WO2000048735A3 - Matrix storage and dispensing system - Google Patents

Matrix storage and dispensing system Download PDF

Info

Publication number
WO2000048735A3
WO2000048735A3 PCT/US2000/003841 US0003841W WO0048735A3 WO 2000048735 A3 WO2000048735 A3 WO 2000048735A3 US 0003841 W US0003841 W US 0003841W WO 0048735 A3 WO0048735 A3 WO 0048735A3
Authority
WO
WIPO (PCT)
Prior art keywords
array
dispensers
reagents
platform assembly
reagent
Prior art date
Application number
PCT/US2000/003841
Other languages
French (fr)
Other versions
WO2000048735A2 (en
Inventor
Charles S Vann
David M Cox
Original Assignee
Perkin Elmer Corp
Charles S Vann
David M Cox
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perkin Elmer Corp, Charles S Vann, David M Cox filed Critical Perkin Elmer Corp
Priority to AT00908647T priority Critical patent/ATE228393T1/en
Priority to EP00908647A priority patent/EP1171230B1/en
Priority to DE60000874T priority patent/DE60000874T2/en
Priority to AU29952/00A priority patent/AU746802B2/en
Priority to JP2000599509A priority patent/JP3844967B2/en
Priority to CA002361275A priority patent/CA2361275C/en
Publication of WO2000048735A2 publication Critical patent/WO2000048735A2/en
Publication of WO2000048735A3 publication Critical patent/WO2000048735A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
    • B01J2219/0031—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks the racks or blocks being mounted in stacked arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00322—Reactor vessels in a multiple arrangement the individual reactor vessels being arranged serially in stacks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00331—Details of the reactor vessels
    • B01J2219/00333—Closures attached to the reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00389—Feeding through valves
    • B01J2219/00409—Solenoids in combination with valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00461—Beads and reaction vessel together
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00461—Beads and reaction vessel together
    • B01J2219/00463—Directed sorting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00466—Beads in a slurry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00468—Beads by manipulation of individual beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547—Bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00691—Automatic using robots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00693—Means for quality control
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G01N2035/00752—Type of codes bar codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0418—Plate elements with several rows of samples
    • G01N2035/042—Plate elements with several rows of samples moved independently, e.g. by fork manipulator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0418—Plate elements with several rows of samples
    • G01N2035/0425—Stacks, magazines or elevators for plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1041—Ink-jet like dispensers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Abstract

The present invention provides a system and process providing variable access to, as well as quick and accurate dispensing of, numerous selected reagents from a mass storage arrangement. According to one embodiment, an array of reagent dispensers is supported over a movable platform assembly. The platform assembly aligns a designated receiving receptacle under a selected dispenser of the array so that a respective reagent can be dispensed therein. The dispensers in the matrix have a gate at the lower outlet region. The reagents can be in fluid or solid form, such as beads for solid phase synthesis. Advantageously, the apparatus and process can be carried out under the control of a programmed computer.
PCT/US2000/003841 1999-02-16 2000-02-15 Matrix storage and dispensing system WO2000048735A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AT00908647T ATE228393T1 (en) 1999-02-16 2000-02-15 MATRIX SYSTEM FOR STORAGE AND DISPENSING
EP00908647A EP1171230B1 (en) 1999-02-16 2000-02-15 Matrix storage and dispensing system
DE60000874T DE60000874T2 (en) 1999-02-16 2000-02-15 MATRIX SYSTEM FOR STORAGE AND DELIVERY
AU29952/00A AU746802B2 (en) 1999-02-16 2000-02-15 Matrix storage and dispensing system
JP2000599509A JP3844967B2 (en) 1999-02-16 2000-02-15 Matrix storage and distribution system
CA002361275A CA2361275C (en) 1999-02-16 2000-02-15 Matrix storage and dispensing system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/251,232 1999-02-16
US09/251,232 US6432719B1 (en) 1999-02-16 1999-02-16 Matrix storage and dispensing system

Publications (2)

Publication Number Publication Date
WO2000048735A2 WO2000048735A2 (en) 2000-08-24
WO2000048735A3 true WO2000048735A3 (en) 2000-12-28

Family

ID=22951044

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/003841 WO2000048735A2 (en) 1999-02-16 2000-02-15 Matrix storage and dispensing system

Country Status (8)

Country Link
US (1) US6432719B1 (en)
EP (2) EP1254703A3 (en)
JP (2) JP3844967B2 (en)
AT (1) ATE228393T1 (en)
AU (1) AU746802B2 (en)
CA (1) CA2361275C (en)
DE (1) DE60000874T2 (en)
WO (1) WO2000048735A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8283165B2 (en) 2008-09-12 2012-10-09 Genvault Corporation Matrices and media for storage and stabilization of biomolecules
US8431384B2 (en) 2004-05-24 2013-04-30 Genvault Corporation Stable protein storage and stable nucleic acid storage in recoverable form

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020102598A1 (en) * 1997-06-16 2002-08-01 Lafferty William Michael Positioning system for moving a selected station of a holding plate to a predetermined location for interaction with a probe
US20030054543A1 (en) * 1997-06-16 2003-03-20 Lafferty William Michael Device for moving a selected station of a holding plate to a predetermined location for interaction with a probe
DE60030957T2 (en) * 1999-02-16 2007-06-14 Applera Corp., Foster City BALL DELIVERY SYSTEM
US7101510B2 (en) * 1999-02-16 2006-09-05 Applera Corporation Matrix storage and dispensing system
US20050100943A1 (en) * 2000-04-11 2005-05-12 Hideki Kambara Method of producing probe arrays for biological materials using fine particles
US6387330B1 (en) * 2000-04-12 2002-05-14 George Steven Bova Method and apparatus for storing and dispensing reagents
US6815198B2 (en) * 2000-04-27 2004-11-09 Hitachi Electronics Engineering Co., Ltd. Apparatus for automated preparation of DNA samples and reactor for preparing DNA samples
US6613284B2 (en) * 2001-02-01 2003-09-02 V&P Scientific, Inc. Microarrayer
US6943036B2 (en) * 2001-04-30 2005-09-13 Agilent Technologies, Inc. Error detection in chemical array fabrication
WO2003035239A2 (en) * 2001-10-26 2003-05-01 Sequenom Inc. Resin dispensing device
US7584240B2 (en) 2001-11-07 2009-09-01 Genvault Corporation Automated biological sample archive for storage, retrieval and analysis of large numbers of samples for remote clients
US20030143329A1 (en) * 2002-01-30 2003-07-31 Shchegrova Svetlana V. Error correction in array fabrication
WO2004042327A2 (en) * 2002-11-04 2004-05-21 Transform Pharmaceuticals, Inc. Method and apparatus for manipulating and measuring solids
DE60321492D1 (en) * 2003-01-06 2008-07-17 Fujirebio Kk DEVICE FOR REMOVING A STAINED WORKPIECE WITH A WIDE END
EP1473085B1 (en) * 2003-03-31 2015-07-22 Canon Kabushiki Kaisha Biochemical reaction cartridge
EP1629285A2 (en) * 2003-06-05 2006-03-01 Bioprocessors Corporation System and method for process automation
DE10327380A1 (en) * 2003-06-18 2005-01-13 Eppendorf Ag System for dosing sample liquid
US7097070B2 (en) * 2003-08-15 2006-08-29 Protedyne Corporation Method and apparatus for handling small volume fluid samples
US20050233472A1 (en) * 2003-09-19 2005-10-20 Kao H P Spotting high density plate using a banded format
US20050226771A1 (en) * 2003-09-19 2005-10-13 Lehto Dennis A High speed microplate transfer
US7570443B2 (en) 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
DE10347311A1 (en) * 2003-10-08 2005-05-12 Ehrfeld Mikrotechnik Ag Method and device for carrying out reactions
US20050186578A1 (en) * 2004-02-20 2005-08-25 Sven Bulow Chamber array arrangement
EP1789194B1 (en) * 2004-07-27 2010-03-24 Protedyne Corporation Method and apparatus for applying pressure diferential to multi-well plate
US20060063159A1 (en) * 2004-09-22 2006-03-23 Applera Corporation Post-synthesis processing system for supported oligonucleotides, and method
US20080269076A1 (en) * 2005-05-06 2008-10-30 Applera Corporation Multiple Capillary Device and Method for Synthesis and Dispensing
WO2007130434A2 (en) * 2006-05-02 2007-11-15 Applera Corporation Variable volume dispenser and method
WO2008002562A2 (en) * 2006-06-26 2008-01-03 Applera Corporation Compressible transparent sealing for open microplates
EP2046940A4 (en) * 2006-06-26 2011-08-10 Life Technologies Corp Heated cover methods and technology
WO2008092116A2 (en) * 2007-01-26 2008-07-31 Biodot, Inc. Non-contact positive dispense solid powder sampling apparatus and method
EP2386357B3 (en) 2007-10-01 2015-01-14 Tecan Trading AG Micro-cuvette assembly and its application
US20100011889A1 (en) * 2008-07-16 2010-01-21 Biodot, Inc. Handheld powder handling devices and related methods
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
BRPI1002708B1 (en) * 2010-07-14 2020-08-04 Tecnotok Indústria De Máquinas Ltda DOSING DEVICE
KR20130111899A (en) * 2012-04-02 2013-10-11 (주)제이브이엠 Injection and related products dispensing apparatus
WO2014094062A1 (en) * 2012-12-21 2014-06-26 Leica Biosystems Melbourne Pty Ltd Method of producing a reagent on-board an instrument
WO2016004171A1 (en) 2014-07-03 2016-01-07 Centrillion Technology Holdings Corporation Device for storage and dispensing of reagents
US10307724B2 (en) 2015-07-02 2019-06-04 Centrillion Technology Holdings Corporation Systems and methods to dispense and mix reagents
FR3057559B1 (en) * 2016-10-13 2018-11-16 Diagnostica Stago DEVICE FOR DISPENSING BALLS, IN PARTICULAR BALLS FOR ANALYSIS CUPES
GB201716135D0 (en) * 2017-10-03 2017-11-15 Ge Healthcare Uk Ltd Improvements in the storage of nucleic acids
US11160353B2 (en) * 2019-04-05 2021-11-02 L'oreal Bead assembly for custom formulation systems

