WO1999030643A1 - Expandable stent having radiopaque marker and method - Google Patents

Expandable stent having radiopaque marker and method Download PDF

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Publication number
WO1999030643A1
WO1999030643A1 PCT/US1998/026748 US9826748W WO9930643A1 WO 1999030643 A1 WO1999030643 A1 WO 1999030643A1 US 9826748 W US9826748 W US 9826748W WO 9930643 A1 WO9930643 A1 WO 9930643A1
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WO
WIPO (PCT)
Prior art keywords
wall
stent
eyelet
insert
framework
Prior art date
Application number
PCT/US1998/026748
Other languages
French (fr)
Inventor
Mir A. Imran
Original Assignee
Cardiovasc, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiovasc, Inc. filed Critical Cardiovasc, Inc.
Priority to AU19200/99A priority Critical patent/AU1920099A/en
Publication of WO1999030643A1 publication Critical patent/WO1999030643A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91508—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other the meander having a difference in amplitude along the band
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91558—Adjacent bands being connected to each other connected peak to peak
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers

Definitions

  • This invention relates to an expandable stent having a radiopaque marker and a method for fabricating the radiopaque marker.
  • Stents herebefore have been provided typically are formed of stainless steel and other metals, which in and of themselves are not readily visible in fluoroscopic imaging systems. It has been found that it is important to be able to visualize the stents during the time that they are being deployed and also to be able to visualize the stents after they have been deployed, at periodic time intervals. Attempts have been made to make such stents more radiopaque by brazing gold or platinum onto the stents. However, even though the desired radiopacity may be achieved, such approaches have not been found to be particularly satisfactory in that the brazing process may cause local annealing of the stent, and may change its mechanical properties. There is therefore a need for a new and improved radiopaque marker for use on stents.
  • Another object of the invention is to provide an expandable stent with a radiopaque marker in which the radiopaque marker does not experience stresses or strains during expansion of the stent.
  • Another object of the invention is to provide an expandable stent having a radiopaque marker in which the radiopaque marker is isolated from the stent pattern so that it does not interfere with the expansion of the stent.
  • Another object of the invention is to provide an expandable stent with a radiopaque marker of the above character in which the radiopaque marker does not protrude from the exterior surface or the interior surface of the stent.
  • Another object of the invention is to provide a radiopaque marker which can be readily and economically fabricated.
  • Figure 1 is a side elevational view of a stent having a radiopaque marker incorporating the present invention.
  • Figure 1A is an enlarged view taken from Figure 1 of a radiopaque marker shown in Figure 1.
  • Figure 2 is a cross-sectional view taken along the line 2-2 of Figure 1.
  • Figures 3A, 3B and 3C illustrate various placements of radiopaque markers on stents and incorporating the present invention in stents.
  • Figure 4 is an enlarged isometric view of the framework provided in the radiopaque marker of the present invention and showing an eyelet provided by the framework.
  • Figure 5 is an isometric view of an insert as provided to fit within the eyelet shown in Figure 3.
  • Figure 6 is a cross-sectional illustration showing the manner in which an insert is placed in an eyelet by use of a mandrel in a stent.
  • Figure 7 is a cross-sectional view of the radiopaque marker after the insert has been forged into the eyelet in accordance with the method of the present invention.
  • the stent having a radiopaque marker therein is comprised of a cylindrical member having a wall defining a central bore extending along a longitudinal axis and having an outside diameter and an inside diameter and a length.
  • the wall has a pattern formed therein with openings therein.
  • At least one radiopaque marker is carried by the wall and is disposed in an opening.
  • the radiopaque marker is comprised of a framework formed in the wall and lying within the inner and outer confines of the wall and is carried by the wall and is disposed in an opening in the pattern so that it is isolated from the pattern so that it does not interfere with the expansion of the stent.
  • the framework has an eyelet therein and an insert formed of a radiopaque material is secured in the stent and lies within the confines of the inner wall and the outer wall.
  • the method for forming a radiopaque marker for use with a cylindrical stent having a wall defining a bore extending therethrough and having an outside diameter and inside diameter and a longitudinal axis with the wall of the stent having a pattern with openings therein comprises forming an eyelet in the wall of the stent so that it is disposed in at least one of the openings in the wall.
  • An insert is provided which has a volume which corresponds to the volume of the eyelet and is mounted in the eyelet so that it is retained in the eyelet and lies within the confines of the inner and outer diameter of the wall.
  • a stent 11 utilized in conjunction with the radiopaque marker of the present invention is shown in Figure 1 and consists of at least one segment 12 and generally a plurality of segments 12.
  • Each segment 12 is comprised of a cylindrical member 13 which has a wall 14 formed of a suitable metal such as stainless steel which defines a bore 16 extending along a longitudinal axis 17.
  • the wall 14 has a thickness so that there is provided an inside surface 18 and an outside surface 19.
  • a pattern 21 is provided in the wall and has a plurality of openings 22 extending through the wall.
  • the stent 11 hereinbefore described is merely one stent on which the radiopaque marker 26 of the present invention can be used.
  • the characteristics of the particular stent 11 shown in Figure 1 are described in detail in co-pending application Serial Number filed (A-65468) and the more detailed features thereof are incorporated herein by reference.
  • At least one radiopaque marker 26 is provided in the stent 11.
  • Different patterns for use of the radiopaque markers are shown in Figures 3A, 3B and 3C.
  • a radiopaque marker 26 is provided in opposite ends of the stent 11.
  • radiopaque markers 26 are provided at opposite ends of the stent 11 and also at an intermediate point of the stent with radiopaque markers 26 also being disposed in each location at diametrically opposite points so that the amount of radial expansion of the stents can be ascertained by observing the locations of the radiopaque markers.
  • a plurality of radiopaque markers 26 are provided which are spaced apart equi-distant along the length of the stent to make possible observation of the elongation or shortening of the stent during expansion.
  • Each of the radiopaque markers 26 consists of a framework 27 which is provided with an eyelet 28 therein (see Figures 1A and 4) .
  • the framework 27 with the eyelet 28 therein typically is formed in the wall 14 during the same time that the pattern 21 is formed and is connected by a link 29 to the pattern.
  • a pattern can be formed by laser cutting or etching. It is important that the framework 27 have the same wall thickness as the wall 14 itself and therefore it is preferable that it be formed of the wall 14 and in the wall 14 so that the framework 27 is disposed in one of the openings 22 in the pattern 21 so that it is not subjected to stresses and strains during expansion of the stent and also so that it does not interfere with the expansion of the stent.
  • the framework 27 is provided with a plurality of circumferentially spaced-apart substantially conical protrusions or projections 31 which are cone shaped as shown in Figures 3 and 4 and lie within the confines of the inner and outer surfaces 18 and 19 of the wall 14.
  • a plurality of such projections 31 are provided in accordance with the present invention and it is desirable to have at least three of such inwardly and radially extending projections and preferably four as shown, but as many as eight.
  • the radiopaque marker 26 also includes an insert 36 which is formed of a suitable radiopaque material such as gold or platinum or alloys thereof.
  • an insert 36 which is formed of a suitable radiopaque material such as gold or platinum or alloys thereof.
  • the volume of the eyelet 28 between the inner and outer surfaces 18 and 19 of the wall, taking into account the volume occupied by the protrusions or projections 31 is precisely calculated.
  • such projections can be provided with the eyelet having a diameter of 0.015 inches and having an inner diameter of 0.010 inches extending between two opposite protrusions or projections 31 with each of the projections extending inwardly by a distance of 0.0025 inches with the wall being of a suitable thickness as for example 0.003 inches.
  • a sheet of the desired radiopaque material is selected as for example of platinum or gold, having a suitable thickness as for example 0.008 is. Since the plug 37 must be of a suitable diameter to as for example 0.010 inches when it is disposed between the projections or spikes 31, the additional volume required is obtained by providing the additional volume in the thickness of the plug which can be obtained by providing a sheet (not shown) of radiopaque material and then rolling it down to the desired thickness to achieve the desired volume for the plug 47 when it is punched up from the sheet. A cylindrical plug 37 (see Figure 5) of the desired diameter is punched therefrom.
  • the plug 37 is then taken and placed in the eyelet 28 of the framework 27 carried by the stent with a cylindrical tight fitting mandrel 38 being disposed within the stent as shown in Figure 6.
  • a suitable force is then applied as for example by an arbor press as indicated by the "F" arrows 39 to press and forge the plug 37 into the eyelet 28 so that it completely fills the volume of the eyelet 28 and so that it overlies and underlies the protrusions 31 within the confines of the inner and outer surfaces 18 and 19, so that it does not protrude from the wall but is substantially flush with both surfaces thereof.
  • the material of the plug 37 is forced to flow over the eyelets 28 and thereby be cold forged into the eyelet 28.
  • this formation of a radiopaque marker or markers in the stent 11 can be accomplished without interfering with the mechanical properties of the stent itself.
  • the method then makes it possible to securely mount the insert within the eyelet to ensure that it will not accidentally pop out.
  • the method provided has made it possible to capture the radiopaque material so that a robust mechanically reliable construction is provided which provides the desired radiopacity needed to observe the stent as hereinbefore described.
  • it can be seen that it is possible to provide a plurality of radiopaque markers in a stent.
  • radiopaque markers can be incorporated into the stent one by one by longitudinal movement or rotation of the stent in the arbor during insertion of the inserts into the eyelets of the radiopaque markers.

