WO2000003660A1 - Biodegradable compositions for the controlled release of encapsulated substances - Google Patents
Biodegradable compositions for the controlled release of encapsulated substances Download PDFInfo
- Publication number
- WO2000003660A1 WO2000003660A1 PCT/US1999/016239 US9916239W WO0003660A1 WO 2000003660 A1 WO2000003660 A1 WO 2000003660A1 US 9916239 W US9916239 W US 9916239W WO 0003660 A1 WO0003660 A1 WO 0003660A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polymer
- lipid
- pharmaceutical composition
- poly
- physiologically active
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU50030/99A AU752225B2 (en) | 1998-07-17 | 1999-07-16 | Biodegradable compositions for the controlled release of encapsulated substances |
IL14089999A IL140899A0 (en) | 1998-07-17 | 1999-07-16 | Lipid/polymer containing pharmaceutical compositions and processes for the preparation thereof |
AT99934132T ATE428371T1 (en) | 1998-07-17 | 1999-07-16 | BIODEGRADABLE ARRANGEMENTS FOR THE CONTROLLED RELEASE OF ENCLOSED SUBSTANCES |
CA002338031A CA2338031C (en) | 1998-07-17 | 1999-07-16 | Biodegradable compositions for the controlled release of encapsulated substances |
JP2000559796A JP2002520120A (en) | 1998-07-17 | 1999-07-16 | Biodegradable compositions for controlled release of encapsulating materials |
EP99934132A EP1098610B1 (en) | 1998-07-17 | 1999-07-16 | Biodegradable compositions for the controlled release of encapsulated substances |
NZ509186A NZ509186A (en) | 1998-07-17 | 1999-07-16 | Biodegradable compositions for the controlled release of encapsulated substances |
DE69940735T DE69940735D1 (en) | 1998-07-17 | 1999-07-16 | BIODEGRADABLE ARRANGEMENTS FOR THE CONTROLLED RELEASE OF INCLUDED SUBSTANCES |
IL140899A IL140899A (en) | 1998-07-17 | 2001-01-15 | Lipid/polymer containing pharmaceutical compositions and processes for the preparation thereof |
NO20010264A NO20010264L (en) | 1998-07-17 | 2001-01-16 | Biodegradable preparations for controlled release of encapsulated substances |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9324398P | 1998-07-17 | 1998-07-17 | |
US10185598P | 1998-09-25 | 1998-09-25 | |
US12309799P | 1999-03-05 | 1999-03-05 | |
US60/123,097 | 1999-03-05 | ||
US60/093,243 | 1999-03-05 | ||
US60/101,855 | 1999-03-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000003660A1 true WO2000003660A1 (en) | 2000-01-27 |
Family
ID=27377463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/016239 WO2000003660A1 (en) | 1998-07-17 | 1999-07-16 | Biodegradable compositions for the controlled release of encapsulated substances |
Country Status (12)
Country | Link |
---|---|
US (2) | US6277413B1 (en) |
EP (1) | EP1098610B1 (en) |
JP (2) | JP2002520120A (en) |
AT (1) | ATE428371T1 (en) |
AU (1) | AU752225B2 (en) |
CA (1) | CA2338031C (en) |
DE (1) | DE69940735D1 (en) |
ES (1) | ES2325141T3 (en) |
IL (2) | IL140899A0 (en) |
NO (1) | NO20010264L (en) |
NZ (1) | NZ509186A (en) |
WO (1) | WO2000003660A1 (en) |
Cited By (21)
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WO1999025319A1 (en) | 1997-11-14 | 1999-05-27 | Depotech Corporation | Production of multivesicular liposomes |
WO2000053161A3 (en) * | 1999-03-11 | 2001-02-01 | Zycos Inc | Microparticles for delivery of nucleic acid |
WO2001028589A2 (en) * | 1999-10-15 | 2001-04-26 | Rainer Rogasch | Shaped body comprising an amphiphilic outer phase and a lipophilic inner phase |
