WO2000037917A3 - Systems and methods for optical examination of samples - Google Patents

Systems and methods for optical examination of samples Download PDF

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Publication number
WO2000037917A3
WO2000037917A3 PCT/US1999/031001 US9931001W WO0037917A3 WO 2000037917 A3 WO2000037917 A3 WO 2000037917A3 US 9931001 W US9931001 W US 9931001W WO 0037917 A3 WO0037917 A3 WO 0037917A3
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WO
WIPO (PCT)
Prior art keywords
systems
methods
sample
certain embodiments
samples
Prior art date
Application number
PCT/US1999/031001
Other languages
French (fr)
Other versions
WO2000037917A2 (en
Inventor
Robert Nordstrom
Mark Modell
Alexander Zelenchuk
Original Assignee
Medispectra Inc
Robert Nordstrom
Mark Modell
Alexander Zelenchuk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medispectra Inc, Robert Nordstrom, Mark Modell, Alexander Zelenchuk filed Critical Medispectra Inc
Priority to EP99968963A priority Critical patent/EP1161178A2/en
Priority to AU27153/00A priority patent/AU759282B2/en
Priority to CA002356623A priority patent/CA2356623C/en
Priority to JP2000589927A priority patent/JP2002533142A/en
Publication of WO2000037917A2 publication Critical patent/WO2000037917A2/en
Publication of WO2000037917A3 publication Critical patent/WO2000037917A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0068—Confocal scanning

Abstract

The present invention relates to systems and methods for examining a sample using a substantially monostatic, substantially confocal optical system comprising transmitting optics that focus an illuminating light upon the sample and receiving optics that collect light emitted from the sample following illumination thereof. In certain embodiments, the receiving optics may be arranged circumferentially around the light path traversed by the illuminating light. In certain embodiments, video apparatus may be included to produce images or to align the system in proximity to the target tissue. The systems and methods of the present invention may be directed towards the examination of a body tissue to provide a medical diagnosis.
PCT/US1999/031001 1998-12-23 1999-12-22 Systems and methods for optical examination of samples WO2000037917A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99968963A EP1161178A2 (en) 1998-12-23 1999-12-22 Systems and methods for optical examination of samples
AU27153/00A AU759282B2 (en) 1998-12-23 1999-12-22 Systems and methods for optical examination of samples
CA002356623A CA2356623C (en) 1998-12-23 1999-12-22 Systems and methods for optical examination of samples
JP2000589927A JP2002533142A (en) 1998-12-23 1999-12-22 Systems and methods for optical testing of samples

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11376198P 1998-12-23 1998-12-23
US60/113,761 1998-12-23

Publications (2)

Publication Number Publication Date
WO2000037917A2 WO2000037917A2 (en) 2000-06-29
WO2000037917A3 true WO2000037917A3 (en) 2001-08-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/031001 WO2000037917A2 (en) 1998-12-23 1999-12-22 Systems and methods for optical examination of samples

Country Status (6)

Country Link
US (6) US6411838B1 (en)
EP (1) EP1161178A2 (en)
JP (1) JP2002533142A (en)
AU (1) AU759282B2 (en)
CA (1) CA2356623C (en)
WO (1) WO2000037917A2 (en)

Families Citing this family (192)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010041843A1 (en) * 1999-02-02 2001-11-15 Mark Modell Spectral volume microprobe arrays
US6826422B1 (en) * 1997-01-13 2004-11-30 Medispectra, Inc. Spectral volume microprobe arrays
EP1161178A2 (en) 1998-12-23 2001-12-12 Medispectra Inc. Systems and methods for optical examination of samples
JP2000275757A (en) * 1999-03-24 2000-10-06 Fuji Photo Film Co Ltd Method and device for evaluating image
US7299080B2 (en) * 1999-10-08 2007-11-20 Sensys Medical, Inc. Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy
WO2000068683A1 (en) * 1999-05-10 2000-11-16 Tomoya Sato Method and apparatus for determining the type and/or condition of disease and method and apparatus for screening drug
US7280866B1 (en) * 1999-10-06 2007-10-09 National Research Council Of Canada Non-invasive screening of skin diseases by visible/near-infrared spectroscopy
US20020007122A1 (en) * 1999-12-15 2002-01-17 Howard Kaufman Methods of diagnosing disease
US20070020662A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computerized control of high-throughput experimental processing and digital analysis of comparative samples for a compound of interest
US20050118637A9 (en) * 2000-01-07 2005-06-02 Levinson Douglas A. Method and system for planning, performing, and assessing high-throughput screening of multicomponent chemical compositions and solid forms of compounds
US7108970B2 (en) * 2000-01-07 2006-09-19 Transform Pharmaceuticals, Inc. Rapid identification of conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state
US20020048610A1 (en) * 2000-01-07 2002-04-25 Cima Michael J. High-throughput formation, identification, and analysis of diverse solid-forms
US20050095696A9 (en) * 2000-01-07 2005-05-05 Lemmo Anthony V. Apparatus and method for high-throughput preparation and characterization of compositions
US20040252299A9 (en) * 2000-01-07 2004-12-16 Lemmo Anthony V. Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions
US20070021929A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computing methods for control of high-throughput experimental processing, digital analysis, and re-arraying comparative samples in computer-designed arrays
US20050089923A9 (en) * 2000-01-07 2005-04-28 Levinson Douglas A. Method and system for planning, performing, and assessing high-throughput screening of multicomponent chemical compositions and solid forms of compounds
GB0008563D0 (en) * 2000-04-07 2000-05-24 Cambridge Discovery Chemistry Investigating different physical and/or chemical forms of materials
US20060211931A1 (en) * 2000-05-02 2006-09-21 Blank Thomas B Noninvasive analyzer sample probe interface method and apparatus
US7606608B2 (en) * 2000-05-02 2009-10-20 Sensys Medical, Inc. Optical sampling interface system for in-vivo measurement of tissue
US7519406B2 (en) * 2004-04-28 2009-04-14 Sensys Medical, Inc. Noninvasive analyzer sample probe interface method and apparatus
US6530882B1 (en) * 2000-06-30 2003-03-11 Inner Vision Imaging, L.L.C. Endoscope having microscopic and macroscopic magnification
WO2002007585A2 (en) * 2000-07-13 2002-01-31 Virginia Commonwealth University Tissue interrogation spectroscopy
US20020160470A1 (en) * 2000-11-13 2002-10-31 Genoptix Methods and apparatus for generating and utilizing linear moving optical gradients
US20020121443A1 (en) * 2000-11-13 2002-09-05 Genoptix Methods for the combined electrical and optical identification, characterization and/or sorting of particles
US20020123112A1 (en) * 2000-11-13 2002-09-05 Genoptix Methods for increasing detection sensitivity in optical dielectric sorting systems
US20030007894A1 (en) * 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
US6936811B2 (en) * 2000-11-13 2005-08-30 Genoptix, Inc. Method for separating micro-particles
US6839661B2 (en) * 2000-12-15 2005-01-04 Medispectra, Inc. System for normalizing spectra
US6638231B2 (en) 2000-12-18 2003-10-28 Biosense, Inc. Implantable telemetric medical sensor and method
US6652464B2 (en) 2000-12-18 2003-11-25 Biosense, Inc. Intracardiac pressure monitoring method
US6636769B2 (en) 2000-12-18 2003-10-21 Biosense, Inc. Telemetric medical system and method
US6783499B2 (en) * 2000-12-18 2004-08-31 Biosense, Inc. Anchoring mechanism for implantable telemetric medical sensor
US20060129329A1 (en) * 2001-04-09 2006-06-15 Kobylecki Ryszard J Investigating different physical and/or chemical forms of materials
