WO2000059424A1 - Vacuum assisted closure system with provision for introduction of agent - Google Patents
Vacuum assisted closure system with provision for introduction of agent Download PDFInfo
- Publication number
- WO2000059424A1 WO2000059424A1 PCT/US2000/008821 US0008821W WO0059424A1 WO 2000059424 A1 WO2000059424 A1 WO 2000059424A1 US 0008821 W US0008821 W US 0008821W WO 0059424 A1 WO0059424 A1 WO 0059424A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- wound
- wound healing
- therapeutic combination
- recited
- porous pad
- Prior art date
Links
- 206010052428 Wound Diseases 0.000 claims abstract description 56
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 55
- 230000029663 wound healing Effects 0.000 claims abstract description 20
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims abstract description 15
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims abstract description 15
- 239000012530 fluid Substances 0.000 claims abstract description 13
- 238000004891 communication Methods 0.000 claims abstract description 7
- 239000004599 antimicrobial Substances 0.000 claims abstract description 6
- 238000007789 sealing Methods 0.000 claims abstract description 5
- 230000001225 therapeutic effect Effects 0.000 claims 12
- 241000124008 Mammalia Species 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 239000006260 foam Substances 0.000 abstract description 23
- 238000000034 method Methods 0.000 abstract description 12
- 238000002560 therapeutic procedure Methods 0.000 abstract description 10
- 238000003780 insertion Methods 0.000 abstract description 5
- 230000037431 insertion Effects 0.000 abstract description 5
- 239000003357 wound healing promoting agent Substances 0.000 abstract description 3
- 230000000845 anti-microbial effect Effects 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 description 12
- 239000003102 growth factor Substances 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 6
- 201000007848 Arts syndrome Diseases 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000008602 contraction Effects 0.000 description 3
- 210000000981 epithelium Anatomy 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 230000005012 migration Effects 0.000 description 3
- 238000013508 migration Methods 0.000 description 3
- 206010033675 panniculitis Diseases 0.000 description 3
- 210000004304 subcutaneous tissue Anatomy 0.000 description 3
- 230000033115 angiogenesis Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 230000037313 granulation tissue formation Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010031256 Osteomyelitis chronic Diseases 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010048031 Wound dehiscence Diseases 0.000 description 1
- 239000003522 acrylic cement Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A61F13/05—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
- A61M1/91—Suction aspects of the dressing
- A61M1/915—Constructional details of the pressure distribution manifold
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/06—Bandages or dressings; Absorbent pads specially adapted for feet or legs; Corn-pads; Corn-rings
- A61F13/064—Bandages or dressings; Absorbent pads specially adapted for feet or legs; Corn-pads; Corn-rings for feet
- A61F13/069—Decubitus ulcer bandages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00157—Wound bandages for burns or skin transplants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/0017—Wound bandages possibility of applying fluid
- A61F2013/00174—Wound bandages possibility of applying fluid possibility of applying pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00246—Wound bandages in a special way pervious to air or vapours
- A61F2013/00255—Wound bandages in a special way pervious to air or vapours with pores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/00412—Plasters use for use with needles, tubes or catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/00519—Plasters use for treating burn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/00536—Plasters use for draining or irrigating wounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/0054—Plasters use for deep wounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00727—Plasters means for wound humidity control
- A61F2013/00731—Plasters means for wound humidity control with absorbing pads
- A61F2013/0074—Plasters means for wound humidity control with absorbing pads containing foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00855—Plasters pervious to air or vapours
- A61F2013/00863—Plasters pervious to air or vapours with pores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/0091—Plasters containing means with disinfecting or anaesthetics means, e.g. anti-mycrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/00927—Plasters containing means with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
Definitions
- the present invention relates to the healing of wounds. More specifically, the present invention relates to the vacuum assisted closure (VAC) of wounds wherein a growth factor or other agent is introduced to a wound site through grafting with a VAC pad m order to facilitate wound healing.