WO2001032180A2 (en) * | 1999-11-01 | 2001-05-10 | Rodeva Limited | Composition for treatment of constipation and irritable bowel syndrome |
WO2002032398A2 (en) * | 2000-10-16 | 2002-04-25 | Massachusetts Institute Of Technology | Lipid-protein-sugar particles for drug delivery |
WO2002032396A2 (en) * | 2000-10-16 | 2002-04-25 | Massachusetts Institute Of Technology | Lipid-protein-sugar particles for delivery of nucleic acids |
WO2003002102A1 (en) * | 2001-06-29 | 2003-01-09 | Smart Drug Systems Inc | Sustained release pharmaceutical composition |
WO2003009833A1 (en) * | 2001-06-29 | 2003-02-06 | Smart Drug Systems Inc | Sustained release delivery system |
EP1292285A1 (en) * | 2000-06-02 | 2003-03-19 | Zycos Inc. | Delivery systems for bioactive agents |
WO2003075892A1 (en) * | 2002-03-13 | 2003-09-18 | Novartis Ag | Pharmaceutical microparticles |
EP1411951A2 (en) † | 2001-07-27 | 2004-04-28 | N.V. Nutricia | Enteral compositions for the prevention and/or treatment of sepsis |
WO2005011741A2 (en) * | 2003-07-10 | 2005-02-10 | Allergan, Inc. | Delivery of a drug via subconjuctival or periocular delivery of a prodrug in a polymeric microparticle |
FR2868704A1 (en) * | 2004-04-07 | 2005-10-14 | Ethypharm Sa | USE OF LIPIDS FOR IMPROVING THE BIOAVAILABILITY OF PROTEIN ACTIVE INGREDIENTS IN INJECTABLE CUTANEOUS OR INTRA-MUSCULAR FORMULATIONS |
US7943179B2 (en) | 2003-09-23 | 2011-05-17 | Massachusetts Institute Of Technology | pH triggerable polymeric particles |
EA016540B1 (en) * | 2008-12-30 | 2012-05-30 | Ооо "Научно-Производственный Комплекс "Наносистема" | Pharmaceutical composition for treating tuberculosis, method for preparing thereof and method for treating thereof |
US8795726B2 (en) | 2010-01-19 | 2014-08-05 | Polypid Ltd. | Sustained-release nucleic acid matrix compositions |
US8877242B2 (en) | 2008-07-14 | 2014-11-04 | Polypid Ltd. | Sustained-release drug carrier composition |
US8992979B2 (en) | 2009-07-14 | 2015-03-31 | Polypid Ltd. | Sustained-release drug carrier composition |
US9668974B2 (en) | 2012-05-10 | 2017-06-06 | Painreform Ltd. | Depot formulations of a local anesthetic and methods for preparation thereof |
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WO2021053171A1 (en) * | 2019-09-19 | 2021-03-25 | Amw Gmbh | Extruded depot form for controlled active substance release |
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US7118921B1 (en) * | 1999-06-24 | 2006-10-10 | Mcmaster University | Incorporation and applications of biomolecular interactions within a carrier |
US7025980B1 (en) * | 1999-09-14 | 2006-04-11 | Tepha, Inc. | Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation |
US20060177416A1 (en) | 2003-10-14 | 2006-08-10 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
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EP1098610B1 (en) | 2009-04-15 |
US6793938B2 (en) | 2004-09-21 |
JP2011063596A (en) | 2011-03-31 |
DE69940735D1 (en) | 2009-05-28 |
AU5003099A (en) | 2000-02-07 |
US20010048945A1 (en) | 2001-12-06 |
EP1098610A1 (en) | 2001-05-16 |
IL140899A0 (en) | 2002-02-10 |
ES2325141T3 (en) | 2009-08-26 |
AU752225B2 (en) | 2002-09-12 |
ATE428371T1 (en) | 2009-05-15 |
NZ509186A (en) | 2005-01-28 |
CA2338031C (en) | 2006-12-05 |
IL140899A (en) | 2007-05-15 |
EP1098610A4 (en) | 2003-09-03 |
CA2338031A1 (en) | 2000-01-27 |
NO20010264L (en) | 2001-03-06 |
JP2002520120A (en) | 2002-07-09 |
NO20010264D0 (en) | 2001-01-16 |
US6277413B1 (en) | 2001-08-21 |
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