US20040009540A1 (en) * 2001-04-27 2004-01-15 Genoptix, Inc Detection and evaluation of cancer cells using optophoretic analysis
US20030124516A1 (en) * 2001-04-27 2003-07-03 Genoptix, Inc. Method of using optical interrogation to determine a biological property of a cell or population of cells
US20040023310A1 (en) * 2001-04-27 2004-02-05 Genoptix, Inc Quantitative determination of protein kinase C activation using optophoretic analysis
US20030194755A1 (en) * 2001-04-27 2003-10-16 Genoptix, Inc. Early detection of apoptotic events and apoptosis using optophoretic analysis
US7822621B1 (en) 2001-05-16 2010-10-26 Perot Systems Corporation Method of and system for populating knowledge bases using rule based systems and object-oriented software
US7831442B1 (en) 2001-05-16 2010-11-09 Perot Systems Corporation System and method for minimizing edits for medical insurance claims processing
US7956996B2 (en) * 2007-02-14 2011-06-07 Chemimage Corporation Distinguishing between invasive ductal carcinoma and invasive lobular carcinoma using raman molecular imaging
US7808633B2 (en) * 2007-02-14 2010-10-05 Chemimage Corporation Spectroscopic system and method for predicting outcome of disease
US20030065477A1 (en) * 2001-08-30 2003-04-03 Opdyke John D. Two-sample permutation tests
US20030106492A1 (en) * 2001-09-07 2003-06-12 Douglas Levinson Apparatus and method for high-throughput preparation, visualization and screening of compositions
JP3944383B2 (en) * 2001-11-16 2007-07-11 株式会社日立製作所 Cardiac magnetic field measuring device
FI113497B (en) * 2002-02-28 2004-04-30 Vaisala Oyj light Radar
US8504128B2 (en) * 2002-03-08 2013-08-06 Glt Acquisition Corp. Method and apparatus for coupling a channeled sample probe to tissue
CN100421615C (en) * 2002-03-08 2008-10-01 三西斯医学股份有限公司 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy
US20050054908A1 (en) * 2003-03-07 2005-03-10 Blank Thomas B. Photostimulation method and apparatus in combination with glucose determination
US20070149868A1 (en) * 2002-03-08 2007-06-28 Blank Thomas B Method and Apparatus for Photostimulation Enhanced Analyte Property Estimation
US20050187439A1 (en) * 2003-03-07 2005-08-25 Blank Thomas B. Sampling interface system for in-vivo estimation of tissue analyte concentration
US8718738B2 (en) * 2002-03-08 2014-05-06 Glt Acquisition Corp. Method and apparatus for coupling a sample probe with a sample site
US7697966B2 (en) * 2002-03-08 2010-04-13 Sensys Medical, Inc. Noninvasive targeting system method and apparatus
US7440786B2 (en) * 2002-03-08 2008-10-21 Sensys Medical, Inc. Method and apparatus for presentation of noninvasive glucose concentration information
US8131332B2 (en) * 2002-04-04 2012-03-06 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence of various sites
US7725144B2 (en) * 2002-04-04 2010-05-25 Veralight, Inc. Determination of disease state using raman spectroscopy of tissue
US20040033539A1 (en) * 2002-05-01 2004-02-19 Genoptix, Inc Method of using optical interrogation to determine a biological property of a cell or population of cells
US20030211461A1 (en) * 2002-05-01 2003-11-13 Genoptix, Inc Optophoretic detection of durgs exhibiting inhibitory effect on Bcr-Abl positive tumor cells
US7309867B2 (en) * 2003-04-18 2007-12-18 Medispectra, Inc. Methods and apparatus for characterization of tissue samples
US7469160B2 (en) * 2003-04-18 2008-12-23 Banks Perry S Methods and apparatus for evaluating image focus
US7459696B2 (en) * 2003-04-18 2008-12-02 Schomacker Kevin T Methods and apparatus for calibrating spectral data
US6818903B2 (en) * 2002-07-09 2004-11-16 Medispectra, Inc. Method and apparatus for identifying spectral artifacts
US6933154B2 (en) * 2002-07-09 2005-08-23 Medispectra, Inc. Optimal windows for obtaining optical data for characterization of tissue samples
US7136518B2 (en) * 2003-04-18 2006-11-14 Medispectra, Inc. Methods and apparatus for displaying diagnostic data
US20040208385A1 (en) * 2003-04-18 2004-10-21 Medispectra, Inc. Methods and apparatus for visually enhancing images
US6768918B2 (en) 2002-07-10 2004-07-27 Medispectra, Inc. Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof
US7373198B2 (en) * 2002-07-12 2008-05-13 Bionova Technologies Inc. Method and apparatus for the estimation of anesthetic depth using wavelet analysis of the electroencephalogram
US7060075B2 (en) * 2002-07-18 2006-06-13 Biosense, Inc. Distal targeting of locking screws in intramedullary nails
US6925322B2 (en) * 2002-07-25 2005-08-02 Biophan Technologies, Inc. Optical MRI catheter system
US20040064053A1 (en) * 2002-09-30 2004-04-01 Chang Sung K. Diagnostic fluorescence and reflectance
US20040121474A1 (en) * 2002-12-19 2004-06-24 Genoptix, Inc Detection and evaluation of chemically-mediated and ligand-mediated t-cell activation using optophoretic analysis
US20040121307A1 (en) * 2002-12-19 2004-06-24 Genoptix, Inc Early detection of cellular differentiation using optophoresis
US7252659B2 (en) * 2003-02-07 2007-08-07 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Implanted surgical drain with sensing and transmitting elements for monitoring internal tissue condition
JP4041421B2 (en) * 2003-03-25 2008-01-30 独立行政法人理化学研究所 Raman probe and Raman scattering measuring apparatus using the same
US7184626B1 (en) * 2003-04-07 2007-02-27 Luxtera, Inc Wafer-level testing of optical and optoelectronic chips
US20050119587A1 (en) * 2003-07-01 2005-06-02 University Of Michigan Method and apparatus for evaluating connective tissue conditions
US8417322B2 (en) 2003-07-01 2013-04-09 Regents Of The University Of Michigan Method and apparatus for diagnosing bone tissue conditions
CA2536360C (en) * 2003-08-28 2013-08-06 Celula, Inc. Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
US20070234300A1 (en) * 2003-09-18 2007-10-04 Leake David W Method and Apparatus for Performing State-Table Driven Regression Testing
US7908690B2 (en) * 2003-09-30 2011-03-22 Sentinelle Medical, Inc. Supine patient support for medical imaging
US20080077005A1 (en) * 2004-08-12 2008-03-27 Piron Cameron A System and Method for Multimodality Breast Imaging
US7970452B2 (en) * 2003-09-30 2011-06-28 Hologic, Inc. Open architecture imaging apparatus and coil system for magnetic resonance imaging
US7379769B2 (en) * 2003-09-30 2008-05-27 Sunnybrook Health Sciences Center Hybrid imaging method to monitor medical device delivery and patient support for use in the method
DE10355150B4 (en) * 2003-11-26 2021-01-14 Leica Microsystems Cms Gmbh Method and system for the analysis of co-localizations
CA2547460A1 (en) * 2003-11-28 2005-06-09 Haishan Zeng Multimodal detection of tissue abnormalities based on raman and background fluorescence spectroscopy
JP4601965B2 (en) 2004-01-09 2010-12-22 浜松ホトニクス株式会社 Laser processing method and laser processing apparatus
JP4598407B2 (en) * 2004-01-09 2010-12-15 浜松ホトニクス株式会社 Laser processing method and laser processing apparatus
JP4509578B2 (en) 2004-01-09 2010-07-21 浜松ホトニクス株式会社 Laser processing method and laser processing apparatus
US20050215876A1 (en) * 2004-03-25 2005-09-29 Eastman Kodak Company Method and system for automatic image adjustment for in vivo image diagnosis
US20080033275A1 (en) * 2004-04-28 2008-02-07 Blank Thomas B Method and Apparatus for Sample Probe Movement Control
US8868147B2 (en) * 2004-04-28 2014-10-21 Glt Acquisition Corp. Method and apparatus for controlling positioning of a noninvasive analyzer sample probe
US7697576B2 (en) * 2004-05-05 2010-04-13 Chem Image Corporation Cytological analysis by raman spectroscopic imaging
US7316904B1 (en) 2004-06-30 2008-01-08 Chromodynamics, Inc. Automated pap screening using optical detection of HPV with or without multispectral imaging
WO2006019991A2 (en) * 2004-07-15 2006-02-23 Cheminage Corporation Method and apparatus for multimodal detection