Abstract

This invention is an expandable stent (11) having a radiopaque marker (26) therein comprising a cylindrical member having a wall defining a central bore extending along a longitudinal axis, and having inner, and outer surfaces, and a length. The wall has a pattern formed therein with openings extending therethrough into the bore. At least one radiopaque marker (26) is carried by the wall, and is disposed in an opening in the wall. The radiopaque marker is comprised of a framework (27) formed in the wall that is disposed in an opening in the wall, and lies within the confines of the wall. The framework (27) is isolated from the pattern so that it does not interfere with the expansion of the expandable stent. The framework has an eyelet (28) therein. An insert (36) formed of a radiopaque material is diposed in the eyelet (28) that is retained in the framework (27) which lies within the confines of the inner surfaces, and outer surfaces of the wall.

Description

EXPANDABLE STENT HAVING RADIOPAQUE MARKER AND METHOD
This invention relates to an expandable stent having a radiopaque marker and a method for fabricating the radiopaque marker.
Stents herebefore have been provided typically are formed of stainless steel and other metals, which in and of themselves are not readily visible in fluoroscopic imaging systems. It has been found that it is important to be able to visualize the stents during the time that they are being deployed and also to be able to visualize the stents after they have been deployed, at periodic time intervals. Attempts have been made to make such stents more radiopaque by brazing gold or platinum onto the stents. However, even though the desired radiopacity may be achieved, such approaches have not been found to be particularly satisfactory in that the brazing process may cause local annealing of the stent, and may change its mechanical properties. There is therefore a need for a new and improved radiopaque marker for use on stents.
In general, it is an object of the present invention to provide an expandable stent having a radiopaque marker and a method for fabricating the same.
Another object of the invention is to provide an expandable stent with a radiopaque marker in which the radiopaque marker does not experience stresses or strains during expansion of the stent. Another object of the invention is to provide an expandable stent having a radiopaque marker in which the radiopaque marker is isolated from the stent pattern so that it does not interfere with the expansion of the stent.
Another object of the invention is to provide an expandable stent with a radiopaque marker of the above character in which the radiopaque marker does not protrude from the exterior surface or the interior surface of the stent.
Another object of the invention is to provide a radiopaque marker which can be readily and economically fabricated.
Additional objects and features of the invention will appear from the following description in which the preferred embodiment is set forth in conjunction with the accompanying drawings.
Figure 1 is a side elevational view of a stent having a radiopaque marker incorporating the present invention.
Figure 1A is an enlarged view taken from Figure 1 of a radiopaque marker shown in Figure 1.
Figure 2 is a cross-sectional view taken along the line 2-2 of Figure 1. Figures 3A, 3B and 3C illustrate various placements of radiopaque markers on stents and incorporating the present invention in stents.
Figure 4 is an enlarged isometric view of the framework provided in the radiopaque marker of the present invention and showing an eyelet provided by the framework.
Figure 5 is an isometric view of an insert as provided to fit within the eyelet shown in Figure 3.
Figure 6 is a cross-sectional illustration showing the manner in which an insert is placed in an eyelet by use of a mandrel in a stent. Figure 7 is a cross-sectional view of the radiopaque marker after the insert has been forged into the eyelet in accordance with the method of the present invention. In general, the stent having a radiopaque marker therein is comprised of a cylindrical member having a wall defining a central bore extending along a longitudinal axis and having an outside diameter and an inside diameter and a length. The wall has a pattern formed therein with openings therein. At least one radiopaque marker is carried by the wall and is disposed in an opening. The radiopaque marker is comprised of a framework formed in the wall and lying within the inner and outer confines of the wall and is carried by the wall and is disposed in an opening in the pattern so that it is isolated from the pattern so that it does not interfere with the expansion of the stent. The framework has an eyelet therein and an insert formed of a radiopaque material is secured in the stent and lies within the confines of the inner wall and the outer wall.
In general, the method for forming a radiopaque marker for use with a cylindrical stent having a wall defining a bore extending therethrough and having an outside diameter and inside diameter and a longitudinal axis with the wall of the stent having a pattern with openings therein. The method comprises forming an eyelet in the wall of the stent so that it is disposed in at least one of the openings in the wall. An insert is provided which has a volume which corresponds to the volume of the eyelet and is mounted in the eyelet so that it is retained in the eyelet and lies within the confines of the inner and outer diameter of the wall. More in particular, a stent 11 utilized in conjunction with the radiopaque marker of the present invention is shown in Figure 1 and consists of at least one segment 12 and generally a plurality of segments 12. Each segment 12 is comprised of a cylindrical member 13 which has a wall 14 formed of a suitable metal such as stainless steel which defines a bore 16 extending along a longitudinal axis 17. The wall 14 has a thickness so that there is provided an inside surface 18 and an outside surface 19. A pattern 21 is provided in the wall and has a plurality of openings 22 extending through the wall.
The stent 11 hereinbefore described is merely one stent on which the radiopaque marker 26 of the present invention can be used. The characteristics of the particular stent 11 shown in Figure 1 are described in detail in co-pending application Serial Number filed (A-65468) and the more detailed features thereof are incorporated herein by reference.
At least one radiopaque marker 26 is provided in the stent 11. However, it is generally desirable to provide more than one radiopaque marker 26 to ascertain the position of the stent and as well, and in many cases, to ascertain the expansion of the stent, the longitudinal positioning of the stent to ascertain whether or not the stent has moved after elapse of periods of time as for example, after a period of six months or twelve months. Different patterns for use of the radiopaque markers are shown in Figures 3A, 3B and 3C. In Figure 3A, a radiopaque marker 26 is provided in opposite ends of the stent 11. In Figure 3B, radiopaque markers 26 are provided at opposite ends of the stent 11 and also at an intermediate point of the stent with radiopaque markers 26 also being disposed in each location at diametrically opposite points so that the amount of radial expansion of the stents can be ascertained by observing the locations of the radiopaque markers. In Figure 3C, a plurality of radiopaque markers 26 are provided which are spaced apart equi-distant along the length of the stent to make possible observation of the elongation or shortening of the stent during expansion. Each of the radiopaque markers 26 consists of a framework 27 which is provided with an eyelet 28 therein (see Figures 1A and 4) . The framework 27 with the eyelet 28 therein typically is formed in the wall 14 during the same time that the pattern 21 is formed and is connected by a link 29 to the pattern. Such a pattern can be formed by laser cutting or etching. It is important that the framework 27 have the same wall thickness as the wall 14 itself and therefore it is preferable that it be formed of the wall 14 and in the wall 14 so that the framework 27 is disposed in one of the openings 22 in the pattern 21 so that it is not subjected to stresses and strains during expansion of the stent and also so that it does not interfere with the expansion of the stent.
The framework 27 is provided with a plurality of circumferentially spaced-apart substantially conical protrusions or projections 31 which are cone shaped as shown in Figures 3 and 4 and lie within the confines of the inner and outer surfaces 18 and 19 of the wall 14. A plurality of such projections 31 are provided in accordance with the present invention and it is desirable to have at least three of such inwardly and radially extending projections and preferably four as shown, but as many as eight.
The radiopaque marker 26 also includes an insert 36 which is formed of a suitable radiopaque material such as gold or platinum or alloys thereof. To provide such an insert 36, the volume of the eyelet 28 between the inner and outer surfaces 18 and 19 of the wall, taking into account the volume occupied by the protrusions or projections 31 is precisely calculated. By way of example, as shown in Figure 3 such projections can be provided with the eyelet having a diameter of 0.015 inches and having an inner diameter of 0.010 inches extending between two opposite protrusions or projections 31 with each of the projections extending inwardly by a distance of 0.0025 inches with the wall being of a suitable thickness as for example 0.003 inches.
As soon as the volume of the eyelet 28 has been ascertained, and knowing the diameter, a calculation is made of the desired thickness for a cylindrical plug 37. A sheet of the desired radiopaque material is selected as for example of platinum or gold, having a suitable thickness as for example 0.008 is. Since the plug 37 must be of a suitable diameter to as for example 0.010 inches when it is disposed between the projections or spikes 31, the additional volume required is obtained by providing the additional volume in the thickness of the plug which can be obtained by providing a sheet (not shown) of radiopaque material and then rolling it down to the desired thickness to achieve the desired volume for the plug 47 when it is punched up from the sheet. A cylindrical plug 37 (see Figure 5) of the desired diameter is punched therefrom. The plug 37 is then taken and placed in the eyelet 28 of the framework 27 carried by the stent with a cylindrical tight fitting mandrel 38 being disposed within the stent as shown in Figure 6. A suitable force is then applied as for example by an arbor press as indicated by the "F" arrows 39 to press and forge the plug 37 into the eyelet 28 so that it completely fills the volume of the eyelet 28 and so that it overlies and underlies the protrusions 31 within the confines of the inner and outer surfaces 18 and 19, so that it does not protrude from the wall but is substantially flush with both surfaces thereof. Thus the material of the plug 37 is forced to flow over the eyelets 28 and thereby be cold forged into the eyelet 28.
It can be seen that this formation of a radiopaque marker or markers in the stent 11 can be accomplished without interfering with the mechanical properties of the stent itself. The method then makes it possible to securely mount the insert within the eyelet to ensure that it will not accidentally pop out. Also, it can be seen that the method provided has made it possible to capture the radiopaque material so that a robust mechanically reliable construction is provided which provides the desired radiopacity needed to observe the stent as hereinbefore described. Thus, it can be seen that it is possible to provide a plurality of radiopaque markers in a stent. Typically, these can be incorporated into the stent one by one by longitudinal movement or rotation of the stent in the arbor during insertion of the inserts into the eyelets of the radiopaque markers. Thus it can be seen that a plurality of radiopaque markers can be provided on a stent in a feasible and economic manner.

