WO1999058962A8 - Improved apparatus and methods for carrying out electrochemiluminescence test measurements - Google Patents

Improved apparatus and methods for carrying out electrochemiluminescence test measurements

Info

Publication number
WO1999058962A8
WO1999058962A8 PCT/US1999/010279 US9910279W WO9958962A8 WO 1999058962 A8 WO1999058962 A8 WO 1999058962A8 US 9910279 W US9910279 W US 9910279W WO 9958962 A8 WO9958962 A8 WO 9958962A8
Authority
WO
WIPO (PCT)
Prior art keywords
carrying
methods
improved apparatus
test measurements
electrochemiluminescence test
Prior art date
Application number
PCT/US1999/010279
Other languages
French (fr)
Other versions
WO1999058962A1 (en
Inventor
Jacob N Wohlstadter
Jue Zhang
David R Gambrel
Sergey Ivanov
John Liljestrand
Charles Quentin Davis
Original Assignee
Igen Int Inc
Jacob N Wohlstadter
Jue Zhang
David R Gambrel
Sergey Ivanov
John Liljestrand
Charles Quentin Davis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igen Int Inc, Jacob N Wohlstadter, Jue Zhang, David R Gambrel, Sergey Ivanov, John Liljestrand, Charles Quentin Davis filed Critical Igen Int Inc
Priority to JP2000548715A priority Critical patent/JP2002514759A/en
Priority to CA002331490A priority patent/CA2331490A1/en
Priority to AU39810/99A priority patent/AU755542B2/en
Priority to EP99922921A priority patent/EP1078247A4/en
Publication of WO1999058962A1 publication Critical patent/WO1999058962A1/en
Publication of WO1999058962A8 publication Critical patent/WO1999058962A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • G01N21/69—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids, e.g. molten metal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Apparatus for the conduct of electrochemiluminescence measurements includes an ECL chamber (130) having a transparent window (127) defining one wall of the chamber and a photodetector (122) mounted closely adjacent thereto. An assay fluid is subject to a magnetic field and is electrically energized. Electrochemiluminescence induced in the fluid is measured by the photodetector.
PCT/US1999/010279 1998-05-11 1999-05-11 Improved apparatus and methods for carrying out electrochemiluminescence test measurements WO1999058962A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000548715A JP2002514759A (en) 1998-05-11 1999-05-11 Improved apparatus and method for performing electrochemiluminescence test measurements
CA002331490A CA2331490A1 (en) 1998-05-11 1999-05-11 Improved apparatus and methods for carrying out electrochemiluminescence test measurements
AU39810/99A AU755542B2 (en) 1998-05-11 1999-05-11 Improved apparatus and methods for carrying out electrochemiluminescence test measurements
EP99922921A EP1078247A4 (en) 1998-05-11 1999-05-11 Improved apparatus and methods for carrying out electrochemiluminescence test measurements

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/076,325 US6200531B1 (en) 1998-05-11 1998-05-11 Apparatus for carrying out electrochemiluminescence test measurements
US09/076,325 1998-05-11

Publications (2)

Publication Number Publication Date
WO1999058962A1 WO1999058962A1 (en) 1999-11-18
WO1999058962A8 true WO1999058962A8 (en) 2000-03-30

Family

ID=22131292

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/010279 WO1999058962A1 (en) 1998-05-11 1999-05-11 Improved apparatus and methods for carrying out electrochemiluminescence test measurements

Country Status (6)

