WO2000060066A8 - Protein-protein from s. cerevisiae and methods of using same - Google Patents

Protein-protein from s. cerevisiae and methods of using same

Info

Publication number
WO2000060066A8
WO2000060066A8 PCT/US2000/008399 US0008399W WO0060066A8 WO 2000060066 A8 WO2000060066 A8 WO 2000060066A8 US 0008399 W US0008399 W US 0008399W WO 0060066 A8 WO0060066 A8 WO 0060066A8
Authority
WO
WIPO (PCT)
Prior art keywords
methods
complexes
same
polypeptide
protein
Prior art date
Application number
PCT/US2000/008399
Other languages
French (fr)
Other versions
WO2000060066A1 (en
Inventor
Loic Giot
Traci A Mansfield
Original Assignee
Curagen Corp
Loic Giot
Traci A Mansfield
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curagen Corp, Loic Giot, Traci A Mansfield filed Critical Curagen Corp
Priority to JP2000609558A priority Critical patent/JP2003524400A/en
Priority to EP00921513A priority patent/EP1165772A1/en
Priority to AU41820/00A priority patent/AU4182000A/en
Priority to CA002365548A priority patent/CA2365548A1/en
Publication of WO2000060066A1 publication Critical patent/WO2000060066A1/en
Publication of WO2000060066A8 publication Critical patent/WO2000060066A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention provides complexes of at least two polypeptides from the yeast S. cerevisiae and methods of using the same. Purified complexes of two polypeptides are provided, including chimeric complexes, and chimeric polypeptides and complexes thereof are also provided, as are nucleic acids encoding chimeric polypeptides and vectors and cells containing the same. Also provided are methods of identifying agents that disrupt polypeptide complexes, methods of identifying complex or polypeptide in a sample, and for removing the same, methods of determining altered expression of a polypeptide in a subject and methods of treating/preventing disorders involving altered levels of complex or polypeptide.
PCT/US2000/008399 1999-04-01 2000-03-30 Protein-protein from s. cerevisiae and methods of using same WO2000060066A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000609558A JP2003524400A (en) 1999-04-01 2000-03-30 S. Cerevisiae-derived protein-protein and methods of using the same
EP00921513A EP1165772A1 (en) 1999-04-01 2000-03-30 Protein-protein complexes from s. cerevisiae and methods of using same
AU41820/00A AU4182000A (en) 1999-04-01 2000-03-30 Protein-protein from s. cerevisiae and methods of using same
CA002365548A CA2365548A1 (en) 1999-04-01 2000-03-30 Protein-protein from s. cerevisiae and methods of using same

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US12735299P 1999-04-01 1999-04-01
US60/127,352 1999-04-01
US17896500P 2000-02-01 2000-02-01
US60/178,965 2000-02-01
US09/538,092 US6753314B1 (en) 1999-04-01 2000-03-29 Protein-protein complexes and methods of using same
US09/538,092 2000-03-29

Publications (2)

Publication Number Publication Date
WO2000060066A1 WO2000060066A1 (en) 2000-10-12
WO2000060066A8 true WO2000060066A8 (en) 2001-03-22

Family

ID=27383564

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/008399 WO2000060066A1 (en) 1999-04-01 2000-03-30 Protein-protein from s. cerevisiae and methods of using same

Country Status (5)

Country Link
US (1) US6753314B1 (en)
EP (1) EP1165772A1 (en)
JP (1) JP2003524400A (en)
CA (1) CA2365548A1 (en)
WO (1) WO2000060066A1 (en)