Claims

HAT IS CLAIMED:
1. An expandable stent having a radiopaque marker therein comprising a cylindrical member having a wall defining a central bore extending along a longitudinal axis and having inner and outer surfaces and a length, the wall having a pattern formed therein with openings extending therethrough into the bore, at least one radiopaque marker carried by the wall and disposed in an opening in the wall, the radiopaque marker being comprised of a framework formed in the wall and disposed in an opening in the wall and lying within the confines of the wall, said framework being isolated from the pattern so that it does not interfere with the expansion of the expandable stent, the framework having an eyelet therein and an insert formed of a radiopaque material disposed in the eyelet and retained in the framework and lying within the confines of the inner and outer surfaces of the wall.
2. A stent as in Claim 1 wherein the framework is provided with circumferentially spaced apart protrusions extending into the eyelet and projecting into the insert to aid in retaining the insert within the eyelet.
3. A stent as in Claim 2 wherein said protrusions are conical in shape and lie within the confines of the inner and outer surfaces of the wall.
4. A stent as in Claim 1, wherein said framework is provided with at least three protrusions.
5. A method for forming a radiopaque marker in a cylindrically stent having a wall defining a bore extending along a longitudinal axis, the wall of the stent having inner and outer surfaces and having a pattern therein with openings extending therethrough comprising forming at least one eyelet in the wall of the stent in at least one of the openings in the wall and having a volume, providing an insert of a radiopaque material that has a volume corresponding to the volume of the eyelet and pressing the insert into the eyelet so that it is retained in the eyelet and so that the insert lies within the confines of the inner and outer surfaces of the wall.
6. A method as in Claim 5, together with the step of forming a plurality of circumferentially spaced apart protrusions in the eyelet so that the insert must be formed around the projections when the insert is pressed into the eyelet.
7. A method as in Claim 5, together with the step of providing a close-fitting mandrel within the bore of the stent and thereafter pressing the insert into the eyelet against the mandrel while the mandrel is within the bore of the stent.
8. A method as in Claim 7 together with the step of providing additional radiopaque markers on the stent utilizing the same mandrel.
PCT/US1998/026748 1997-12-16 1998-12-15 Expandable stent having radiopaque marker and method WO1999030643A1 (en)

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002078762A1 (en) * 2001-03-29 2002-10-10 Cordis Corporation Radiopaque intraluminal medical device
US6814746B2 (en) 2002-11-01 2004-11-09 Ev3 Peripheral, Inc. Implant delivery system with marker interlock
WO2005028014A1 (en) * 2003-09-16 2005-03-31 Campus Gmbh & Co.Kg Device for being introduced into body organs and having a marker element for controlling the position thereof
DE102004054084A1 (en) * 2004-11-09 2006-05-11 Admedes Schuessler Gmbh Stent, comprising marker visible under use of x-rays and designed as string accommodated in groove
DE19937638B4 (en) * 1999-08-12 2006-11-02 Alveolus Inc. Tracheal Stent
EP1849435A2 (en) * 2003-06-16 2007-10-31 Endotex Interventional Systems, Inc. Stent with attached sleeve marker
US8197535B2 (en) 2001-06-19 2012-06-12 Cordis Corporation Low profile improved radiopacity intraluminal medical device
US10052185B2 (en) 2016-02-12 2018-08-21 Covidien Lp Vascular device marker attachment
US10265089B2 (en) 2016-02-12 2019-04-23 Covidien Lp Vascular device visibility
US11376140B1 (en) 2021-03-26 2022-07-05 Vesper Medical, Inc. Medical implants with structural members having barbs for retaining radiopaque markers
CN114985907A (en) * 2022-05-19 2022-09-02 深圳泰德激光技术股份有限公司 Blood vessel stent and manufacturing method thereof
US11819430B2 (en) 2017-11-03 2023-11-21 Ceroflo Limited Expandable stent and a method for promoting a natural intracranial angiogenesis process, and use of the expandable stent in the method for promoting a natural intracranial angiogenesis process