Country Link
US (3) US6200531B1 (en)
EP (1) EP1078247A4 (en)
JP (1) JP2002514759A (en)
AU (1) AU755542B2 (en)
CA (1) CA2331490A1 (en)
WO (1) WO1999058962A1 (en)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2764381A1 (en) * 1997-06-09 1998-12-11 Univ De Neuchatel ELECTROCHEMICOLUMINESCENT DETECTOR
US6200531B1 (en) * 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US6381484B1 (en) * 1999-07-12 2002-04-30 Steve T Ayanruoh Palm sized medical examination device
US6487326B1 (en) * 1999-11-29 2002-11-26 Board Of Regents, The University Of Texas System Thin film fiber optic electrode sensor array and apparatus
US6927851B2 (en) * 2000-03-31 2005-08-09 Neogen Corporation Methods and apparatus to improve the sensitivity and reproducibility of bioluminescent analytical methods
GB2368903A (en) * 2000-11-08 2002-05-15 Proimmune Ltd Analysis of biological and biochemical assays
DE10106138B4 (en) * 2001-02-10 2006-02-23 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Modular measuring and / or testing device
EP2295971B1 (en) * 2001-03-09 2016-09-07 TrovaGene, Inc. Conjugate probes and optical detection of analytes
WO2002089208A2 (en) * 2001-04-30 2002-11-07 Mergeoptics Gmbh Arrangement comprising at least two different electronic semiconductor circuits
CA2451789C (en) 2001-06-29 2012-03-27 Meso Scale Technologies, Llc. Assay plates, reader systems and methods for luminescence test measurements
AU2002365119A1 (en) 2001-07-30 2003-09-04 Meso Scale Technologies, Llc. Assay electrodes having immobilized lipid/protein layers and methods of making and using the same
WO2003022028A2 (en) 2001-09-10 2003-03-20 Meso Scale Technologies, Llc Methods, reagents, kits and apparatus for protein function analysis
BRPI0214680B1 (en) * 2001-12-06 2018-09-18 Biocontrol Systems Inc instrument for use in monitoring a product, ingredient, environment or process, instrument for detecting light emission from a sample and method for monitoring a sample of a product, ingredient, process or environment
US9429509B2 (en) * 2002-01-28 2016-08-30 Sysmex Corporation Particle analyzer and particle analysis method
WO2003072830A1 (en) 2002-02-22 2003-09-04 Purdue Research Foundation Magnetic nanomaterials and methods for detection of biological materials
AU2003220147A1 (en) * 2002-03-11 2003-09-29 Meso Scale Technologies, Llc. System and method for flexibly representing and processing assay plates
AU2002303358A1 (en) * 2002-03-14 2003-09-29 Arizona Board Of Regents Enzyme-based photoelectrochemical cell for electric current generation
KR20050013592A (en) * 2002-06-20 2005-02-04 아이젠인터내셔널인코포레이티드 Electrochemiluminescence flow cell and flow cell components
AU2003256285A1 (en) * 2002-06-28 2004-01-19 Igen International, Inc. Improved assay systems and components
JP4098008B2 (en) * 2002-07-03 2008-06-11 オリンパス株式会社 Optical gain correction filter and bar code reader having the same
KR100434690B1 (en) * 2002-07-19 2004-06-04 소광섭 Apparatus and method for detecting luminescence from biological systems in response to magnetic fields
RU2221236C1 (en) * 2002-09-16 2004-01-10 Калачев Алексей Александрович Process of analysis of physical and/or chemical properties of surface layer of solid body ( variants )
US6807062B2 (en) * 2002-11-07 2004-10-19 Hewlett-Packard Development Company, L.P. Employment of an over-bent ledge of a rack component to support an over-bent ledge of a drop-in chassis
EP1560930A4 (en) * 2002-11-15 2007-05-16 Applera Corp Nucleic acid sequence detection
EP1583950B1 (en) * 2002-12-26 2017-04-05 Meso Scale Technologies, LLC. Assay cartridges and methods of using the same
US20040166520A1 (en) * 2003-01-03 2004-08-26 Connolly D. Michael Identifying items with nucleic acid taggants
WO2004083806A2 (en) * 2003-01-22 2004-09-30 University Of South Florida Autonomous genosensor apparatus and methods for use
US7173705B2 (en) * 2003-02-26 2007-02-06 Hamamatsu Photonics K.K. Measuring device for immunochromatography test piece
JP2005030847A (en) * 2003-07-10 2005-02-03 Sysmex Corp Electronic apparatus and analysis system
JP4261546B2 (en) * 2003-09-26 2009-04-30 三菱レイヨン株式会社 Electrophoresis apparatus and electrophoresis method
US7393504B2 (en) * 2003-10-09 2008-07-01 Jyh-Myng Zen Flow injection electrochemical detecting device
US7438853B2 (en) * 2004-05-19 2008-10-21 Jyh-Myng Zen Photoelectrocatalytic method and photoelectrochemical detector for electrochemical analysis
AU2005326758B2 (en) 2004-06-23 2011-07-14 Board Of Regents Of The University Of Texas System Methods and compositions for the detection of biological molecules using a two particle complex
US20060275841A1 (en) * 2004-12-20 2006-12-07 Martin Blankfard Assay method and apparatus with reduced sample matrix effects
CN101031802B (en) * 2005-01-07 2012-11-07 积水化学工业株式会社 Detection device using cartridge
CA2599576C (en) 2005-03-10 2015-09-15 Gen-Probe Incorporated Systems and methods to perform assays for detecting or quantifying analytes within samples
KR101762424B1 (en) 2005-05-09 2017-07-28 테라노스, 인코포레이티드 Point-of-care fluidic systems and uses thereof
US8206974B2 (en) * 2005-05-19 2012-06-26 Netbio, Inc. Ruggedized apparatus for analysis of nucleic acid and proteins
AU2011203525B8 (en) * 2005-05-19 2014-03-06 Ande Corporation An apparatus for analyzing/processing a sample of biomolecular analyte, device and method
US8211279B2 (en) * 2005-06-03 2012-07-03 Board Of Regents Of The University Of Texas System Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode
WO2007002580A2 (en) * 2005-06-23 2007-01-04 Bioveris Corporation Diagnostic as say system with multi -well reagent container
US7630849B2 (en) * 2005-09-01 2009-12-08 Applied Biosystems, Llc Method of automated calibration and diagnosis of laboratory instruments
US20090001294A1 (en) * 2005-10-07 2009-01-01 Korea Atomic Energy Research Institute Neutron Coincidence Counter for Non-Destructive Accounting for Nuclear Material and the Handling Thereof
US7537934B2 (en) * 2005-12-30 2009-05-26 Intel Corporation Chemiluminescence sensor array
US20070170056A1 (en) * 2006-01-26 2007-07-26 Arnold Don W Microscale electrochemical cell and methods incorporating the cell
US8119066B2 (en) * 2006-02-08 2012-02-21 Molecular Devices, Llc Multimode reader
US8968658B2 (en) 2006-02-08 2015-03-03 Molecular Devices, Llc Luminescence measurement utilizing cartridge with integrated detector
US8496879B2 (en) 2006-02-08 2013-07-30 Molecular Devices, Llc Optical detection utilizing cartridge with tunable filter assembly
US7515259B2 (en) * 2006-03-10 2009-04-07 Dionex Corporation Flow cell for optical detector and method of forming same
JP2008109864A (en) * 2006-10-30 2008-05-15 Hitachi Ltd Genetic sequence analysis system
US20080182136A1 (en) * 2007-01-26 2008-07-31 Arnold Don W Microscale Electrochemical Cell And Methods Incorporating The Cell
JP5557733B2 (en) 2007-04-04 2014-07-23 ネットバイオ・インコーポレーテッド Plastic microfluidic separation and detection platform
JP5026851B2 (en) * 2007-04-23 2012-09-19 株式会社日立製作所 Chemiluminescence detector
WO2009046227A1 (en) 2007-10-02 2009-04-09 Theranos, Inc. Modular point-of-care devices and uses thereof
SI2271938T1 (en) 2008-04-11 2014-07-31 Board Of Regents Of The University Of Texas System Method and apparatus for nanoparticle electrogenerated chemiluminescence amplification
JP5583116B2 (en) 2008-05-08 2014-09-03 ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム Luminescent nanostructured materials for use in electrogenic chemiluminescence
US20100261292A1 (en) 2009-04-10 2010-10-14 Meso Scale Technologies, Llc Methods for Conducting Assays
