WO2000047062A3 - Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same - Google Patents

Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same Download PDF

Info

Publication number
WO2000047062A3
WO2000047062A3 PCT/US2000/002687 US0002687W WO0047062A3 WO 2000047062 A3 WO2000047062 A3 WO 2000047062A3 US 0002687 W US0002687 W US 0002687W WO 0047062 A3 WO0047062 A3 WO 0047062A3
Authority
WO
WIPO (PCT)
Prior art keywords
filtrate
proanthocyanidin
proanthocyanidin polymer
dietary supplements
retentate
Prior art date
Application number
PCT/US2000/002687
Other languages
French (fr)
Other versions
WO2000047062A2 (en
Inventor
David F Sesin
Shivanand D Jolad
Chow San-Laung
George J Lee
John W S Chow
Thomas J Carlson
Original Assignee
Shaman Pharmaceuticals Inc
David F Sesin
Shivanand D Jolad
San Laung Chow
George J Lee
John W S Chow
Thomas J Carlson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shaman Pharmaceuticals Inc, David F Sesin, Shivanand D Jolad, San Laung Chow, George J Lee, John W S Chow, Thomas J Carlson filed Critical Shaman Pharmaceuticals Inc
Priority to AU29790/00A priority Critical patent/AU2979000A/en
Publication of WO2000047062A2 publication Critical patent/WO2000047062A2/en
Publication of WO2000047062A3 publication Critical patent/WO2000047062A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates

Abstract

The present invention provides for a method for preparing a proanthocyanidin enriched composition useful as a dietary supplement. The proanthocyanidin polymer composition can be synthesized by the method comprising the steps of precipitating Croton ssp latex by adjusting the pH of the latex; removing precipitated residue from the precipitated latex to produce a filtrate; concentrating the filtrate to obtain a retentate; and drying the filtrate, the filtrate being essentially free of anti-foaming agents. A further optional additional step includes removing additional taspine from the retentate by contacting said retentate with chromatographic media. A proanthocyanidin composition product made by this process is also described. Dietary supplements containing a proanthocyanidin polymer enriched composition as well as dietary supplements containing a proanthocyanidin polymer enriched composition and an additional herbal agent, e.g., ginger, cinnamon, and peppermint oil are also described.
PCT/US2000/002687 1999-02-01 2000-02-01 Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same WO2000047062A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU29790/00A AU2979000A (en) 1999-02-01 2000-02-02 Enteric formulations of proanthocyanidin polymer dietary supplements and methodsfor preparing same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24319799A 1999-02-01 1999-02-01
US09/243,197 1999-02-01
US36424899A 1999-07-29 1999-07-29
US09/364,248 1999-07-29

Publications (2)

Publication Number Publication Date
WO2000047062A2 WO2000047062A2 (en) 2000-08-17
WO2000047062A3 true WO2000047062A3 (en) 2000-12-14

Family

ID=26935660

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/002687 WO2000047062A2 (en) 1999-02-01 2000-02-01 Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same

Country Status (2)

Country Link
AU (1) AU2979000A (en)
WO (1) WO2000047062A2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1143807A3 (en) * 1999-08-13 2002-09-11 Dry Creek Nutrition, Inc. Novel polyphenolic polymeric compositions, method of their isolation, and a method of altering and improving taste characteristics of edible consumables
US6960360B2 (en) 2000-08-31 2005-11-01 Phenolics, Llc Efficient method for producing compositions enriched in total phenols
FR2825899B1 (en) * 2001-06-14 2004-10-01 Phytosynthese PREPARATION FOR ANIMALS, ESPECIALLY POULTRY
US7208183B2 (en) * 2002-10-05 2007-04-24 Bobrowski Paul J Methods and preparations of the latex from the croton species
FR2852842A1 (en) * 2003-03-31 2004-10-01 Silab Sa Process for preparing an active component from the resin exudate of fruits of Daemonorops or Croton, useful for dermatological application to protect against free radicals
EP1502594A1 (en) * 2003-07-31 2005-02-02 Pynogin GmbH A health care composition for decreasing the risk of thrombosis including a mixture of proanthocyanidins and sesquiterpenes
EP2529626B1 (en) 2006-05-01 2017-11-22 Napo Pharmaceuticals, Inc. Compositions and methods for treating or preventing colon cancer
US20070254050A1 (en) * 2006-05-01 2007-11-01 Quart Barry D Method for treatment of diarrhea-predominant irritable bowel syndrome
WO2007130892A2 (en) * 2006-05-01 2007-11-15 Napo Pharmaceuticals, Inc. Method for treatment of constipation-predominant irritable bowel syndrome
AU2013205344B2 (en) * 2006-05-01 2016-11-10 Napo Pharmaceuticals, Inc. Method for treatment of diarrhea-predominant irritable bowel syndrome
US8048413B2 (en) * 2006-05-17 2011-11-01 Helene Huguet Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules
BRPI0704096E2 (en) 2006-12-27 2009-09-15 Kraft Foods Holdings Inc method for significantly reducing astringency and bitterness levels in polyphenol compositions, and, composition
US8445040B2 (en) 2008-02-19 2013-05-21 Management and Holdings—Ardom Extracts of Sclerocarya birrea
US9210945B2 (en) 2009-07-31 2015-12-15 The Iams Company Animal food having low water activity
US8691303B2 (en) 2009-07-31 2014-04-08 The Iams Company Dusted animal food
US20110027417A1 (en) 2009-07-31 2011-02-03 Patrick Joseph Corrigan Process for Dusting Animal Food
US9173423B2 (en) 2009-07-31 2015-11-03 The Iams Company Animal food kibble with electrostatically adhered dusting
US10104903B2 (en) 2009-07-31 2018-10-23 Mars, Incorporated Animal food and its appearance
EA023814B1 (en) * 2009-08-26 2016-07-29 Гленмарк Фармасьютикалс Лтд. Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations
MX348184B (en) * 2010-10-31 2017-06-02 Napo Pharmaceuticals Inc Methods and compositions for treating hiv-associated diarrhea.
RU2593014C2 (en) * 2011-01-27 2016-07-27 Гленмарк Фармасьютикалс Лимитед Method for production of proanthocyanidin polymer composition
CN104383491A (en) * 2014-11-20 2015-03-04 王正琦 Traditional Chinese medicine composition for treating chronic diarrhea
EP3242557A4 (en) * 2015-01-09 2018-09-05 Jaguar Health, Inc. Methods of treating diarrhea in companion animals
CN104587352A (en) * 2015-02-15 2015-05-06 赵世明 Traditional Chinese medicinal composition for treating diarrhea
WO2016133909A1 (en) 2015-02-16 2016-08-25 Mars, Incorporated Interlocking kibble
CN107529789A (en) 2015-04-28 2018-01-02 马斯公司 The method for preparing sterilizing wet pet foodstuffs
JOP20190275A1 (en) 2017-05-31 2019-11-27 Napo Pharmaceuticals Inc Methods and compositions for treating congenital diarrhea disorder
JOP20190276A1 (en) 2017-05-31 2019-11-27 Napo Pharmaceuticals Inc Methods and compositions for treating bile acid diarrhea, diarrhea associated with small intestine resection or gallbladder removal, and short bowel syndrome

