WO2000009757A1 - Optically characterizing polymers - Google Patents
Optically characterizing polymers Download PDFInfo
- Publication number
- WO2000009757A1 WO2000009757A1 PCT/US1999/018438 US9918438W WO0009757A1 WO 2000009757 A1 WO2000009757 A1 WO 2000009757A1 US 9918438 W US9918438 W US 9918438W WO 0009757 A1 WO0009757 A1 WO 0009757A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polymer
- radiation
- units
- constructed
- optical
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/44—Resins; rubber; leather
- G01N33/442—Resins, plastics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y20/00—Nanooptics, e.g. quantum optics or photonic crystals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL14131099A IL141310A0 (en) | 1998-08-13 | 1999-08-13 | Optically characterizing polymers |
AU55606/99A AU5560699A (en) | 1998-08-13 | 1999-08-13 | Optically characterizing polymers |
JP2000565191A JP2002522780A (en) | 1998-08-13 | 1999-08-13 | Optical characterization of polymers |
EP99942167A EP1105535A1 (en) | 1998-08-13 | 1999-08-13 | Optically characterizing polymers |
CA002340228A CA2340228A1 (en) | 1998-08-13 | 1999-08-13 | Optically characterizing polymers |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9654498P | 1998-08-13 | 1998-08-13 | |
US60/096,544 | 1998-08-13 | ||
US12041499P | 1999-02-14 | 1999-02-14 | |
US60/120,414 | 1999-02-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000009757A1 true WO2000009757A1 (en) | 2000-02-24 |
WO2000009757A9 WO2000009757A9 (en) | 2000-10-12 |
Family
ID=26791804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/018438 WO2000009757A1 (en) | 1998-08-13 | 1999-08-13 | Optically characterizing polymers |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1105535A1 (en) |
JP (1) | JP2002522780A (en) |
CN (1) | CN1323355A (en) |
AU (1) | AU5560699A (en) |
CA (1) | CA2340228A1 (en) |
IL (1) | IL141310A0 (en) |
WO (1) | WO2000009757A1 (en) |
Cited By (61)
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JP2002048765A (en) * | 2000-08-03 | 2002-02-15 | Masabumi Youda | Sample introduction device for horizontal plane type gel electrophorestic device, horizontal plane type gel electrophorestic system, its sample introduction method and its sample collection method |
EP1210578A1 (en) * | 1999-08-13 | 2002-06-05 | U.S. Genomics | Methods and apparatuses for stretching polymers |
US6528258B1 (en) | 1999-09-03 | 2003-03-04 | Lifebeam Technologies, Inc. | Nucleic acid sequencing using an optically labeled pore |
US6627067B1 (en) | 1999-06-22 | 2003-09-30 | President And Fellows Of Harvard College | Molecular and atomic scale evaluation of biopolymers |
US6696022B1 (en) | 1999-08-13 | 2004-02-24 | U.S. Genomics, Inc. | Methods and apparatuses for stretching polymers |
WO2004035212A1 (en) * | 2002-10-18 | 2004-04-29 | Wisconsin Alumni Research Foundation | Micro-channel long molecule manipulation system |
WO2004046709A1 (en) * | 2002-11-20 | 2004-06-03 | Richard Fritz Sauter | Method for analyzing molecules for molecule sequencing and spectrometer therefor |
US6762059B2 (en) | 1999-08-13 | 2004-07-13 | U.S. Genomics, Inc. | Methods and apparatuses for characterization of single polymers |
US6772070B2 (en) | 1998-08-13 | 2004-08-03 | U.S. Genomics, Inc. | Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer |
WO2004066185A1 (en) * | 2003-01-23 | 2004-08-05 | U.S. Genomics, Inc. | Methods for analyzing polymer populations |
US6908736B1 (en) | 1999-10-06 | 2005-06-21 | Medical Biosystems, Ltd. | DNA sequencing method |
EP1543155A2 (en) * | 2002-07-17 | 2005-06-22 | U.S. Genomics, Inc. | Methods and compositions for analyzing polymers using chimeric tags |
