WO1999066921A1 - Enhancement of exercise performance by augmenting endogenous nitric oxide production or activity - Google Patents
Enhancement of exercise performance by augmenting endogenous nitric oxide production or activity Download PDFInfo
- Publication number
- WO1999066921A1 WO1999066921A1 PCT/US1999/012022 US9912022W WO9966921A1 WO 1999066921 A1 WO1999066921 A1 WO 1999066921A1 US 9912022 W US9912022 W US 9912022W WO 9966921 A1 WO9966921 A1 WO 9966921A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mice
- exercise
- arginine
- mammal
- enhancing
- Prior art date
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99957148A EP1105115A1 (en) | 1998-06-23 | 1999-05-28 | Enhancement of exercise performance by augmenting endogenous nitric oxide production or activity |
CA002346954A CA2346954A1 (en) | 1998-06-23 | 1999-05-28 | Enhancement of exercise performance by augmenting endogenous nitric oxide production or activity |
AU43223/99A AU4322399A (en) | 1998-06-23 | 1999-05-28 | Enhancement of exercise performance by augmenting endogenous nitric oxide production or activity |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/103,340 US6117872A (en) | 1998-06-23 | 1998-06-23 | Enhancement of exercise performance by augmenting endogenous nitric oxide production or activity |
US09/103,340 | 1998-06-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999066921A1 true WO1999066921A1 (en) | 1999-12-29 |
Family
ID=22294659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/012022 WO1999066921A1 (en) | 1998-06-23 | 1999-05-28 | Enhancement of exercise performance by augmenting endogenous nitric oxide production or activity |
Country Status (5)
Country | Link |
---|---|
US (1) | US6117872A (en) |
EP (1) | EP1105115A1 (en) |
AU (1) | AU4322399A (en) |
CA (1) | CA2346954A1 (en) |
WO (1) | WO1999066921A1 (en) |
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US6635273B1 (en) | 1999-10-29 | 2003-10-21 | Trustees Of Boston University | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
US7235237B2 (en) | 1999-10-29 | 2007-06-26 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
WO2008105730A1 (en) * | 2007-02-26 | 2008-09-04 | Jon Lundberg | Performance enhancing composition and use thereof |
US7537785B2 (en) | 1999-10-29 | 2009-05-26 | Nitromed, Inc. | Composition for treating vascular diseases characterized by nitric oxide insufficiency |
US7708989B2 (en) | 1999-10-29 | 2010-05-04 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
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US20060014773A1 (en) * | 2001-04-19 | 2006-01-19 | Mccleary Edward L | Mental agility lozenge, edible strip, food or drink |
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US7740878B2 (en) * | 2001-10-22 | 2010-06-22 | Danisco A/S | Use of betaine to enhance exercise performance |
US7217426B1 (en) | 2002-06-21 | 2007-05-15 | Advanced Cardiovascular Systems, Inc. | Coatings containing polycationic peptides for cardiovascular therapy |
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EP0259167A2 (en) * | 1986-09-05 | 1988-03-09 | Phillip Lowell Millman | Nutrient composition for athletes and method of making and using the same |
SU1653714A1 (en) * | 1988-03-17 | 1991-06-07 | Всесоюзный Научно-Исследовательский Институт Коневодства | Method of feeding sporting horses |
US5026721A (en) * | 1989-06-05 | 1991-06-25 | Dudrick Stanley J | Amino acid nutritional supplement and regimen for enhancing physical performance through sound nutrition |
EP0680945A2 (en) * | 1994-05-02 | 1995-11-08 | Omeara (Proprietary) Limited | Amino acid, carnitine and magnesium supplementation |
WO1996036327A1 (en) * | 1995-05-18 | 1996-11-21 | Novartis Nutrition Ag | Method of modulating microcirculation |
DE29620015U1 (en) * | 1995-11-16 | 1997-01-09 | Nutrend S R O | Food supplement composition and products obtained therewith |
DE19720818A1 (en) * | 1996-11-15 | 1998-05-20 | Sportmedizin Team Muenchen Arz | Composition enhancing sports performance |
-
1998
- 1998-06-23 US US09/103,340 patent/US6117872A/en not_active Expired - Lifetime
-
1999
- 1999-05-28 EP EP99957148A patent/EP1105115A1/en not_active Withdrawn
- 1999-05-28 CA CA002346954A patent/CA2346954A1/en not_active Abandoned
- 1999-05-28 AU AU43223/99A patent/AU4322399A/en not_active Abandoned
- 1999-05-28 WO PCT/US1999/012022 patent/WO1999066921A1/en active Application Filing
Patent Citations (7)
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EP0259167A2 (en) * | 1986-09-05 | 1988-03-09 | Phillip Lowell Millman | Nutrient composition for athletes and method of making and using the same |
SU1653714A1 (en) * | 1988-03-17 | 1991-06-07 | Всесоюзный Научно-Исследовательский Институт Коневодства | Method of feeding sporting horses |
US5026721A (en) * | 1989-06-05 | 1991-06-25 | Dudrick Stanley J | Amino acid nutritional supplement and regimen for enhancing physical performance through sound nutrition |
EP0680945A2 (en) * | 1994-05-02 | 1995-11-08 | Omeara (Proprietary) Limited | Amino acid, carnitine and magnesium supplementation |
