WO1999042602A2 - Fermentative preparation process for cytostatics and crystal forms thereof - Google Patents
Fermentative preparation process for cytostatics and crystal forms thereof Download PDFInfo
- Publication number
- WO1999042602A2 WO1999042602A2 PCT/EP1999/001025 EP9901025W WO9942602A2 WO 1999042602 A2 WO1999042602 A2 WO 1999042602A2 EP 9901025 W EP9901025 W EP 9901025W WO 9942602 A2 WO9942602 A2 WO 9942602A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cyclodextrin
- epothilones
- weak
- epothilone
- medium
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/167—Heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Saccharide Compounds (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
Description
Claims
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99911678A EP1054994B1 (en) | 1998-02-19 | 1999-02-17 | Fermentative preparation process for cytostatics and crystal forms thereof |
SK5014-2008A SK287677B6 (en) | 1998-02-19 | 1999-02-17 | The crystalline form of epothilone B, a pharmaceutical composition thereof, and the use of the crystalline form of epothilone B |
DE69921966T DE69921966T2 (en) | 1998-02-19 | 1999-02-17 | METHOD FOR THE FERMENTATIVE MANUFACTURE OF CYTOSTATICS AND THEIR CRYSTAL FORMS |
SK1240-2000A SK286517B6 (en) | 1998-02-19 | 1999-02-17 | Fermentative preparation process for cytostatics and crystal forms thereof |
IL13769199A IL137691A0 (en) | 1998-02-19 | 1999-02-17 | Fermentative preparation process for cytostatics and crystal forms thereof |
PL342423A PL196787B1 (en) | 1998-02-19 | 1999-02-17 | Method of obtaining cytostatic drugs and their crystalline forms by fermentation |
CA002318818A CA2318818A1 (en) | 1998-02-19 | 1999-02-17 | Fermentative preparation process for cytostatics and crystal forms thereof |
IL15963199A IL159631A0 (en) | 1998-02-19 | 1999-02-17 | Fermentative preparation process for cytostatics and crystal forms thereof |
JP2000532542A JP3681109B2 (en) | 1998-02-19 | 1999-02-17 | Fermentative production method of cell growth inhibitor and crystals thereof |
SK5029-2009A SK288058B6 (en) | 1998-02-19 | 1999-02-17 | Process for separating epothilones |
BR9908119-9A BR9908119A (en) | 1998-02-19 | 1999-02-17 | Fermentative preparation process for cytostatics and crystal forms thereof |
SI9930738T SI1054994T1 (en) | 1998-02-19 | 1999-02-17 | Fermentative preparation process for cytostatics and crystal forms thereof |
DK99911678T DK1054994T3 (en) | 1998-02-19 | 1999-02-17 | Fermentation process for cytostatic agents and crystal forms thereof |
NZ506138A NZ506138A (en) | 1998-02-19 | 1999-02-17 | Process for concentrating epothilones in culture medium and epothilone B and its uses in treatment |
AU30287/99A AU746294B2 (en) | 1998-02-19 | 1999-02-17 | Fermentative preparation process for cytostatics and crystal forms thereof |
AT99911678T ATE282710T1 (en) | 1998-02-19 | 1999-02-17 | METHOD FOR THE FERMENTATIVE PRODUCTION OF CYTOSTATICS AND THEIR CRYSTAL FORMS |
HU0100855A HU225851B1 (en) | 1998-02-19 | 1999-02-17 | Fermentative preparation process for epothilone cytostatics |
IL137691A IL137691A (en) | 1998-02-19 | 2000-08-03 | Fermentative preparation of epothilones |
NO20004114A NO322588B1 (en) | 1998-02-19 | 2000-08-17 | Process for concentrating and preparing epothilones and culture medium. |
HK01102978A HK1034100A1 (en) | 1998-02-19 | 2001-04-25 | Fermentative preparation process for cytostatics and crystal forms thereof. |
IL159631A IL159631A (en) | 1998-02-19 | 2003-12-29 | Reversed phase chromatographic separation of epothilones a and b, two crystalline forms of epothilone b and pharmaceutical compositions containing them |
NO20052034A NO321596B1 (en) | 1998-02-19 | 2005-04-26 | Procedure for separating epothilones |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH39698 | 1998-02-19 | ||
CH396/98 | 1998-02-19 | ||
CH1007/98 | 1998-05-05 | ||
CH100798 | 1998-05-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999042602A2 true WO1999042602A2 (en) | 1999-08-26 |
WO1999042602A3 WO1999042602A3 (en) | 1999-11-25 |
Family
ID=25684443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1999/001025 WO1999042602A2 (en) | 1998-02-19 | 1999-02-17 | Fermentative preparation process for cytostatics and crystal forms thereof |
Country Status (25)
Country | Link |
---|---|
US (8) | US6194181B1 (en) |
EP (2) | EP1428826A3 (en) |
JP (3) | JP3681109B2 (en) |
KR (4) | KR100595774B1 (en) |
CN (2) | CN1229502C (en) |