- VAC vacuum assisted closure
- Wound closure involves the mward migration of epithelial and subcutaneous tissue adjacent the wound. This migration is ordinarily assisted through the inflammatory process, whereby blood flow is increased and various functional cell types are activated. Through the inflammatory process, blood flow through damaged or broken vessels is stopped by capillary level occlusion, whereafter cleanup and rebuilding operations may begin. Unfortunately, this process is hampered when a wound is large or has become infected. In such wounds, a zone of stasis (i.e. an area m which localized swelling of tissue restricts the flow of blood to the tissues) forms near the surface of the wound.
- a zone of stasis i.e. an area m which localized swelling of tissue restricts the flow of blood to the tissues
- the epithelial and subcutaneous tissues surrounding the wound not only receive diminished oxygen and nutrients, but are also less able to successfully fight bacterial infection and thus are less able to naturally close the wound.
- sutures or staples Although still widely practiced and often effective, such mechanical closure techniques suffer a major disadvantage in that they produce tension on the skm tissue adjacent the wound.
- the tensile force required in order to achieve closure using sutures or staples causes very high localized stresses at the suture or staple insertion point. These stresses commonly result in the rupture of the tissue at the insertion points, which can eventually cause wound dehiscence and additional tissue loss.
- wounds not reparable by suturing or stapling generally require prolonged hospitahzation, with its attendant high cost, and major surgical procedures, such as grafts of surrounding tissues
- Examples of wounds not readily treatable with staples or suturing include large, deep, open wounds; decubitus ulcers; ulcers resulting from chronic osteomyelitis; and partial thickness burns that subsequently develop into full thickness burns.
- VAC vacuum assisted closure
- VAC therapy has been highly successful in the promotion of wound closure, healing many wounds previously thought largely untreatable, some difficulty remains. Because the inflammatory process is very unique to the individual patient, even the addition of VAC therapy does not result m a fast enough response, especially during the occlusion and initial cleanup and rebuilding stages, for adequate healing of some wounds. It is therefore a principle object of the present invention to provide a method and apparatus whereby the known VAC therapy modalities are improved through the introduction of growth factors and/or other agents that facilitate wound healing.
- the present invention a method and apparatus for the introduction to a wound undergoing vacuum assisted closure (VAC) therapy of a wound healing agent - generally comprises a foam pad for insertion substantially into a wound site and a wound drape for sealing enclosure of the foam pad at the wound site
- the foam pad is placed in fluid communication with a vacuum source for promotion of fluid drainage.
- the foam pad is predisposed, through grafting or other techniques known to those of ordinary skill in the art, with basic fibroblast growth factor (bFGF), anti-microbials or other factors, also known to those of ordinary skill in the art, for the promotion of increased wound healing.
- bFGF basic fibroblast growth factor
- a growth factor or other wound healing agent is added to the previously known VAC therapy through modification as necessary of the VAC system's foam pad.
- growth factors as the basic fibroblast growth factor (bFGF) are known to accelerate wound healing due to their potent angiogenesis and granulation tissue formation activities.
- bFGF basic fibroblast growth factor
- the combination of VAC therapy with growth factor introduction, through the modification of the foam pad and predisposition thereof with the bFGF is therefore thought to be an important contribution to the wound healing arts.
- the figure shows, in partially cut away perspective view, the preferred embodiment of the present invention as applied to a mammalian wound site.
- the present invention 10 is shown to generally comprise a foam pad 11 for insertion substantially into a wound site 12 and a wound drape 13 for sealing enclosure of the foam pad 11 at the wound site 12.
- the foam pad 11 is placed in fluid communication with a vacuum source for promotion of fluid drainage.
- the foam pad 11 is predisposed, through grafting or other techniques known to those of ordinary skill m the art, with basic fibroblast growth factor (bFGF), antimicrobials or other factors, also known to those of ordinary skill in the art, for the promotion of increased wound healing.
- bFGF basic fibroblast growth factor
- the foam pad 11 , wound drape 13 and vacuum source are implemented as known in the prior art, each of which is detailed in U.S. patent application Serial No. 08/517,901 filed August 22, 1995.
- U.S. patent application Serial No. 08/517,901 filed August 22, 1995.
- the full disclosure of U.S. patent application Serial No. 08/517,901 (“the '901 application"), including the claims and the drawings, is incorporated herein as though now set forth in its entirety.
- such a VAC system is readily commercially available through Kinetic Concepts, Inc. of San Antonio, Texas, U.S.A. and/or its subsidiary companies.
- the foam pad 11 preferably comprises a highly reticulated, open-cell polyurethane or polyether foam for good permeability of wound fluids while under suction, but m this application may comprise a conventional sponge cellulose type dressing as necessary for introduction of the desired agent.
- the foam pad 11 is preferably placed in fluid communication, via a plastic or like material hose 14, with a vacuum source, which preferably comprises a canister safely placed under vacuum through fluid communication, via an interposed hydrophobic membrane filter, with a vacuum pump.
- the wound drape 13 which preferably comprises an elastome ⁇ c material at least peripherally covered with a pressure sensitive, acrylic adhesive for sealing application over the wound site 12.
- those components as are described in the '901 application are generally employed as known m the art with the exception that the foam pad 11 of the present invention is modified as necessary for the introduction of a growth factor.
- growth factors as the basic fibroblast growth factor (bFGF) are known to accelerate wound healing due to their potent angiogenesis and granulation tissue formation activities
- bFGF basic fibroblast growth factor
- the combination of VAC therapy with growth factor introduction, through the modification of the foam pad 11 and predisposition thereof with the bFGF, is therefore thought to be an important contribution to the wound healing arts.
- the present method presents an excellent opportunity for the introduction to the wound site 12 of anti-microbial agents, whether alone or m combination with bFGF or other agents.
- the desired agent may be injected with a needle and syringe, or the like, through the wound drape 13 and into the foam pad 11.
- the present invention is applicable to the wound healing arts.
Abstract
Description
Claims
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00920067.6A EP1168997B1 (en) | 1999-04-02 | 2000-03-31 | Vacuum assisted closure system with provision for introduction of agent |
JP2000608989A JP2004516228A (en) | 1999-04-02 | 2000-03-31 | Vacuum assisted closing system with equipment for introducing the drug |
BR0009511-7A BR0009511A (en) | 1999-04-02 | 2000-03-31 | Therapeutic combination designed to promote wound healing in breasts |
AU40661/00A AU773002B2 (en) | 1999-04-02 | 2000-03-31 | Vacuum assisted closure system with provision for introduction of agent |
IL14562900A IL145629A0 (en) | 1999-04-02 | 2000-03-31 | Vacuum assisted closute system with provision for introduction of agent |
NZ514481A NZ514481A (en) | 1999-04-02 | 2000-03-31 | Vacuum assisted closure system with provision for introduction of agent |
US09/937,942 US7534240B1 (en) | 1999-04-02 | 2000-03-31 | Negative pressure wound therapy system with provision for introduction of an agent |
MXPA01009908A MXPA01009908A (en) | 1999-04-02 | 2000-03-31 | Vacuum assisted closure system with provision for introduction of agent. |
CA002369024A CA2369024A1 (en) | 1999-04-02 | 2000-03-31 | Negative pressure wound therapy system with provision for introduction of agent |
IL145629A IL145629A (en) | 1999-04-02 | 2001-09-25 | Vacuum assisted closure system with provision for introduction of agent |
HK02104604.8A HK1044698A1 (en) | 1999-04-02 | 2002-06-20 | Vacuum assisted closure system with provision for introduction of agent |