US7254501B1 (en) * 2004-12-10 2007-08-07 Ahura Corporation Spectrum searching method that uses non-chemical qualities of the measurement
US7298938B2 (en) * 2004-10-01 2007-11-20 University Of Washington Configuration memory for a scanning beam device
US8929688B2 (en) * 2004-10-01 2015-01-06 University Of Washington Remapping methods to reduce distortions in images
JP2006145810A (en) * 2004-11-19 2006-06-08 Canon Inc Automatic focusing apparatus, laser beam machining apparatus and laser beam cutter
JP5367267B2 (en) * 2004-11-26 2013-12-11 ロレアル How to observe biological tissue, especially human skin
FR2878424B1 (en) * 2004-11-26 2008-02-01 Oreal METHOD FOR OBSERVING A BIOLOGICAL TISSUE, IN PARTICULAR HUMAN SKIN
US7854705B2 (en) * 2004-12-16 2010-12-21 Olga Pawluczyk Ex vivo verification of biopsy tissue samples
US8244332B2 (en) * 2004-12-22 2012-08-14 Siemens Medical Solutions Usa, Inc. Three-dimensional breast anatomy imaging system
US7159782B2 (en) * 2004-12-23 2007-01-09 University Of Washington Methods of driving a scanning beam device to achieve high frame rates
US7784697B2 (en) 2004-12-23 2010-08-31 University Of Washington Methods of driving a scanning beam device to achieve high frame rates
US7524445B2 (en) * 2004-12-31 2009-04-28 Boston Scientific Scimed, Inc. Method for making ePTFE and structure containing such ePTFE, such as a vascular graft
US8057083B2 (en) * 2005-01-21 2011-11-15 Optiscan Pty, Ltd. Fibre bundle confocal endomicroscope
US7189961B2 (en) * 2005-02-23 2007-03-13 University Of Washington Scanning beam device with detector assembly
US20060217602A1 (en) * 2005-03-04 2006-09-28 Alan Abul-Haj Method and apparatus for noninvasive targeting
US7219038B2 (en) * 2005-03-22 2007-05-15 College Of William And Mary Automatic peak identification method
US20060226231A1 (en) * 2005-03-29 2006-10-12 University Of Washington Methods and systems for creating sequential color images
US7627059B2 (en) * 2005-04-05 2009-12-01 Samsung Electronics Co., Ltd. Method of robust timing detection and carrier frequency offset estimation for OFDM systems
US7616699B2 (en) * 2005-04-12 2009-11-10 Samsung Electronics Co., Ltd. Method of soft bit metric calculation with direct matrix inversion MIMO detection
EP1902301A4 (en) 2005-07-14 2010-09-22 Chemimage Corp Time and space resolved standoff hyperspectral ied explosives lidar detector
US7679740B2 (en) * 2005-07-14 2010-03-16 Chemimage Corporation Method and apparatus for multimodal detection
US8582089B2 (en) * 2006-06-09 2013-11-12 Chemimage Corporation System and method for combined raman, SWIR and LIBS detection
US7395967B2 (en) * 2005-07-21 2008-07-08 University Of Washington Methods and systems for counterbalancing a scanning beam device
US7312879B2 (en) * 2005-08-23 2007-12-25 University Of Washington Distance determination in a scanned beam image capture device
US8514385B2 (en) * 2005-08-26 2013-08-20 Camtek Ltd Device and method for inspecting an object
US7729749B2 (en) * 2005-09-01 2010-06-01 The Regents Of The University Of Michigan Method and apparatus for evaluating connective tissue conditions
US7450228B2 (en) 2005-11-09 2008-11-11 Chemimage Corporation Spectral imaging of biofilms
US20070178067A1 (en) * 2005-11-09 2007-08-02 John Maier System and method for cytological analysis by raman spectroscopic imaging
US20070161876A1 (en) 2005-11-18 2007-07-12 Spectrx, Inc. Method and apparatus for rapid detection and diagnosis of tissue abnormalities
US7751506B2 (en) 2005-12-01 2010-07-06 Samsung Electronics Co., Ltd. Method for the soft bit metric calculation with linear MIMO detection for LDPC codes
US8368880B2 (en) * 2005-12-23 2013-02-05 Chemimage Corporation Chemical imaging explosives (CHIMED) optical sensor using SWIR
US7692776B2 (en) * 2005-12-23 2010-04-06 Chem Image Corporation Chemical imaging explosives (CHIMED) optical sensor
US8379197B2 (en) * 2006-01-05 2013-02-19 Chemimage Corporation Spectroscopic systems and methods for classifying and pharmaceutically treating cells
WO2007081874A2 (en) * 2006-01-05 2007-07-19 Chemimage Corporation System and method for clasifying cells and the pharmaceutical treatment of such cells using raman spectroscopy
US7996173B2 (en) 2006-07-31 2011-08-09 Visualant, Inc. Method, apparatus, and article to facilitate distributed evaluation of objects using electromagnetic energy
JP2009545746A (en) 2006-07-31 2009-12-24 ヴィジュアラント，インコーポレイテッド System and method for evaluating objects using electromagnetic energy
US8081304B2 (en) 2006-07-31 2011-12-20 Visualant, Inc. Method, apparatus, and article to facilitate evaluation of objects using electromagnetic energy
US7680373B2 (en) * 2006-09-13 2010-03-16 University Of Washington Temperature adjustment in scanning beam devices
US7447415B2 (en) * 2006-12-15 2008-11-04 University Of Washington Attaching optical fibers to actuator tubes with beads acting as spacers and adhesives
US7738762B2 (en) * 2006-12-15 2010-06-15 University Of Washington Attaching optical fibers to actuator tubes with beads acting as spacers and adhesives
US8305432B2 (en) 2007-01-10 2012-11-06 University Of Washington Scanning beam device calibration
US7990532B2 (en) 2007-01-16 2011-08-02 Chemimage Corporation Method and apparatus for multimodal detection
US8155417B2 (en) 2007-03-27 2012-04-10 Hologic, Inc. Post-acquisition adaptive reconstruction of MRI data
US7583872B2 (en) * 2007-04-05 2009-09-01 University Of Washington Compact scanning fiber device
US7608842B2 (en) * 2007-04-26 2009-10-27 University Of Washington Driving scanning fiber devices with variable frequency drive signals
US20080281207A1 (en) * 2007-05-08 2008-11-13 University Of Washington Image acquisition through filtering in multiple endoscope systems
US20080281159A1 (en) * 2007-05-08 2008-11-13 University Of Washington Coordinating image acquisition among multiple endoscopes
US8212884B2 (en) * 2007-05-22 2012-07-03 University Of Washington Scanning beam device having different image acquisition modes
US8437587B2 (en) * 2007-07-25 2013-05-07 University Of Washington Actuating an optical fiber with a piezoelectric actuator and detecting voltages generated by the piezoelectric actuator
GB2451442B (en) * 2007-07-30 2013-03-06 Lein Applied Diagnostics Ltd Optical measurement apparatus and method therefor
US20090036759A1 (en) * 2007-08-01 2009-02-05 Ault Timothy E Collapsible noninvasive analyzer method and apparatus
US8013991B2 (en) * 2007-08-08 2011-09-06 Chemimage Corporation Raman difference spectra based disease classification
US7522813B1 (en) * 2007-10-04 2009-04-21 University Of Washington Reducing distortion in scanning fiber devices
EP2209412B1 (en) * 2007-11-12 2018-08-29 Cornell University Multi-path, multi-magnification, non-confocal fluorescence emission endoscopy apparatus and methods
US8290569B2 (en) 2007-11-23 2012-10-16 Hologic, Inc. Open architecture tabletop patient support and coil system
US8411922B2 (en) * 2007-11-30 2013-04-02 University Of Washington Reducing noise in images acquired with a scanning beam device
US8725477B2 (en) * 2008-04-10 2014-05-13 Schlumberger Technology Corporation Method to generate numerical pseudocores using borehole images, digital rock samples, and multi-point statistics
US9581723B2 (en) 2008-04-10 2017-02-28 Schlumberger Technology Corporation Method for characterizing a geological formation traversed by a borehole
US20110004080A1 (en) * 2008-04-11 2011-01-06 Glucovista, Llc Method for non-invasive analysis of a substance concentration within a body
US8611975B2 (en) * 2009-10-28 2013-12-17 Gluco Vista, Inc. Apparatus and method for non-invasive measurement of a substance within a body
CA3194784A1 (en) 2008-05-20 2009-11-26 University Health Network Device and method for fluorescence-based imaging and monitoring