Families Citing this family (189)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503271B2 (en) * 1998-01-09 2003-01-07 Cordis Corporation Intravascular device with improved radiopacity
US6461380B1 (en) 1998-07-28 2002-10-08 Advanced Cardiovascular Systems, Inc. Stent configuration
US6371980B1 (en) * 1999-08-30 2002-04-16 Cardiovasc, Inc. Composite expandable device with impervious polymeric covering and bioactive coating thereon, delivery apparatus and method
US6451050B1 (en) 2000-04-28 2002-09-17 Cardiovasc, Inc. Stent graft and method
US6520984B1 (en) 2000-04-28 2003-02-18 Cardiovasc, Inc. Stent graft assembly and method
US20030114918A1 (en) 2000-04-28 2003-06-19 Garrison Michi E. Stent graft assembly and method
US6616689B1 (en) 2000-05-03 2003-09-09 Advanced Cardiovascular Systems, Inc. Intravascular stent
WO2001089421A2 (en) 2000-05-22 2001-11-29 Orbus Medical Technologies Inc. Self-expanding stent
US6652579B1 (en) 2000-06-22 2003-11-25 Advanced Cardiovascular Systems, Inc. Radiopaque stent
GB0020491D0 (en) 2000-08-18 2000-10-11 Angiomed Ag Stent with attached element and method of making such a stent
DE60124285T3 (en) * 2000-09-29 2011-03-17 Cordis Corp., Miami Lakes COATED MEDICAL EQUIPMENT
US7261735B2 (en) * 2001-05-07 2007-08-28 Cordis Corporation Local drug delivery devices and methods for maintaining the drug coatings thereon
US6923927B2 (en) * 2000-10-03 2005-08-02 Atrium Medical Corporation Method for forming expandable polymers having drugs or agents included therewith
US6616876B1 (en) * 2000-10-03 2003-09-09 Atrium Medical Corporation Method for treating expandable polymer materials
US6492615B1 (en) 2000-10-12 2002-12-10 Scimed Life Systems, Inc. Laser polishing of medical devices
WO2003061502A1 (en) 2000-10-26 2003-07-31 Scimed Life Systems, Inc. Stent having radiopaque markers and method of fabricating the same
DE10064596A1 (en) 2000-12-18 2002-06-20 Biotronik Mess & Therapieg Application of a marker element to an implant, especially a stent, comprises introducing a solidifiable material into a recess and solidifying the material in the recess
US6929660B1 (en) 2000-12-22 2005-08-16 Advanced Cardiovascular Systems, Inc. Intravascular stent
US6569194B1 (en) 2000-12-28 2003-05-27 Advanced Cardiovascular Systems, Inc. Thermoelastic and superelastic Ni-Ti-W alloy
US6635082B1 (en) 2000-12-29 2003-10-21 Advanced Cardiovascular Systems Inc. Radiopaque stent
US6547812B1 (en) 2000-12-29 2003-04-15 Advanced Cardiovascular Systems, Inc. Radiation therapy using a radioactive implantable device and a radiosensitizer agent
US6641607B1 (en) 2000-12-29 2003-11-04 Advanced Cardiovascular Systems, Inc. Double tube stent
US6939373B2 (en) * 2003-08-20 2005-09-06 Advanced Cardiovascular Systems, Inc. Intravascular stent
US6629994B2 (en) * 2001-06-11 2003-10-07 Advanced Cardiovascular Systems, Inc. Intravascular stent
US6635083B1 (en) 2001-06-25 2003-10-21 Advanced Cardiovascular Systems, Inc. Stent with non-linear links and method of use
US6749629B1 (en) 2001-06-27 2004-06-15 Advanced Cardiovascular Systems, Inc. Stent pattern with figure-eights
US20030100945A1 (en) 2001-11-23 2003-05-29 Mindguard Ltd. Implantable intraluminal device and method of using same in treating aneurysms
GB0121980D0 (en) 2001-09-11 2001-10-31 Cathnet Science Holding As Expandable stent
US20030060872A1 (en) * 2001-09-26 2003-03-27 Gary Gomringer Stent with radiopaque characteristics
US7182779B2 (en) * 2001-12-03 2007-02-27 Xtent, Inc. Apparatus and methods for positioning prostheses for deployment from a catheter
US7309350B2 (en) * 2001-12-03 2007-12-18 Xtent, Inc. Apparatus and methods for deployment of vascular prostheses
US8080048B2 (en) * 2001-12-03 2011-12-20 Xtent, Inc. Stent delivery for bifurcated vessels
US7892273B2 (en) * 2001-12-03 2011-02-22 Xtent, Inc. Custom length stent apparatus
US7137993B2 (en) 2001-12-03 2006-11-21 Xtent, Inc. Apparatus and methods for delivery of multiple distributed stents
US7147656B2 (en) * 2001-12-03 2006-12-12 Xtent, Inc. Apparatus and methods for delivery of braided prostheses
US7351255B2 (en) * 2001-12-03 2008-04-01 Xtent, Inc. Stent delivery apparatus and method
US20040186551A1 (en) 2003-01-17 2004-09-23 Xtent, Inc. Multiple independent nested stent structures and methods for their preparation and deployment
US20030135266A1 (en) * 2001-12-03 2003-07-17 Xtent, Inc. Apparatus and methods for delivery of multiple distributed stents
US7294146B2 (en) 2001-12-03 2007-11-13 Xtent, Inc. Apparatus and methods for delivery of variable length stents
DE10201151B4 (en) * 2002-01-15 2007-10-04 Qualimed Innovative Medizinprodukte Gmbh Stent with marker
US7691461B1 (en) * 2002-04-01 2010-04-06 Advanced Cardiovascular Systems, Inc. Hybrid stent and method of making
EP2529707B1 (en) * 2002-05-08 2015-04-15 Abbott Laboratories Endoprosthesis having foot extensions
US20030225448A1 (en) * 2002-05-28 2003-12-04 Scimed Life Systems, Inc. Polar radiopaque marker for stent
US6656220B1 (en) 2002-06-17 2003-12-02 Advanced Cardiovascular Systems, Inc. Intravascular stent
US20040015229A1 (en) * 2002-07-22 2004-01-22 Syntheon, Llc Vascular stent with radiopaque markers
EP1393771B1 (en) * 2002-08-06 2007-10-24 Abbott Laboratories Vascular Enterprises Limited Balloon catheter with radioopaque marker
