WO2000037063A2 - Triazineone compounds for treating diseases due to sarcosystis, neospora and toxoplasma - Google Patents
Triazineone compounds for treating diseases due to sarcosystis, neospora and toxoplasma Download PDFInfo
- Publication number
- WO2000037063A2 WO2000037063A2 PCT/US1999/030281 US9930281W WO0037063A2 WO 2000037063 A2 WO2000037063 A2 WO 2000037063A2 US 9930281 W US9930281 W US 9930281W WO 0037063 A2 WO0037063 A2 WO 0037063A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ponazuril
- neospora
- toxoplasma
- administered
- sarcocystis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Definitions
- Neospora caninum produces both a neurologic and abortigenic disease in animals. It was first isolated from dogs in 1988. It was previously confused with Toxoplasma gondii. The disease caused by this parasite occurs most severely in transplacentally infected puppies and is characterized by progressive ascending paralysis in the puppies, particularly of the hind limbs; polymyositis and hepatitis may also occur. This disease has more recently been recognized as a major cause of abortion and neurologically-associated limb defects in newborn calves. Microscopic lesions of non-suppurative encephalitis and myocarditis in aborted fetuses may be seen in the brain, spinal cord and heart. A definitive host for Neospora caninum has recently been identified to be the dog. At this time there is no approved treatment or prophylaxis for either Neospora caninum of dogs or bovines or Neospora hugesi of horses.
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR9916391-8A BR9916391A (en) | 1998-12-22 | 1999-12-18 | Triazineone compounds for the treatment of diseases caused by sarcosiste, neopora and toxoplasma |
DK99968140T DK1140103T3 (en) | 1998-12-22 | 1999-12-18 | Ponazuril for the treatment of neurological and abortion-causing diseases caused by Coccidia |
DE69926794T DE69926794T2 (en) | 1998-12-22 | 1999-12-18 | PONAZURIL FOR THE TREATMENT OF DISORDERS CAUSED BY COCCIDIA NEUROLOGICAL AND "ABORTIGENIC" |
CA002355825A CA2355825C (en) | 1998-12-22 | 1999-12-18 | Triazineone compounds for treating diseases due to sarcocystis, neospora and toxoplasma |
HU0104595A HUP0104595A3 (en) | 1998-12-22 | 1999-12-18 | Triazineone compounds for treating diseases due to sarcosystis, neospora and toxoplasma |
AT99968140T ATE302011T1 (en) | 1998-12-22 | 1999-12-18 | PONAZURIL FOR THE TREATMENT OF DISEASES CAUSED BY COCCIDIA NEUROLOGICAL AND ABORTIGENICS |
JP2000589174A JP2002532544A (en) | 1998-12-22 | 1999-12-18 | Triazine-on compounds for treating diseases caused by sarcocystis, neospora and toxoplasma |
EP99968140A EP1140103B1 (en) | 1998-12-22 | 1999-12-18 | Ponazuril for treating neurologic and abortigenic diseases caused by coccidia. |
AU24817/00A AU764608B2 (en) | 1998-12-22 | 1999-12-18 | Triazineone compounds for treating diseases due to sarcosystis, neospora and toxoplasma |
NZ512477A NZ512477A (en) | 1998-12-22 | 1999-12-18 | Triazineone compounds for treating diseases due to sarcosystis, neospora and toxoplasma |
HK02106846.1A HK1045266B (en) | 1998-12-22 | 2002-09-19 | Triazineone compounds for treating diseases due to sarcosystis, neospora and toxoplasma |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/218,323 US6150361A (en) | 1998-12-22 | 1998-12-22 | Triazineone compounds for treating diseases due to sarcosystis, neospora and toxoplasma |
US09/218,323 | 1998-12-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000037063A2 true WO2000037063A2 (en) | 2000-06-29 |
WO2000037063A3 WO2000037063A3 (en) | 2000-10-19 |
Family
ID=22814646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/030281 WO2000037063A2 (en) | 1998-12-22 | 1999-12-18 | Triazineone compounds for treating diseases due to sarcosystis, neospora and toxoplasma |
