WO1999032897A3 - Nmr apparatus and method for non-invasive in vivo testing of a patient's body fluid glucose levels - Google Patents

Nmr apparatus and method for non-invasive in vivo testing of a patient's body fluid glucose levels Download PDF

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Publication number
WO1999032897A3
WO1999032897A3 PCT/US1998/027478 US9827478W WO9932897A3 WO 1999032897 A3 WO1999032897 A3 WO 1999032897A3 US 9827478 W US9827478 W US 9827478W WO 9932897 A3 WO9932897 A3 WO 9932897A3
Authority
WO
WIPO (PCT)
Prior art keywords
patient
permanent magnets
body fluid
magnets
invasive
Prior art date
Application number
PCT/US1998/027478
Other languages
French (fr)
Other versions
WO1999032897A2 (en
Inventor
Marvin H Anderson
Thomas W Schleich
Boban K John
James N Schoolery
Original Assignee
American Biotechnology Workgro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Biotechnology Workgro filed Critical American Biotechnology Workgro
Priority to EP98965479A priority Critical patent/EP1053483A2/en
Priority to AU20938/99A priority patent/AU2093899A/en
Priority to CA002316365A priority patent/CA2316365A1/en
Priority to NZ505419A priority patent/NZ505419A/en
Priority to JP2000525765A priority patent/JP2001526920A/en
Publication of WO1999032897A2 publication Critical patent/WO1999032897A2/en
Publication of WO1999032897A3 publication Critical patent/WO1999032897A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
    • G01R33/383—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field using permanent magnets

Abstract

A magnet assembly (10) for a small scale NMR spectroscopy apparatus suitable for laboratory or home use, comprising two permanent magnets (11) facing one another, a tapered pole cap (12) on each of the two facing surfaces of the permanent magnets, and a plurality of radially polarized annular canceling magnets (18) disposed about the permanent magnets and pole caps. The design and position of the radially polarized canceling magnets reduces leakage of the magnetic field, to maintain the magnetic field strength and homogeneity within the test region, without a disadvantageous increase in the size, weight and cost of the NMR apparatus. Also provided is a method for in vivo measurement of glucose concentration in a patient's body fluid using NMR spectroscopy. The method comprises spectral editing, e.g. double quantum filtering to isolate scalar coupled resonances of glucose.
PCT/US1998/027478 1997-12-23 1998-12-23 Nmr apparatus and method for non-invasive in vivo testing of a patient's body fluid glucose levels WO1999032897A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP98965479A EP1053483A2 (en) 1997-12-23 1998-12-23 NMR APPARATUS AND METHOD FOR NON-INVASIVE $i(IN-VIVO) TESTING OF A PATIENT'S BODY FLUID GLUCOSE LEVELS
AU20938/99A AU2093899A (en) 1997-12-23 1998-12-23 Nmr apparatus and method for non-invasive (in-vivo) testing of a patient's body fluid glucose levels
CA002316365A CA2316365A1 (en) 1997-12-23 1998-12-23 Nmr apparatus and method for non-invasive in vivo testing of a patient's body fluid glucose levels
NZ505419A NZ505419A (en) 1997-12-23 1998-12-23 A magnet assembly for an NMR apparatus has opposed magnets with polar cap members and annual cancelling magnets
JP2000525765A JP2001526920A (en) 1997-12-23 1998-12-23 NMR apparatus and method for non-invasive in vivo testing of patient fluid glucose levels

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/997,072 1997-12-23
US08/997,072 US6163154A (en) 1997-12-23 1997-12-23 Small scale NMR spectroscopic apparatus and method

Publications (2)

Publication Number Publication Date
WO1999032897A2 WO1999032897A2 (en) 1999-07-01
WO1999032897A3 true WO1999032897A3 (en) 1999-09-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/027478 WO1999032897A2 (en) 1997-12-23 1998-12-23 Nmr apparatus and method for non-invasive in vivo testing of a patient's body fluid glucose levels

Country Status (7)

Country Link
US (2) US6163154A (en)
EP (1) EP1053483A2 (en)
JP (1) JP2001526920A (en)
AU (1) AU2093899A (en)
CA (1) CA2316365A1 (en)
NZ (1) NZ505419A (en)
WO (1) WO1999032897A2 (en)

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Also Published As

Publication number Publication date
EP1053483A2 (en) 2000-11-22
NZ505419A (en) 2002-05-31
CA2316365A1 (en) 1999-07-01
US6404197B1 (en) 2002-06-11
AU2093899A (en) 1999-07-12
US6163154A (en) 2000-12-19
WO1999032897A2 (en) 1999-07-01
JP2001526920A (en) 2001-12-25

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