US8954133B1 (en) * 2008-08-08 2015-02-10 The United States Of America As Represented By The Department Of Veterans Affairs Spectroscopic detection of brain damage
US8077386B2 (en) * 2008-10-22 2011-12-13 Microbrightfield, Inc. Movable objective lens assembly for an optical microscope and optical microscopes having such an assembly
WO2010118178A2 (en) 2009-04-07 2010-10-14 Garfield Robert E Uterine electrical stimulation system and method
US20110004447A1 (en) * 2009-07-01 2011-01-06 Schlumberger Technology Corporation Method to build 3D digital models of porous media using transmitted laser scanning confocal mircoscopy and multi-point statistics
US8311788B2 (en) * 2009-07-01 2012-11-13 Schlumberger Technology Corporation Method to quantify discrete pore shapes, volumes, and surface areas using confocal profilometry
EP2445413B1 (en) * 2009-06-23 2020-02-12 Invivo Corporation Variable angle guide holder for a biopsy guide plug
WO2011017706A1 (en) * 2009-08-07 2011-02-10 Catholic Healthcare West Cervical, fetal-membrane, and amniotic examination and assessment device and method
US9103714B2 (en) * 2009-10-06 2015-08-11 Chemimage Corporation System and methods for explosives detection using SWIR
US8903466B2 (en) 2009-10-28 2014-12-02 Glucovista Inc. Apparatus and method for non-invasive measurement of a substance within a body
US9019262B2 (en) * 2009-11-27 2015-04-28 Hologic, Inc. Systems and methods for tracking positions between imaging modalities and transforming a displayed three-dimensional image corresponding to a position and orientation of a probe
US8988680B2 (en) 2010-04-30 2015-03-24 Chemimage Technologies Llc Dual polarization with liquid crystal tunable filters
US7884933B1 (en) 2010-05-05 2011-02-08 Revolutionary Business Concepts, Inc. Apparatus and method for determining analyte concentrations
US9151769B2 (en) * 2010-07-02 2015-10-06 Idexx Laboratories, Inc. Automated calibration method and system for a diagnostic analyzer
JP5604248B2 (en) * 2010-09-28 2014-10-08 富士フイルム株式会社 Endoscopic image display device
CA3023152C (en) 2010-10-27 2020-01-07 Dignity Health Uterine electrical stimulation system and method
US9872983B2 (en) 2010-10-27 2018-01-23 Dignity Health Uterine electrical stimulation system and method
US9913596B2 (en) 2010-11-25 2018-03-13 Invivo Corporation Systems and methods for MRI guided trans-orifice and transperineal intervention apparatus with adjustable biopsy needle insertion
KR101691156B1 (en) * 2010-12-14 2016-12-30 삼성전자주식회사 Optical system having integrated illumination and imaging systems and 3D image acquisition apparatus including the optical system
EP2665408B1 (en) * 2011-01-18 2021-08-11 University Health Network (UHN) Device for swallowing impairment detection
WO2013119824A1 (en) 2012-02-10 2013-08-15 Visualant, Inc. Systems, methods and articles related to machine-readable indicia and symbols
EP2852324A4 (en) 2012-05-21 2016-02-24 Univ Colorado Regents Three-dimensional mapping and therapy of prostate cancer
US9814448B2 (en) 2012-05-21 2017-11-14 Precision Biopsy, Inc. Three-dimensional optical imaging and therapy of prostate cancer
US9076246B2 (en) 2012-08-09 2015-07-07 Hologic, Inc. System and method of overlaying images of different modalities
JP2014106116A (en) * 2012-11-28 2014-06-09 Shimadzu Corp Plastic determination device
US9316581B2 (en) 2013-02-04 2016-04-19 Visualant, Inc. Method, apparatus, and article to facilitate evaluation of substances using electromagnetic energy
WO2014121389A1 (en) * 2013-02-05 2014-08-14 Rafal Pawluczyk Fibre optic probe for remote spectroscopy
US9041920B2 (en) 2013-02-21 2015-05-26 Visualant, Inc. Device for evaluation of fluids using electromagnetic energy
WO2014165003A1 (en) 2013-03-12 2014-10-09 Visualant, Inc. Systems and methods for fluid analysis using electromagnetic energy
EP2973217B1 (en) 2013-03-15 2023-10-25 Hologic, Inc. System and method for reviewing and analyzing cytological specimens
CA2866035A1 (en) 2013-10-04 2015-04-04 Tidi Products, Llc Sheath for a medical or dental instrument
WO2015093470A1 (en) * 2013-12-16 2015-06-25 日本電信電話株式会社 End-surface observation device
JP2016028229A (en) * 2014-07-08 2016-02-25 キヤノン株式会社 Data processing apparatus, data display system having the same, sample information acquisition system, data processing method, program, and storage medium
JP6769949B2 (en) 2014-07-24 2020-10-14 ユニバーシティー ヘルス ネットワーク Data collection and analysis for diagnostic purposes
DE102014013179A1 (en) * 2014-09-04 2016-03-10 Diehl Bgt Defence Gmbh & Co. Kg Targeting device for a guided missile
EP3430377A4 (en) 2016-03-16 2019-11-27 Ohio State Innovation Foundation System and method for the discrimination of tissues using a fast infrared cancer probe
DE202016008966U1 (en) * 2016-03-22 2021-02-04 Jenoptik Industrial Metrology Germany Gmbh Bore inspection device
CA3111935A1 (en) * 2018-09-06 2020-03-12 Shaw Industries Group, Inc. Turf playability testing
US11328435B2 (en) * 2020-06-08 2022-05-10 KLA Corp. Image alignment setup for specimens with intra- and inter-specimen variations using unsupervised learning and adaptive database generation methods
US11848094B2 (en) 2022-04-08 2023-12-19 Ohio State Innovation Foundation Multidimensional optical tissue classification and display

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5261410A (en) * 1991-02-07 1993-11-16 Alfano Robert R Method for determining if a tissue is a malignant tumor tissue, a benign tumor tissue, or a normal or benign tissue using Raman spectroscopy
US5421339A (en) * 1993-05-12 1995-06-06 Board Of Regents, The University Of Texas System Diagnosis of dysplasia using laser induced fluoroescence
EP0689045A1 (en) * 1994-06-23 1995-12-27 Koninklijke Philips Electronics N.V. Multi-frequency modulation spectrometer
US5693043A (en) * 1985-03-22 1997-12-02 Massachusetts Institute Of Technology Catheter for laser angiosurgery
US5769792A (en) * 1991-07-03 1998-06-23 Xillix Technologies Corp. Endoscopic imaging system for diseased tissue
US5833617A (en) * 1996-03-06 1998-11-10 Fuji Photo Film Co., Ltd. Fluorescence detecting apparatus

Family Cites Families (243)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013467A (en) 1957-11-07 1961-12-19 Minsky Marvin Microscopy apparatus
US3632865A (en) * 1969-12-23 1972-01-04 Bell Telephone Labor Inc Predictive video encoding using measured subject velocity
US3809072A (en) 1971-10-07 1974-05-07 Med General Inc Sterile sheath apparatus for fiber optic illuminator with compatible lens
IT985204B (en) * 1972-05-26 1974-11-30 Adelman Stuart Lee IMPROVEMENT IN ENDOSCOPES AND THE LIKE
US3890462A (en) 1974-04-17 1975-06-17 Bell Telephone Labor Inc Speed and direction indicator for video systems
US3963019A (en) 1974-11-25 1976-06-15 Quandt Robert S Ocular testing method and apparatus
US4017192A (en) 1975-02-06 1977-04-12 Neotec Corporation Optical analysis of biomedical specimens
US4071020A (en) * 1976-06-03 1978-01-31 Xienta, Inc. Apparatus and methods for performing in-vivo measurements of enzyme activity
GB1595422A (en) 1977-04-28 1981-08-12 Nat Res Dev Scaning microscopes
FR2430754A1 (en) 1978-07-13 1980-02-08 Groux Jean ULTRAVIOLET ENDOSCOPE
US4218703A (en) 1979-03-16 1980-08-19 Bell Telephone Laboratories, Incorporated Technique for estimation of displacement and/or velocity of objects in video scenes
US4357075A (en) 1979-07-02 1982-11-02 Hunter Thomas M Confocal reflector system
US4254421A (en) 1979-12-05 1981-03-03 Communications Satellite Corporation Integrated confocal electromagnetic wave lens and feed antenna system
DE2951459C2 (en) 1979-12-20 1984-03-29 Heimann Gmbh, 6200 Wiesbaden Optical arrangement for a smoke detector based on the light scattering principle
US4515165A (en) * 1980-02-04 1985-05-07 Energy Conversion Devices, Inc. Apparatus and method for detecting tumors
ATE23752T1 (en) 1980-08-21 1986-12-15 Oriel Scient Ltd OPTICAL ANALYZER.
