WO1999039823A1 - Method of producing material for purification of physiological liquids of organism, and method of producing the material - Google Patents
Method of producing material for purification of physiological liquids of organism, and method of producing the material Download PDFInfo
- Publication number
- WO1999039823A1 WO1999039823A1 PCT/US1998/027739 US9827739W WO9939823A1 WO 1999039823 A1 WO1999039823 A1 WO 1999039823A1 US 9827739 W US9827739 W US 9827739W WO 9939823 A1 WO9939823 A1 WO 9939823A1
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- WIPO (PCT)
- Prior art keywords
- vinyl groups
- surface exposed
- groups
- physiological
- vinyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/40—Introducing phosphorus atoms or phosphorus-containing groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
- B01J20/261—Synthetic macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
- B01J20/264—Synthetic macromolecular compounds derived from different types of monomers, e.g. linear or branched copolymers, block copolymers, graft copolymers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
- B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
- B01J20/3208—Polymeric carriers, supports or substrates
- B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
- B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3278—Polymers being grafted on the carrier
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2800/00—Copolymer characterised by the proportions of the comonomers expressed
- C08F2800/20—Copolymer characterised by the proportions of the comonomers expressed as weight or mass percentages
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2810/00—Chemical modification of a polymer
- C08F2810/20—Chemical modification of a polymer leading to a crosslinking, either explicitly or inherently
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249987—With nonvoid component of specified composition
Definitions
- the present invention relates to a method of and material for purification of physiological liquids of organism, and method of producing the material.
- physiological liquids of organisms such as blood, plasma, peritoneal liquid etc.
- various toxicants in the case of poisoning the organism as well as in the case of diseases, in particular diseases of liver and kidneys. It is therefore advisable to remove the toxicants from the physiological liquids to significantly improve the situation of the patient.
- a plurality of methods have been invented and have been utilized for removing toxicants from blood, plasma and other physiological liquids.
- One of the most efficient methods is hemodialysis. This method, however, is generally restricted to removing small toxic molecules, whereas toxins belonging to the so-called middle-size molecules
- SUBSTITUTE SHEET (RULE 25) respect to above toxicants having larger molecular sizes, for the purpose of preventing propagation of diseases or curing the disease.
- a wider spectrum of toxic compounds should be removable from blood or other physiological fluids, if conventional hemodialysis procedure is supplemented with an adsorption procedure.
- the latter should be responsible for removing iargertoxins which diffusion through the membrane of the dialyser is too slow.
- the adsorbing material should both exhibit high adsorption capacity toward toxins in the middle range of molecular weights and disply sufficient compatibility with blood or the corresponding physiological fluid.
- Designing suitable polymeric adsorbing material is one of the aims of present invention.
- Macroporous styrene-divinylbenzene copolymers represents the most popular type of polymeric adsorbing materials. Many companies manufacture adsorbents of this category. Amberlite XAD-4 (by Rohm and others).
- the three- dimensional network of these polymers has to be sufficiently rigid, i.e., it must contain a high proportion of crosslinking divinylbenzene.
- the latter product when in pure state, is rather expensive. The more available technical
- SUBSTTTUTE SHEET (RULE 26) -3- product contains up to 30-40% of ethylvinyl styrene, so that commercially available macroporous adsorbents should be better referred to as copolymers of DVB, ethylvinyl styrene and styrene.
- this monomer mixture is provided with organic solvents serving as the diluters which cause a micro phase separation during the polymerization procedure and thus resulting in the macroporous structure of the final material.
- the chemical modification of the surface of macroporous DVB- copolymers reiies on chemical reactions of the surface-exposed pendant vinyl groups and aims at converting these groups into more hydrophiiic functional groups.
- This conversion provides the initial hydrophobic adsorbing material with the property of hemocompatibility, since the hydrophiiic surfaces adsorb less blood ceils and plasma proteins and do not activate the clotting cascades as rapidly as does the initial hydrophobic surface.
- the method of purification of physiological liquids of organism comprises removing a physiological liquid containing toxicants from a patient; passing the physiological liquid through a porous hydrophobic divinylbenzene copolymer which initially has surface exposed vinyl groups and thereafter the vinyl groups are chemically modified so as to form different surface exposed functional groups with a greater hydrophilicity and a greater biocompatibility than those of the vinyl groups.
- the material for purification of physiological liquids of organism is proposed, which is composed of a porous hydrophobic divinylbenzene copolymer which initially has surface exposed vinyl groups in which thereafterthe vinyl groups are chemically modified so as to form different surface exposed functional groups with a greater hydrophilicity and greater biocompatibility than those of the vinyl groups.
- a purification of physiological liquids of organism by removing toxicants is proposed.
