1999-06-17 |
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ATE267215T1 (en) | 2004-06-15 |
US7226998B2 (en) | 2007-06-05 |
PT1037927E (en) | 2004-10-29 |
CA2693296C (en) | 2013-09-10 |
US6838260B2 (en) | 2005-01-04 |
EP1489100A2 (en) | 2004-12-22 |
US20050137384A1 (en) | 2005-06-23 |
DE69824039T2 (en) | 2005-08-18 |
EP1489100A3 (en) | 2012-06-06 |
EP1037927B1 (en) | 2004-05-19 |
EP1489100B1 (en) | 2016-06-15 |
US7879319B2 (en) | 2011-02-01 |
DK1037927T3 (en) | 2004-09-06 |
CA2312188A1 (en) | 1999-06-17 |
US20080311655A1 (en) | 2008-12-18 |
EP1037927A2 (en) | 2000-09-27 |
AU1716099A (en) | 1999-06-28 |
WO1999029732A2 (en) | 1999-06-17 |
CA2312188C (en) | 2010-06-29 |
ES2590912T3 (en) | 2016-11-24 |
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