WO1999046285A3 - Method of promoting production of living tissue equivalents - Google Patents

Method of promoting production of living tissue equivalents Download PDF

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Publication number
WO1999046285A3
WO1999046285A3 PCT/US1999/005261 US9905261W WO9946285A3 WO 1999046285 A3 WO1999046285 A3 WO 1999046285A3 US 9905261 W US9905261 W US 9905261W WO 9946285 A3 WO9946285 A3 WO 9946285A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue equivalents
analogues
aii
living tissue
promoting production
Prior art date
Application number
PCT/US1999/005261
Other languages
French (fr)
Other versions
WO1999046285A2 (en
Inventor
Kathleen E Rodgers
Gere Dizerega
Original Assignee
Univ Southern California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Southern California filed Critical Univ Southern California
Priority to AU30772/99A priority Critical patent/AU3077299A/en
Publication of WO1999046285A2 publication Critical patent/WO1999046285A2/en
Publication of WO1999046285A3 publication Critical patent/WO1999046285A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/32—Angiotensins [AT], angiotensinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides

Abstract

The present invention provides methods, improved cell culture medium and kits for accelerating the generation of tissue equivalents, and for improving the quality of tissue equivalents, by growth in the presence of angiotensinogen, AI, AI analogues, AI fragments and analogues thereof, AII, AII analogues, AII fragments and analogues thereof and/or AII AT2 type 2 receptor agonists.
PCT/US1999/005261 1998-03-11 1999-03-11 Method of promoting production of living tissue equivalents WO1999046285A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU30772/99A AU3077299A (en) 1998-03-11 1999-03-11 Method of promoting production of living tissue equivalents

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7749998P 1998-03-11 1998-03-11
US60/077,499 1998-03-11
US8906498P 1998-06-12 1998-06-12
US60/089,064 1998-06-12

Publications (2)

Publication Number Publication Date
WO1999046285A2 WO1999046285A2 (en) 1999-09-16
WO1999046285A3 true WO1999046285A3 (en) 1999-11-04

Family

ID=26759341

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/005261 WO1999046285A2 (en) 1998-03-11 1999-03-11 Method of promoting production of living tissue equivalents

Country Status (3)

Country Link
US (2) US6498138B1 (en)
AU (1) AU3077299A (en)
WO (1) WO1999046285A2 (en)

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Publication number Priority date Publication date Assignee Title
US6335195B1 (en) * 1997-01-28 2002-01-01 Maret Corporation Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
US6916783B2 (en) * 1998-07-13 2005-07-12 University Of Southern California Methods for accelerating bone and cartilage growth and repair
DE69911609T2 (en) * 1998-07-13 2004-07-01 University Of Southern California, Los Angeles PROCESS FOR ACCELERATING THE GROWTH AND HEALING OF BONES AND CARTILES
US6730775B1 (en) 1999-03-23 2004-05-04 University Of Southern California Methods for limiting scar and adhesion formation
US6821953B1 (en) 1999-12-16 2004-11-23 University Of Southern California Methods for treating and preventing damage to mucosal tissue
WO2001046220A2 (en) * 1999-12-22 2001-06-28 Polymun Scientific Immunbiologische Forschung Gmbh Bioactive oligopeptides
US6759510B1 (en) * 2000-06-30 2004-07-06 Becton, Dickinson And Company Peptides for use in culture media
DK1395566T3 (en) 2001-05-31 2008-01-07 Vicore Pharma Ab Tricyclic compounds useful as angiotensin II agonists
US7041506B2 (en) 2001-11-19 2006-05-09 Becton Dickinson And Company Peptides promoting cell adherence, growth and secretion
WO2008152640A2 (en) * 2007-06-13 2008-12-18 Pluristem Ltd. Three dimensional biocompatible scaffolds for ex-vivo expansion and transplantation of stem cells
WO2009114461A2 (en) * 2008-03-10 2009-09-17 University Of Southern California Angiotensin (1-7) dosage forms and uses thereof
EP2455388A1 (en) 2010-11-23 2012-05-23 LanthioPep B.V. Novel angiotensin type 2 (AT2) receptor agonists and uses thereof.
CA2793515C (en) 2011-02-02 2015-05-12 University Of Southern California Methods for treating diabetic foot ulcers
EP2849773A1 (en) 2012-05-14 2015-03-25 University of Southern California Methods for limiting development of a skin wound
US8557958B1 (en) 2012-06-18 2013-10-15 Tarix Pharmaceuticals Ltd. Compositions and methods for treatment of diabetes
US8633158B1 (en) 2012-10-02 2014-01-21 Tarix Pharmaceuticals Ltd. Angiotensin in treating brain conditions
EP3935944A1 (en) 2013-03-15 2022-01-12 University Of Southern California, USC Stevens Compounds for the treatment of musculoskeletal diseases
US9623084B2 (en) 2013-03-15 2017-04-18 University Of Southern California Methods for treating multiple sclerosis
CA2916701A1 (en) 2013-07-03 2015-01-08 The Arizona Board Of Regents On Behalf Of The University Of Arizona Method for treating cognitive dysfunction
US9333233B2 (en) 2014-02-25 2016-05-10 Tarix Pharmaceuticals Ltd. Methods and compositions for the delayed treatment of stroke
US10183055B2 (en) 2014-07-21 2019-01-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications
WO2016014342A2 (en) 2014-07-21 2016-01-28 Arizona Board Of Regents For The University Of Arizona Ang-(1-7) derviative oligopeptides and methods for using and producing the same
WO2021023698A1 (en) 2019-08-02 2021-02-11 Lanthiopep B.V Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer

Citations (3)

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Publication number Priority date Publication date Assignee Title
US4837379A (en) * 1988-06-02 1989-06-06 Organogenesis Inc. Fibrin-collagen tissue equivalents and methods for preparation thereof
WO1996014858A1 (en) * 1994-11-14 1996-05-23 University Of Southern California Use of angiotensin ii fragments and analogs thereof in tissue repair
WO1998026795A1 (en) * 1996-12-16 1998-06-25 The University Of Southern California Use of peptides for improving the incorporation of skin grafts

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US4546500A (en) 1981-05-08 1985-10-15 Massachusetts Institute Of Technology Fabrication of living blood vessels and glandular tissues
US4485096A (en) 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
US4485097A (en) 1982-05-26 1984-11-27 Massachusetts Institute Of Technology Bone-equivalent and method for preparation thereof
US4604346A (en) 1984-10-09 1986-08-05 Massachusetts Institute Of Technology Skin-equivalent prepared by the use of punch biopsy
US5628781A (en) 1985-06-06 1997-05-13 Thomas Jefferson University Implant materials, methods of treating the surface of implants with microvascular endothelial cells, and the treated implants themselves
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US5510254A (en) 1986-04-18 1996-04-23 Advanced Tissue Sciences, Inc. Three dimensional cell and tissue culture system
US4835102A (en) 1987-03-31 1989-05-30 Eugene Bell Tissue equivalent test systems
JP2678945B2 (en) 1989-04-17 1997-11-19 有限会社ナイセム Artificial blood vessel, method for producing the same, and substrate for artificial blood vessel
US5521087A (en) 1989-05-10 1996-05-28 Massachusetts Institute Of Technology Method for producing oriented connective tissue cells in a ligament configuration
CA2018228C (en) 1989-06-05 1996-02-27 Nancy L. Parenteau Cell culture systems and media
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IL95429A (en) 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
US5256418A (en) 1990-04-06 1993-10-26 Organogenesis, Inc. Collagen constructs
US5052934A (en) 1990-04-20 1991-10-01 The United States Of America As Represented By The Department Of Health And Human Services Phantom for evaluation of prosthetic valves and cardiac ultrasound procedures
HUT63319A (en) 1990-04-24 1993-08-30 Mark Eisenberg Method for producing composition equivalent with living skin
US5192312A (en) 1991-03-05 1993-03-09 Colorado State University Research Foundation Treated tissue for implantation and methods of treatment and use
US5589452A (en) 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5478739A (en) 1992-10-23 1995-12-26 Advanced Tissue Sciences, Inc. Three-dimensional stromal cell and tissue culture system
WO1995008565A1 (en) 1993-09-24 1995-03-30 The University Of Southern California Use of angiotensin ii analogs in tissue repair
JPH09502977A (en) 1993-09-24 1997-03-25 ザ ユニバーシティ オブ サザーン カリフォルニア Use of Angiotensin III and its analogs in tissue repair
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CA2223590A1 (en) 1995-06-07 1996-12-19 The University Of Southern California Method for reducing or preventing post-surgical adhesion formation using 5-lipoxygenase inhibitors
US6335195B1 (en) 1997-01-28 2002-01-01 Maret Corporation Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
AU6650098A (en) 1997-02-04 1998-08-25 University Of Southern California Method for accelerating healing of thermal injuries

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837379A (en) * 1988-06-02 1989-06-06 Organogenesis Inc. Fibrin-collagen tissue equivalents and methods for preparation thereof
WO1996014858A1 (en) * 1994-11-14 1996-05-23 University Of Southern California Use of angiotensin ii fragments and analogs thereof in tissue repair
WO1998026795A1 (en) * 1996-12-16 1998-06-25 The University Of Southern California Use of peptides for improving the incorporation of skin grafts

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
OKUYAMA N ET AL: "Angiotensin II improves random-flap viability in a rat model.", ANNALS OF PLASTIC SURGERY, (1999 MAR) 42 (3) 313-9. JOURNAL CODE: 5VB. ISSN: 0148-7043., United States, XP002110167 *
RODGERS K E ET AL: "Histologic alterations in dermal repair after thermal injury effects of topical angiotensin II.", JOURNAL OF BURN CARE AND REHABILITATION, (1997 SEP-OCT) 18 (5) 381-8. JOURNAL CODE: HLK. ISSN: 0273-8481., XP002110168 *
RODGERS, KATHLEEN (1) ET AL: "Acceleration of dermal tissue repair by angiotensin II.", WOUND REPAIR AND REGENERATION, (1997) VOL. 5, NO. 2, PP. 175-183. ISSN: 1067-1927., XP002110169 *

Also Published As

Publication number Publication date
US6498138B1 (en) 2002-12-24
WO1999046285A2 (en) 1999-09-16
AU3077299A (en) 1999-09-27
US20040033956A1 (en) 2004-02-19

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