- a patient's blood is withdrawn from an arterial blood circulatory access point, passed through a material in accordance with the present invention which removes toxicants, and re-enters the patient through a venous access point.
- the material has a size, a shape, and a structure selected so as to remove the toxic compounds in the molecular range of 300 to 30,000 Dalton from the physiological liquid.
- the material in accordance with the present invention which is used in the inventive method for purification of physiological liquids of organism and which is produced in accordance with the inventive production method, is a porous hydrophobic divinylbenzene copolymer which initially has surface exposed vinyl groups in which thereafter the vinyl groups are chemically modified so as to form different surface exposed functional groups with a greater hydrophilicity and greater biocompatibility than those of the vinyl groups.
- the modification of the surface vinyl groups was made in aqueous or aqueous organic media in the following three principal directions: grafting hydrophiiic polymer chains by a radial polymerization of 2- hydroxyethyl methacrylate, N-vinylpyrrolidone, N-vinylcaprolactame, or other water soluble monomers, oxidation of the vinyl groups to epoxy groups with the subsequent reaction of the epoxy groups with water, ethylene glycol, amines or 2- amonoethanol molecules, and • depositing high-molecular-weight hemocompatible polymer, in particular poly(trifluorethyoxy) phosphazene onto the surface of the polymeric beads.
- the surface-modified materials were shown to exhibit good hemocompatibility, i.e., they did not change noticeably the coagulation time of blood, caused no hemolysis and showed no cytotoxicity effects. When contacted with plasma or whole blood, the materials effectively removed the pool of middle-sized molecules, as could be easily followed by conventional spectrophotometric measurements.
- a solution of 130 g p-ethylstyrene, 132 g divinylbenzene (a mixture of para and metha-isomers of about 1 :1 ) and 2.62 g benzoyl peroxide in a mixture of 150 mi toluene and 100 ml iso-amyl alcohol was suspended in 4 liters of pure water containing 1% cellulose stabilizer. After 39 min stirring at room temperature, the mixture was heated at 40°C for 1 hours, 60°C for 2 hours, 80°C for 5 hours and 90°C for 2 hours. After cooling the mixture to " room temperature, the beads of the material obtained were filtered and washed with hot water, methanol and water. The polymer was dried in an oven at 80°C within one day.
- Example 1 The polymer prepared in Example 1 was washed with ethanol and then rinsed with water, which results in a material fully wetted by water with all its pores filled with water.
- the material contains 40% polymer and
- Example 2 To 1 g of the wetted with water polymer prepared in Example 1 , 1.0 ml of 6% aqueous solution of N-vinylpyrrolidone, and 0.2 ml of 10% aqueous solution of ammonium persulfate were added, and the mixture was stirred for 2 h at a temperature of 40°C. The polymer was filtered, washed with water and dried.
- Example 2 To 1 g of the polymer wetted with water and prepared in Example 1 2.0 ml of 3% N-vinylpyrrolidone, 0.3 ml of aqueous 10% solution of sodium persulfate and 0.3 ml of sodium sulfite solution were added and the mixture was stirred at 25°C for 2 h. The polymer was filtered and treated as above.
- Example 2 To 6 g of dry polymer prepared in Example 1 , 25 ml of acetic anhydride were added, the mixture was cooled to 0°C, slowly provided with
- Example 9 The product obtained in Example 9 was dried in vacuum. A solution of 0.3 mg poly(trifluoroethoxy) phosphazene (molecular weight 20
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UA99105411A UA63943C2 (en) | 1998-02-06 | 1998-12-30 | Method for purification of physiological liquids of organism, polymer adsorbent for its realization and method for production of polymer adsorbent |
EP98964992A EP0998350A1 (en) | 1998-02-06 | 1998-12-30 | Method of producing material for purification of physiological liquids of organism, and method of producing the material |
EA199900797A EA001871B1 (en) | 1998-02-06 | 1998-12-30 | Method of producing material for purification of physiological liquids of organism, and method of producing the material |
JP54042799A JP2001524878A (en) | 1998-02-06 | 1998-12-30 | Method and substance for purifying physiological fluid of an organism and method for producing the substance |