US6927065B2 (en) | 1999-08-13 | 2005-08-09 | U.S. Genomics, Inc. | Methods and apparatus for characterization of single polymers |
WO2005085849A2 (en) * | 2003-10-24 | 2005-09-15 | U S. Genomics, Inc | Biohazard identification by fluorescent immunoassay and single molecule detection |
EP1579201A1 (en) * | 2002-12-26 | 2005-09-28 | Applied Precision, LLC | System and method of illuminating living cells for imaging |
US7033764B2 (en) | 1999-05-19 | 2006-04-25 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
WO2006136991A1 (en) * | 2005-06-23 | 2006-12-28 | Koninklijke Philips Electronics N.V. | Luminescence sensors using sub-wavelength apertures or slits |
US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
US7175811B2 (en) | 2000-04-28 | 2007-02-13 | Edgelight Biosciences | Micro-array evanescent wave fluorescence detection device |
US7189503B2 (en) | 1995-03-17 | 2007-03-13 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US7217562B2 (en) | 2002-04-16 | 2007-05-15 | Princeton University | Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof |
US7238485B2 (en) | 2004-03-23 | 2007-07-03 | President And Fellows Of Harvard College | Methods and apparatus for characterizing polynucleotides |
US7262859B2 (en) | 2004-10-13 | 2007-08-28 | U.S. Genomics, Inc. | Systems and methods for measurement optimization |
US7282330B2 (en) | 2002-05-28 | 2007-10-16 | U.S. Genomics, Inc. | Methods and apparati using single polymer analysis |
US7302146B2 (en) | 2004-09-17 | 2007-11-27 | Pacific Biosciences Of California, Inc. | Apparatus and method for analysis of molecules |
US7351538B2 (en) | 2004-08-23 | 2008-04-01 | U.S. Genomics | Systems and methods for detecting and analyzing polymers |
US7371520B2 (en) | 2002-05-28 | 2008-05-13 | U.S. Genomics, Inc. | Methods and apparati using single polymer analysis |
EP1922419A2 (en) * | 2005-06-10 | 2008-05-21 | Applera Corporation | Method and system for multiplex genetic analysis |
WO2008078263A1 (en) | 2006-12-21 | 2008-07-03 | Koninklijke Philips Electronics N.V. | Aperture biosensor with trenches |
US7595160B2 (en) | 2004-01-13 | 2009-09-29 | U.S. Genomics, Inc. | Analyte detection using barcoded polymers |
US7670770B2 (en) | 2001-07-25 | 2010-03-02 | The Trustees Of Princeton University | Nanochannel arrays and their preparation and use for high throughput macromolecular analysis |
US7775368B2 (en) | 1995-04-03 | 2010-08-17 | Wisconsin Alumni Research Foundation | Micro-channel long molecule manipulation system |
US7846738B2 (en) | 2003-08-15 | 2010-12-07 | President And Fellows Of Harvard College | Study of polymer molecules and conformations with a nanopore |
US7888011B2 (en) | 2004-10-18 | 2011-02-15 | U.S. Genomics, Inc. | Methods for isolation of nucleic acids from prokaryotic spores |
US7939264B1 (en) | 1999-10-06 | 2011-05-10 | Gen-Probe Incorporated | DNA sequencing method |
US7977048B2 (en) | 2004-01-13 | 2011-07-12 | Pathogenetix, Inc. | Detection and quantification of analytes in solution using polymers |
US8142708B2 (en) | 1995-04-03 | 2012-03-27 | Wisconsin Alumni Research Foundation | Micro fluidic system for single molecule imaging |
US8168380B2 (en) | 1997-02-12 | 2012-05-01 | Life Technologies Corporation | Methods and products for analyzing polymers |
US8188223B2 (en) | 2005-05-18 | 2012-05-29 | Ablynx N.V. | Serum albumin binding proteins |
EP2465943A2 (en) | 2001-03-16 | 2012-06-20 | Kalim Mir | Linear polymer display |
US8423294B2 (en) | 2001-09-18 | 2013-04-16 | Pathogenetix, Inc. | High resolution linear analysis of polymers |