DE10237981A1 (en) * 2002-08-14 2004-03-11 Strecker, Ernst Peter, Prof. Dr.med. Meandering stent comprises long wire adopting form of looped spiral with series of interrupted single turns
US6878162B2 (en) * 2002-08-30 2005-04-12 Edwards Lifesciences Ag Helical stent having improved flexibility and expandability
US9561123B2 (en) 2002-08-30 2017-02-07 C.R. Bard, Inc. Highly flexible stent and method of manufacture
US7331986B2 (en) * 2002-10-09 2008-02-19 Boston Scientific Scimed, Inc. Intraluminal medical device having improved visibility
US20040143317A1 (en) * 2003-01-17 2004-07-22 Stinson Jonathan S. Medical devices
US7264633B2 (en) * 2003-03-20 2007-09-04 Cordis Corp. Anvil bridge stent design
US7214240B2 (en) * 2003-03-20 2007-05-08 Cordis Corporation Split-bridge stent design
US20100196345A1 (en) * 2003-04-27 2010-08-05 Protalix Production of high mannose proteins in plant culture
US7951557B2 (en) * 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
US7625401B2 (en) * 2003-05-06 2009-12-01 Abbott Laboratories Endoprosthesis having foot extensions
US20040236409A1 (en) 2003-05-20 2004-11-25 Pelton Alan R. Radiopacity intraluminal medical device
DE10325678A1 (en) * 2003-06-02 2004-12-23 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Connection system for connecting a stent to a radio-opaque marker and method for establishing a connection between a stent and two or more radio-opaque markers
US7241308B2 (en) * 2003-06-09 2007-07-10 Xtent, Inc. Stent deployment systems and methods
US20050060025A1 (en) * 2003-09-12 2005-03-17 Mackiewicz David A. Radiopaque markers for medical devices
US7553324B2 (en) * 2003-10-14 2009-06-30 Xtent, Inc. Fixed stent delivery devices and methods
US20050080475A1 (en) * 2003-10-14 2005-04-14 Xtent, Inc. A Delaware Corporation Stent delivery devices and methods
US7175654B2 (en) * 2003-10-16 2007-02-13 Cordis Corporation Stent design having stent segments which uncouple upon deployment
US20070156225A1 (en) * 2003-12-23 2007-07-05 Xtent, Inc. Automated control mechanisms and methods for custom length stent apparatus
US7326236B2 (en) 2003-12-23 2008-02-05 Xtent, Inc. Devices and methods for controlling and indicating the length of an interventional element
US8337545B2 (en) 2004-02-09 2012-12-25 Cook Medical Technologies Llc Woven implantable device
US7243408B2 (en) * 2004-02-09 2007-07-17 Boston Scientific Scimed, Inc. Process method for attaching radio opaque markers to shape memory stent
US7323006B2 (en) * 2004-03-30 2008-01-29 Xtent, Inc. Rapid exchange interventional devices and methods
US8216299B2 (en) * 2004-04-01 2012-07-10 Cook Medical Technologies Llc Method to retract a body vessel wall with remodelable material
EP1737390A1 (en) * 2004-04-08 2007-01-03 Cook Incorporated Implantable medical device with optimized shape
US20050228477A1 (en) * 2004-04-09 2005-10-13 Xtent, Inc. Topographic coatings and coating methods for medical devices
US20050273156A1 (en) * 2004-06-07 2005-12-08 Rober Burgermeister Biocompatible alloy for implantable medical devices
US20050276718A1 (en) * 2004-06-09 2005-12-15 Robert Burgermeister Cobalt-nickel-chromium biocompatible alloy for implantable medical devices
US20050283226A1 (en) * 2004-06-18 2005-12-22 Scimed Life Systems, Inc. Medical devices
US8317859B2 (en) 2004-06-28 2012-11-27 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
US20050288766A1 (en) * 2004-06-28 2005-12-29 Xtent, Inc. Devices and methods for controlling expandable prostheses during deployment
US7794493B2 (en) 2004-06-30 2010-09-14 Cordis Corporation Magnetic resonance imaging compatibility alloy for implantable medical devices
US20060060266A1 (en) * 2004-09-01 2006-03-23 Pst, Llc Stent and method for manufacturing the stent
US7763067B2 (en) 2004-09-01 2010-07-27 C. R. Bard, Inc. Stent and method for manufacturing the stent
US20060069424A1 (en) * 2004-09-27 2006-03-30 Xtent, Inc. Self-constrained segmented stents and methods for their deployment
US20060100692A1 (en) * 2004-11-09 2006-05-11 Robert Burgermeister Cobalt-chromium-molybdenum fatigue resistant alloy for intravascular medical devices
US20060096672A1 (en) * 2004-11-09 2006-05-11 Robert Burgermeister Quaternary cobalt-nickel-chromium-molybdenum fatigue resistant alloy for intravascular medical devices
US20060292077A1 (en) * 2005-03-18 2006-12-28 Zhao Jonathon Z Dendritic and star-shaped contrast agents for medical devices and bioabsorbable radiopaque bulk material and method for producing same
DE102005013547B4 (en) * 2005-03-23 2009-02-05 Admedes Schuessler Gmbh Aneurysm stent and process for its preparation
JP5523700B2 (en) 2005-04-04 2014-06-18 フレキシブル ステンティング ソリューションズ，インク． Flexible stent
DE102005019612B4 (en) * 2005-04-27 2010-11-25 Admedes Schuessler Gmbh Mechanical locking of an X-ray marker in the eyelet of a stent or in another body implant
US8652193B2 (en) 2005-05-09 2014-02-18 Angiomed Gmbh & Co. Medizintechnik Kg Implant delivery device
EP2364676B1 (en) 2005-06-30 2018-12-19 Abbott Laboratories Endoprosthesis having foot extensions
DE102005039136B4 (en) * 2005-08-18 2011-07-28 Admedes Schuessler GmbH, 75179 Improving the radiopacity and corrosion resistance of NiTi stents using sandwiched rivets
US20070156230A1 (en) * 2006-01-04 2007-07-05 Dugan Stephen R Stents with radiopaque markers
US20070179587A1 (en) * 2006-01-30 2007-08-02 Xtent, Inc. Apparatus and methods for deployment of custom-length prostheses