CA002285942A CA2285942C (en) | 1998-02-06 | 1998-12-30 | Material for purification of physiological liquids of organism, and method of producing the material |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US09/019,583 | 1998-02-06 | ||
US09/019,583 US6114466A (en) | 1998-02-06 | 1998-02-06 | Material for purification of physiological liquids of organism |
Publications (1)
Publication Number | Publication Date |
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WO1999039823A1 true WO1999039823A1 (en) | 1999-08-12 |
Family
ID=21793971
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/027739 WO1999039823A1 (en) | 1998-02-06 | 1998-12-30 | Method of producing material for purification of physiological liquids of organism, and method of producing the material |
Country Status (8)
Country | Link |
---|---|
US (7) | US6114466A (en) |
EP (1) | EP0998350A1 (en) |
JP (1) | JP2001524878A (en) |
CN (1) | CN1143732C (en) |
CA (1) | CA2285942C (en) |
EA (1) | EA001871B1 (en) |
UA (1) | UA63943C2 (en) |
WO (1) | WO1999039823A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000043120A1 (en) | 1999-01-22 | 2000-07-27 | The Dow Chemical Company | Surface modified divinylbenzene resin having a hemocompatible coating |
US6632752B2 (en) * | 2001-02-14 | 2003-10-14 | Renal Tech International Llc | Protective clothing |
KR100825656B1 (en) * | 2000-08-29 | 2008-04-29 | 말린크로트 베이커, 인코포레이티드 | Functionalized polymeric media for separation of analytes |
WO2019222048A1 (en) * | 2018-05-15 | 2019-11-21 | Cytosorbents, Inc. | Process for functionalizing a biocompatible polymeric bead, the functionalized beads, and the beads produced thereby |
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SE9700768D0 (en) * | 1997-03-04 | 1997-03-04 | Pharmacia Biotech Ab | Procedure for introducing functionality |
US20020197249A1 (en) | 2001-04-10 | 2002-12-26 | Renal Tech International | Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood products |
US8329388B2 (en) * | 1997-07-30 | 2012-12-11 | Cytosorbents, Inc. | Biocompatible devices, systems, and methods for reducing levels of proinflammatory of antiinflammatory stimulators or mediators in the blood |
US20020198487A1 (en) * | 2001-04-10 | 2002-12-26 | Renal Tech International | Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in physiologic fluids |
US6416487B1 (en) * | 1997-07-30 | 2002-07-09 | Renal Tech International Llc | Method of removing beta-2 microglobulin from blood |
US20020159995A1 (en) * | 1997-07-30 | 2002-10-31 | Renal Tech International | Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood, generated as a result of extracorporeal blood processing |
US20020197250A1 (en) * | 2001-04-10 | 2002-12-26 | Renal Tech International | Biocompatible devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood |
AU2001241095A1 (en) * | 2000-03-13 | 2001-09-24 | Hisamitsu Pharmaceutical Co. Inc. | Preventives and/or remedies for hyperphosphatemia |
US6527735B1 (en) * | 2000-04-27 | 2003-03-04 | Renaltech International Llc | Method of peritoneal dialysis |
US6759442B2 (en) * | 2000-06-02 | 2004-07-06 | Showa Denko Kabushiki Kaisha | Packing material for solid phase extraction and solid phase extraction method |
US6602418B2 (en) | 2001-01-22 | 2003-08-05 | Bechtel Bwxt Idaho, Llc | Solution dewatering with concomitant ion removal |
US6589224B2 (en) * | 2001-02-14 | 2003-07-08 | Renal Tech International Llc | Method of introducing fluids into a patient's body |
US20020197252A1 (en) * | 2001-04-10 | 2002-12-26 | Renal Tech International | Selective adsorption devices and systems |
US6878127B2 (en) | 2001-04-10 | 2005-04-12 | Renaltech International, Llc | Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood |
US20030060527A1 (en) * | 2001-09-17 | 2003-03-27 | Vadim Davankov | Hemo-and biocompatible polymeric adsorbing material for purification of physiological fluids of organism, and a method of producing the material, and a method of and device for purification of physiological fluids of organism with the use of the material |
JP2005510609A (en) * | 2001-11-26 | 2005-04-21 | アメルシャム・バイオサイエンシーズ・アクチボラグ | Post-modification of porous support |
AU2002353736B2 (en) * | 2001-11-26 | 2008-05-08 | Ge Healthcare Bio-Sciences Ab | Post-modification of a porous support |
US7629049B2 (en) * | 2002-10-18 | 2009-12-08 | Medasorb, Inc. | Hemocompatible polymer systems and related devices |
US7112620B2 (en) | 2002-10-18 | 2006-09-26 | Albright Robert L | Hemocompatible polymer systems & related methods |