WO1996036327A1 (en) * | 1995-05-18 | 1996-11-21 | Novartis Nutrition Ag | Method of modulating microcirculation |
DE29620015U1 (en) * | 1995-11-16 | 1997-01-09 | Nutrend S R O | Food supplement composition and products obtained therewith |
DE19720818A1 (en) * | 1996-11-15 | 1998-05-20 | Sportmedizin Team Muenchen Arz | Composition enhancing sports performance |
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Title |
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AIMASHEVA, N.P. ET AL: "Donor of nitric oxide improves, while NO-synthase inhibitor impairs resistnce and adaption to strenuous physical exercise", BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, vol. 125, no. 4, April 1998 (1998-04-01), pages 336 - 339, XP000856317 * |
COSENTINO, F. ET AL: "Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries", CIRCULATION, vol. 91, no. 1, 1995, pages 139 - 144, XP000856340 * |
DATABASE WPI Week 199210, Derwent World Patents Index; AN 1992-077870, XP002124604 * |
FRYBURG, D.A.: "NG-monomethyl-L-arginine inhibits the blood flow but not the insulin-like response of forearm muscle to IGF-1", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 97, no. 5, March 1996 (1996-03-01), pages 1319 - 1328, XP000856350 * |
HIRAI, T. ET AL: "Effects of nitric oxide synthase inhibition on the muscle blood flow response to exercise in rats with heart failure", CARDIOVASCULAR RESEARCH, vol. 30, no. 3, September 1996 (1996-09-01), pages 469 - 476, XP000856371 * |
KOIZUMI, T. ET AL: "Changes in pulmonary vascular tone during exercise", THE JOURNAL OF CLINICAL INVETIGATION, vol. 94, no. 6, December 1994 (1994-12-01), pages 2275 - 2282, XP000856348 * |
MAXWELL, A. J. ET AL: "Hypercholesterolaemia impairs exercise capacity: Role of nitric oxide", SUPPLEMENT TO THE JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 29, no. 2 A, 1997, pages 2A, XP000856928 * |
MAXWELL, A.J. ET AL: "Limb blood flow uring exercise is dependent on nitric oxide", CIRCULATION, vol. 98, no. 4, July 1998 (1998-07-01), pages 369 - 374, XP000856341 * |
PUYBASSET, L. ET AL: "Effets hémodynamiques résultant du blocage sub-chronique de la NO-synthétase chez le chien éveillé: rôle de l'EDRF/NO dans l'exercise musculaire", ARCHIVE DES MALADIE DU COEUR ET DES VAISSEAUX, vol. 88, no. 8, 1995, pages 1217 - 1221, XP000856327 * |
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US6784177B2 (en) | 1999-09-08 | 2004-08-31 | Nitro Med, Inc. | Methods using hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate |
US6465463B1 (en) | 1999-09-08 | 2002-10-15 | Nitromed, Inc. | Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate |
US6635273B1 (en) | 1999-10-29 | 2003-10-21 | Trustees Of Boston University | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
US7235237B2 (en) | 1999-10-29 | 2007-06-26 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
US7537785B2 (en) | 1999-10-29 | 2009-05-26 | Nitromed, Inc. | Composition for treating vascular diseases characterized by nitric oxide insufficiency |
US7556824B2 (en) | 1999-10-29 | 2009-07-07 | Nitromed, Inc. | Transdermal patch composition for treating vascular diseases characterized by nitric oxide insufficiency |
US7708989B2 (en) | 1999-10-29 | 2010-05-04 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
US9084671B2 (en) | 2002-06-21 | 2015-07-21 | Advanced Cardiovascular Systems, Inc. | Methods of forming a micronized peptide coated stent |
US10842813B2 (en) | 2007-02-26 | 2020-11-24 | Heartbeet Ltd | Compositions of nitrates and methods of use thereof |
JP2010519335A (en) * | 2007-02-26 | 2010-06-03 | ルンドベルク,ヨン | Composition for improving athletic performance and use thereof |
US9180140B2 (en) | 2007-02-26 | 2015-11-10 | Heartbeet Ltd. | Performance enhancing composition and use thereof |
US10821132B2 (en) | 2007-02-26 | 2020-11-03 | Heartbeet Ltd | Compositions of nitrates and methods of use thereof |
US10835555B2 (en) | 2007-02-26 | 2020-11-17 | Heartbeet Ltd | Compositions of nitrates and methods of use thereof |
WO2008105730A1 (en) * | 2007-02-26 | 2008-09-04 | Jon Lundberg | Performance enhancing composition and use thereof |
US11083747B2 (en) | 2007-02-26 | 2021-08-10 | Heartbeet Ltd. | Compositions of nitrates and methods of use thereof |
US11096409B2 (en) | 2007-02-26 | 2021-08-24 | Heartbeet Ltd. | Compositions of nitrates and methods of use thereof |
US11723917B2 (en) | 2007-02-26 | 2023-08-15 | Heartbeet Ltd. | Compositions of nitrates and methods of use thereof |
US11759477B2 (en) | 2007-02-26 | 2023-09-19 | Heartbeet Ltd. | Compositions of nitrates and methods of use thereof |
ITMI20101600A1 (en) * | 2010-09-03 | 2012-03-04 | Andrea Poli | DIETARY SUPPLEMENT |
WO2012028935A1 (en) * | 2010-09-03 | 2012-03-08 | Salvini, Liliana | Dietary supplement |
Also Published As
Publication number | Publication date |
---|---|
EP1105115A1 (en) | 2001-06-13 |
AU4322399A (en) | 2000-01-10 |
CA2346954A1 (en) | 1999-12-29 |
US6117872A (en) | 2000-09-12 |
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