WO2000041545A3 - Regulators of the pct or smoothened pathway, compositions and uses related thereto - Google Patents
Regulators of the pct or smoothened pathway, compositions and uses related thereto Download PDFInfo
- Publication number
- WO2000041545A3 WO2000041545A3 PCT/US2000/000873 US0000873W WO0041545A3 WO 2000041545 A3 WO2000041545 A3 WO 2000041545A3 US 0000873 W US0000873 W US 0000873W WO 0041545 A3 WO0041545 A3 WO 0041545A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- function
- hedgehog
- smoothened
- gain
- loss
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000593166A JP2003517279A (en) | 1999-01-13 | 2000-01-13 | Hedgehog pathway regulators, compositions and uses thereof |
IL14414700A IL144147A0 (en) | 1999-01-13 | 2000-01-13 | Regulators of the pct or smoothened pathway, compositions and uses related thereto |
CA002370042A CA2370042A1 (en) | 1999-01-13 | 2000-01-13 | Regulators of the pct or smoothened pathway, compositions and uses related thereto |
EP00906910A EP1143961A2 (en) | 1999-01-13 | 2000-01-13 | Regulators of the ptc or smoothened pathway, compositions and uses related thereto |
AU28491/00A AU778866B2 (en) | 1999-01-13 | 2000-01-13 | Regulators of the PCT or smoothened pathway, compositions and uses related thereto |
IL144147A IL144147A (en) | 1999-01-13 | 2001-07-04 | Uses of camp agonists in the manufacture of preparations and compositions for inhibiting altered growth state of a cell or for inhibiting the progression of basal cell carcinoma |
AU2005201269A AU2005201269C1 (en) | 1999-01-13 | 2005-03-23 | Regulators of the PCT or smoothened pathway, compositions and uses related thereto |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11564299P | 1999-01-13 | 1999-01-13 | |
US60/115,642 | 1999-01-13 | ||
US11959499P | 1999-02-10 | 1999-02-10 | |
US60/119,594 | 1999-02-10 | ||
US14212499P | 1999-07-02 | 1999-07-02 | |
US60/142,124 | 1999-07-02 | ||
US09/417,564 US6291516B1 (en) | 1999-01-13 | 1999-10-14 | Regulators of the hedgehog pathway, compositions and uses related thereto |
US09/417,564 | 1999-10-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000041545A2 WO2000041545A2 (en) | 2000-07-20 |
WO2000041545A3 true WO2000041545A3 (en) | 2000-09-28 |
Family
ID=27494029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/000873 WO2000041545A2 (en) | 1999-01-13 | 2000-01-13 | Regulators of the pct or smoothened pathway, compositions and uses related thereto |
Country Status (7)
Country | Link |
---|---|
US (4) | US6291516B1 (en) |
EP (1) | EP1143961A2 (en) |
JP (1) | JP2003517279A (en) |
AU (1) | AU778866B2 (en) |
CA (1) | CA2370042A1 (en) |
IL (2) | IL144147A0 (en) |
WO (1) | WO2000041545A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8895576B2 (en) | 2006-12-28 | 2014-11-25 | Infinity Pharmaceuticals, Inc. | Methods of use of cyclopamine analogs |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6713065B2 (en) | 1997-02-10 | 2004-03-30 | President And Fellows Of Harvard College | Methods of using hedgehog proteins to modulate hematopoiesis and vascular growth |
US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
US6291516B1 (en) * | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
JP2003501395A (en) * | 1999-06-08 | 2003-01-14 | ローランティス・リミテッド | Therapeutic use |
US20070021493A1 (en) | 1999-09-16 | 2007-01-25 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
JP5420128B2 (en) | 1999-10-13 | 2014-02-19 | ジョンズ ホプキンス ユニバーシティ スクール オブ メディシン | Hedgehog pathway modulators and related compositions and methods of use |
US8168178B2 (en) * | 1999-11-30 | 2012-05-01 | Curis, Inc. | Methods and compositions for regulating lymphocyte activity |
IL133809A0 (en) * | 1999-12-30 | 2001-04-30 | Yeda Res & Dev | Steroidal alkaloids and pharmaceutical compositions comprising them |
US6683192B2 (en) * | 2000-03-30 | 2004-01-27 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
EP1272168B2 (en) † | 2000-03-30 | 2009-10-28 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
US7498304B2 (en) | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
US20030022819A1 (en) * | 2000-06-16 | 2003-01-30 | Ling Leona E. | Angiogenesis-modulating compositions and uses |
US8044259B2 (en) * | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
WO2002011752A1 (en) * | 2000-08-04 | 2002-02-14 | Takeda Chemical Industries, Ltd. | Use of gli1 gene |
US7708998B2 (en) | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
CA2425356C (en) * | 2000-10-13 | 2015-10-06 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
US7682607B2 (en) * | 2001-05-01 | 2010-03-23 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
US20030044409A1 (en) * | 2001-05-01 | 2003-03-06 | Carson Dennis A. | Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens |
CA2452152A1 (en) * | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
BR0117063A (en) * | 2001-07-02 | 2004-07-27 | Sinan Tas | Use of cyclopamine to treat basal cell carcinoma and other tumors |
EP1482928B1 (en) * | 2001-07-27 | 2009-09-23 | Curis, Inc. | Mediators of hedgehog signaling pathways,compositions and uses related thereto |
GB0221539D0 (en) * | 2002-09-17 | 2002-10-23 | Medical Res Council | Methods of treatment |
WO2005032343A2 (en) * | 2003-10-01 | 2005-04-14 | The Johns Hopkins University | Hedgehog signaling in prostate regeneration neoplasia and metastasis |
US20070231828A1 (en) * | 2003-10-01 | 2007-10-04 | Johns Hopkins University | Methods of predicting behavior of cancers |
JP2005305107A (en) * | 2004-03-25 | 2005-11-04 | Sei Matsuoka | Apparatus and method for measuring quantitative value of information |
DK1730280T3 (en) | 2004-03-26 | 2019-02-04 | Curis Inc | RNA interference modulators for hedgehog signaling and applications thereof |
ES2578728T3 (en) * | 2004-08-27 | 2016-07-29 | Infinity Pharmaceuticals, Inc. | Process for the preparation of cyclopamine analogs |
US20070281040A1 (en) * | 2004-09-30 | 2007-12-06 | The University Of Chicago | Combination therapy of hedgehog inhibitors, radiation and chemotherapeutic agents |
US20060165739A1 (en) * | 2005-01-06 | 2006-07-27 | Mary Kay Inc. | Alcohol-free microemulsion composition |
US8309057B2 (en) * | 2005-06-10 | 2012-11-13 | The Invention Science Fund I, Llc | Methods for elevating neurotrophic agents |
US8273701B2 (en) * | 2005-08-16 | 2012-09-25 | Trustees Of Dartmouth College | Method for diagnosing non-small cell lung carcinoma |
AU2006308870B2 (en) | 2005-10-31 | 2012-08-16 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
WO2007053648A2 (en) | 2005-10-31 | 2007-05-10 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
US20090156611A1 (en) * | 2005-11-11 | 2009-06-18 | Licentia Ltd. | Mammalian hedgehog signaling modulators |
WO2008121102A2 (en) * | 2006-02-21 | 2008-10-09 | The Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
US20110034498A1 (en) * | 2006-03-24 | 2011-02-10 | Mcgovern Karen J | Dosing regimens for the treatment of cancer |
WO2008057468A1 (en) | 2006-11-02 | 2008-05-15 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
US20100099116A1 (en) * | 2007-01-12 | 2010-04-22 | Infinity Discovery, Inc. | Methods for Analysis of Hedgehog Pathway Inhibitors |
EP2106439B1 (en) | 2007-01-24 | 2014-11-12 | The Regents of the University of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
WO2008090517A2 (en) * | 2007-01-26 | 2008-07-31 | Piramal Life Sciences Limited | Enriched plant extract, compound, and methods for the treatment of proliferative disorders |