US6884829B2 (en) * | 2002-10-18 | 2005-04-26 | Robert L. Albright | Hemocompatible coated polymer and related one-step methods |
US6861473B2 (en) | 2003-02-28 | 2005-03-01 | Baxter International Inc. | Macromolecular ketoaldehydes |
US8211310B2 (en) | 2006-11-20 | 2012-07-03 | Cytosorbents, Inc. | Size-selective polymer system |
US7875182B2 (en) * | 2006-11-20 | 2011-01-25 | Cytosorbents, Inc. | Size-selective hemoperfusion polymeric adsorbents |
US9604196B2 (en) | 2006-11-20 | 2017-03-28 | Cytosorbent, Inc. | Size-selective hemocompatible polymer system |
ES2932951T3 (en) * | 2011-01-06 | 2023-01-30 | Cytosorbents Inc | Methods that are useful for selectively modifying the internal and external surfaces of porous polymeric beads |
WO2013002909A1 (en) | 2011-05-20 | 2013-01-03 | Waters Technologies Corporation | Porous materials for solid phase extraction and chromatography and processes for preparation and use thereof |
AU2012295350B2 (en) | 2011-08-12 | 2016-09-22 | Cytosorbents Corporation | Polymeric sorbent for removal of impurities from whole blood and blood products |
US10465153B2 (en) | 2013-11-28 | 2019-11-05 | Ge Healthcare Bioprocess R&D Ab | Stabilization of fermented beverages |
US20190176126A1 (en) * | 2016-03-11 | 2019-06-13 | Hitachi Chemical Company, Ltd. | Separation material, column provided with said separation material, and method for producing separation material |
JP7033083B2 (en) | 2016-05-26 | 2022-03-09 | サイトソーベンツ・コーポレーション | Use of blood-compatible porous polymer bead sorbent to remove endotoxin-inducing molecules |
RU2653125C1 (en) * | 2017-05-23 | 2018-05-07 | Акционерное общество "ПЕРСПЕКТИВНЫЕ МЕДИЦИНСКИЕ ТЕХНОЛОГИИ" | Polymeric sorbent, method of its production and use |
CN115672263B (en) * | 2022-12-02 | 2024-02-13 | 东莞理工学院 | Preparation method of halloysite nanotube composite material and application of halloysite nanotube composite material in uranium pollution treatment |
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US4427793A (en) * | 1980-01-28 | 1984-01-24 | Rohm And Haas Company | Vinylbenzyl alcohol polymer beads and thermally crosslinked derivatives thereof |
US5037857A (en) * | 1987-10-26 | 1991-08-06 | Rohm And Haas Company | High-surface-area fiber |
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Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2000043120A1 (en) | 1999-01-22 | 2000-07-27 | The Dow Chemical Company | Surface modified divinylbenzene resin having a hemocompatible coating |
US6238795B1 (en) | 1999-01-22 | 2001-05-29 | The Dow Chemical Company | Surface modified polymer beads |
US6325939B2 (en) | 1999-01-22 | 2001-12-04 | The Dow Chemical Company | Surface modified polymer beads |
US6338801B2 (en) | 1999-01-22 | 2002-01-15 | The Dow Chemical Company | Surface modified polymer beads |
US6419830B2 (en) | 1999-01-22 | 2002-07-16 | The Dow Chemical Company | Surface modified polymer beads |
US6423024B1 (en) | 1999-01-22 | 2002-07-23 | The Dow Chemical Company | Device for removing toxins from blood or plasma |
EP1148944B1 (en) * | 1999-01-22 | 2010-04-21 | Dow Global Technologies Inc. | Surface modified divinylbenzene resin having a hemocompatible coating |
EP2189213A1 (en) * | 1999-01-22 | 2010-05-26 | Dow Global Technologies Inc. | Method for producing a surface modified divinylbenzene resin having a hemocompatible coating |
KR100825656B1 (en) * | 2000-08-29 | 2008-04-29 | 말린크로트 베이커, 인코포레이티드 | Functionalized polymeric media for separation of analytes |
US6632752B2 (en) * | 2001-02-14 | 2003-10-14 | Renal Tech International Llc | Protective clothing |
WO2019222048A1 (en) * | 2018-05-15 | 2019-11-21 | Cytosorbents, Inc. | Process for functionalizing a biocompatible polymeric bead, the functionalized beads, and the beads produced thereby |
US10889665B2 (en) | 2018-05-15 | 2021-01-12 | Cytosorbents, Inc. | Process for functionalizing a biocompatible polymeric bead, the functionalized beads, and the beads produced thereby |
Also Published As
Publication number | Publication date |
---|---|
US6153707A (en) | 2000-11-28 |
US6303702B1 (en) | 2001-10-16 |
US20030057139A1 (en) | 2003-03-27 |
CN1252739A (en) | 2000-05-10 |
CA2285942C (en) | 2007-07-03 |
US6114466A (en) | 2000-09-05 |
US6156851A (en) | 2000-12-05 |
UA63943C2 (en) | 2004-02-16 |
EA001871B1 (en) | 2001-10-22 |
CA2285942A1 (en) | 1999-08-12 |
EA199900797A1 (en) | 2000-06-26 |
CN1143732C (en) | 2004-03-31 |
US6087300A (en) | 2000-07-11 |
JP2001524878A (en) | 2001-12-04 |
US6133393A (en) | 2000-10-17 |
EP0998350A1 (en) | 2000-05-10 |
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