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5211944A (en) * 1990-10-12 1993-05-18 Shaman Pharmaceuticals, Inc. Proanthocyanidin polymers having antiviral activity and methods of obtaining same
WO1997044407A1 (en) * 1996-05-23 1997-11-27 Ian Alexander Gilmour Process for extraction of proanthocyanidins from botanical material
WO1998016111A1 (en) * 1996-10-16 1998-04-23 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer antidiarrheal compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5211944A (en) * 1990-10-12 1993-05-18 Shaman Pharmaceuticals, Inc. Proanthocyanidin polymers having antiviral activity and methods of obtaining same
US5494661A (en) * 1990-10-12 1996-02-27 Shaman Pharmaceuticals, Inc. Methods for using proanthocyanidin polymers having antiviral activity
WO1997044407A1 (en) * 1996-05-23 1997-11-27 Ian Alexander Gilmour Process for extraction of proanthocyanidins from botanical material
WO1998016111A1 (en) * 1996-10-16 1998-04-23 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer antidiarrheal compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1987, NAMBA T. ET AL.: "Studies on the natural medicinal resources from Sri-Lanka ...", XP002142639 *

Also Published As

Publication number Publication date
WO2000047062A2 (en) 2000-08-17
AU2979000A (en) 2000-08-29

Similar Documents

Publication Publication Date Title
WO2000047062A3 (en) Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same
ATE297213T1 (en) SOY EXTRACT, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION
DE69825003D1 (en) Process for the production and use of phytochemicals
EP1319667A3 (en) Solid phase method for the synthesis of peptide-spacer-lipid conjugates, conjugates synthesized thereby and targeted liposomes containing the same
DE69021019D1 (en) A process for producing an extract from gingko biloba leaves.
CA2295444A1 (en) A method for the production of sterile skimmed milk
Lawhon et al. Combining aqueous extraction and membrane isolation techniques to recover protein and oil from soybeans
ATE138923T1 (en) METHOD FOR PRODUCING PURIFIED GLYCOLIPIDES BY MEMBRANE SEPARATION PROCESS
US4793996A (en) Method of making soybean extract inhibitor
DE60002081D1 (en) A COMPLEX CONTAINING LIGNAN, PHENOLIC AND ALIPHATIC SUBSTANCES ISOLATED FROM FLAX AND METHOD FOR THE PRODUCTION THEREOF
HUP9900009A2 (en) Ginkgo biloba flavonoid extract which is terpene-free and/or has a high flavonoid heteroside content
WO2003068784A3 (en) Acyl- and bisacylphosphine derivatives
CA2757925A1 (en) Process for removing pesticides from ginkgo biloba extracts, and extracts obtainable by said process
WO2001068729A8 (en) Compositions and methods for selectively binding amines or amino acid enantiomers over their counter-enantiomers
WO2003046199A3 (en) Process for the production of alginate having a high mannuronic acid-content
Allen et al. An enantiomeric assay for the flavonoids medicarpin and vestitone using capillary electrophoresis
DE60117158D1 (en) METHOD FOR PRODUCING A MODIFIED CEREAL SOURCE PRODUCT
WO2004009632A3 (en) Method for the production of an immunostimulating mucin (muc1)
EP1531182A3 (en) Process for obtaining sterols and polar lipids from lecithin by ulrafiltration and pretreatment by glycosl hydrolases
AU5909196A (en) Extract from the leaves of ginkgo biloba
DE692480T1 (en) Process for the preparation of extracts containing polyphenalic oligomeric compounds of catechin type from plant-like sources, and extracts obtained therefrom
WO2000068395A3 (en) Sulfohydrolases, corresponding amino acid and nucleotide sequences, sulfohydrolase preparations, processes, and products thereof
DE59813491D1 (en) Process for the preparation of a preparation containing a hyaluronidase
HUP0102518A2 (en) 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them
EP0796915A3 (en) Process for the preparation and use of acarviosyl-transferase in the conversion of ascarbose-homologous in acarbose and in the preparation of acarbose-homologous

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase