WO1999066831A3 - Verwendung von 5-aminolävulinsäure oder eines derivates davon zur photodynamischen diagnose und/oder photodynamischen therapie von erkrankungen des zahnhalteapparates und der zähne - Google Patents

Verwendung von 5-aminolävulinsäure oder eines derivates davon zur photodynamischen diagnose und/oder photodynamischen therapie von erkrankungen des zahnhalteapparates und der zähne Download PDF

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Publication number
WO1999066831A3
WO1999066831A3 PCT/EP1999/004242 EP9904242W WO9966831A3 WO 1999066831 A3 WO1999066831 A3 WO 1999066831A3 EP 9904242 W EP9904242 W EP 9904242W WO 9966831 A3 WO9966831 A3 WO 9966831A3
Authority
WO
WIPO (PCT)
Prior art keywords
photodynamic
aminolevulinic acid
derivative
utilization
parodontium
Prior art date
Application number
PCT/EP1999/004242
Other languages
English (en)
French (fr)
Other versions
WO1999066831A2 (de
Inventor
Klaus M Irion
Rainer Hahn
Original Assignee
Storz Karl Gmbh & Co Kg
Klaus M Irion
Rainer Hahn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Storz Karl Gmbh & Co Kg, Klaus M Irion, Rainer Hahn filed Critical Storz Karl Gmbh & Co Kg
Priority to EP99929276A priority Critical patent/EP1087794B8/de
Priority to DE59913260T priority patent/DE59913260D1/de
Publication of WO1999066831A2 publication Critical patent/WO1999066831A2/de
Publication of WO1999066831A3 publication Critical patent/WO1999066831A3/de
Priority to US09/741,204 priority patent/US6860879B2/en
Priority to US10/288,773 priority patent/US20030060719A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0088—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for oral or dental tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0073—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form semi-solid, gel, hydrogel, ointment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/90—Compositions for taking dental impressions

Abstract

Die Erfindung betrifft die Verwendung von 5-Aminolävulinsäure oder eines Derivates davon zur Herstellung eines pharmazeutischen Präparates zur photodynamischen Diagnose und/oder phostodynamischen Therapie. Diese Phänomen beruht auf der Gabe von 5-Aminolävulinsäure und einer dadurch induzierten Bildung von photosensiblem Protoporphyrin IX (PPIX). 5-Aminolävulinsäure ist ein Prekursor für den Photosensitizer Protoporphyrin IX, so dass durch Verabreichung dieses Prekursors die Menge an Protoporphyrin IX erhöht werden kann. Von gesundem Gewebe wird der Prekursor nicht angereichert und in PPIX umgesetzt. Die Erfindung betrifft ferner eine Lichtapplikationseinheit zur kombinierten photodynamischen Diagnose und/oder photodynamischen Therapie sowie eine Vorrichtung zum Applizieren des pharmazeutischen Präparates.
PCT/EP1999/004242 1998-06-19 1999-06-18 Verwendung von 5-aminolävulinsäure oder eines derivates davon zur photodynamischen diagnose und/oder photodynamischen therapie von erkrankungen des zahnhalteapparates und der zähne WO1999066831A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99929276A EP1087794B8 (de) 1998-06-19 1999-06-18 Lichtapplikationseinrichtung zur photodynamischen diagnose und/oder photodynamischen therapie von erkrankungen des zahnhalteapparates und der zähne
DE59913260T DE59913260D1 (de) 1998-06-19 1999-06-18 Lichtapplikationseinrichtung zur photodynamischen diagnose und/oder photodynamischen therapie von erkrankungen des zahnhalteapparates und der zähne
US09/741,204 US6860879B2 (en) 1998-06-19 2000-12-19 Use of 5-aminolevulinic acid or a derivate thereof for photodynamic diagnosis and/or photodynamic therapy
US10/288,773 US20030060719A1 (en) 1998-06-19 2002-11-06 Use of 5-aminolevulinic acid or a derivate thereof for photodynamic diagnosis and /or photodynamic therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1998127417 DE19827417B4 (de) 1998-06-19 1998-06-19 Material zur unterschiedlichen Modifizierung der optischen Eigenschaften unterschiedlicher Zellen
DE19827417.3 1998-06-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/741,204 Continuation US6860879B2 (en) 1998-06-19 2000-12-19 Use of 5-aminolevulinic acid or a derivate thereof for photodynamic diagnosis and/or photodynamic therapy

Publications (2)

Publication Number Publication Date
WO1999066831A2 WO1999066831A2 (de) 1999-12-29
WO1999066831A3 true WO1999066831A3 (de) 2000-08-24

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP1999/003778 WO2000001350A2 (de) 1998-06-19 1999-06-01 Material zur modifizierung der optischen eigenschaften unterschiedlicher zellen, gerät zum applizieren dieses materiales, diagnosegärat zum bestimmen der optischen eigenschaften von zellen, sowie gerät zum bestrahlen von zellen
PCT/EP1999/004242 WO1999066831A2 (de) 1998-06-19 1999-06-18 Verwendung von 5-aminolävulinsäure oder eines derivates davon zur photodynamischen diagnose und/oder photodynamischen therapie von erkrankungen des zahnhalteapparates und der zähne

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/003778 WO2000001350A2 (de) 1998-06-19 1999-06-01 Material zur modifizierung der optischen eigenschaften unterschiedlicher zellen, gerät zum applizieren dieses materiales, diagnosegärat zum bestimmen der optischen eigenschaften von zellen, sowie gerät zum bestrahlen von zellen

Country Status (7)

Country Link
US (6) US6699040B1 (de)
EP (2) EP1087793B1 (de)
AT (1) ATE317704T1 (de)
AU (1) AU4372599A (de)
CA (1) CA2335113A1 (de)
DE (3) DE19827417B4 (de)
WO (2) WO2000001350A2 (de)

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