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2099803A (en) * 1981-05-20 1982-12-15 Goshe Dr Karabi Tablet dispenser
US4991628A (en) * 1988-04-15 1991-02-12 Kone Oy Valve system, e.g. for analyzers
EP0475533A2 (en) * 1990-09-11 1992-03-18 Prince Technologies B.V. Method and apparatus for the introduction of a volume of at least one fluid in a tube, in particular suitable for capillary electrophoresis systems and method and apparatus for separating and/or analyzing a fluid material
US5306510A (en) * 1988-01-14 1994-04-26 Cyberlab, Inc. Automated pipetting system
WO1996036436A1 (en) * 1995-04-25 1996-11-21 Irori Remotely programmable matrices with memories and uses thereof
US5620853A (en) * 1993-08-23 1997-04-15 Chiron Corporation Assay device with captured particle reagent
EP0803452A1 (en) * 1996-04-26 1997-10-29 Fluidelec Storage and delivery system for articles having different shapes and dimensions
WO1998015825A2 (en) * 1996-10-07 1998-04-16 Irori Matrices with memories in automated drug discovery and units therefor
WO1998038122A1 (en) * 1997-02-26 1998-09-03 Sarnoff Corporation Bead dispersement devices
WO1998040159A2 (en) * 1997-03-10 1998-09-17 Trega Biosciences, Inc. Apparatus and method for combinatorial chemistry synthesis
US5812410A (en) * 1995-12-14 1998-09-22 Rx Excel, Inc. System for dispensing drugs