AU556742B2 (en) 1982-02-01 1986-11-20 Sony Corporation Digital tape jitter compensation
US4619268A (en) 1983-08-11 1986-10-28 Vitacomm, Ltd. Esophageal stethoscope and vital signs monitor system
US5139025A (en) 1983-10-14 1992-08-18 Somanetics Corporation Method and apparatus for in vivo optical spectroscopic examination
SU1223092A1 (en) 1984-03-11 1986-04-07 Предприятие П/Я Р-6681 Small-angle nephelometer
SE455736B (en) 1984-03-15 1988-08-01 Sarastro Ab PROCEDURE KIT AND MICROPHOTOMETRATION AND ADDITIONAL IMAGE COMPOSITION
US4641352A (en) * 1984-07-12 1987-02-03 Paul Fenster Misregistration correction
US4662360A (en) 1984-10-23 1987-05-05 Intelligent Medical Systems, Inc. Disposable speculum
US5179936A (en) 1984-10-23 1993-01-19 Intelligent Medical Systems, Inc. Disposable speculum with membrane bonding ring
US4646722A (en) * 1984-12-10 1987-03-03 Opielab, Inc. Protective endoscope sheath and method of installing same
US4803049A (en) * 1984-12-12 1989-02-07 The Regents Of The University Of California pH-sensitive optrode
US5199431A (en) 1985-03-22 1993-04-06 Massachusetts Institute Of Technology Optical needle for spectroscopic diagnosis
DK130586A (en) * 1985-03-22 1986-09-23 Massachusetts Inst Technology LASER CATHETS FOR ENTRY INTO ARTERIES
US4930516B1 (en) 1985-11-13 1998-08-04 Laser Diagnostic Instr Inc Method for detecting cancerous tissue using visible native luminescence
US5042494A (en) 1985-11-13 1991-08-27 Alfano Robert R Method and apparatus for detecting cancerous tissue using luminescence excitation spectra
JPS62138819A (en) 1985-12-13 1987-06-22 Hitachi Ltd Scanning type laser microscope
JPS62247232A (en) 1986-04-21 1987-10-28 Agency Of Ind Science & Technol Fluorescence measuring apparatus
US5011243A (en) 1986-09-16 1991-04-30 Laser Precision Corporation Reflectance infrared microscope having high radiation throughput
US4852955A (en) 1986-09-16 1989-08-01 Laser Precision Corporation Microscope for use in modular FTIR spectrometer system
US4741326A (en) 1986-10-01 1988-05-03 Fujinon, Inc. Endoscope disposable sheath
US4891829A (en) 1986-11-19 1990-01-02 Exxon Research And Engineering Company Method and apparatus for utilizing an electro-optic detector in a microtomography system
NL8603108A (en) 1986-12-08 1988-07-01 Philips Nv MICROSALE.
US4810875A (en) 1987-02-02 1989-03-07 Wyatt Technology Corporation Method and apparatus for examining the interior of semi-opaque objects
CA1300369C (en) 1987-03-24 1992-05-12 Timothy P. Dabbs Distance measuring device
US5235457A (en) 1987-09-24 1993-08-10 Washington University Kit for converting a standard microscope into a single aperture confocal scanning epi-illumination microscope
US4945478A (en) 1987-11-06 1990-07-31 Center For Innovative Technology Noninvasive medical imaging system and method for the identification and 3-D display of atherosclerosis and the like
US4800571A (en) * 1988-01-11 1989-01-24 Tektronix, Inc. Timing jitter measurement display
US4844617A (en) 1988-01-20 1989-07-04 Tencor Instruments Confocal measuring microscope with automatic focusing
FR2626383B1 (en) 1988-01-27 1991-10-25 Commissariat Energie Atomique EXTENDED FIELD SCAN AND DEPTH CONFOCAL OPTICAL MICROSCOPY AND DEVICES FOR CARRYING OUT THE METHOD
US4997242A (en) 1988-03-07 1991-03-05 Medical Research Council Achromatic scanning system
US4934811A (en) 1988-04-01 1990-06-19 Syntex (U.S.A.) Inc. Apparatus and method for detection of fluorescence or light scatter
US5032720A (en) 1988-04-21 1991-07-16 White John G Confocal imaging system
US4877033A (en) 1988-05-04 1989-10-31 Seitz Jr H Michael Disposable needle guide and examination sheath for transvaginal ultrasound procedures
DE8808299U1 (en) 1988-06-25 1989-07-20 Effner Gmbh, 1000 Berlin, De
EP0393165B2 (en) 1988-07-13 2007-07-25 Optiscan Pty Ltd Scanning confocal endoscope
EP1034714A3 (en) 1988-07-15 2001-05-30 Anatomic Research, Inc. Rounded midsole sides
CA1325537C (en) 1988-08-01 1993-12-28 Timothy Peter Dabbs Confocal microscope
US5036853A (en) 1988-08-26 1991-08-06 Polartechnics Ltd. Physiological probe
US4972258A (en) 1989-07-31 1990-11-20 E. I. Du Pont De Nemours And Company Scanning laser microscope system and methods of use
US5101825A (en) * 1988-10-28 1992-04-07 Blackbox, Inc. Method for noninvasive intermittent and/or continuous hemoglobin, arterial oxygen content, and hematocrit determination
US5205291A (en) * 1988-11-08 1993-04-27 Health Research, Inc. In vivo fluorescence photometer
EP0449883B1 (en) 1988-12-21 1996-01-31 Massachusetts Institute Of Technology A method for laser induced fluorescence of tissue
US5022757A (en) 1989-01-23 1991-06-11 Modell Mark D Heterodyne system and method for sensing a target substance
US4878485A (en) 1989-02-03 1989-11-07 Adair Edwin Lloyd Rigid video endoscope with heat sterilizable sheath
US5003979A (en) 1989-02-21 1991-04-02 University Of Virginia System and method for the noninvasive identification and display of breast lesions and the like
US5421337A (en) 1989-04-14 1995-06-06 Massachusetts Institute Of Technology Spectral diagnosis of diseased tissue
US5201318A (en) 1989-04-24 1993-04-13 Rava Richard P Contour mapping of spectral diagnostics
JPH0378720A (en) 1989-08-22 1991-04-03 Nikon Corp Confocal laser scanning microscope
US5065008A (en) 1989-10-18 1991-11-12 Fuji Photo Film Co., Ltd. Scanning microscope and scanning mechanism for the same
DE8912757U1 (en) 1989-10-27 1989-12-07 Fa. Carl Zeiss, 7920 Heidenheim, De
US4979498A (en) 1989-10-30 1990-12-25 Machida Incorporated Video cervicoscope system
US5034613A (en) 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
US5257617A (en) 1989-12-25 1993-11-02 Asahi Kogaku Kogyo Kabushiki Kaisha Sheathed endoscope and sheath therefor
US5028802A (en) 1990-01-11 1991-07-02 Eye Research Institute Of Retina Foundation Imaging apparatus and methods utilizing scannable microlaser source