Country Status (17)
Country | Link |
---|---|
US (1) | US6150361A (en) |
EP (1) | EP1140103B1 (en) |
JP (1) | JP2002532544A (en) |
KR (1) | KR100661111B1 (en) |
CN (1) | CN1221265C (en) |
AT (1) | ATE302011T1 (en) |
AU (1) | AU764608B2 (en) |
BR (1) | BR9916391A (en) |
CA (1) | CA2355825C (en) |
DE (1) | DE69926794T2 (en) |
DK (1) | DK1140103T3 (en) |
ES (1) | ES2247863T3 (en) |
HK (1) | HK1045266B (en) |
HU (1) | HUP0104595A3 (en) |
NZ (1) | NZ512477A (en) |
WO (1) | WO2000037063A2 (en) |
ZA (1) | ZA200103920B (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001039778A2 (en) * | 1999-12-03 | 2001-06-07 | Bayer Aktiengesellschaft | Triazinone compounds for treating diseases resulting from infestation with parasitic protozoans |
DE102007025908A1 (en) | 2007-06-01 | 2008-12-04 | Bayer Healthcare Ag | Formulations containing triazinones and iron |
CZ300020B6 (en) * | 2000-08-17 | 2009-01-14 | Bayer Aktiengesellschaft | Use of triazinetrione sulfones for preparing medicaments and veterinary formulation in which the triazinetrione sulfones are comprised |
RU2484825C2 (en) * | 2006-08-16 | 2013-06-20 | Байер Интеллектуэль Проперти Гмбх | Transdermal use of triazines for coccidial infection control |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1189175C (en) * | 1998-10-08 | 2005-02-16 | 高新研究公司 | Novel compsns. and methods for prevention and treatment of protozoal disease |
CA2407517A1 (en) * | 2000-04-25 | 2001-11-01 | Wyeth | Equine protozoal myeloencephalitis vaccine |
DE102004001558A1 (en) * | 2004-01-10 | 2005-08-18 | Bayer Healthcare Ag | Medicinal products for topical application in animals |
DE102009012423A1 (en) * | 2009-03-10 | 2010-09-16 | Bayer Animal Health Gmbh | Preparation based on oil |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4219552A (en) * | 1977-04-27 | 1980-08-26 | Bayer Aktiengesellschaft | 1-(4-Phenoxy-phenyl)-1,3,5-triazines, their use as growth promoters |
WO1998043644A1 (en) * | 1997-03-31 | 1998-10-08 | David Granstrom | Formulations and methods to treat and prevent equine protozoal myeloencephalitis |
DE19824483A1 (en) * | 1998-06-02 | 1999-12-09 | Bayer Ag | Semi-solid aqueous preparations for oral application of toltrazuril sulfone |
WO2000019964A2 (en) * | 1998-10-08 | 2000-04-13 | New Ace Research Company | Novel compositions and methods for prevention and treatment of protozoal disease |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4933341A (en) * | 1988-10-08 | 1990-06-12 | Bayer Aktiengesellschaft | Substituted 1,3,5-triazinetriones, for use against parasitic protozoa |
US5883095A (en) * | 1997-08-07 | 1999-03-16 | University Of Kentucky Research Foundation | Formulations and methods to treat and prevent equine protozoal myeloencephalitis |
-
1998
- 1998-12-22 US US09/218,323 patent/US6150361A/en not_active Expired - Fee Related
-
1999
- 1999-12-18 JP JP2000589174A patent/JP2002532544A/en not_active Withdrawn
- 1999-12-18 DE DE69926794T patent/DE69926794T2/en not_active Expired - Lifetime
- 1999-12-18 CN CNB998148342A patent/CN1221265C/en not_active Expired - Fee Related
- 1999-12-18 AU AU24817/00A patent/AU764608B2/en not_active Ceased
- 1999-12-18 DK DK99968140T patent/DK1140103T3/en active
- 1999-12-18 BR BR9916391-8A patent/BR9916391A/en not_active Application Discontinuation
- 1999-12-18 ES ES99968140T patent/ES2247863T3/en not_active Expired - Lifetime
- 1999-12-18 KR KR1020017006549A patent/KR100661111B1/en not_active IP Right Cessation
- 1999-12-18 EP EP99968140A patent/EP1140103B1/en not_active Expired - Lifetime
- 1999-12-18 WO PCT/US1999/030281 patent/WO2000037063A2/en active IP Right Grant
- 1999-12-18 CA CA002355825A patent/CA2355825C/en not_active Expired - Fee Related
