WO1999042804A3 - Methods for microfluidic aspirating and dispensing - Google Patents

Methods for microfluidic aspirating and dispensing Download PDF

Info

Publication number
WO1999042804A3
WO1999042804A3 PCT/US1999/003677 US9903677W WO9942804A3 WO 1999042804 A3 WO1999042804 A3 WO 1999042804A3 US 9903677 W US9903677 W US 9903677W WO 9942804 A3 WO9942804 A3 WO 9942804A3
Authority
WO
WIPO (PCT)
Prior art keywords
dispensing
aspirating
aspirate
reagent
methods
Prior art date
Application number
PCT/US1999/003677
Other languages
French (fr)
Other versions
WO1999042804A2 (en
Inventor
Tony Lemmo
Don Rose
Original Assignee
Cartesian Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cartesian Technologies Inc filed Critical Cartesian Technologies Inc
Priority to AU27757/99A priority Critical patent/AU2775799A/en
Publication of WO1999042804A2 publication Critical patent/WO1999042804A2/en
Publication of WO1999042804A3 publication Critical patent/WO1999042804A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L13/00—Cleaning or rinsing apparatus
    • B01L13/02—Cleaning or rinsing apparatus for receptacle or instruments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0265—Drop counters; Drop formers using valves to interrupt or meter fluid flow, e.g. using solenoids or metering valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezo-electric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

A method and apparatus is provided for actively controlling the hydraulic pressure within an aspirate-dispense system (10) for aspirating and dispensing precise and/or predetermined quantities of fluid or reagent (14). The method provides an efficient pressure compensation scheme to achieve the optimal pressures for aspirating and dispensing. The optimized pressure are achieved by a series of operations of a positive displacement pump (22) and a drop-on-demand valve (12) of the aspirate-dispense system (10). Advantageously, the method increases process speed, improves reliability and accuracy, and reduces dilution and wastage of reagent (14).
PCT/US1999/003677 1998-02-20 1999-02-19 Methods for microfluidic aspirating and dispensing WO1999042804A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU27757/99A AU2775799A (en) 1998-02-20 1999-02-19 Methods for microfluidic aspirating and dispensing

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7540398P 1998-02-20 1998-02-20
US60/075,403 1998-02-20
US25312399A 1999-02-19 1999-02-19
US09/253,123 1999-02-19

Publications (2)

Publication Number Publication Date
WO1999042804A2 WO1999042804A2 (en) 1999-08-26
WO1999042804A3 true WO1999042804A3 (en) 1999-09-30

Family

ID=26756810

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/003677 WO1999042804A2 (en) 1998-02-20 1999-02-19 Methods for microfluidic aspirating and dispensing

Country Status (2)

Country Link
AU (1) AU2775799A (en)
WO (1) WO1999042804A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537505B1 (en) 1998-02-20 2003-03-25 Bio Dot, Inc. Reagent dispensing valve
US6589791B1 (en) 1999-05-20 2003-07-08 Cartesian Technologies, Inc. State-variable control system
IL148611A0 (en) * 1999-09-14 2002-09-12 Pharmacopeia Inc Flow control elements for use in liquid dispensers
US6447723B1 (en) 2000-03-13 2002-09-10 Packard Instrument Company, Inc. Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments
US6878554B1 (en) 2000-03-20 2005-04-12 Perkinelmer Las, Inc. Method and apparatus for automatic pin detection in microarray spotting instruments
US7521245B1 (en) 2000-06-05 2009-04-21 Perkinelmer Las, Inc. Method for washing and drying pins in microarray spotting instruments
AU2001295360A1 (en) 2000-11-17 2002-05-27 Tecan Trading Ag Device and method for separating samples from a liquid
JP4663894B2 (en) * 2001-03-27 2011-04-06 武蔵エンジニアリング株式会社 Droplet forming method and droplet quantitative discharge apparatus
EP1658894A1 (en) 2002-02-22 2006-05-24 Biodot, Inc. Apparatus for dispersing reagent droplets below a fluid surface using non-contact dispensing
US7759062B2 (en) 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
US20080227663A1 (en) 2007-01-19 2008-09-18 Biodot, Inc. Systems and methods for high speed array printing and hybridization
WO2012100205A2 (en) 2011-01-21 2012-07-26 Biodot, Inc. Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube
DE102012001438A1 (en) * 2012-01-26 2013-08-01 Munich Metrology Gmbh Apparatus and method for dosing liquids

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4926701A (en) * 1986-08-14 1990-05-22 Kontron Instruments Holdings, Nv. Pipetting method and apparatus
US5506142A (en) * 1991-12-13 1996-04-09 Dade International Inc. Probe wash for liquid analysis apparatus
US5593893A (en) * 1994-03-15 1997-01-14 Toa Medical Electronics Co., Ltd Dispensing device with syringe driving compensator for flexible tube
US5738728A (en) * 1996-07-26 1998-04-14 Bio Dot, Inc. Precision metered aerosol dispensing apparatus
US5763278A (en) * 1995-11-01 1998-06-09 Tecan Ag Automated pipetting of small volumes
US5925732A (en) * 1994-09-21 1999-07-20 Isis Pharmaceuticals, Inc. Chemical reaction apparatus for performing multiple reaction on a surface and collecting the product

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4926701A (en) * 1986-08-14 1990-05-22 Kontron Instruments Holdings, Nv. Pipetting method and apparatus
US5506142A (en) * 1991-12-13 1996-04-09 Dade International Inc. Probe wash for liquid analysis apparatus
US5593893A (en) * 1994-03-15 1997-01-14 Toa Medical Electronics Co., Ltd Dispensing device with syringe driving compensator for flexible tube
US5925732A (en) * 1994-09-21 1999-07-20 Isis Pharmaceuticals, Inc. Chemical reaction apparatus for performing multiple reaction on a surface and collecting the product
US5763278A (en) * 1995-11-01 1998-06-09 Tecan Ag Automated pipetting of small volumes
US5738728A (en) * 1996-07-26 1998-04-14 Bio Dot, Inc. Precision metered aerosol dispensing apparatus

Also Published As

Publication number Publication date
AU2775799A (en) 1999-09-06
WO1999042804A2 (en) 1999-08-26

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