WO2010147654A2 (en) 2009-06-15 2010-12-23 Netbio Inc. Improved methods for forensic dna quantitation
CN106018857B (en) 2009-07-27 2019-06-18 梅索磅秤技术有限公司 Assay device, consumptive material and method
US8203118B2 (en) * 2009-12-11 2012-06-19 Honeywell International, Inc. Ion-trap mass spectrometer driven by a monolithic photodiode array
JP5286299B2 (en) * 2010-01-28 2013-09-11 株式会社日立ハイテクノロジーズ Analysis equipment
US20110312654A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ptd Apparatus for loading oligonucleotide spotting devices and spotting oligonucleotide probes
US9046507B2 (en) 2010-07-29 2015-06-02 Gen-Probe Incorporated Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure
JP5943927B2 (en) 2010-10-14 2016-07-05 メソ スケール テクノロジーズ エルエルシー Reagent storage in assay devices
ES2581553T3 (en) 2010-10-25 2016-09-06 F. Hoffmann-La Roche Ag Use of signal enhancing compounds in electrochemiluminescent detection
CA3097861A1 (en) 2011-01-21 2012-07-26 Labrador Diagnostics Llc Systems and methods for sample use maximization
AU2012222178B2 (en) 2011-02-24 2014-12-18 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
EP2716026A4 (en) * 2011-05-23 2014-12-24 Datamax O Neil Corp Sensing apparatus for detecting and determining the width of media along a feed path
US8687032B2 (en) 2011-06-06 2014-04-01 Datamax-O'neil Corporation Printing ribbon security apparatus and method
US8736650B2 (en) 2011-06-23 2014-05-27 Datamax-O'neil Corporation Print station
US8730287B2 (en) 2011-06-24 2014-05-20 Datamax-O'neil Corporation Ribbon drive assembly
CA2840210A1 (en) 2011-06-24 2012-12-27 Datamax-O'neil Corporation Apparatus and method for determining and adjusting printhead pressure
CA2841613A1 (en) 2011-07-14 2013-01-17 Datamax-O'neil Corporation Automatically adjusting printing parameters using media identification
US8842143B2 (en) 2011-08-05 2014-09-23 Datamax-O'neil Corporation Printing system
EP2739480A4 (en) 2011-08-05 2016-02-24 Datamax O Neil Corp Print station system
WO2013059551A1 (en) 2011-10-20 2013-04-25 Source Technologies, Llc Top of form sensor
JP6300727B2 (en) 2011-11-11 2018-03-28 イーライ・エヌ・グレザー Co-binder assisted assay
CA2856420A1 (en) 2011-11-22 2013-05-30 Datamax-O'neil Corporation Synchronized media hanger/guide
US9024988B2 (en) 2011-12-22 2015-05-05 Datamax-O'neil Corporation Media detection apparatus and method
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9075042B2 (en) * 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
US9061527B2 (en) 2012-12-07 2015-06-23 Datamax-O'neil Corporation Thermal printer with single latch, adjustable media storage and centering assemblies and print assembly
CA3071710C (en) 2013-01-04 2021-03-16 Meso Scale Technologies, Llc. Assay apparatuses, methods and reagents
JP6239243B2 (en) 2013-02-08 2017-11-29 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Automatic analyzer
EP2972353B1 (en) 2013-03-11 2023-02-22 Meso Scale Technologies, LLC Improved methods for conducting multiplexed assays
DE102013102438B3 (en) 2013-03-12 2014-03-20 Dionex Softron Gmbh Flow cell for measuring e.g. permittivity of sample fluid in HPLC application, has capillary tubes arranged within protective tube to obviate unwanted mechanical application on side of capillary tubes surrounded along longitudinal direction
DE102013102440B3 (en) 2013-03-12 2014-05-15 Dionex Softron Gmbh Positioning unit for flow cell for optical detection in HPLC field, has front end facing away from flow cell formed by outer surface of flange of cell, and terminal piece whose front end is connected with light conductor and sample supply
DE102013102439B4 (en) 2013-03-12 2021-09-02 Dionex Softron Gmbh Process for the production of a fluidic connection component for chromatography
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
