WO2000040604A3 - METHODS AND COMPOSITIONS FOR MODULATING CYTOKINE RELEASE BY αEβ7-EXPRESSING CELLS - Google Patents

METHODS AND COMPOSITIONS FOR MODULATING CYTOKINE RELEASE BY αEβ7-EXPRESSING CELLS Download PDF

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Publication number
WO2000040604A3
WO2000040604A3 PCT/US1999/030992 US9930992W WO0040604A3 WO 2000040604 A3 WO2000040604 A3 WO 2000040604A3 US 9930992 W US9930992 W US 9930992W WO 0040604 A3 WO0040604 A3 WO 0040604A3
Authority
WO
WIPO (PCT)
Prior art keywords
αeβ7
methods
compositions
expressing cells
cytokine release
Prior art date
Application number
PCT/US1999/030992
Other languages
French (fr)
Other versions
WO2000040604A2 (en
Inventor
Michael B Brenner
Christina M Parker
Michelle Woldemar Carr
Anu Arya
Original Assignee
Brigham & Womens Hospital
Michael B Brenner
Christina M Parker
Michelle Woldemar Carr
Anu Arya
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital, Michael B Brenner, Christina M Parker, Michelle Woldemar Carr, Anu Arya filed Critical Brigham & Womens Hospital
Priority to AU23904/00A priority Critical patent/AU2390400A/en
Publication of WO2000040604A2 publication Critical patent/WO2000040604A2/en
Publication of WO2000040604A3 publication Critical patent/WO2000040604A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/06—Methods of screening libraries by measuring effects on living organisms, tissues or cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/53—Colony-stimulating factor [CSF]
    • G01N2333/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/555—Interferons [IFN]
    • G01N2333/57—IFN-gamma
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

Abstract

The present invention relates to methods and compositions for modulating the release of cytokines by αEβ7-expressing cells. Binding polypeptides and other molecules which selectively bind to αEβ7 and, thereby, block or enhance the Th2 cytokine response by the αEβ7-expressing cell, also are provided. The antagonists and agonists of the invention are useful in screening assays to identify pharmaceutical lead compounds which are capable of modulating cytokine release by αEβ7-expressing cells. Methods and pharmaceutical compositions for modifying the Th2 cytokine response by an αEβ7-expressing cell, in vitro and in vivo also are provided.
PCT/US1999/030992 1999-01-08 1999-12-28 METHODS AND COMPOSITIONS FOR MODULATING CYTOKINE RELEASE BY αEβ7-EXPRESSING CELLS WO2000040604A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU23904/00A AU2390400A (en) 1999-01-08 1999-12-28 Methods and compositions for modulating cytokine release by alphaebeta7-expressing cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11505599P 1999-01-08 1999-01-08
US60/115,055 1999-01-08

Publications (2)

Publication Number Publication Date
WO2000040604A2 WO2000040604A2 (en) 2000-07-13
WO2000040604A3 true WO2000040604A3 (en) 2000-11-09

Family

ID=22359050

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/030992 WO2000040604A2 (en) 1999-01-08 1999-12-28 METHODS AND COMPOSITIONS FOR MODULATING CYTOKINE RELEASE BY αEβ7-EXPRESSING CELLS

Country Status (2)

Country Link
AU (1) AU2390400A (en)
WO (1) WO2000040604A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104710532A (en) * 2004-09-03 2015-06-17 健泰科生物技术公司 Humanized anti-beta7 antagonists and uses therefor

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5594120A (en) * 1994-02-18 1997-01-14 Brigham And Women's Hospital, Inc. Integrin alpha subunit
US5610281A (en) * 1994-05-03 1997-03-11 Brigham & Women's Hospital, Inc. Antibodies for modulating heterotypic E-cadherin interactions with human T lymphocytes
WO1997025423A1 (en) * 1996-01-05 1997-07-17 Icos Corporation Cytoplasmic modulators of integrin binding
WO1998025144A1 (en) * 1996-12-06 1998-06-11 The Scripps Research Institute Methods and cell lines for identification of regulators of integrin activation and compositions identified thereby
JPH10218790A (en) * 1997-02-10 1998-08-18 Kazuo Tsubota Adhesion inhibitor of secretory gland cell to lymphocyte

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5594120A (en) * 1994-02-18 1997-01-14 Brigham And Women's Hospital, Inc. Integrin alpha subunit
US5610281A (en) * 1994-05-03 1997-03-11 Brigham & Women's Hospital, Inc. Antibodies for modulating heterotypic E-cadherin interactions with human T lymphocytes
WO1997025423A1 (en) * 1996-01-05 1997-07-17 Icos Corporation Cytoplasmic modulators of integrin binding
WO1998025144A1 (en) * 1996-12-06 1998-06-11 The Scripps Research Institute Methods and cell lines for identification of regulators of integrin activation and compositions identified thereby
JPH10218790A (en) * 1997-02-10 1998-08-18 Kazuo Tsubota Adhesion inhibitor of secretory gland cell to lymphocyte

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
B LUDVIKSSON ET AL: "Administration of mAb against alphaEbeta7 prevents and ameliorates immunization-induced colitis in IL-2-/- mice", JOURNAL OF IMMUNOLOGY,US,THE WILLIAMS AND WILKINS CO. BALTIMORE, vol. 162, no. 8, 15 April 1999 (1999-04-15), pages 4975 - 4982-4982, XP002129086, ISSN: 0022-1767 *
C JORGENSEN ET AL: "Inhibition of human mucosal lymphocytes migration in rheumatoid synovium engrafted in SCID mice by antibodies against LFA-1 and alphaEbeta7 adhesion molecules", ARTHRITIS AND RHEUMATISM,US,LIPPINCOTT, PHILADELPHIA, vol. 37, no. 9, SUPPL, September 1994 (1994-09-01), pages 5220, XP002129083, ISSN: 0004-3591 *
CEPEK K.L. ET AL.: "Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha-E-beta-7 integrin", NATURE, vol. 372, 1994, pages 190 - 193, XP002137720 *
JORGENSEN C ET AL: "Overexpression of integrin alpha-E-beta-7 on synovial fluid lymphocytes in rheumatoid arthritis and its regulation by sulfasalazine, sulfapyridine, 5-ASA and methotrexate", ARTHRITIS AND RHEUMATISM,US,LIPPINCOTT, PHILADELPHIA, vol. 37, no. 9, SUPPL, 1994, pages S255, XP002138709, ISSN: 0004-3591 *
PANG M ET AL: "UP-REGULATION OF ALPHAEBETA7, A NOVEL INTEGRIN ADHESION MOLECULE, ON T CELLS FROM SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS WITH SPECIFIC EPITHELIAL INVOLVEMENT", ARTHRITIS AND RHEUMATISM,US,LIPPINCOTT, PHILADELPHIA, vol. 41, no. 8, August 1998 (1998-08-01), pages 1456 - 1463-1463, XP000867228, ISSN: 0004-3591 *
PARKER C.M. ET AL.: "A family of beta-7 integrins on human mucosal lymphocytes", PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 1294 - 1298, XP002137721 *
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 13 30 November 1998 (1998-11-30) *
RUSSELL G J ET AL: "DISTINCT STRUCTURAL AND FUNCTIONAL EPITOPES OF THE ALPHAE BETA7 INTEGRIN", EUROPEAN JOURNAL OF IMMUNOLOGY,DE,WEINHEIM, vol. 24, 1 November 1994 (1994-11-01), pages 2832 - 2841, XP000672907, ISSN: 0014-2980 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104710532A (en) * 2004-09-03 2015-06-17 健泰科生物技术公司 Humanized anti-beta7 antagonists and uses therefor
CN104710532B (en) * 2004-09-03 2019-01-18 健泰科生物技术公司 The anti-beta 7 antagonists of humanization and its application

Also Published As

Publication number Publication date
WO2000040604A2 (en) 2000-07-13
AU2390400A (en) 2000-07-24

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