US5274240A (en) 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
US5091652A (en) 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
DE69118429T2 (en) 1990-01-26 1996-09-12 Canon Kk Method of measuring a species using fluorescent light
JPH0742401Y2 (en) 1990-02-01 1995-10-04 株式会社町田製作所 Endoscope cover
JPH03101903U (en) 1990-02-01 1991-10-23
US5074306A (en) 1990-02-22 1991-12-24 The General Hospital Corporation Measurement of burn depth in skin
CA2037324C (en) 1990-03-01 2000-01-11 X-Rite, Incorporated Apparatus and method for calibration in a spectrophotometer
US5083220A (en) 1990-03-22 1992-01-21 Tandem Scanning Corporation Scanning disks for use in tandem scanning reflected light microscopes and other optical systems
JP2613118B2 (en) 1990-04-10 1997-05-21 富士写真フイルム株式会社 Confocal scanning microscope
US5048946A (en) 1990-05-15 1991-09-17 Phoenix Laser Systems, Inc. Spectral division of reflected light in complex optical diagnostic and therapeutic systems
EP0458601B1 (en) 1990-05-22 1996-08-28 Research Development Corporation Of Japan Method of and apparatus for measuring spectral absorption in opaque specimens and method of and apparatus for measuring microscopic absorption distribution
GB9014263D0 (en) 1990-06-27 1990-08-15 Dixon Arthur E Apparatus and method for spatially- and spectrally- resolvedmeasurements
GB9016587D0 (en) 1990-07-27 1990-09-12 Isis Innovation Infra-red scanning microscopy
US5324979A (en) 1990-09-26 1994-06-28 Futrex, Inc. Method and means for generating synthetic spectra allowing quantitative measurement in near infrared measuring instruments
US5239178A (en) 1990-11-10 1993-08-24 Carl Zeiss Optical device with an illuminating grid and detector grid arranged confocally to an object
US5168157A (en) 1990-11-20 1992-12-01 Fuji Photo Film Co., Ltd. Scanning microscope with means for detecting a first and second polarized light beams along first and second optical receiving paths
US5193525A (en) * 1990-11-30 1993-03-16 Vision Sciences Antiglare tip in a sheath for an endoscope
US5720293A (en) * 1991-01-29 1998-02-24 Baxter International Inc. Diagnostic catheter with memory
JP3103894B2 (en) * 1991-02-06 2000-10-30 ソニー株式会社 Apparatus and method for correcting camera shake of video data
US5162641A (en) 1991-02-19 1992-11-10 Phoenix Laser Systems, Inc. System and method for detecting, correcting and measuring depth movement of target tissue in a laser surgical system
US5303026A (en) 1991-02-26 1994-04-12 The Regents Of The University Of California Los Alamos National Laboratory Apparatus and method for spectroscopic analysis of scattering media
US5260578A (en) 1991-04-10 1993-11-09 Mayo Foundation For Medical Education And Research Confocal imaging system for visible and ultraviolet light
DE4111903A1 (en) 1991-04-12 1992-10-15 Bayer Ag SPECTROSCOPY-CORRECTED LIGHT-SCREEN MICROSCOPY
US5257085A (en) 1991-04-24 1993-10-26 Kaman Aerospace Corporation Spectrally dispersive imaging lidar system
EP0581871B2 (en) 1991-04-29 2009-08-12 Massachusetts Institute Of Technology Apparatus for optical imaging and measurement
CA2042075C (en) * 1991-05-08 2001-01-23 Branko Palcic Endoscopic imaging system
SK399892A3 (en) * 1991-05-24 1993-07-07 British Broadcasting Corp Video image processing
JP2975719B2 (en) 1991-05-29 1999-11-10 オリンパス光学工業株式会社 Confocal optics
US5319200A (en) 1991-06-05 1994-06-07 Zeltex, Inc. Rapid near-infrared measurement of nonhomogeneous samples
US5201908A (en) 1991-06-10 1993-04-13 Endomedical Technologies, Inc. Sheath for protecting endoscope from contamination
US5313567A (en) 1991-06-13 1994-05-17 At&T Bell Laboratories Arrangement for determining and displaying volumetric data in an imaging system
US5237984A (en) 1991-06-24 1993-08-24 Xomed-Treace Inc. Sheath for endoscope
US5203328A (en) * 1991-07-17 1993-04-20 Georgia Tech Research Corporation Apparatus and methods for quantitatively measuring molecular changes in the ocular lens
US5162941A (en) 1991-07-23 1992-11-10 The Board Of Governors Of Wayne State University Confocal microscope
JPH0527177A (en) 1991-07-25 1993-02-05 Fuji Photo Film Co Ltd Scanning type microscope
JP3082346B2 (en) 1991-09-12 2000-08-28 株式会社ニコン Fluorescence confocal microscope
US5383874A (en) * 1991-11-08 1995-01-24 Ep Technologies, Inc. Systems for identifying catheters and monitoring their use
US5467767A (en) * 1991-11-25 1995-11-21 Alfano; Robert R. Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy
JP3018687B2 (en) 1991-12-12 2000-03-13 松下電器産業株式会社 Scanning laser microscope
US5253071A (en) 1991-12-20 1993-10-12 Sony Corporation Of America Method and apparatus for stabilizing an image produced in a video camera
US5398685A (en) 1992-01-10 1995-03-21 Wilk; Peter J. Endoscopic diagnostic system and associated method
US5284149A (en) 1992-01-23 1994-02-08 Dhadwal Harbans S Method and apparatus for determining the physical characteristics of ocular tissue
US5248876A (en) 1992-04-21 1993-09-28 International Business Machines Corporation Tandem linear scanning confocal imaging system with focal volumes at different heights
GB9213978D0 (en) 1992-07-01 1992-08-12 Skidmore Robert Medical devices
US5325846A (en) 1992-07-27 1994-07-05 Linvatec Corporation Endoscopic draping apparatus and method
US5609560A (en) 1992-08-19 1997-03-11 Olympus Optical Co., Ltd. Medical operation device control system for controlling a operation devices accessed respectively by ID codes
US5306902A (en) 1992-09-01 1994-04-26 International Business Machines Corporation Confocal method and apparatus for focusing in projection lithography
US5402768A (en) 1992-09-01 1995-04-04 Adair; Edwin L. Endoscope with reusable core and disposable sheath with passageways
US5704892A (en) 1992-09-01 1998-01-06 Adair; Edwin L. Endoscope with reusable core and disposable sheath with passageways
CH684556A5 (en) 1992-09-14 1994-10-14 Cerberus Ag Optical Smoke Detector.