US11/497,457 US20070014837A1 (en) | 1999-04-02 | 2006-08-01 | System and method for use of agent in combination with subatmospheric pressure tissue treatment |
IL179968A IL179968A0 (en) | 1999-04-02 | 2006-12-11 | Vacuum assisted closure system with provision for introduction of agent |
US12/431,667 US20090270820A1 (en) | 1999-04-02 | 2009-04-28 | System and method for use of agent in combination with subatmospheric pressure tissue treatment |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12759599P | 1999-04-02 | 1999-04-02 | |
US60/127,595 | 1999-04-02 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/494,171 Continuation-In-Part US20070021697A1 (en) | 1999-04-02 | 2006-07-26 | System and method for use of agent in combination with subatmospheric tissue treatment |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/497,457 Continuation-In-Part US20070014837A1 (en) | 1999-04-02 | 2006-08-01 | System and method for use of agent in combination with subatmospheric pressure tissue treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000059424A1 true WO2000059424A1 (en) | 2000-10-12 |
Family
ID=22430917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/008821 WO2000059424A1 (en) | 1999-04-02 | 2000-03-31 | Vacuum assisted closure system with provision for introduction of agent |
Country Status (14)
Country | Link |
---|---|
US (1) | US7534240B1 (en) |
EP (1) | EP1168997B1 (en) |
JP (1) | JP2004516228A (en) |
CN (1) | CN1226973C (en) |
AU (1) | AU773002B2 (en) |
BR (1) | BR0009511A (en) |
CA (1) | CA2369024A1 (en) |
HK (1) | HK1044698A1 (en) |
IL (3) | IL145629A0 (en) |
MX (1) | MXPA01009908A (en) |
NZ (1) | NZ514481A (en) |
RU (1) | RU2247548C2 (en) |
WO (1) | WO2000059424A1 (en) |
ZA (1) | ZA200107857B (en) |
Cited By (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1297325C (en) * | 2001-08-24 | 2007-01-31 | Kci特许公司 | Vacuum assisted tissue treatment system |
EP1771138A2 (en) * | 2004-07-26 | 2007-04-11 | KCI Licensing, Inc. | Method for coating substrate with antimicrobial agent and product formed thereby |
EP1884223A1 (en) * | 2006-08-04 | 2008-02-06 | IP Randwyck B.V. | Wound-stimulating unit |
US7361184B2 (en) | 2003-09-08 | 2008-04-22 | Joshi Ashok V | Device and method for wound therapy |
EP2111896A1 (en) | 2008-04-21 | 2009-10-28 | N.V. Nutricia | Device for medical radiation |
WO2009134967A2 (en) * | 2008-04-30 | 2009-11-05 | Kci Licensing, Inc. | Use of nucleic acids with reduced pressure therapy |
US7615036B2 (en) | 2006-05-11 | 2009-11-10 | Kalypto Medical, Inc. | Device and method for wound therapy |
EP2224966A1 (en) * | 2008-01-04 | 2010-09-08 | KCI Licensing, Inc. | Improved reduced pressure dressing coated with biomolecules |
US7799004B2 (en) * | 2001-03-05 | 2010-09-21 | Kci Licensing, Inc. | Negative pressure wound treatment apparatus and infection identification system and method |
US7880050B2 (en) | 2007-02-09 | 2011-02-01 | Kci Licensing, Inc. | Breathable interface system for topical reduced pressure |
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Also Published As
Publication number | Publication date |
---|---|
EP1168997A4 (en) | 2004-11-17 |
AU773002B2 (en) | 2004-05-13 |
IL145629A0 (en) | 2002-06-30 |
US7534240B1 (en) | 2009-05-19 |
MXPA01009908A (en) | 2003-07-28 |
HK1044698A1 (en) | 2002-11-01 |
JP2004516228A (en) | 2004-06-03 |
ZA200107857B (en) | 2004-05-26 |
IL145629A (en) | 2007-05-15 |
CN1226973C (en) | 2005-11-16 |
IL179968A0 (en) | 2007-05-15 |
AU4066100A (en) | 2000-10-23 |
CA2369024A1 (en) | 2000-10-12 |
EP1168997B1 (en) | 2013-04-24 |
RU2247548C2 (en) | 2005-03-10 |
CN1356883A (en) | 2002-07-03 |
NZ514481A (en) | 2003-11-28 |
EP1168997A1 (en) | 2002-01-09 |
BR0009511A (en) | 2004-06-08 |
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