US20070191926A1 (en) * 2006-02-14 2007-08-16 Advanced Cardiovascular Systems, Inc. Stent pattern for high stent retention
CA2640234C (en) 2006-02-14 2017-01-03 Angiomed Gmbh & Co. Medizintechnik Kg Highly flexible stent and method of manufacture
JP2009530060A (en) 2006-03-20 2009-08-27 エックステント・インコーポレーテッド Apparatus and method for deploying connected prosthetic segments
GB0609841D0 (en) 2006-05-17 2006-06-28 Angiomed Ag Bend-capable tubular prosthesis
GB0609911D0 (en) 2006-05-18 2006-06-28 Angiomed Ag Bend-capable stent prosthesis
US8752268B2 (en) 2006-05-26 2014-06-17 Abbott Cardiovascular Systems Inc. Method of making stents with radiopaque markers
US20070281117A1 (en) * 2006-06-02 2007-12-06 Xtent, Inc. Use of plasma in formation of biodegradable stent coating
GB0613670D0 (en) * 2006-07-10 2006-08-16 Angiomed Ag Tubular metal prosthesis and method of making it
US20080015684A1 (en) 2006-07-11 2008-01-17 Wu Patrick P Method And Apparatus For Attaching Radiopaque Markers To A Stent
US8016879B2 (en) * 2006-08-01 2011-09-13 Abbott Cardiovascular Systems Inc. Drug delivery after biodegradation of the stent scaffolding
US20080269865A1 (en) * 2006-08-07 2008-10-30 Xtent, Inc. Custom Length Stent Apparatus
GB0616729D0 (en) * 2006-08-23 2006-10-04 Angiomed Ag Method of welding a component to a shape memory alloy workpiece
GB0616999D0 (en) * 2006-08-29 2006-10-04 Angiomed Ag Annular mesh
US8500793B2 (en) * 2006-09-07 2013-08-06 C. R. Bard, Inc. Helical implant having different ends
US8414637B2 (en) * 2006-09-08 2013-04-09 Boston Scientific Scimed, Inc. Stent
US8778009B2 (en) * 2006-10-06 2014-07-15 Abbott Cardiovascular Systems Inc. Intravascular stent
GB0622465D0 (en) 2006-11-10 2006-12-20 Angiomed Ag Stent
US9622888B2 (en) 2006-11-16 2017-04-18 W. L. Gore & Associates, Inc. Stent having flexibly connected adjacent stent elements
GB0624419D0 (en) * 2006-12-06 2007-01-17 Angiomed Ag Stenting ring with marker
US20080166526A1 (en) * 2007-01-08 2008-07-10 Monk Russell A Formed panel structure
US8333799B2 (en) 2007-02-12 2012-12-18 C. R. Bard, Inc. Highly flexible stent and method of manufacture
EP4005537A1 (en) * 2007-02-12 2022-06-01 C.R. Bard Inc. Highly flexible stent and method of manufacture
US20080199510A1 (en) * 2007-02-20 2008-08-21 Xtent, Inc. Thermo-mechanically controlled implants and methods of use
GB0703379D0 (en) * 2007-02-21 2007-03-28 Angiomed Ag Stent with radiopaque marker
US8486132B2 (en) 2007-03-22 2013-07-16 J.W. Medical Systems Ltd. Devices and methods for controlling expandable prostheses during deployment
US8545548B2 (en) * 2007-03-30 2013-10-01 DePuy Synthes Products, LLC Radiopaque markers for implantable stents and methods for manufacturing the same
GB0706499D0 (en) 2007-04-03 2007-05-09 Angiomed Ag Bendable stent
ES2660667T3 (en) * 2007-05-07 2018-03-23 Protalix Ltd. Large-scale disposable bioreactor
US7810223B2 (en) * 2007-05-16 2010-10-12 Boston Scientific Scimed, Inc. Method of attaching radiopaque markers to intraluminal medical devices, and devices formed using the same
US20090005858A1 (en) * 2007-06-26 2009-01-01 Eugene Young Integration of markers into bar arms using a warm-forming process
US20090005853A1 (en) * 2007-06-26 2009-01-01 Karim Osman Integration Of Markers Into Bar Arms
US7988723B2 (en) 2007-08-02 2011-08-02 Flexible Stenting Solutions, Inc. Flexible stent
GB0717481D0 (en) 2007-09-07 2007-10-17 Angiomed Ag Self-expansible stent with radiopaque markers
US20090076584A1 (en) * 2007-09-19 2009-03-19 Xtent, Inc. Apparatus and methods for deployment of multiple custom-length prostheses
US7846199B2 (en) * 2007-11-19 2010-12-07 Cook Incorporated Remodelable prosthetic valve
US7896911B2 (en) 2007-12-12 2011-03-01 Innovasc Llc Device and method for tacking plaque to blood vessel wall
US10022250B2 (en) 2007-12-12 2018-07-17 Intact Vascular, Inc. Deployment device for placement of multiple intraluminal surgical staples
US8128677B2 (en) 2007-12-12 2012-03-06 Intact Vascular LLC Device and method for tacking plaque to a blood vessel wall
US10166127B2 (en) 2007-12-12 2019-01-01 Intact Vascular, Inc. Endoluminal device and method
US8926688B2 (en) * 2008-01-11 2015-01-06 W. L. Gore & Assoc. Inc. Stent having adjacent elements connected by flexible webs
US9101503B2 (en) * 2008-03-06 2015-08-11 J.W. Medical Systems Ltd. Apparatus having variable strut length and methods of use
EP2262443A2 (en) * 2008-03-10 2010-12-22 NFocus Neuromedical, Inc. Stents and stent grafts
EP2633823B1 (en) 2008-04-21 2016-06-01 Covidien LP Braid-ball embolic devices and delivery systems
US9675482B2 (en) 2008-05-13 2017-06-13 Covidien Lp Braid implant delivery systems
GB0813659D0 (en) 2008-07-25 2008-09-03 Smith & Nephew Fracture putty
EP2358307B1 (en) 2008-09-15 2021-12-15 Medtronic Ventor Technologies Ltd. Prosthetic heart valve having identifiers for aiding in radiographic positioning
US8821562B2 (en) 2008-09-25 2014-09-02 Advanced Bifurcation Systems, Inc. Partially crimped stent
CN102215780B (en) 2008-09-25 2015-10-14 高级分支系统股份有限公司 Part crimped stent
US8769796B2 (en) 2008-09-25 2014-07-08 Advanced Bifurcation Systems, Inc. Selective stent crimping
US11298252B2 (en) 2008-09-25 2022-04-12 Advanced Bifurcation Systems Inc. Stent alignment during treatment of a bifurcation
US8795347B2 (en) 2008-09-25 2014-08-05 Advanced Bifurcation Systems, Inc. Methods and systems for treating a bifurcation with provisional side branch stenting