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US6995018B1 (en) * 1999-04-09 2006-02-07 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Complex formed by N-linked glycoproteins (SIBLINGS)and Factor H
US7208581B1 (en) * 1999-11-05 2007-04-24 The Burnham Institute TRAF family proteins
US6936424B1 (en) * 1999-11-16 2005-08-30 Matritech, Inc. Materials and methods for detection and treatment of breast cancer
US7211563B2 (en) * 2001-04-02 2007-05-01 Develogen Aktiengesellschaft Fur Entwicklungsbiologische Forschung Protein disulfide isomerase and ABC transporter homologous proteins involved in the regulation of energy homeostasis
ATE421693T1 (en) * 2001-05-29 2009-02-15 Pride Proteomics As PROTEINS IN DIABETES PROTEOM ANALYSIS
WO2003025213A2 (en) * 2001-09-21 2003-03-27 Mds Proteomics Inc. Yeast proteome analysis
WO2003033667A2 (en) * 2001-10-18 2003-04-24 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Use of mx gtpases in the prognosis and treatment of cancer
US20060275747A1 (en) * 2001-12-07 2006-12-07 Hardy Stephen F Endogenous retrovirus up-regulated in prostate cancer
GB0202871D0 (en) * 2002-02-07 2002-03-27 Cancer Res Ventures Ltd Assays,methods and means
US7074893B2 (en) * 2002-06-03 2006-07-11 Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
US20050164201A1 (en) * 2002-06-10 2005-07-28 Harvey Diane M. Isolated nucleic acid molecule encoding a novel centromere-associated motor protein, and uses therof
ATE545651T1 (en) * 2002-06-13 2012-03-15 Novartis Vaccines & Diagnostic VECTORS FOR EXPRESSING HML-2 POLYPEPTIDES
AU2003258127A1 (en) * 2002-08-06 2004-02-23 Diadexus, Inc. Compositions and methods relating to ovarian specific genes and proteins
US20060057147A1 (en) * 2002-10-04 2006-03-16 Mitsubishi Pharma Corporation Antibody recognizing antibody
EP1713930B1 (en) * 2004-01-17 2010-11-03 Korea Research Institute of Bioscience and Biotechnology Rapid screening method of translational fusion partners for producing recombinant proteins and translational fusion partners screened therefrom
CA2560066A1 (en) 2004-03-01 2005-09-15 The Cbr Institute For Biomedical Research, Inc. Natural igm antibodies and inhibitors thereof
US20100136684A1 (en) * 2004-03-01 2010-06-03 Carroll Michael C Natural IgM Antibodies
WO2006013010A2 (en) * 2004-07-31 2006-02-09 Metanomics Gmbh Preparation of organisms with faster growth and/or higher yield
US7485468B2 (en) * 2004-10-15 2009-02-03 Galapagos Bv Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
US8673268B2 (en) 2004-10-15 2014-03-18 Galapagos N.V. Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
US7795390B2 (en) * 2005-06-24 2010-09-14 Teijin Pharma Limited Biological substance nesfatin and its related substances and uses thereof
CA2613257A1 (en) * 2005-06-24 2006-12-28 Teijin Pharma Limited A novel biological substance nesfatin and its related substances and uses thereof
AU2007223596B2 (en) * 2006-03-01 2010-07-01 Suntory Holdings Limited Gene encoding glycogen synthesis initiator and use thereof
CA2651800A1 (en) * 2006-04-24 2007-11-08 Shantha West, Inc. Agrm2 antigen
WO2008070179A2 (en) 2006-12-06 2008-06-12 Monsanto Technology, Llc Genes and uses for plant improvement
WO2011021386A1 (en) * 2009-08-21 2011-02-24 Oncotherapy Science, Inc. Cstf2 for target genes of lung cancer therapy and diagnosis
EP2330122A1 (en) 2009-12-02 2011-06-08 Asklepios Kliniken Hamburg Gmbh OFA/iLRP derived modified peptide
KR20130028044A (en) * 2009-12-08 2013-03-18 헬스 리서치 인코포레이티드 Methods and compositions using peroxiredoxin1 (prx1) as an adjuvant
US20140017748A1 (en) * 2010-02-12 2014-01-16 Gevo, Inc. Modified alcohol dehydrogenases for the production of fuels and chemicals
KR20120129953A (en) 2010-02-12 2012-11-28 캘리포니아 인스티튜트 오브 테크놀로지 Yeast microorganisms with reduced by-product accumulation for improved production of fuels, chemicals, and amino acids
CA2858350A1 (en) 2011-01-14 2013-07-19 The Regents Of The University Of California Therapeutic antibodies against ror-1 protein and methods for use of same
US9340584B2 (en) 2011-03-29 2016-05-17 The General Hospital Corporation Engineered thioredoxin-like fold proteins
CN102286499A (en) * 2011-06-16 2011-12-21 山西农业大学 CDNA of alpaca hair color formation associated cyclin-dependent kinase 5(CDK5-A) gene
JP6196034B2 (en) * 2012-12-20 2017-09-13 ライオン株式会社 Marker peptide for determining hyperglycemia risk and use thereof
US9243059B2 (en) 2013-03-12 2016-01-26 Decimmune Therapeutics, Inc. Humanized anti-N2 antibodies and methods of treating ischemia-reperfusion injury
CN103756984B (en) * 2014-02-18 2015-10-14 吉林大学 High vigor Selenoperoxidase GPX2 mutant and preparation method thereof
CN105693825A (en) * 2016-04-22 2016-06-22 南通大学 Cancer inhibition polypeptide 127aa and expression vector and application thereof
CN105949305A (en) * 2016-06-30 2016-09-21 南通大学 {0><}0{>Sept2 truncated protamine as well as vector and application thereof
US11578108B2 (en) * 2021-03-24 2023-02-14 Chungbuk National University Industrial-Academic Cooperation Foundation Amphiphysin-I mutant having anti-senescence activity and use thereof
CN116162644B (en) * 2022-07-07 2024-04-05 昆明理工大学 New application of phenylalanine ammonia lyase gene pal

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020025552A1 (en) 1998-01-06 2002-02-28 Institut Pasteur Screening interactor molecules with whole genome oligonucleotide or polynucleotide arrays
WO2000046406A2 (en) 1999-02-05 2000-08-10 Alphagene, Inc. Arrays for investigating protein protein interactions

Also Published As

Publication number Publication date
WO2000060066A1 (en) 2000-10-12
JP2003524400A (en) 2003-08-19
US6753314B1 (en) 2004-06-22
CA2365548A1 (en) 2000-10-12
EP1165772A1 (en) 2002-01-02

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