US8685708B2 (en) | 2012-04-18 | 2014-04-01 | Pathogenetix, Inc. | Device for preparing a sample |
US8703131B2 (en) | 2005-05-21 | 2014-04-22 | Ablynx N.V. | Nanobodies against tumor necrosis factor-alpha |
US8722327B2 (en) | 2007-03-28 | 2014-05-13 | Bionano Genomics, Inc. | Methods of macromolecular analysis using nanochannel arrays |
US8828211B2 (en) | 2010-06-08 | 2014-09-09 | President And Fellows Of Harvard College | Nanopore device with graphene supported artificial lipid membrane |
US8926813B2 (en) | 2008-09-03 | 2015-01-06 | Nabsys, Inc. | Devices and methods for determining the length of biopolymers and distances between probes bound thereto |
US8986528B2 (en) | 1995-03-17 | 2015-03-24 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US9028776B2 (en) | 2012-04-18 | 2015-05-12 | Toxic Report Llc | Device for stretching a polymer in a fluid sample |
US9051609B2 (en) | 2007-10-01 | 2015-06-09 | Nabsys, Inc. | Biopolymer Sequencing By Hybridization of probes to form ternary complexes and variable range alignment |
US9156905B2 (en) | 2001-10-24 | 2015-10-13 | Vib Vzw | Functional heavy chain antibodies, fragments thereof, library thereof and methods of production thereof |
EP2872652A4 (en) * | 2012-04-18 | 2016-03-09 | Pathogenetix Inc | Devices and methods for nucleic acid preparation and analysis |
US9434981B2 (en) | 2010-09-27 | 2016-09-06 | Nabsys 2.0 Llc | Assay methods using nicking endonucleases |
US9650668B2 (en) | 2008-09-03 | 2017-05-16 | Nabsys 2.0 Llc | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels |
US9678038B2 (en) | 2001-07-25 | 2017-06-13 | The Trustees Of Princeton University | Nanochannel arrays and their preparation and use for high throughput macromolecular analysis |
US9702003B2 (en) | 2010-11-16 | 2017-07-11 | Nabsys 2.0 Llc | Methods for sequencing a biomolecule by detecting relative positions of hybridized probes |
US9845500B2 (en) | 2000-12-01 | 2017-12-19 | Life Technologies Corporation | Enzymatic nucleic acid synthesis: compositions and methods for inhibiting pyrophosphorolysis |
US9914966B1 (en) | 2012-12-20 | 2018-03-13 | Nabsys 2.0 Llc | Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation |
WO2019021108A1 (en) | 2017-07-27 | 2019-01-31 | Universität Hamburg | A method to determine the throughput speed of a pore |
US10294516B2 (en) | 2013-01-18 | 2019-05-21 | Nabsys 2.0 Llc | Enhanced probe binding |
US11274341B2 (en) | 2011-02-11 | 2022-03-15 | NABsys, 2.0 LLC | Assay methods using DNA binding proteins |
US11705217B2 (en) | 2008-03-28 | 2023-07-18 | Pacific Biosciences Of California, Inc. | Sequencing using concatemers of copies of sense and antisense strands |
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JP2006522940A (en) * | 2003-04-10 | 2006-10-05 | ユー.エス. ジェノミクス, インコーポレイテッド | Manipulating polymers in microchannels |
US7580120B2 (en) * | 2005-04-07 | 2009-08-25 | Sysmex Corporation | Blood analyzer, sample analyzer, and flow cytometer |
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JP2009543023A (en) * | 2005-07-18 | 2009-12-03 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Light emitting sensor using multi-layer substrate structure |
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Citations (5)
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WO1996030508A1 (en) * | 1995-03-24 | 1996-10-03 | Ely Michael Rabani | Assembly of complex molecular and supramolecular objects and devices and uses thereof |
WO1996031522A1 (en) * | 1995-04-03 | 1996-10-10 | New York University | Methods for measuring physical characteristics of nucleic acids by microscopic imaging |
