WO2000009652A3 - Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof - Google Patents

Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof Download PDF

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Publication number
WO2000009652A3
WO2000009652A3 PCT/IB1999/001416 IB9901416W WO0009652A3 WO 2000009652 A3 WO2000009652 A3 WO 2000009652A3 IB 9901416 W IB9901416 W IB 9901416W WO 0009652 A3 WO0009652 A3 WO 0009652A3
Authority
WO
WIPO (PCT)
Prior art keywords
loaded
sol
products obtained
microcapsules
functional molecules
Prior art date
Application number
PCT/IB1999/001416
Other languages
French (fr)
Other versions
WO2000009652A2 (en
Inventor
Shlomo Magdassi
David Avnir
Alon Seri-Levy
Noa Lapidot
Claudio Rottman
Yoram Sorek
Zazon Orit Ben
Original Assignee
Sol Gel Technologies Ltd
Shlomo Magdassi
David Avnir
Seri Levy Alon
Noa Lapidot
Claudio Rottman
Yoram Sorek
Zazon Orit Ben
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sol Gel Technologies Ltd, Shlomo Magdassi, David Avnir, Seri Levy Alon, Noa Lapidot, Claudio Rottman, Yoram Sorek, Zazon Orit Ben filed Critical Sol Gel Technologies Ltd
Priority to IL14141199A priority Critical patent/IL141411A0/en
Priority to EP99939560A priority patent/EP1104287B9/en
Priority to AT99939560T priority patent/ATE546131T1/en
Priority to ES99939560T priority patent/ES2382536T3/en
Priority to DE1104287T priority patent/DE1104287T1/en
Priority to JP2000565089A priority patent/JP4920132B2/en
Priority to AU53825/99A priority patent/AU5382599A/en
Publication of WO2000009652A2 publication Critical patent/WO2000009652A2/en
Publication of WO2000009652A3 publication Critical patent/WO2000009652A3/en
Priority to IL141411A priority patent/IL141411A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
    • A23L27/72—Encapsulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Abstract

The present invention relates to a novel process for preparing sol-gel microcapsules loaded with up to 95 % (w/w) functional molecules or substances and to the products obtained by said process. Said process is conducted in two steps: (a) creating an oil-in-water emulsion by emulsification of a water insoluble solution comprising the sol-gel precursors and the molecules to be loaded, in an aqueous solution under appropriate shear forces; (b) mixing and stirring said emulsion with an aqueous solution at a suitably selected pH to obtain loaded sol-gel microcapsules in suspension. The microcapsules so obtained can further be subjected to cycles of isolation and rinsing. Incorporation of the final product, either in the form of a suspension or a powder, in cosmetic formulations affords a transparent cream when applying to skin and has a smooth and pleasant contact.
PCT/IB1999/001416 1998-08-13 1999-08-11 Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof WO2000009652A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IL14141199A IL141411A0 (en) 1998-08-13 1999-08-11 Method for the preparation of oxide microcapsules loaded with functional molecules and the product obtained thereof
EP99939560A EP1104287B9 (en) 1998-08-13 1999-08-11 Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof
AT99939560T ATE546131T1 (en) 1998-08-13 1999-08-11 METHOD FOR PRODUCING OXIDE MICROCAPSULES LOADED WITH FUNCTIONALIZED MOLECULES AND THE PRODUCTS OBTAINED THEREFROM
ES99939560T ES2382536T3 (en) 1998-08-13 1999-08-11 Procedure for preparing oxide microcapsules loaded with functional molecules and products obtained therefrom
DE1104287T DE1104287T1 (en) 1998-08-13 1999-08-11 METHOD FOR PRODUCING OXIDE MICROCAPSULES LOADED WITH FUNCTIONALIZED MOLECULES AND THE PRODUCTS OBTAINED FROM THEM
JP2000565089A JP4920132B2 (en) 1998-08-13 1999-08-11 Process for the preparation of oxide microcapsules filled with functional molecules and the products obtained thereby
AU53825/99A AU5382599A (en) 1998-08-13 1999-08-11 Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof
IL141411A IL141411A (en) 1998-08-13 2001-02-13 Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereby

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9755298P 1998-08-13 1998-08-13
US60/097,552 1998-08-13
US09/372,176 1999-08-11
US09/372,176 US6303149B1 (en) 1998-08-13 1999-08-11 Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof

Publications (2)

Publication Number Publication Date
WO2000009652A2 WO2000009652A2 (en) 2000-02-24
WO2000009652A3 true WO2000009652A3 (en) 2000-06-08

Family

ID=26793403

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1999/001416 WO2000009652A2 (en) 1998-08-13 1999-08-11 Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof

Country Status (9)

Country Link
US (1) US6303149B1 (en)
EP (1) EP1104287B9 (en)
JP (1) JP4920132B2 (en)
AT (1) ATE546131T1 (en)
AU (1) AU5382599A (en)
DE (1) DE1104287T1 (en)
ES (1) ES2382536T3 (en)
IL (2) IL141411A0 (en)
WO (1) WO2000009652A2 (en)

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EP1104287B1 (en) 2012-02-22
WO2000009652A2 (en) 2000-02-24
ATE546131T1 (en) 2012-03-15
DE1104287T1 (en) 2001-12-20
EP1104287A2 (en) 2001-06-06
AU5382599A (en) 2000-03-06
IL141411A0 (en) 2002-03-10
US6303149B1 (en) 2001-10-16
EP1104287A4 (en) 2004-12-15
ES2382536T9 (en) 2013-03-14
IL141411A (en) 2006-10-31
EP1104287B9 (en) 2012-12-19
JP2003525100A (en) 2003-08-26
JP4920132B2 (en) 2012-04-18

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