- 1999-12-18 NZ NZ512477A patent/NZ512477A/en not_active IP Right Cessation
- 1999-12-18 HU HU0104595A patent/HUP0104595A3/en unknown
- 1999-12-18 AT AT99968140T patent/ATE302011T1/en not_active IP Right Cessation
-
2001
- 2001-05-15 ZA ZA200103920A patent/ZA200103920B/en unknown
-
2002
- 2002-09-19 HK HK02106846.1A patent/HK1045266B/en not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4219552A (en) * | 1977-04-27 | 1980-08-26 | Bayer Aktiengesellschaft | 1-(4-Phenoxy-phenyl)-1,3,5-triazines, their use as growth promoters |
WO1998043644A1 (en) * | 1997-03-31 | 1998-10-08 | David Granstrom | Formulations and methods to treat and prevent equine protozoal myeloencephalitis |
DE19824483A1 (en) * | 1998-06-02 | 1999-12-09 | Bayer Ag | Semi-solid aqueous preparations for oral application of toltrazuril sulfone |
WO2000019964A2 (en) * | 1998-10-08 | 2000-04-13 | New Ace Research Company | Novel compositions and methods for prevention and treatment of protozoal disease |
Non-Patent Citations (2)
Title |
---|
KRAMPITZ H E ET AL: "EXPERIMENTAL TREATMENT OF HEPATOZOON INFECTIONS WITH THE ANTICOCCIDIAL AGENT TOLTRAZURIL" JOURNAL OF VETERINARY MEDICINE. SERIES B - ZENTRALBLATT FUER VETERINAERMEDIZIN. REINE B,DE,PAUL PAREY, BERLIN, vol. 35, no. 2, 1988, pages 131-137, XP000882187 ISSN: 0931-1793 * |
LINDSAY D S ET AL: "Examination of the activities of 43 chemotherapeutic agents against Neospora caninum tachyzoites in cultured cells" AMERICAN JOURNAL OF VETERINARY RESEARCH,XX,XX, vol. 55, no. 7, July 1994 (1994-07), pages 976-981-981, XP002101367 ISSN: 0002-9645 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001039778A2 (en) * | 1999-12-03 | 2001-06-07 | Bayer Aktiengesellschaft | Triazinone compounds for treating diseases resulting from infestation with parasitic protozoans |
WO2001039778A3 (en) * | 1999-12-03 | 2002-01-31 | Bayer Ag | Triazinone compounds for treating diseases resulting from infestation with parasitic protozoans |
US9399037B2 (en) | 1999-12-03 | 2016-07-26 | Bayer Intellectual Property Gmbh | Triazinone compounds for treating diseases resulting from infestation with parasitic protozoans |
CZ300020B6 (en) * | 2000-08-17 | 2009-01-14 | Bayer Aktiengesellschaft | Use of triazinetrione sulfones for preparing medicaments and veterinary formulation in which the triazinetrione sulfones are comprised |
RU2484825C2 (en) * | 2006-08-16 | 2013-06-20 | Байер Интеллектуэль Проперти Гмбх | Transdermal use of triazines for coccidial infection control |
RU2484825C9 (en) * | 2006-08-16 | 2013-11-20 | Байер Интеллектуэль Проперти Гмбх | Transdermal use of triazines for coccidial infection control |
DE102007025908A1 (en) | 2007-06-01 | 2008-12-04 | Bayer Healthcare Ag | Formulations containing triazinones and iron |
EP3692993A1 (en) | 2007-06-01 | 2020-08-12 | Bayer Animal Health GmbH | Formulations containing triazinones and iron |
Also Published As
Publication number | Publication date |
---|---|
HUP0104595A2 (en) | 2002-04-29 |
DE69926794T2 (en) | 2006-01-19 |
US6150361A (en) | 2000-11-21 |
AU2481700A (en) | 2000-07-12 |
HK1045266B (en) | 2006-07-07 |
EP1140103B1 (en) | 2005-08-17 |
HUP0104595A3 (en) | 2003-10-28 |
ATE302011T1 (en) | 2005-09-15 |
BR9916391A (en) | 2001-09-18 |
CA2355825A1 (en) | 2000-06-29 |
CA2355825C (en) | 2008-07-08 |
KR100661111B1 (en) | 2006-12-26 |
AU764608B2 (en) | 2003-08-28 |
DK1140103T3 (en) | 2005-12-19 |
DE69926794D1 (en) | 2005-09-22 |
ES2247863T3 (en) | 2006-03-01 |
CN1342081A (en) | 2002-03-27 |
WO2000037063A3 (en) | 2000-10-19 |
JP2002532544A (en) | 2002-10-02 |
NZ512477A (en) | 2004-05-28 |
ZA200103920B (en) | 2002-05-15 |
HK1045266A1 (en) | 2002-11-22 |
EP1140103A2 (en) | 2001-10-10 |
KR20010080570A (en) | 2001-08-22 |
CN1221265C (en) | 2005-10-05 |
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