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WO1998035012A2 (en) * | 1997-02-12 | 1998-08-13 | Chan Eugene Y | Methods and products for analyzing polymers |
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US6150089A (en) * | 1988-09-15 | 2000-11-21 | New York University | Method and characterizing polymer molecules or the like |
US5624845A (en) * | 1995-03-16 | 1997-04-29 | International Business Machines Corporation | Assembly and a method suitable for identifying a code |
-
1999
- 1999-08-13 AU AU55606/99A patent/AU5560699A/en not_active Abandoned
- 1999-08-13 CA CA002340228A patent/CA2340228A1/en not_active Abandoned
- 1999-08-13 WO PCT/US1999/018438 patent/WO2000009757A1/en active Application Filing
- 1999-08-13 EP EP99942167A patent/EP1105535A1/en not_active Withdrawn
- 1999-08-13 IL IL14131099A patent/IL141310A0/en unknown
- 1999-08-13 CN CN99811963A patent/CN1323355A/en active Pending
- 1999-08-13 JP JP2000565191A patent/JP2002522780A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US5538898A (en) * | 1995-03-16 | 1996-07-23 | International Business Machines Corporation | Method suitable for identifying a code sequence of a biomolecule |
WO1996030508A1 (en) * | 1995-03-24 | 1996-10-03 | Ely Michael Rabani | Assembly of complex molecular and supramolecular objects and devices and uses thereof |
WO1996031522A1 (en) * | 1995-04-03 | 1996-10-10 | New York University | Methods for measuring physical characteristics of nucleic acids by microscopic imaging |
US5699157A (en) * | 1996-07-16 | 1997-12-16 | Caliper Technologies Corp. | Fourier detection of species migrating in a microchannel |
WO1998035012A2 (en) * | 1997-02-12 | 1998-08-13 | Chan Eugene Y | Methods and products for analyzing polymers |
Cited By (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9046483B2 (en) | 1995-03-17 | 2015-06-02 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US8986528B2 (en) | 1995-03-17 | 2015-03-24 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US7189503B2 (en) | 1995-03-17 | 2007-03-13 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US7775368B2 (en) | 1995-04-03 | 2010-08-17 | Wisconsin Alumni Research Foundation | Micro-channel long molecule manipulation system |
US8142708B2 (en) | 1995-04-03 | 2012-03-27 | Wisconsin Alumni Research Foundation | Micro fluidic system for single molecule imaging |
US8168380B2 (en) | 1997-02-12 | 2012-05-01 | Life Technologies Corporation | Methods and products for analyzing polymers |
US6772070B2 (en) | 1998-08-13 | 2004-08-03 | U.S. Genomics, Inc. | Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer |
US7943305B2 (en) | 1999-05-19 | 2011-05-17 | Cornell Research Foundation | High speed nucleic acid sequencing |
US7052847B2 (en) | 1999-05-19 | 2006-05-30 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
US7943307B2 (en) | 1999-05-19 | 2011-05-17 | Cornell Research Foundation | Methods for analyzing nucleic acid sequences |
US7485424B2 (en) | 1999-05-19 | 2009-02-03 | Cornell Research Foundation, Inc. | Labeled nucleotide phosphate (NP) probes |
US7416844B2 (en) | 1999-05-19 | 2008-08-26 | Cornell Research Foundation, Inc. | Composition for nucleic acid sequencing |
US7361466B2 (en) | 1999-05-19 | 2008-04-22 | Cornell Research Foundation, Inc. | Nucleic acid analysis using terminal-phosphate-labeled nucleotides |
US7056676B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
US7033764B2 (en) | 1999-05-19 | 2006-04-25 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
US6627067B1 (en) | 1999-06-22 | 2003-09-30 | President And Fellows Of Harvard College | Molecular and atomic scale evaluation of biopolymers |
