WO2000003004A3 - Presenilin 2 specific ribozyme - Google Patents
Presenilin 2 specific ribozyme Download PDFInfo
- Publication number
- WO2000003004A3 WO2000003004A3 PCT/EP1999/004804 EP9904804W WO0003004A3 WO 2000003004 A3 WO2000003004 A3 WO 2000003004A3 EP 9904804 W EP9904804 W EP 9904804W WO 0003004 A3 WO0003004 A3 WO 0003004A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- presenilin
- ribozyme
- ribozymes
- recombinant vector
- alzheimer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002332497A CA2332497A1 (en) | 1998-07-09 | 1999-07-08 | Presenilin 2 specific ribozyme |
AU50339/99A AU5033999A (en) | 1998-07-09 | 1999-07-08 | Presenilin 2 specific ribozyme |
JP2000559226A JP2002520016A (en) | 1998-07-09 | 1999-07-08 | Presenilin 2-specific ribozymes |
EP99934633A EP1095138A2 (en) | 1998-07-09 | 1999-07-08 | Presenilin 2 specific ribozyme |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98112653 | 1998-07-09 | ||
EP98112653.5 | 1998-07-09 | ||
US12620099P | 1999-03-25 | 1999-03-25 | |
US60/126,200 | 1999-03-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000003004A2 WO2000003004A2 (en) | 2000-01-20 |
WO2000003004A3 true WO2000003004A3 (en) | 2000-04-20 |
Family
ID=45569968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1999/004804 WO2000003004A2 (en) | 1998-07-09 | 1999-07-08 | Presenilin 2 specific ribozyme |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1095138A2 (en) |
JP (1) | JP2002520016A (en) |
AR (1) | AR020329A1 (en) |
AU (1) | AU5033999A (en) |
CA (1) | CA2332497A1 (en) |
WO (1) | WO2000003004A2 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8691754B2 (en) | 2003-09-22 | 2014-04-08 | Bioarray Solutions, Ltd. | Microparticles with enhanced covalent binding capacity and their uses |
US8691594B2 (en) | 1996-04-25 | 2014-04-08 | Bioarray Solutions, Ltd. | Method of making a microbead array with attached biomolecules |
US9147037B2 (en) | 2004-08-02 | 2015-09-29 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
US9251583B2 (en) | 2002-11-15 | 2016-02-02 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
US9377388B2 (en) | 1997-03-14 | 2016-06-28 | Trustees Of Tufts College | Methods for detecting target analytes and enzymatic reactions |
US9436088B2 (en) | 2001-06-21 | 2016-09-06 | Bioarray Solutions, Ltd. | Un-supported polymeric film with embedded microbeads |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030027126A1 (en) | 1997-03-14 | 2003-02-06 | Walt David R. | Methods for detecting target analytes and enzymatic reactions |
US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
JP2003012548A (en) * | 2001-06-27 | 2003-01-15 | Japan Science & Technology Corp | Medicine composition |
EP2722395B1 (en) | 2001-10-15 | 2018-12-19 | Bioarray Solutions Ltd | Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection |
EP1692298A4 (en) | 2003-10-28 | 2008-08-13 | Bioarray Solutions Ltd | Optimization of gene expression analysis using immobilized capture probes |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0558944A2 (en) * | 1992-02-06 | 1993-09-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | RNA and DNA molecules for producing virus resistance |
WO1995031541A2 (en) * | 1994-05-18 | 1995-11-23 | Ribozyme Pharmaceuticals, Inc. | Methods and compositions for treatment of restenosis and cancer using ribozymes |
WO1996010080A1 (en) * | 1994-09-29 | 1996-04-04 | Hybridon, Inc. | Finderons and methods of their preparation and use |
WO1996034099A2 (en) * | 1995-04-28 | 1996-10-31 | Hsc Research And Development Limited Partnership | Genetic sequences and proteins related to alzheimer's disease, and uses therefor |
WO1997043404A2 (en) * | 1996-05-13 | 1997-11-20 | Hybridon, Inc. | Ribozyme variants with improved catalytic activity under low magnesium conditions |
WO1997046678A1 (en) * | 1996-06-06 | 1997-12-11 | Bayer Corporation | Nucleic acids and polypeptides related to presenilin |
WO1998058057A1 (en) * | 1997-06-19 | 1998-12-23 | Innovir Laboratories, Inc. | Compositions inducing cleavage of rna motifs |
-
1999
- 1999-07-07 AR ARP990103296A patent/AR020329A1/en active Pending
- 1999-07-08 EP EP99934633A patent/EP1095138A2/en not_active Withdrawn
- 1999-07-08 WO PCT/EP1999/004804 patent/WO2000003004A2/en not_active Application Discontinuation
- 1999-07-08 JP JP2000559226A patent/JP2002520016A/en active Pending
- 1999-07-08 AU AU50339/99A patent/AU5033999A/en not_active Abandoned
- 1999-07-08 CA CA002332497A patent/CA2332497A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0558944A2 (en) * | 1992-02-06 | 1993-09-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | RNA and DNA molecules for producing virus resistance |
WO1995031541A2 (en) * | 1994-05-18 | 1995-11-23 | Ribozyme Pharmaceuticals, Inc. | Methods and compositions for treatment of restenosis and cancer using ribozymes |
WO1996010080A1 (en) * | 1994-09-29 | 1996-04-04 | Hybridon, Inc. | Finderons and methods of their preparation and use |
WO1996034099A2 (en) * | 1995-04-28 | 1996-10-31 | Hsc Research And Development Limited Partnership | Genetic sequences and proteins related to alzheimer's disease, and uses therefor |
WO1997043404A2 (en) * | 1996-05-13 | 1997-11-20 | Hybridon, Inc. | Ribozyme variants with improved catalytic activity under low magnesium conditions |
WO1997046678A1 (en) * | 1996-06-06 | 1997-12-11 | Bayer Corporation | Nucleic acids and polypeptides related to presenilin |
WO1998058057A1 (en) * | 1997-06-19 | 1998-12-23 | Innovir Laboratories, Inc. | Compositions inducing cleavage of rna motifs |
Non-Patent Citations (3)
Title |
---|
LEVY-LAHAD, E. ET AL.: "Candidate gene for the chromosome 1 familial Alzheimer's Disease locus", SCIENCE, vol. 269, 18 August 1995 (1995-08-18), pages 973 - 977, XP000616667 * |
SCHMIDT, S. ET AL.: "Base and sugar requirements for RNA cleavage of essential nucleoside residues in internal loop B of the hairpin ribozyme: implications for secondary structure", NUCLEIC ACIDS RESEARCH, vol. 24, no. 4, 1996, pages 573 - 581, XP002129026 * |
VITO, P. ET AL.: "Requirement of the familial Alzheimer's Disease gene PS2 for apoptosis", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 49, 6 December 1996 (1996-12-06), pages 31025 - 31028, XP002097004 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8691594B2 (en) | 1996-04-25 | 2014-04-08 | Bioarray Solutions, Ltd. | Method of making a microbead array with attached biomolecules |
US9400259B2 (en) | 1996-04-25 | 2016-07-26 | Bioarray Solutions, Ltd. | Method of making a microbead array with attached biomolecules |
US9377388B2 (en) | 1997-03-14 | 2016-06-28 | Trustees Of Tufts College | Methods for detecting target analytes and enzymatic reactions |
US9436088B2 (en) | 2001-06-21 | 2016-09-06 | Bioarray Solutions, Ltd. | Un-supported polymeric film with embedded microbeads |
US9251583B2 (en) | 2002-11-15 | 2016-02-02 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
US8691754B2 (en) | 2003-09-22 | 2014-04-08 | Bioarray Solutions, Ltd. | Microparticles with enhanced covalent binding capacity and their uses |
US9147037B2 (en) | 2004-08-02 | 2015-09-29 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
Also Published As
Publication number | Publication date |
---|---|
EP1095138A2 (en) | 2001-05-02 |
WO2000003004A2 (en) | 2000-01-20 |
CA2332497A1 (en) | 2000-01-20 |
JP2002520016A (en) | 2002-07-09 |
AU5033999A (en) | 2000-02-01 |
AR020329A1 (en) | 2002-05-08 |
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