US5285490A (en) * 1992-10-22 1994-02-08 Eastman Kodak Company Imaging combination for detecting soft tissue anomalies
US5337734A (en) 1992-10-29 1994-08-16 Advanced Polymers, Incorporated Disposable sheath with optically transparent window formed continuously integral therewith
US5469853A (en) 1992-12-11 1995-11-28 Tetrad Corporation Bendable ultrasonic probe and sheath for use therewith
US5418797A (en) 1993-01-15 1995-05-23 The United States Of America As Represented By The Secretary Of The Navy Time gated imaging through scattering material using polarization and stimulated raman amplification
US5294799A (en) 1993-02-01 1994-03-15 Aslund Nils R D Apparatus for quantitative imaging of multiple fluorophores
US5545121A (en) 1993-02-02 1996-08-13 Olympus Optical Co., Ltd. Cover-type endoscope apparatus
US5415157A (en) 1993-02-05 1995-05-16 Welcome; Steven Damage preventing endoscope head cover
US5536236A (en) 1993-02-12 1996-07-16 Olympus Optical Co., Ltd. Covered endoscope system
US5419311A (en) 1993-02-18 1995-05-30 Olympus Optical Co., Ltd. Endoscope apparatus of a type having cover for covering the endoscope
US5556367A (en) 1993-03-05 1996-09-17 Olympus Optical Co., Ltd. Cover type endoscope apparatus
US5458133A (en) 1993-03-15 1995-10-17 Olympus Optical Co., Ltd. Cover type endoscope apparatus
US5458132A (en) 1993-03-15 1995-10-17 Olympus Optical Co., Ltd. Endoscope cover-sheathed endoscope system
US5551945A (en) 1993-03-16 1996-09-03 Olympus Optical Co., Ltd. Endoscope system including endoscope and protection cover
US5424543A (en) 1993-04-19 1995-06-13 Surface Optics Corporation Imaging spectroradiometer
US5413108A (en) 1993-04-21 1995-05-09 The Research Foundation Of City College Of New York Method and apparatus for mapping a tissue sample for and distinguishing different regions thereof based on luminescence measurements of cancer-indicative native fluorophor
US5817015A (en) 1993-06-22 1998-10-06 Adair; Edwin L. Endoscope with reusable core and disposable sheath with passageways
US5596992A (en) 1993-06-30 1997-01-28 Sandia Corporation Multivariate classification of infrared spectra of cell and tissue samples
US5995645A (en) 1993-08-18 1999-11-30 Applied Spectral Imaging Ltd. Method of cancer cell detection
US5598842A (en) 1993-09-03 1997-02-04 Toa Medical Electronics Co., Ltd. Non-invasive blood analyzer and method using the same
US5496259A (en) * 1993-09-13 1996-03-05 Welch Allyn, Inc. Sterile protective sheath and drape for video laparoscope and method of use
US5412563A (en) * 1993-09-16 1995-05-02 General Electric Company Gradient image segmentation method
US5587832A (en) 1993-10-20 1996-12-24 Biophysica Technologies, Inc. Spatially light modulated confocal microscope and method
ZA948393B (en) 1993-11-01 1995-06-26 Polartechnics Ltd Method and apparatus for tissue type recognition
US5725477A (en) 1993-11-18 1998-03-10 Asahi Kogaku Kogyo Kabushiki Kaisha Front end structure of endoscope
JP3257209B2 (en) 1993-11-30 2002-02-18 ソニー株式会社 Digital signal recording circuit
US5983125A (en) 1993-12-13 1999-11-09 The Research Foundation Of City College Of New York Method and apparatus for in vivo examination of subcutaneous tissues inside an organ of a body using optical spectroscopy
US5406939A (en) 1994-02-14 1995-04-18 Bala; Harry Endoscope sheath
US5529235A (en) 1994-04-28 1996-06-25 Ethicon Endo-Surgery, Inc. Identification device for surgical instrument
US5493444A (en) 1994-04-28 1996-02-20 The United States Of America As Represented By The Secretary Of The Air Force Photorefractive two-beam coupling nonlinear joint transform correlator
US5450857A (en) 1994-05-19 1995-09-19 Board Of Regents, The University Of Texas System Method for the diagnosis of cervical changes
JP3379821B2 (en) 1994-05-31 2003-02-24 オリンパス光学工業株式会社 Endoscope
JPH0843204A (en) * 1994-06-23 1996-02-16 Philips Electron Nv Multiplex-frequency spectrometer
US5477382A (en) 1994-08-05 1995-12-19 Northrop Grumman Corporation Optical correlator system
JP2802244B2 (en) 1994-08-29 1998-09-24 オリンパス光学工業株式会社 Endoscope sheath
US5599717A (en) * 1994-09-02 1997-02-04 Martin Marietta Energy Systems, Inc. Advanced synchronous luminescence system
US5579773A (en) 1994-09-30 1996-12-03 Martin Marietta Energy Systems, Inc. Laser-induced differential normalized fluorescence method for cancer diagnosis
JP3732865B2 (en) * 1995-01-18 2006-01-11 ペンタックス株式会社 Endoscope device
DE19504174A1 (en) 1995-02-07 1996-08-08 Siemens Ag Method for the spectroscopic examination of a biological tissue
US5894340A (en) * 1995-02-17 1999-04-13 The Regents Of The University Of California Method for quantifying optical properties of the human lens
JP3490817B2 (en) 1995-03-13 2004-01-26 ペンタックス株式会社 Endoscope tip
US5991653A (en) 1995-03-14 1999-11-23 Board Of Regents, The University Of Texas System Near-infrared raman spectroscopy for in vitro and in vivo detection of cervical precancers
US5697373A (en) 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
US5735276A (en) * 1995-03-21 1998-04-07 Lemelson; Jerome Method and apparatus for scanning and evaluating matter
US5612540A (en) * 1995-03-31 1997-03-18 Board Of Regents, The University Of Texas Systems Optical method for the detection of cervical neoplasias using fluorescence spectroscopy
US5699795A (en) 1995-03-31 1997-12-23 Board Of Regents, The University Of Texas System Optical probe for the detection of cervical neoplasia using fluorescence spectroscopy and apparatus incorporating same
JP3543027B2 (en) 1995-04-10 2004-07-14 オリンパス株式会社 Curved sheath for probe
JP3476958B2 (en) 1995-04-12 2003-12-10 アークレイ株式会社 A method for stabilizing spectra in spectrometry.
US5690106A (en) 1995-06-30 1997-11-25 Siemens Corporate Research, Inc. Flexible image registration for rotational angiography
US6411835B1 (en) 1997-01-13 2002-06-25 Medispectra, Inc. Spectral volume microprobe arrays
US6104945A (en) 1995-08-01 2000-08-15 Medispectra, Inc. Spectral volume microprobe arrays
US5813987A (en) 1995-08-01 1998-09-29 Medispectra, Inc. Spectral volume microprobe for analysis of materials
US5713364A (en) 1995-08-01 1998-02-03 Medispectra, Inc. Spectral volume microprobe analysis of materials
US5730701A (en) 1995-09-12 1998-03-24 Olympus Optical Co., Ltd. Endoscope
JPH0998938A (en) * 1995-10-04 1997-04-15 Fuji Photo Optical Co Ltd Protector of insertion part of endoscope
US6146897A (en) 1995-11-13 2000-11-14 Bio-Rad Laboratories Method for the detection of cellular abnormalities using Fourier transform infrared spectroscopy
US5795632A (en) 1996-02-06 1998-08-18 Parker Laboratories Protective cover set for a medical probe
US5647368A (en) 1996-02-28 1997-07-15 Xillix Technologies Corp. Imaging system for detecting diseased tissue using native fluorsecence in the gastrointestinal and respiratory tract
US5865726A (en) 1996-03-27 1999-02-02 Asahi Kogaku Kogyo Kabushiki Kaisha Front end structure of side-view type endoscope
US5717209A (en) * 1996-04-29 1998-02-10 Petrometrix Ltd. System for remote transmission of spectral information through communication optical fibers for real-time on-line hydrocarbons process analysis by near infra red spectroscopy
US5807248A (en) 1996-05-15 1998-09-15 Ohmeda Inc. Medical monitoring probe with modular device housing
US5860913A (en) 1996-05-16 1999-01-19 Olympus Optical Co., Ltd. Endoscope whose distal cover can be freely detachably attached to main distal part thereof with high positioning precision
US5931779A (en) * 1996-06-06 1999-08-03 Wisconsin Alumni Research Foundation Real-time in-vivo measurement of myoglobin oxygen saturation
US5773835A (en) 1996-06-07 1998-06-30 Rare Earth Medical, Inc. Fiber optic spectroscopy
WO1997050003A1 (en) * 1996-06-26 1997-12-31 Morphometrix Technologies Inc. Confocal ultrasonic imaging system
US5842995A (en) 1996-06-28 1998-12-01 Board Of Regents, The Univerisity Of Texas System Spectroscopic probe for in vivo measurement of raman signals
US5685822A (en) 1996-08-08 1997-11-11 Vision-Sciences, Inc. Endoscope with sheath retaining device
US5791346A (en) 1996-08-22 1998-08-11 Western Research Company, Inc. Colposcope device and method for measuring areas of cervical lesions
US6119031A (en) 1996-11-21 2000-09-12 Boston Scientific Corporation Miniature spectrometer