EP1210578A4 (en) * | 1999-08-13 | 2007-02-21 | U S Genomics | Methods and apparatuses for stretching polymers |
EP1210578A1 (en) * | 1999-08-13 | 2002-06-05 | U.S. Genomics | Methods and apparatuses for stretching polymers |
US6762059B2 (en) | 1999-08-13 | 2004-07-13 | U.S. Genomics, Inc. | Methods and apparatuses for characterization of single polymers |
US6696022B1 (en) | 1999-08-13 | 2004-02-24 | U.S. Genomics, Inc. | Methods and apparatuses for stretching polymers |
US6927065B2 (en) | 1999-08-13 | 2005-08-09 | U.S. Genomics, Inc. | Methods and apparatus for characterization of single polymers |
US6528258B1 (en) | 1999-09-03 | 2003-03-04 | Lifebeam Technologies, Inc. | Nucleic acid sequencing using an optically labeled pore |
US7939264B1 (en) | 1999-10-06 | 2011-05-10 | Gen-Probe Incorporated | DNA sequencing method |
US6908736B1 (en) | 1999-10-06 | 2005-06-21 | Medical Biosystems, Ltd. | DNA sequencing method |
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JP2002048765A (en) * | 2000-08-03 | 2002-02-15 | Masabumi Youda | Sample introduction device for horizontal plane type gel electrophorestic device, horizontal plane type gel electrophorestic system, its sample introduction method and its sample collection method |
US9845500B2 (en) | 2000-12-01 | 2017-12-19 | Life Technologies Corporation | Enzymatic nucleic acid synthesis: compositions and methods for inhibiting pyrophosphorolysis |
EP2801624A1 (en) | 2001-03-16 | 2014-11-12 | Kalim Mir | Arrays and methods of use |
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US10161001B2 (en) | 2001-07-25 | 2018-12-25 | The Trustees Of Princeton University | Nanochannel arrays and their preparation and use for high throughput macromolecular analysis |
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US9389217B2 (en) | 2001-07-25 | 2016-07-12 | The Trustees Of Princeton University | Nanochannel arrays and their preparation and use for high throughput macromolecular analysis |
US7670770B2 (en) | 2001-07-25 | 2010-03-02 | The Trustees Of Princeton University | Nanochannel arrays and their preparation and use for high throughput macromolecular analysis |
US8423294B2 (en) | 2001-09-18 | 2013-04-16 | Pathogenetix, Inc. | High resolution linear analysis of polymers |
US9156905B2 (en) | 2001-10-24 | 2015-10-13 | Vib Vzw | Functional heavy chain antibodies, fragments thereof, library thereof and methods of production thereof |
US7217562B2 (en) | 2002-04-16 | 2007-05-15 | Princeton University | Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof |
US10551319B2 (en) | 2002-04-16 | 2020-02-04 | Princeton University | Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof |
US8333934B2 (en) | 2002-04-16 | 2012-12-18 | Princeton University | Gradient structures interfacing microfluidics and nanofluidics |
EP2484751A3 (en) * | 2002-04-16 | 2013-10-23 | Princeton University | Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof |
US9733185B2 (en) | 2002-04-16 | 2017-08-15 | Princeton University | Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof |
US7282330B2 (en) | 2002-05-28 | 2007-10-16 | U.S. Genomics, Inc. | Methods and apparati using single polymer analysis |
US7371520B2 (en) | 2002-05-28 | 2008-05-13 | U.S. Genomics, Inc. | Methods and apparati using single polymer analysis |
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CN1323355A (en) | 2001-11-21 |
AU5560699A (en) | 2000-03-06 |
WO2000009757A9 (en) | 2000-10-12 |
JP2002522780A (en) | 2002-07-23 |
EP1105535A1 (en) | 2001-06-13 |
IL141310A0 (en) | 2002-03-10 |
CA2340228A1 (en) | 2000-02-24 |
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