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3568735A (en) * 1968-06-26 1971-03-09 Cooke Eng Co Laboratory microtitration dispensing apparatus
GB1444614A (en) * 1972-09-07 1976-08-04 Kurpanek W H Permanently implantable artificial heart
US3843053A (en) 1973-03-29 1974-10-22 Kontes Glass Co Spotter for use in thin layer chromatography and method of forming drops therewith
US4272510A (en) * 1976-04-26 1981-06-09 Smith Kendall O Magnetic attraction transfer process for use in solid phase radioimmunoassays and in other assay methods
US4101284A (en) 1977-10-25 1978-07-18 Abbott Laboratories Multiple bead dispenser for diagnostic assay
US4444336A (en) 1980-08-27 1984-04-24 Burns, Philp & Company, Ltd. Dispensing unit
US4415098A (en) 1981-06-15 1983-11-15 Abbott Laboratories Single bead dispenser
WO1984002090A1 (en) 1982-11-20 1984-06-07 Thomas Paterson Whitehead Dispensing device and recording apparatus
US4937048A (en) * 1983-01-31 1990-06-26 Olympus Optical Company Limited Carrier transporting apparatus and carrier container for use in an immunological analysis
FR2543429B1 (en) * 1983-03-30 1986-09-26 Curie Universite Pierre Et Mar ARTIFICIAL HEART VALVE WITH ACTIVE OPENING
FR2554016B1 (en) * 1983-10-27 1986-08-08 Pasteur Institut IMPROVEMENTS IN MAGNETIC MEANS FOR REMOVING MAGNETIC GEL BALLS FROM A DOSING FLUID
DE3407849A1 (en) 1984-02-29 1985-08-29 Alois 3201 Algermissen Höft METHOD AND DEVICE FOR SIMULTANEOUSLY APPLYING A VARIETY OF LIQUID SAMPLES TO A SLIDE
US4952518A (en) 1984-10-01 1990-08-28 Cetus Corporation Automated assay machine and assay tray
US4681742A (en) 1984-10-01 1987-07-21 Cetus Corporation Assay tray
US4648529A (en) 1985-06-12 1987-03-10 Cetus Corporation Dispensing apparatus for storing, draining and dispensing beads
US5011779A (en) 1988-01-21 1991-04-30 Long Island Jewish Medical Center Apparatus for rapid deposition of test samples on an absorbent support
US4979955A (en) * 1988-06-06 1990-12-25 Smith Robert M Power assisted prosthetic heart valve
US5046539A (en) 1989-05-26 1991-09-10 The Rockefeller University Automatic fluid dispenser for multi-welled dish
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5525302A (en) * 1991-02-01 1996-06-11 Astle; Thomas W. Method and device for simultaneously transferring plural samples
EP0916396B1 (en) 1991-11-22 2005-04-13 Affymetrix, Inc. (a Delaware Corporation) Combinatorial strategies for polymer synthesis
US5508200A (en) 1992-10-19 1996-04-16 Tiffany; Thomas Method and apparatus for conducting multiple chemical assays
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
GB9413754D0 (en) * 1994-07-07 1994-08-24 Boc Group Plc Liquid dispensing apparatus
US5616299A (en) 1995-06-06 1997-04-01 Pharmacia Biotech, Inc. Dispenser for dried biological reagent spheres
US5571258A (en) 1995-07-13 1996-11-05 Pearson; Walter G. Semi-automated medication dispenser
US5722470A (en) 1995-11-09 1998-03-03 Glaxo Group Limited Bead dispensing device and methods
US5649576A (en) * 1996-02-26 1997-07-22 Pharmacopeia, Inc. Partitioning device
US5788814A (en) 1996-04-09 1998-08-04 David Sarnoff Research Center Chucks and methods for positioning multiple objects on a substrate
US5846595A (en) 1996-04-09 1998-12-08 Sarnoff Corporation Method of making pharmaceutical using electrostatic chuck
US6074609A (en) 1996-04-24 2000-06-13 Glaxo Wellcome Inc. Systems for arraying beads
US5958342A (en) 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
US5773296A (en) 1996-06-28 1998-06-30 Dpc Cirrus, Inc. Bead dispenser and bead dispenser system for immunoassay analysis
DE19628178C1 (en) 1996-07-12 1997-09-18 Bruker Franzen Analytik Gmbh Loading matrix-assisted laser desorption-ionisation sample plate for mass spectrometric analysis
EP1007966A4 (en) 1996-08-21 2001-10-17 Smithkline Beecham Corp Rapid process for arraying and synthesizing bead-based combinatorial libraries
WO1998017383A1 (en) 1996-10-21 1998-04-30 Smithkline Beecham Plc Apparatus and method for distributing beads
WO1998032000A1 (en) * 1997-01-17 1998-07-23 Smithkline Beecham Corporation Apparatus and process for arraying beads
US5978251A (en) * 1997-11-14 1999-11-02 Ramtron International Corporation Plate line driver circuit for a 1T/1C ferroelectric memory

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2099803A (en) * 1981-05-20 1982-12-15 Goshe Dr Karabi Tablet dispenser
US5306510A (en) * 1988-01-14 1994-04-26 Cyberlab, Inc. Automated pipetting system
US4991628A (en) * 1988-04-15 1991-02-12 Kone Oy Valve system, e.g. for analyzers
EP0475533A2 (en) * 1990-09-11 1992-03-18 Prince Technologies B.V. Method and apparatus for the introduction of a volume of at least one fluid in a tube, in particular suitable for capillary electrophoresis systems and method and apparatus for separating and/or analyzing a fluid material
US5620853A (en) * 1993-08-23 1997-04-15 Chiron Corporation Assay device with captured particle reagent
WO1996036436A1 (en) * 1995-04-25 1996-11-21 Irori Remotely programmable matrices with memories and uses thereof
US5812410A (en) * 1995-12-14 1998-09-22 Rx Excel, Inc. System for dispensing drugs
EP0803452A1 (en) * 1996-04-26 1997-10-29 Fluidelec Storage and delivery system for articles having different shapes and dimensions
WO1998015825A2 (en) * 1996-10-07 1998-04-16 Irori Matrices with memories in automated drug discovery and units therefor
WO1998038122A1 (en) * 1997-02-26 1998-09-03 Sarnoff Corporation Bead dispersement devices
WO1998040159A2 (en) * 1997-03-10 1998-09-17 Trega Biosciences, Inc. Apparatus and method for combinatorial chemistry synthesis

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8431384B2 (en) 2004-05-24 2013-04-30 Genvault Corporation Stable protein storage and stable nucleic acid storage in recoverable form
US8283165B2 (en) 2008-09-12 2012-10-09 Genvault Corporation Matrices and media for storage and stabilization of biomolecules
US8951719B2 (en) 2008-09-12 2015-02-10 Gentegra, LLC. Matrices and media for storage and stabilization of biomolecules

Also Published As

Publication number Publication date
EP1171230B1 (en) 2002-11-27
EP1171230A2 (en) 2002-01-16
EP1254703A2 (en) 2002-11-06
US6432719B1 (en) 2002-08-13
WO2000048735A2 (en) 2000-08-24
CA2361275C (en) 2005-09-06
JP2006047320A (en) 2006-02-16
DE60000874D1 (en) 2003-01-09
AU2995200A (en) 2000-09-04
JP3844967B2 (en) 2006-11-15
AU746802B2 (en) 2002-05-02
CA2361275A1 (en) 2000-08-24
JP2002537043A (en) 2002-11-05
EP1254703A3 (en) 2004-01-02
ATE228393T1 (en) 2002-12-15
DE60000874T2 (en) 2003-08-28

Similar Documents

Publication Publication Date Title
WO2000048735A3 (en) Matrix storage and dispensing system
FR2715916B1 (en) Device for dispensing a liquid or powdery product.
AU5130098A (en) Method and apparatus for transferring and combining reagents
EP1148289A4 (en) System for storing dissolved methane-base gas
CA2476466A1 (en) Apparatuses and methods for dispensing cards
WO2009131697A1 (en) Apparatuses and methods for wireless monitoring and control of supplies for environmental sampling and chromatographic apparatuses
HUP0001759A2 (en) Valve for aerosol container
DE69529903D1 (en) DISPENSER
AU4716199A (en) Method and apparatus for measuring the size of drops of a viscous material dispensed from a dispensing system
BR9915213A (en) semi-automatic automotive paint distribution system
WO2002068203A3 (en) Systems and methods for dispensing postage stamps
WO2008066757A3 (en) Dispensing systems and methods for liquid materials
WO2007110764A3 (en) Automated colorimetric machine
FR2850192B1 (en) DOSING INDICATOR FOR FLUID PRODUCT DISPENSING DEVICE.
AU7389694A (en) Method for detecting biological interactions especially in receptor binding assays
GB0012175D0 (en) Methods and apparatus for measuring the contents of liquid containers and the flow rate of liquids dispensed from liquid containers and stock control system
WO1998042613A3 (en) Pressurisable beverage dispense system
FR2857769B1 (en) IMPROVED DOSAGE INDICATOR FOR FLUID PRODUCT DISPENSING DEVICE.
WO2005003754A8 (en) Computer-controlled automated titration apparatus for optically determining incompatibility of petroleum oils
CA2323132A1 (en) Concentration-gradient-based mechanism for the distribution of a compound
FR2890952B1 (en) DEVICE FOR DISPENSING A LIQUID OR PASTY PRODUCT ON A SUPPORT FROM A BAND
CA2585429A1 (en) Filling apparatus
WO2007056395A1 (en) Fluid handling device
IE810887L (en) Refining molten metal.
WO2007045512A3 (en) Fluid dispenser

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 29952/00

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2361275

Country of ref document: CA

Ref country code: CA

Ref document number: 2361275

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2000908647

Country of ref document: EP

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 599509

Kind code of ref document: A

Format of ref document f/p: F

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2000908647

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 29952/00

Country of ref document: AU

WWG Wipo information: grant in national office

Ref document number: 2000908647

Country of ref document: EP