CA2904181A1 (en) 2013-03-13 2014-10-09 Anahit Aghvanyan Sandwich immunoassay comprising anchoring reagent
US20140270080A1 (en) * 2013-03-15 2014-09-18 Lawrence Livermore National Security, Llc Electrochemical Test Cell For Enabling In-Situ X-Ray Diffraction and Scattering Studies of Scale Formation and Microstructural Changes in Materials with Flow Through Solution
CN105209532B (en) 2013-03-15 2017-11-28 路博润先进材料公司 CPVC compositions without heavy metal
TWD165449S (en) * 2013-11-25 2015-01-11 日立化成股份有限公司 Cell-collecting cartridge
EP2927005B1 (en) 2014-03-27 2019-08-28 Datamax-O'Neil Corporation Systems and methods for automatic printer configuration
CA2947747C (en) 2014-05-09 2024-03-05 Meso Scale Technologies, Llc. Graphene-modified electrodes
KR20230022268A (en) 2014-05-15 2023-02-14 메소 스케일 테크놀러지즈, 엘엘시 Improved assay methods
EP3230739B1 (en) 2014-12-08 2019-01-23 F.Hoffmann-La Roche Ag Method for measurement of vitamin d
GB2541743B (en) * 2015-08-28 2019-05-22 Chelsea Tech Group Ltd Ballast water monitoring device
CN108367256B (en) * 2015-09-22 2022-02-25 怀亚特技术公司 Method and apparatus for measuring multiple signals from a liquid sample
CN105806828B (en) * 2015-10-29 2019-05-14 北京联众泰克科技有限公司 A kind of Electrogenerated chemiluminescent immunoassay system and its flow cell component
WO2017153574A1 (en) 2016-03-11 2017-09-14 Roche Diagnostics Gmbh Branched-chain amines in electrochemiluminescence detection
CN106052561B (en) * 2016-08-05 2019-07-09 京东方科技集团股份有限公司 Position sensor and including its conveyer and utilize its carry out position correction method
FI127861B (en) 2017-06-29 2019-04-15 Labmaster Oy A method and a device for dynamic generation of hot electrons into aqueous solutions
WO2019025224A1 (en) * 2017-08-01 2019-02-07 Roche Diagnostics Gmbh Method of monitoring an operation of detection of an analyte in a liquid sample
CN108152210B (en) * 2017-11-24 2020-03-31 东南大学 Special electrochemiluminescence detection pool for screen printing electrode
EP4310184A3 (en) 2018-02-23 2024-05-01 Meso Scale Technologies, LLC. Methods of screening antigen-binding molecules by normalizing for the concentration of antigen-binding molecule
CN109030468B (en) * 2018-08-14 2024-03-22 四川理工学院 Electric enhancement gas-liquid phase chemiluminescence detection device and detection method
JP6757079B2 (en) * 2018-08-24 2020-09-16 国立大学法人東北大学 Electrochemical sensor and manufacturing method of electrochemical sensor
KR20210146884A (en) 2019-01-03 2021-12-06 메소 스케일 테크놀러지즈, 엘엘시 Compositions and methods for performing assay measurements
EP3931201A1 (en) 2019-03-01 2022-01-05 Meso Scale Technologies, LLC Electrochemiluminescent labeled probes for use in immunoassay methods, methods using such and kits comprising same
CN113939599A (en) 2019-06-07 2022-01-14 豪夫迈·罗氏有限公司 Hybrid all-LNA oligonucleotides
CN111693515B (en) * 2020-05-07 2022-06-17 四川轻化工大学 Flow type electrochemical luminescence real-time detection device and detection method
CN111693516B (en) * 2020-05-07 2023-04-21 四川轻化工大学 Gas-liquid phase electrochemical luminescence detection device and detection method
WO2021236584A1 (en) 2020-05-19 2021-11-25 Meso Scale Technologies, Llc. Methods, compositions, and kits for nucleic acid detection
US20220018785A1 (en) 2020-07-01 2022-01-20 Meso Scale Technologies, Llc. Compositions and methods for assay measurements
CN116635083A (en) 2020-12-22 2023-08-22 豪夫迈·罗氏有限公司 Method for detecting target analytes in a sample
US11808146B2 (en) * 2021-01-25 2023-11-07 Saudi Arabian Oil Company Apparatus and method for observing performance of a treatment fluid in a core sample
WO2023129884A1 (en) 2021-12-30 2023-07-06 Meso Scale Technologies, Llc. Methods for electrochemiluminescence detection
WO2023156510A1 (en) 2022-02-18 2023-08-24 F. Hoffmann-La Roche Ag Method for detecting an analyte of interest in a sample