BRPI0808444A2 (en) * | 2007-03-07 | 2017-06-06 | Infinity Discovery Inc | cyclopamine analogues lactate and methods of use |
NZ579361A (en) * | 2007-03-07 | 2012-04-27 | Infinity Discovery Inc | Heterocyclic cyclopamine analogs and methods of use thereof |
US20100216828A1 (en) | 2007-08-16 | 2010-08-26 | Christine Dierks | Methods and compositions for treating cancers |
US20090098220A1 (en) * | 2007-10-12 | 2009-04-16 | Lance Ashworth | Liquid pharmaceutical preparation comprising forskolin for promoting lean body mass |
US8575141B2 (en) | 2007-10-30 | 2013-11-05 | The Wistar Institute | Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer |
US8669243B2 (en) | 2007-10-30 | 2014-03-11 | The Wistar Institute | Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer |
US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
WO2009086451A1 (en) | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
AU2008345151A1 (en) * | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Therapeutic cancer treatments |
WO2009112266A1 (en) * | 2008-03-12 | 2009-09-17 | Ludwig-Maximilians-Universität | Active substance combination with gemcitabine for the treatment of epithelial cancer |
WO2010019450A2 (en) * | 2008-08-09 | 2010-02-18 | Nyles Bauer | Synergizing active compounds for treating inflammation and other conditions |
EP2334686B1 (en) | 2008-08-28 | 2019-02-27 | President and Fellows of Harvard College | Cortistatin analogues and syntheses therof |
NZ592338A (en) | 2008-09-26 | 2012-11-30 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
JP2009143963A (en) * | 2009-03-25 | 2009-07-02 | Sinan Tas | Pharmaceutical composition for treating tumor using hedgehog/smoothened signal for inhibiting apoptosis of tumor cell |
FR2948367A1 (en) | 2009-07-24 | 2011-01-28 | Centre Nat Rech Scient | ACYL-GUANIDINE DERIVATIVES MODULATORS OF THE HEDGEHOG PROTEIN SIGNALING PATHWAY |
JP6141015B2 (en) | 2009-08-05 | 2017-06-07 | インフィニティ ファーマスーティカルズ、インク. | Enzymatic transamination of cyclopamine analogues. |
PT2470173E (en) | 2009-08-25 | 2016-06-15 | Abraxis Bioscience Llc | Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors |
EP2501237A1 (en) * | 2009-11-06 | 2012-09-26 | Infinity Pharmaceuticals, Inc. | Oral formulations of a hedgehog pathway inhibitor |
TWI535445B (en) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt antagonists and methods of treatment and screening |
US20110183948A1 (en) * | 2010-01-15 | 2011-07-28 | Infinity Pharmaceuticals, Inc. | Treatment of fibrotic conditions using hedgehog inhibitors |
NZ602700A (en) | 2010-04-01 | 2014-10-31 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
US9394313B2 (en) | 2010-09-14 | 2016-07-19 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
FR2967498B1 (en) | 2010-11-16 | 2015-01-02 | Centre Nat Rech Scient | USE OF QUINOLINONE DERIVATIVES AS A RESEARCH TOOL |
FR2980477B1 (en) | 2011-09-23 | 2013-10-18 | Centre Nat Rech Scient | NOVEL MODULATING COMPOUNDS OF THE HEDGEHOG PROTEIN SIGNALING PATH, THEIR MARKED FORMS, AND APPLICATIONS |
GB201201298D0 (en) | 2012-01-26 | 2012-03-07 | Universitat Leipzig | Therapeutic use of activators of zinc finger protein gli3 |
US8741247B2 (en) | 2012-03-27 | 2014-06-03 | Alstom Technology Ltd | Method and system for low energy carbon dioxide removal |
JP2015536933A (en) | 2012-10-23 | 2015-12-24 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Methods of treating neuroendocrine tumors using Wnt pathway binding agents |
JP2016510411A (en) | 2013-02-04 | 2016-04-07 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Methods and monitoring of treatment with WNT pathway inhibitors |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
WO2014149895A1 (en) * | 2013-03-15 | 2014-09-25 | Boston Scientific Neuromodulation Corporation | Neuromodulation system for providing multiple modulation patterns in a single channel |