US9149376B2 (en) * 2008-10-06 2015-10-06 Cordis Corporation Reconstrainable stent delivery system
JP2012524641A (en) * 2009-04-24 2012-10-18 フレキシブル ステンティング ソリューションズ，インク． Flexible device
US8808353B2 (en) 2010-01-30 2014-08-19 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds having a low crossing profile
US8568471B2 (en) 2010-01-30 2013-10-29 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds
WO2011119883A1 (en) 2010-03-24 2011-09-29 Advanced Bifurcation Systems, Inc. Stent alignment during treatment of a bifurcation
CA2794080A1 (en) 2010-03-24 2011-09-29 Advanced Bifurcation Systems, Inc. System and methods for treating a bifurcation
EP3354210B1 (en) 2010-09-10 2022-10-26 Covidien LP Devices for the treatment of vascular defects
US8998947B2 (en) 2010-09-10 2015-04-07 Medina Medical, Inc. Devices and methods for the treatment of vascular defects
JP2014508559A (en) 2010-12-30 2014-04-10 ボストン サイエンティフィック サイムド，インコーポレイテッド Multi-stage open stent design
WO2012109382A2 (en) 2011-02-08 2012-08-16 Advanced Bifurcation Systems, Inc. Multi-stent and multi-balloon apparatus for treating bifurcations and methods of use
EP2672932B1 (en) 2011-02-08 2018-09-19 Advanced Bifurcation Systems, Inc. System for treating a bifurcation with a fully crimped stent
US8790388B2 (en) 2011-03-03 2014-07-29 Boston Scientific Scimed, Inc. Stent with reduced profile
WO2012118526A1 (en) 2011-03-03 2012-09-07 Boston Scientific Scimed, Inc. Low strain high strength stent
US10390977B2 (en) 2011-06-03 2019-08-27 Intact Vascular, Inc. Endovascular implant
US8726483B2 (en) 2011-07-29 2014-05-20 Abbott Cardiovascular Systems Inc. Methods for uniform crimping and deployment of a polymer scaffold
DE102012100362B4 (en) * 2012-01-17 2015-11-05 Acandis Gmbh & Co. Kg Arrangement comprising a wire and a medical implant
US10940167B2 (en) 2012-02-10 2021-03-09 Cvdevices, Llc Methods and uses of biological tissues for various stent and other medical applications
US9233015B2 (en) 2012-06-15 2016-01-12 Trivascular, Inc. Endovascular delivery system with an improved radiopaque marker scheme
KR102309795B1 (en) 2012-11-13 2021-10-08 코비디엔 엘피 Occlusive devices
AU2014214700B2 (en) 2013-02-11 2018-01-18 Cook Medical Technologies Llc Expandable support frame and medical device
US9545301B2 (en) 2013-03-15 2017-01-17 Covidien Lp Coated medical devices and methods of making and using same
US9320592B2 (en) 2013-03-15 2016-04-26 Covidien Lp Coated medical devices and methods of making and using same
EP2995281B1 (en) * 2013-05-07 2019-12-11 Kaneka Corporation Stent, method for producing same and device for producing same
US9668890B2 (en) 2013-11-22 2017-06-06 Covidien Lp Anti-thrombogenic medical devices and methods
DE102013020689B3 (en) * 2013-12-04 2015-02-19 Admedes Schuessler Gmbh A body implant and method of making the same and method of improving radiopacity
CN106456347B (en) 2014-03-18 2018-11-13 波士顿科学国际有限公司 Reduce the support Design of granulation and inflammation
US10299948B2 (en) 2014-11-26 2019-05-28 W. L. Gore & Associates, Inc. Balloon expandable endoprosthesis
US9789228B2 (en) 2014-12-11 2017-10-17 Covidien Lp Antimicrobial coatings for medical devices and processes for preparing such coatings
US9433520B2 (en) 2015-01-29 2016-09-06 Intact Vascular, Inc. Delivery device and method of delivery
US9375336B1 (en) 2015-01-29 2016-06-28 Intact Vascular, Inc. Delivery device and method of delivery
US9999527B2 (en) * 2015-02-11 2018-06-19 Abbott Cardiovascular Systems Inc. Scaffolds having radiopaque markers
US9737368B2 (en) 2015-02-24 2017-08-22 Abbott Cardiovascular Systems Inc. System and method for attaching a radiopaque marker bead to an endoprosthesis
US9375333B1 (en) 2015-03-06 2016-06-28 Covidien Lp Implantable device detachment systems and associated devices and methods
US9700443B2 (en) 2015-06-12 2017-07-11 Abbott Cardiovascular Systems Inc. Methods for attaching a radiopaque marker to a scaffold
US10993824B2 (en) 2016-01-01 2021-05-04 Intact Vascular, Inc. Delivery device and method of delivery
US10568752B2 (en) 2016-05-25 2020-02-25 W. L. Gore & Associates, Inc. Controlled endoprosthesis balloon expansion
US10478195B2 (en) 2016-08-04 2019-11-19 Covidien Lp Devices, systems, and methods for the treatment of vascular defects
RU2753447C2 (en) * 2016-10-04 2021-08-16 Ясухиро СЁБАЯСИ Flexible stent
US10238513B2 (en) 2017-07-19 2019-03-26 Abbott Cardiovascular Systems Inc. Intravascular stent
US11660218B2 (en) 2017-07-26 2023-05-30 Intact Vascular, Inc. Delivery device and method of delivery
US10675036B2 (en) 2017-08-22 2020-06-09 Covidien Lp Devices, systems, and methods for the treatment of vascular defects
EP3716907B1 (en) * 2017-12-01 2023-06-07 C. R. Bard, Inc. Adjustable vascular graft for custom inner diameter reduction and related methods
CN111388045A (en) 2018-12-17 2020-07-10 柯惠有限合伙公司 Occlusion device
US11406403B2 (en) * 2019-06-14 2022-08-09 Neuravi Limited Visibility of mechanical thrombectomy device during diagnostic imaging
US11517457B2 (en) 2019-07-03 2022-12-06 Abbott Cardiovascular Systems Inc. Intravascular stent
US11504816B2 (en) 2019-11-04 2022-11-22 Covidien Lp Systems and methods for treating aneurysms
US11931041B2 (en) 2020-05-12 2024-03-19 Covidien Lp Devices, systems, and methods for the treatment of vascular defects