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3816795A (en) 1965-10-23 1974-06-11 American Cyanamid Co Method for providing electroluminescent light from a polycyclic heterocyclic compound in an aprotic solvent under electric current
US3583230A (en) * 1968-06-12 1971-06-08 Sondell Research Dev Co Sample injection method and apparatus
NL7001235A (en) 1970-01-29 1971-08-02
GB1509186A (en) 1974-05-08 1978-05-04 Secr Social Service Brit Specimen agitation apparatus
US3900418A (en) * 1973-04-12 1975-08-19 Bell Northern Research Ltd Electrochemical luminescent solutions and devices incorporating such solutions
FR2247732A1 (en) 1973-10-16 1975-05-09 Accumulateurs Fixes
US3984688A (en) 1975-04-21 1976-10-05 Source Gas Analyzers, Inc. Monitor for detection of chemiluminescent reactions
US4132605A (en) * 1976-12-27 1979-01-02 Rockwell International Corporation Method for evaluating the quality of electroplating baths
US4210724A (en) 1977-03-28 1980-07-01 Olympus Optical Co., Ltd. Apparatus for liquid disposal and distribution in automatic culture system
US4213703A (en) 1978-05-30 1980-07-22 Beckman Instruments, Inc. Photometer with stationary sample holder and rotatable shutter
US4443713A (en) 1978-10-30 1984-04-17 Phillips Petroleum Company Waveform generator
US4280815A (en) 1979-06-18 1981-07-28 Technicon Instruments Corporation Electrochemiluminescent immunoassay and apparatus therefor
DE3013765A1 (en) 1980-04-10 1981-10-15 Philips Patentverwaltung Gmbh, 2000 Hamburg DETECTOR ARRANGEMENT, ESPECIALLY FOR LIQUID CHROMATOGRAPHY
US4297105A (en) 1980-06-27 1981-10-27 Alcan Research And Development Limited Automatic photometric titrator
US4303410A (en) 1980-11-03 1981-12-01 The United States Of America As Represented By The Secretary Of The Navy Light burst activity analyzer
US4537861A (en) 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
EP0141780A1 (en) * 1983-10-11 1985-05-15 Battelle Memorial Institute Electrochemical water purification method
JPS60117503A (en) * 1983-11-29 1985-06-25 松下電器産業株式会社 Transparent conductive film forming coating liquid and forming method thereof
US5500188A (en) * 1984-03-01 1996-03-19 Molecular Devices Corporation Device for photoresponsive detection and discrimination
US5310687A (en) 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
JPS6235326A (en) 1985-08-09 1987-02-16 Canon Inc Display element
US5147806A (en) 1988-04-29 1992-09-15 Igen, Inc. Method and apparatus for conducting electrochemiluminescence measurements
WO1987007386A1 (en) 1986-05-22 1987-12-03 Unilever Plc Solid phase immunoassay method
US4849340A (en) 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
JPS6443745A (en) 1987-08-12 1989-02-16 Hitachi Ltd Instrument for measuring light emitted by organism
JPH01247962A (en) 1988-03-29 1989-10-03 Hisaka Works Ltd Heat pump
US5093268A (en) 1988-04-28 1992-03-03 Igen, Inc. Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
US5068088A (en) 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
US5247243A (en) 1988-11-03 1993-09-21 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
US5296191A (en) 1988-11-03 1994-03-22 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
US5705402A (en) 1988-11-03 1998-01-06 Igen International, Inc. Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
US5779976A (en) 1988-11-03 1998-07-14 Igen International, Inc. Apparatus for improved luminescence assays
US5746974A (en) * 1988-11-03 1998-05-05 Igen International, Inc. Apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence and chemiluminescence detection
US5061445A (en) 1988-11-03 1991-10-29 Igen, Inc. Apparatus for conducting measurements of electrochemiluminescent phenomena
JPH02137275A (en) * 1988-11-17 1990-05-25 Nec Corp Photo coupler