WO2015036405A1 (en) | 2013-09-10 | 2015-03-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating basal cell carcinoma |
JP2014028835A (en) * | 2013-09-18 | 2014-02-13 | Sinan Tas | Use method of cyclopamine in treatment of basal cell cancer and other tumor |
AU2014369834B2 (en) | 2013-12-24 | 2018-12-20 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses and uses thereof |
EP3294298A4 (en) | 2015-05-08 | 2018-10-17 | President and Fellows of Harvard College | Cortistatin analogues, syntheses, and uses thereof |
BR112017026103B1 (en) | 2015-06-04 | 2023-10-03 | Sol-Gel Technologies Ltd | TOPICAL COMPOSITIONS WITH HEDGEHOG INHIBITOR COMPOUND, TOPICAL DELIVERY SYSTEM AND THEIR USES |
EP3316889A4 (en) | 2015-07-01 | 2018-11-14 | President and Fellows of Harvard College | Cortistatin analogues and syntheses and uses thereof |
US10772813B2 (en) | 2016-06-03 | 2020-09-15 | Colradel, LLC | Compositions and methods of administering a colchicine based topical composition for the prevention of radiation fibrosis |
US10548908B2 (en) * | 2016-09-15 | 2020-02-04 | Nostopharma, LLC | Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification |
CN110392686A (en) | 2016-12-30 | 2019-10-29 | 频率治疗公司 | 1H- pyrrole-2,5-diones compound and making be used to induction it is dry/method of ancestral's sertoli cell self-renewing |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0020029A1 (en) * | 1979-05-02 | 1980-12-10 | Aruba (Qld.) Pty. Ltd. | Pharmaceutical compositions comprising steroid alkaloids |
US4634706A (en) * | 1983-10-28 | 1987-01-06 | Sankyo Company Limited | Griseolic acid derivatives, and their use as enzyme inhibitors |
US4751224A (en) * | 1983-07-21 | 1988-06-14 | Brown University Research Foundation | Treatment of metastasis |
WO1989011487A1 (en) * | 1988-05-23 | 1989-11-30 | United States Of America, Represented By The Secre | Derivatives of cyclic amp as treatment for cancer |
WO1991010743A1 (en) * | 1990-01-18 | 1991-07-25 | Cura Nominees Pty Ltd | Glycoalkaloids |
WO1993021929A1 (en) * | 1992-05-01 | 1993-11-11 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Phosphorothioate derivatives of cyclic amp analogues |
WO1998058650A1 (en) * | 1997-06-20 | 1998-12-30 | University Of Utah Research Foundation | Use of plant-alkaloids to enhance innate immunity defense mechanisms |
WO1999052534A1 (en) * | 1998-04-09 | 1999-10-21 | Johns Hopkins University School Of Medicine | Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4007268A (en) * | 1973-01-16 | 1977-02-08 | The Regents Of The University Of Michigan | Process for alleviating proliferative skin diseases |
US4353888A (en) | 1980-12-23 | 1982-10-12 | Sefton Michael V | Encapsulation of live animal cells |
US5041138A (en) | 1986-11-20 | 1991-08-20 | Massachusetts Institute Of Technology | Neomorphogenesis of cartilage in vivo from cell culture |
US5092871A (en) | 1987-03-13 | 1992-03-03 | Brown University Research Foundation | Electrically-charged nerve guidance channels |
US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
US4955892A (en) | 1988-10-24 | 1990-09-11 | Louisiana State University | Neural cell adhesion protein nerve prosthesis |
WO1991007087A1 (en) | 1989-11-13 | 1991-05-30 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
EP0448029B1 (en) * | 1990-03-23 | 1995-12-20 | Nippon Kayaku Kabushiki Kaisha | Novel pharmaceutical uses of forskolin derivatives |
ES2155822T3 (en) | 1990-12-06 | 2001-06-01 | Affymetrix Inc | COMPOUNDS AND ITS USE IN A BINARY SYNTHESIS STRATEGY. |
AU665012B2 (en) | 1991-07-08 | 1995-12-14 | Neurospheres Holdings Ltd | Novel growth factor-responsive progenitor cells which can be proliferated (in vitro) |
IL99368A (en) * | 1991-09-02 | 1996-01-19 | Teva Pharma | Compositions for topical treatment of psoriasis and atopic dermatitis comprising a xanthine derivative |
AU675054B2 (en) | 1991-11-22 | 1997-01-23 | Affymetrix, Inc. | Combinatorial strategies for polymer synthesis |
US5359115A (en) | 1992-03-26 | 1994-10-25 | Affymax Technologies, N.V. | Methods for the synthesis of phosphonate esters |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
EP0665897B1 (en) | 1992-10-01 | 2003-07-09 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
WO1994009229A1 (en) | 1992-10-12 | 1994-04-28 | Jack Uhlmann | A method in arrangement for holding objects and an arrangement for carrying out the method |
PT669973E (en) | 1992-10-28 | 2003-06-30 | Neurospheres Holdings Ltd | BIOLOGICAL FACTORS AND NEURAL ESTAMINAL CELLS |
AU687785B2 (en) | 1993-01-29 | 1998-03-05 | Neurospheres Holdings Ltd | Genetic modification of neural stem cells |
US5519035A (en) * | 1993-07-02 | 1996-05-21 | Cornell Research Foundation, Inc. | Treatment of stroke or in anticipation of the occurrence of brain ischemia |
US5362899A (en) | 1993-09-09 | 1994-11-08 | Affymax Technologies, N.V. | Chiral synthesis of alpha-aminophosponic acids |
US5712171A (en) | 1995-01-20 | 1998-01-27 | Arqule, Inc. | Method of generating a plurality of chemical compounds in a spatially arranged array |
US5891875A (en) * | 1996-05-20 | 1999-04-06 | Eli Lilly And Company | Morpholinyl tachykinin receptor antagonists |
US6291516B1 (en) * | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
-
1999
- 1999-10-14 US US09/417,564 patent/US6291516B1/en not_active Expired - Lifetime
-
2000
- 2000-01-13 WO PCT/US2000/000873 patent/WO2000041545A2/en active IP Right Grant
- 2000-01-13 CA CA002370042A patent/CA2370042A1/en not_active Abandoned
- 2000-01-13 EP EP00906910A patent/EP1143961A2/en not_active Withdrawn
- 2000-01-13 JP JP2000593166A patent/JP2003517279A/en active Pending
- 2000-01-13 AU AU28491/00A patent/AU778866B2/en not_active Ceased
- 2000-01-13 IL IL14414700A patent/IL144147A0/en active IP Right Grant
-
2001
- 2001-05-29 US US09/867,311 patent/US6686388B2/en not_active Expired - Lifetime
- 2001-07-04 IL IL144147A patent/IL144147A/en not_active IP Right Cessation
-
2003
- 2003-12-12 US US10/735,116 patent/US20040127474A1/en not_active Abandoned
-
2005
- 2005-09-19 US US11/230,063 patent/US20060020020A1/en not_active Abandoned
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0020029A1 (en) * | 1979-05-02 | 1980-12-10 | Aruba (Qld.) Pty. Ltd. | Pharmaceutical compositions comprising steroid alkaloids |
US4751224A (en) * | 1983-07-21 | 1988-06-14 | Brown University Research Foundation | Treatment of metastasis |
US4634706A (en) * | 1983-10-28 | 1987-01-06 | Sankyo Company Limited | Griseolic acid derivatives, and their use as enzyme inhibitors |
WO1989011487A1 (en) * | 1988-05-23 | 1989-11-30 | United States Of America, Represented By The Secre | Derivatives of cyclic amp as treatment for cancer |
WO1991010743A1 (en) * | 1990-01-18 | 1991-07-25 | Cura Nominees Pty Ltd | Glycoalkaloids |
WO1993021929A1 (en) * | 1992-05-01 | 1993-11-11 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Phosphorothioate derivatives of cyclic amp analogues |
WO1998058650A1 (en) * | 1997-06-20 | 1998-12-30 | University Of Utah Research Foundation | Use of plant-alkaloids to enhance innate immunity defense mechanisms |
WO1999052534A1 (en) * | 1998-04-09 | 1999-10-21 | Johns Hopkins University School Of Medicine | Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8895576B2 (en) | 2006-12-28 | 2014-11-25 | Infinity Pharmaceuticals, Inc. | Methods of use of cyclopamine analogs |
US9492435B2 (en) | 2006-12-28 | 2016-11-15 | Infinity Pharmaceuticals, Inc. | Cyclopamine analogs |
Also Published As
Publication number | Publication date |
---|---|
WO2000041545A2 (en) | 2000-07-20 |
JP2003517279A (en) | 2003-05-27 |
EP1143961A2 (en) | 2001-10-17 |
AU2849100A (en) | 2000-08-01 |
CA2370042A1 (en) | 2000-07-20 |
IL144147A0 (en) | 2002-05-23 |
AU778866B2 (en) | 2004-12-23 |
US20010034337A1 (en) | 2001-10-25 |
US6291516B1 (en) | 2001-09-18 |
US6686388B2 (en) | 2004-02-03 |
US20040127474A1 (en) | 2004-07-01 |
IL144147A (en) | 2015-03-31 |
US20060020020A1 (en) | 2006-01-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2000041545A3 (en) | Regulators of the pct or smoothened pathway, compositions and uses related thereto | |
WO2003027234A3 (en) | Small organic molecule regulators of cell proliferation | |
WO2002030421A3 (en) | Mediators of hedgehog signaling pathways, compositions and uses related thereto | |
WO2001026644A3 (en) | Mediators of hedgehog signaling pathways, compositions and uses related thereto | |
AU4966401A (en) | Small organic molecule regulators of cell proliferation | |
WO2003011219A3 (en) | Mediators of hedgehog signaling pathways, compositions and uses related thereto | |
WO2001019800A3 (en) | Mediators of hedgehog signaling pathways, compositions and uses related thereto | |
EP1997494A3 (en) | Modulators of hedgehog signaling pathways, compositions and uses related thereto | |
WO2002048115A3 (en) | Quinazolinones and pyridinopyrimidinones for controlling invertebrate pests | |
WO2004046129A3 (en) | Novel anthranilamide insecticides | |
WO2001027135A3 (en) | Regulators of the hedgehog pathway, compositions and uses related thereto | |
WO2003029264A3 (en) | 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof | |
WO2008014291A3 (en) | Compounds and compositions as hedgehog signaling pathway modulators | |
IL160700A0 (en) | 3-substituted-4-pyrimidone derivatives | |
UA66837C2 (en) | 3-hydroxy-4-aryl-5-oxopyrazoline derivatives revealing herbicidal activity | |
WO2007003603A3 (en) | Fungicide mixtures based on 3-monosubstituted pyrazole carboxylic acid biphenyl amides | |
AU2005205408A1 (en) | Differentiation regulating agent containing gene which regulating differentiation from stem cells into natural killer cells as effective ingredient | |
EP1291344A4 (en) | Rice blast control agents | |
EP1864670A4 (en) | Sucrase activity inhibitor, glucoamylase activity inhibitor and food and feed containing the same | |
EP1333029A4 (en) | Pyrimidine derivatives and herbicides containing the same | |
EP1676892A4 (en) | Ink composition | |
WO2002006512A3 (en) | Method for detecting uracil biosynthesis inhibitors and their use as herbicides | |
WO2001078654A3 (en) | Halogentated 2-amino-3, 4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors | |
EP1011724A4 (en) | Regulation of osteoclast formation by inhibition of osteoblastic stem cell factor | |
WO2003075662A8 (en) | Fungicidal composition for control of rice plant disease |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 144147 Country of ref document: IL |
|
WWE | Wipo information: entry into national phase |
Ref document number: 28491/00 Country of ref document: AU |
|
ENP | Entry into the national phase |
Ref document number: 2370042 Country of ref document: CA Kind code of ref document: A Ref document number: 2370042 Country of ref document: CA |
|
ENP | Entry into the national phase |
Ref document number: 2000 593166 Country of ref document: JP Kind code of ref document: A |
|
REEP | Request for entry into the european phase |
Ref document number: 2000906910 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2000906910 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2000906910 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWG | Wipo information: grant in national office |
Ref document number: 28491/00 Country of ref document: AU |