AT (1) | ATE282710T1 (en) |
AU (1) | AU746294B2 (en) |
BR (1) | BR9908119A (en) |
CA (1) | CA2318818A1 (en) |
CZ (1) | CZ301517B6 (en) |
DE (1) | DE69921966T2 (en) |
DK (1) | DK1054994T3 (en) |
ES (1) | ES2233028T3 (en) |
HK (1) | HK1034100A1 (en) |
HU (1) | HU225851B1 (en) |
IL (4) | IL137691A0 (en) |
NO (4) | NO322588B1 (en) |
NZ (2) | NZ525622A (en) |
PL (2) | PL404926A1 (en) |
PT (1) | PT1054994E (en) |
RU (1) | RU2268306C2 (en) |
SI (1) | SI1054994T1 (en) |
SK (3) | SK286517B6 (en) |
TR (2) | TR200101634T2 (en) |
WO (1) | WO1999042602A2 (en) |
Cited By (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000031247A2 (en) | 1998-11-20 | 2000-06-02 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
WO2002014323A2 (en) * | 2000-08-16 | 2002-02-21 | Bristol-Myers Squibb Company | Polymorphs of an epothilone analog |
US6365749B1 (en) | 1997-12-04 | 2002-04-02 | Bristol-Myers Squibb Company | Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs |
US6380395B1 (en) | 1998-04-21 | 2002-04-30 | Bristol-Myers Squibb Company | 12, 13-cyclopropane epothilone derivatives |
WO2002046196A1 (en) * | 2000-12-07 | 2002-06-13 | Novartis Ag | Process for the isolation and purification of epothilones |
US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
US6498257B1 (en) | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
US6518421B1 (en) | 2000-03-20 | 2003-02-11 | Bristol-Myers Squibb Company | Process for the preparation of epothilone analogs |
US6576651B2 (en) | 2001-01-25 | 2003-06-10 | Bristol-Myers Squibb Company | Pharmaceutical compositions, dosage forms and methods for oral administration of epothilones |
US6589968B2 (en) | 2001-02-13 | 2003-07-08 | Kosan Biosciences, Inc. | Epothilone compounds and methods for making and using the same |
US6593115B2 (en) | 2000-03-24 | 2003-07-15 | Bristol-Myers Squibb Co. | Preparation of epothilone intermediates |
US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
US6613912B2 (en) | 1995-11-17 | 2003-09-02 | Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) | Epothilons C and D, preparation and compositions |
US6670384B2 (en) | 2001-01-25 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of administering epothilone analogs for the treatment of cancer |
US6686380B2 (en) | 2001-02-20 | 2004-02-03 | Bristol-Myers Squibb Company | Treatment of refractory tumors using epothilone derivatives |
WO2004032866A2 (en) * | 2002-10-09 | 2004-04-22 | Kosan Biosciences, Inc. | Therapeutic formulations |
US6727276B2 (en) | 2001-02-20 | 2004-04-27 | Bristol-Myers Squibb Company | Epothilone derivatives for the treatment of refractory tumors |
US6800653B2 (en) | 2001-06-01 | 2004-10-05 | Bristol-Myers Squibb Compnay | Epothilone derivatives |
US6893859B2 (en) | 2001-02-13 | 2005-05-17 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
US6936628B2 (en) | 2002-04-04 | 2005-08-30 | Bristol-Myers Squibb Company | Oral administration of epothilones |
US6989450B2 (en) | 2000-10-13 | 2006-01-24 | The University Of Mississippi | Synthesis of epothilones and related analogs |
US6998256B2 (en) * | 2000-04-28 | 2006-02-14 | Kosan Biosciences, Inc. | Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate |
US7008936B2 (en) | 2002-06-14 | 2006-03-07 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
US7022330B2 (en) | 2001-01-25 | 2006-04-04 | Bristol-Myers Squibb Company | Parenteral formulation for epothilone analogs |
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US7053069B2 (en) | 2002-05-15 | 2006-05-30 | Bristol-Myers Squibb Company | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
US7091226B2 (en) | 1998-02-25 | 2006-08-15 | Novartis Ag | Cancer treatment with epothilones |
US7172884B2 (en) | 2002-09-23 | 2007-02-06 | Bristol-Myers Squibb Company | Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B |
US7211593B2 (en) | 2002-03-12 | 2007-05-01 | Bristol-Myers Squibb Co. | C12-cyano epothilone derivatives |
US7312237B2 (en) | 2001-03-14 | 2007-12-25 | Bristol-Myers Squibb Co. | Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolilferative diseases |
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US7846952B2 (en) | 1996-11-18 | 2010-12-07 | Helmholtz-Zentrum Fuer Infektionsforschung Gmbh | Epothilones C, D, E, and F, preparation and compositions |
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US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
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