US5324457A (en) 1989-10-02 1994-06-28 Board Of Regents, The University Of Tx System Devices and methods for generating electrogenerated chemiluminescence
US5189549A (en) * 1990-02-26 1993-02-23 Molecular Displays, Inc. Electrochromic, electroluminescent and electrochemiluminescent displays
US5298427A (en) 1990-04-24 1994-03-29 The Board Of Trustees Of The University Of Arkansas Chemiluminescent detection of amino acids
US5132227A (en) 1990-05-02 1992-07-21 Batelle Memorial Institute Monitoring formaldehyde
US7462322B2 (en) * 1991-02-06 2008-12-09 Bioveris Corporation Methods and apparatus for improved luminescence assays
IL100867A (en) 1991-02-06 1995-12-08 Igen Inc Method and apparatus for improved luminescence assays
JPH0534345A (en) 1991-02-19 1993-02-09 Tdk Corp Measuring method of antigen-antibody utilizing chemiluminescence
US5376313A (en) 1992-03-27 1994-12-27 Abbott Laboratories Injection molding a plastic assay cuvette having low birefringence
JPH0634548A (en) * 1992-07-16 1994-02-08 Omron Corp Device for measuring electrochemical emission
US5466416A (en) 1993-05-14 1995-11-14 Ghaed; Ali Apparatus and methods for carrying out electrochemiluminescence test measurements
US5541113A (en) * 1993-09-22 1996-07-30 Beckman Instruments, Inc. Method for detecting an analyte using an electrochemical luminescent transition metal label
US5965452A (en) * 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US5429893A (en) * 1994-02-04 1995-07-04 Motorola, Inc. Electrochemical capacitors having dissimilar electrodes
JP3559998B2 (en) * 1994-06-28 2004-09-02 株式会社堀場製作所 Chemiluminescence analyzer
DE4429857C2 (en) * 1994-08-23 2000-06-29 Balluff Gebhard Feinmech Magnetic position detector
US5786141A (en) * 1994-08-26 1998-07-28 Bard; Allen J. Electrogenerated chemiluminescence labels for analysis and/or referencing
JP3302186B2 (en) * 1994-09-01 2002-07-15 触媒化成工業株式会社 Substrate with transparent conductive film, method for producing the same, and display device provided with the substrate
DE4435107C1 (en) 1994-09-30 1996-04-04 Biometra Biomedizinische Analy Miniaturized flow thermal cycler
US5744367A (en) 1994-11-10 1998-04-28 Igen International, Inc. Magnetic particle based electrochemiluminescent detection apparatus and method
US5538687A (en) * 1994-12-16 1996-07-23 Behringer Mannheim Gmbh Apparatus for generating optically detectable signals by applying electrical potentials to sample liquids
US5993740A (en) * 1995-01-20 1999-11-30 Hitachi, Ltd. Immunoassay method and analyzer using magnetic particles
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
CN1661115A (en) * 1995-03-10 2005-08-31 梅索磅秤技术有限公司 Multi-array, multi-specific electrochemiluminescence testing
AU5854396A (en) * 1995-05-08 1996-11-29 Igen, Inc. Electrochemiluminescent metal chelate labels and means for d etection
US5589136A (en) * 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
EP0791821A4 (en) * 1995-09-12 1999-10-27 Eisai Co Ltd Method and apparatus for detecting electrochemiluminescence
CA2255083C (en) * 1996-05-20 2006-10-24 Dinex A/S A method and a reactor for electrochemical conversion of a material e.g. soot particles being insoluble in a fluid
US5833925A (en) * 1996-11-13 1998-11-10 Beckman Instruments, Inc. Automatic chemistry analyzer with improved ion selective electrode assembly
JP4088721B2 (en) * 1997-03-13 2008-05-21 日産化学工業株式会社 Conductive tin oxide fine powder and method for producing conductive tin oxide sol
US6200531B1 (en) * 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US6136268A (en) * 1999-08-17 2000-10-24 Orion Diagnostica Method for luminescence measurements
KR20050013592A (en) * 2002-06-20 2005-02-04 아이젠인터내셔널인코포레이티드 Electrochemiluminescence flow cell and flow cell components
US8211279B2 (en) * 2005-06-03 2012-07-03 Board Of Regents Of The University Of Texas System Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode

Also Published As

Publication number Publication date
US20010008612A1 (en) 2001-07-19
CA2331490A1 (en) 1999-11-18
US20030118477A1 (en) 2003-06-26
EP1078247A4 (en) 2002-12-04
US6517777B2 (en) 2003-02-11
AU755542B2 (en) 2002-12-12
WO1999058962A1 (en) 1999-11-18
EP1078247A1 (en) 2001-02-28
AU3981099A (en) 1999-11-29
US6200531B1 (en) 2001-03-13
JP2002514759A (en) 2002-05-21

Similar Documents

Publication Publication Date Title
WO1999058962A8 (en) Improved apparatus and methods for carrying out electrochemiluminescence test measurements
CA2538701A1 (en) Method for generating histogram
WO1995007457A3 (en) Bio-luminescence monitoring apparatus and method
AU584351B2 (en) Fluctuation analysis for enhanced particle detection
NO900582D0 (en) Measurement methods.
EP0266103A3 (en) Magnetic flux leakage probe for use in nondestructive testing
WO1992019957A3 (en) Method for optically measuring chemical analytes
DE69712139T2 (en) Device for measuring the concentration of an analyte with remote metering
DE69809752D1 (en) DEVICE FOR TESTING ANALYTICAL CONCENTRATION IN A LIQUID
DE59915078D1 (en)
CA2251861A1 (en) Apparatus and method for determining a parameter of a particle in a fluid
AU2001295361A1 (en) Method and device for determining the volume of a sample of a liquid
EP0249110A3 (en) Sensor for a metal detector
CA2331904A1 (en) Detecting tool motion effects on spin echoes obtained with nuclear magnetic resonance measurements
AU1799900A (en) Method and apparatus for measuring sample by luminescence
EP0919790A3 (en) Optical sensor apparatus and signal processing circuit used therein
DE69808071D1 (en) PROOF TEST USING MAGNETIC PARTICLES
IL109115A (en) Methods for measurement of nmr-detectable xenobiotic compounds
EP0274385A3 (en) Detection device for gases with a diffusion measuring chamber which is sealable from the sample space during measurement
EP0408748A4 (en) Light emitting probe complex for measuring ph and method of ph measurement
GB2155628A (en) Optical probe to measure the depth of a cavity
GB2191294B (en) Apparatus determining the concentration of a paramagnetic gas by measuring its pressure when subjected to an ac magnetic field
CA2297199A1 (en) Method and device for displaying signal generated by measurement probe
EP0290167A3 (en) Improvements in or relating to the detection of ultraviolet radiation
EP0632133A4 (en) Highly sensitive determination of d-3-hydroxybutyric acid or acetoacetic acid and composition therefor.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: C1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page

Free format text: REVISED ABSTRACT RECEIVED BY THE INTERNATIONAL BUREAU AFTER COMPLETION OF THE TECHNICAL PREPARATIONS FOR INTERNATIONAL PUBLICATION

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 39810/99

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1999922921

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2331490

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: KR

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 548715

Kind code of ref document: A

Format of ref document f/p: F

WWP Wipo information: published in national office

Ref document number: 1999922921

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10031868

Country of ref document: US

WWG Wipo information: grant in national office

Ref document number: 39810/99

Country of ref document: AU