US5768333A (en) 1996-12-02 1998-06-16 Philips Electronics N.A. Corporation Mass detection in digital radiologic images using a two stage classifier
CA2192036A1 (en) 1996-12-04 1998-06-04 Harvey Lui Fluorescence scope system for dermatologic diagnosis
US6847490B1 (en) * 1997-01-13 2005-01-25 Medispectra, Inc. Optical probe accessory device for use in vivo diagnostic procedures
JP3654325B2 (en) * 1997-02-13 2005-06-02 富士写真フイルム株式会社 Fluorescence detection device
US5855551A (en) 1997-03-17 1999-01-05 Polartechnics Limited Integral sheathing apparatus for tissue recognition probes
US5941834A (en) 1997-03-17 1999-08-24 Polartechnics Limited Sheath for a side view probe
US5830146A (en) 1997-03-17 1998-11-03 Polartechnics Limited Sheathed probes for tissue type recognition
US5920399A (en) 1997-03-18 1999-07-06 Sandia Corporation Multispectral imaging method and apparatus
US5929985A (en) 1997-03-18 1999-07-27 Sandia Corporation Multispectral imaging probe
US5989184A (en) 1997-04-04 1999-11-23 Medtech Research Corporation Apparatus and method for digital photography useful in cervical cancer detection
US6008889A (en) 1997-04-16 1999-12-28 Zeng; Haishan Spectrometer system for diagnosis of skin disease
FR2763721B1 (en) * 1997-05-21 1999-08-06 Inst Nat Rech Inf Automat ELECTRONIC IMAGE PROCESSING DEVICE FOR DETECTING DIMENSIONAL VARIATIONS
US6124597A (en) 1997-07-07 2000-09-26 Cedars-Sinai Medical Center Method and devices for laser induced fluorescence attenuation spectroscopy
US6096065A (en) 1997-09-29 2000-08-01 Boston Scientific Corporation Sheath for tissue spectroscopy
US6058322A (en) 1997-07-25 2000-05-02 Arch Development Corporation Methods for improving the accuracy in differential diagnosis on radiologic examinations
US6317617B1 (en) 1997-07-25 2001-11-13 Arch Development Corporation Method, computer program product, and system for the automated analysis of lesions in magnetic resonance, mammogram and ultrasound images
US5921926A (en) 1997-07-28 1999-07-13 University Of Central Florida Three dimensional optical imaging colposcopy
WO1999020314A1 (en) 1997-10-20 1999-04-29 Board Of Regents, The University Of Texas System Acetic acid as a signal enhancing contrast agent in fluorescence spectroscopy
US6091985A (en) * 1998-01-23 2000-07-18 Research Foundation Of City College Of New York Detection of cancer and precancerous conditions in tissues and/or cells using native fluorescence excitation spectroscopy
US6364829B1 (en) * 1999-01-26 2002-04-02 Newton Laboratories, Inc. Autofluorescence imaging system for endoscopy
CA2318180A1 (en) * 1998-01-26 1999-07-29 Massachusetts Institute Of Technology Fluorescence imaging endoscope
AU3102699A (en) * 1998-03-19 1999-10-11 Board Of Regents, The University Of Texas System Fiber-optic confocal imaging apparatus and methods of use
US6505059B1 (en) * 1998-04-06 2003-01-07 The General Hospital Corporation Non-invasive tissue glucose level monitoring
US6285639B1 (en) 1998-04-29 2001-09-04 Sony Corporation On-the-fly of jitter during optical disc mastering/recording
US6571118B1 (en) * 1998-05-04 2003-05-27 Board Of Regents, The University Of Texas System Combined fluorescence and reflectance spectroscopy
US6246471B1 (en) 1998-06-08 2001-06-12 Lj Laboratories, Llc Apparatus and method for measuring optical characteristics of an object
US6246479B1 (en) * 1998-06-08 2001-06-12 Lj Laboratories, L.L.C. Integrated spectrometer assembly and methods
US6243601B1 (en) * 1998-09-18 2001-06-05 Abund Ottokar Wist Transillumination imaging instrumentation with scattered light discrimination
US6377842B1 (en) * 1998-09-22 2002-04-23 Aurora Optics, Inc. Method for quantitative measurement of fluorescent and phosphorescent drugs within tissue utilizing a fiber optic probe
US6169817B1 (en) 1998-11-04 2001-01-02 University Of Rochester System and method for 4D reconstruction and visualization
US6507747B1 (en) * 1998-12-02 2003-01-14 Board Of Regents, The University Of Texas System Method and apparatus for concomitant structural and biochemical characterization of tissue
EP1161178A2 (en) 1998-12-23 2001-12-12 Medispectra Inc. Systems and methods for optical examination of samples
EP1139864A1 (en) 1998-12-23 2001-10-10 Medispectra Inc. Optical methods and systems for cervical screening
US6556720B1 (en) * 1999-05-24 2003-04-29 Ge Medical Systems Global Technology Company Llc Method and apparatus for enhancing and correcting digital images
US6697666B1 (en) * 1999-06-22 2004-02-24 Board Of Regents, The University Of Texas System Apparatus for the characterization of tissue of epithelial lined viscus
US6208887B1 (en) * 1999-06-24 2001-03-27 Richard H. Clarke Catheter-delivered low resolution Raman scattering analyzing system for detecting lesions
US6717668B2 (en) * 2000-03-07 2004-04-06 Chemimage Corporation Simultaneous imaging and spectroscopy apparatus
JP2001157658A (en) 1999-12-02 2001-06-12 Fuji Photo Film Co Ltd Fluorescent image display device
US20020007122A1 (en) * 1999-12-15 2002-01-17 Howard Kaufman Methods of diagnosing disease
GR1004180B (en) * 2000-03-28 2003-03-11 ����������� ����� ��������� (����) Method and system for characterization and mapping of tissue lesions
US6377841B1 (en) * 2000-03-31 2002-04-23 Vanderbilt University Tumor demarcation using optical spectroscopy
US6312385B1 (en) 2000-05-01 2001-11-06 Ge Medical Systems Global Technology Company, Llc Method and apparatus for automatic detection and sizing of cystic objects
JP4191884B2 (en) * 2000-08-18 2008-12-03 ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー Image processing method, image processing apparatus, and image photographing apparatus
US6718055B1 (en) * 2000-12-05 2004-04-06 Koninklijke Philips Electronics, N.V. Temporal and spatial correction for perfusion quantification system
US6839661B2 (en) * 2000-12-15 2005-01-04 Medispectra, Inc. System for normalizing spectra
USD453832S1 (en) * 2001-02-09 2002-02-19 Medispectra, Inc. Sheath for cervical optical probe
USD460821S1 (en) 2001-02-09 2002-07-23 Medispectra, Inc. Sheath for cervical optical probe
USD453964S1 (en) * 2001-02-09 2002-02-26 Medispectra, Inc. Sheath for cervical optical probe
USD453962S1 (en) * 2001-02-09 2002-02-26 Medispectra, Inc. Sheath for cervical optical probe
USD453963S1 (en) * 2001-02-09 2002-02-26 Medispectra, Inc. Sheath for cervical optical probe
US7282723B2 (en) * 2002-07-09 2007-10-16 Medispectra, Inc. Methods and apparatus for processing spectral data for use in tissue characterization
US6933154B2 (en) * 2002-07-09 2005-08-23 Medispectra, Inc. Optimal windows for obtaining optical data for characterization of tissue samples
US6818903B2 (en) * 2002-07-09 2004-11-16 Medispectra, Inc. Method and apparatus for identifying spectral artifacts
US7103401B2 (en) * 2002-07-10 2006-09-05 Medispectra, Inc. Colonic polyp discrimination by tissue fluorescence and fiberoptic probe
US6768918B2 (en) * 2002-07-10 2004-07-27 Medispectra, Inc. Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof
WO2004095359A2 (en) * 2003-04-18 2004-11-04 Medispectra, Inc. Systems for identifying, displaying, marking, and treating suspect regions of tissue

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693043A (en) * 1985-03-22 1997-12-02 Massachusetts Institute Of Technology Catheter for laser angiosurgery
US5261410A (en) * 1991-02-07 1993-11-16 Alfano Robert R Method for determining if a tissue is a malignant tumor tissue, a benign tumor tissue, or a normal or benign tissue using Raman spectroscopy
US5769792A (en) * 1991-07-03 1998-06-23 Xillix Technologies Corp. Endoscopic imaging system for diseased tissue
US5421339A (en) * 1993-05-12 1995-06-06 Board Of Regents, The University Of Texas System Diagnosis of dysplasia using laser induced fluoroescence
EP0689045A1 (en) * 1994-06-23 1995-12-27 Koninklijke Philips Electronics N.V. Multi-frequency modulation spectrometer
US5833617A (en) * 1996-03-06 1998-11-10 Fuji Photo Film Co., Ltd. Fluorescence detecting apparatus

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CA2356623A1 (en) 2000-06-29
US20020183626A1 (en) 2002-12-05
US6421553B1 (en) 2002-07-16
US20050033186A1 (en) 2005-02-10
US6385484B2 (en) 2002-05-07
US20010020132A1 (en) 2001-09-06
US6760613B2 (en) 2004-07-06
AU759282B2 (en) 2003-04-10
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US6411838B1 (en) 2002-06-25
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