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5632771A (en) * 1993-07-23 1997-05-27 Cook Incorporated Flexible stent having a pattern formed from a sheet of material

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2825452B2 (en) * 1994-04-25 1998-11-18 アドヴァンスド カーディオヴァスキュラー システムズ インコーポレーテッド Radiopak stent marker
US5824042A (en) * 1996-04-05 1998-10-20 Medtronic, Inc. Endoluminal prostheses having position indicating markers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5632771A (en) * 1993-07-23 1997-05-27 Cook Incorporated Flexible stent having a pattern formed from a sheet of material

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19937638B4 (en) * 1999-08-12 2006-11-02 Alveolus Inc. Tracheal Stent
US6863685B2 (en) 2001-03-29 2005-03-08 Cordis Corporation Radiopacity intraluminal medical device
WO2002078762A1 (en) * 2001-03-29 2002-10-10 Cordis Corporation Radiopaque intraluminal medical device
US8882829B2 (en) 2001-06-19 2014-11-11 Cordis Corporation Low profile improved radiopacity intraluminal medical device
US8197535B2 (en) 2001-06-19 2012-06-12 Cordis Corporation Low profile improved radiopacity intraluminal medical device
US8696729B2 (en) 2002-11-01 2014-04-15 Covidien Lp Implant delivery system with marker interlock
US6814746B2 (en) 2002-11-01 2004-11-09 Ev3 Peripheral, Inc. Implant delivery system with marker interlock
US9597212B2 (en) 2002-11-01 2017-03-21 Covidien Lp Implant delivery system with marker interlock
EP1849435A2 (en) * 2003-06-16 2007-10-31 Endotex Interventional Systems, Inc. Stent with attached sleeve marker
EP1849435A3 (en) * 2003-06-16 2009-06-17 Endotex Interventional Systems, Inc. Stent with attached sleeve marker
WO2005028014A1 (en) * 2003-09-16 2005-03-31 Campus Gmbh & Co.Kg Device for being introduced into body organs and having a marker element for controlling the position thereof
DE102004054084B4 (en) * 2004-11-09 2007-08-02 Admedes Schuessler Gmbh Stent with a marker for improving the radiopacity, the use and a method for producing such a stent
DE102004054084A1 (en) * 2004-11-09 2006-05-11 Admedes Schuessler Gmbh Stent, comprising marker visible under use of x-rays and designed as string accommodated in groove
US10265089B2 (en) 2016-02-12 2019-04-23 Covidien Lp Vascular device visibility
US10052185B2 (en) 2016-02-12 2018-08-21 Covidien Lp Vascular device marker attachment
US10799332B2 (en) 2016-02-12 2020-10-13 Covidien Lp Vascular device marker attachment
US11045215B2 (en) 2016-02-12 2021-06-29 Covidien Lp Vascular device visibility
US11801116B2 (en) 2016-02-12 2023-10-31 Covidien Lp Vascular device marker attachment
US11819430B2 (en) 2017-11-03 2023-11-21 Ceroflo Limited Expandable stent and a method for promoting a natural intracranial angiogenesis process, and use of the expandable stent in the method for promoting a natural intracranial angiogenesis process
US11376140B1 (en) 2021-03-26 2022-07-05 Vesper Medical, Inc. Medical implants with structural members having barbs for retaining radiopaque markers
WO2022203714A1 (en) * 2021-03-26 2022-09-29 Vesper Medical, Inc. Medical implants with structural members having barbs for retaining radiopaque markers
US11938046B2 (en) 2021-03-26 2024-03-26 Vesper Medical, Inc. Medical implants with structural members having barbs for retaining radiopaque markers
CN114985907A (en) * 2022-05-19 2022-09-02 深圳泰德激光技术股份有限公司 Blood vessel stent and manufacturing method thereof

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