WO2000060352A3 - Fluidic devices - Google Patents

Fluidic devices Download PDF

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Publication number
WO2000060352A3
WO2000060352A3 PCT/GB2000/001257 GB0001257W WO0060352A3 WO 2000060352 A3 WO2000060352 A3 WO 2000060352A3 GB 0001257 W GB0001257 W GB 0001257W WO 0060352 A3 WO0060352 A3 WO 0060352A3
Authority
WO
WIPO (PCT)
Prior art keywords
layer
define
fluid passages
fluidic devices
fluidic
Prior art date
Application number
PCT/GB2000/001257
Other languages
French (fr)
Other versions
WO2000060352A2 (en
Inventor
Peter Jones
Mark Tracey
Nicola Sutton
Neil Butt
Original Assignee
Whatman Plc
Peter Jones
Mark Tracey
Nicola Sutton
Neil Butt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whatman Plc, Peter Jones, Mark Tracey, Nicola Sutton, Neil Butt filed Critical Whatman Plc
Priority to AU35697/00A priority Critical patent/AU3569700A/en
Priority to EP00914303A priority patent/EP1166109A2/en
Publication of WO2000060352A2 publication Critical patent/WO2000060352A2/en
Publication of WO2000060352A3 publication Critical patent/WO2000060352A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

Abstract

Apparatus for performing a chemical and/or biological process comprising: a first layer of material comprising fluid passages that define a microfluidic structure; and a second layer of material comprising fluid passages that define a larger-scale fluidic structure; the layers being bonded such that the fluid passages of the first layer communicate with those of the second layer to define a fluidic device.
PCT/GB2000/001257 1999-04-01 2000-04-03 Fluidic devices WO2000060352A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU35697/00A AU3569700A (en) 1999-04-01 2000-04-03 Fluidic devices
EP00914303A EP1166109A2 (en) 1999-04-01 2000-04-03 Fluidic devices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9907665.5A GB9907665D0 (en) 1999-04-01 1999-04-01 Fluidic devices
GB9907665.5 1999-04-01

Publications (2)

Publication Number Publication Date
WO2000060352A2 WO2000060352A2 (en) 2000-10-12
WO2000060352A3 true WO2000060352A3 (en) 2001-08-09

Family

ID=10850916

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/001257 WO2000060352A2 (en) 1999-04-01 2000-04-03 Fluidic devices

Country Status (4)

Country Link
EP (1) EP1166109A2 (en)
AU (1) AU3569700A (en)
GB (1) GB9907665D0 (en)
WO (1) WO2000060352A2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645359B1 (en) 2000-10-06 2003-11-11 Roche Diagnostics Corporation Biosensor
US6319719B1 (en) 1999-10-28 2001-11-20 Roche Diagnostics Corporation Capillary hematocrit separation structure and method
US6451264B1 (en) 2000-01-28 2002-09-17 Roche Diagnostics Corporation Fluid flow control in curved capillary channels
US7473398B2 (en) 2001-05-25 2009-01-06 Roche Diagnostics Operations, Inc. Biosensor
ATE349276T1 (en) * 2001-06-08 2007-01-15 Centre Nat Rech Scient METHOD FOR PRODUCING A MICROLIQUID STRUCTURE, IN PARTICULAR A ßBIOCHIPSß, AND STRUCTURE PRODUCED THEREFROM
SE0103110D0 (en) * 2001-09-18 2001-09-18 Aamic Ab Microscale fluid handling system
US7338760B2 (en) * 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
US7069952B1 (en) 2001-11-14 2006-07-04 Caliper Life Sciences, Inc. Microfluidic devices and methods of their manufacture
EP1499706A4 (en) 2002-04-01 2010-11-03 Fluidigm Corp Microfluidic particle-analysis systems
US20040086872A1 (en) * 2002-10-31 2004-05-06 Childers Winthrop D. Microfluidic system for analysis of nucleic acids
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
US9354156B2 (en) 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
US9376658B2 (en) 2008-01-03 2016-06-28 Emd Millipore Corporation Cell culture array system for automated assays and methods of operation and manufacture thereof
ES2865180T3 (en) 2005-07-07 2021-10-15 Univ California Apparatus for cell culture formation
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
US8656949B2 (en) 2006-08-15 2014-02-25 University Of Maryland College Park Microfluidic devices and methods of fabrication
CA2751455C (en) * 2009-02-03 2019-03-12 Netbio, Inc. Nucleic acid purification
US20110186165A1 (en) * 2009-10-05 2011-08-04 Borenstein Jeffrey T Three-dimensional microfluidic platforms and methods of use and manufacture thereof
US9353342B2 (en) 2010-01-21 2016-05-31 Emd Millipore Corporation Cell culture and gradient migration assay methods and devices
US10526572B2 (en) 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
CN104245917B (en) 2011-12-03 2017-07-21 Emd密理博公司 Miniature culture system and method for Microfluidic cell culture
JP6169111B2 (en) 2012-02-29 2017-07-26 フリューダイム・コーポレイション Methods, systems, and devices for capturing and processing multiple single cells using microfluidics
WO2014181500A1 (en) * 2013-05-08 2014-11-13 ソニー株式会社 Flow channel device, analytical apparatus, and fluid apparatus
EP3281009A4 (en) 2015-04-09 2018-11-14 Axela Inc. Disposable bioassay cartridge and method of performing multiple assay steps and fluid transfer within the cartridge
GB2546233A (en) * 2015-08-19 2017-07-19 Cambsolv Ltd Modular microfluidic device for analytical bioassay
EP3791960A1 (en) * 2015-11-24 2021-03-17 Vanderbilt University Multicompartment layered and stackable microfluidic bioreactors and applications of same
WO2019193004A1 (en) * 2018-04-06 2019-10-10 Boehringer Ingelheim Vetmedica Gmbh Analysis device, cartridge, analysis system and method for testing a sample

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382207A2 (en) * 1989-02-09 1990-08-16 Fuji Photo Film Co., Ltd. Analytical element for whole blood
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
WO1996015576A1 (en) * 1994-11-10 1996-05-23 David Sarnoff Research Center, Inc. Liquid distribution system
WO1996014933A1 (en) * 1994-11-14 1996-05-23 Trustees Of The University Of Pennsylvania Mesoscale devices for analysis of motile cells
WO1998022811A1 (en) * 1996-11-19 1998-05-28 Caliper Technologies Corporation Improved microfluidic systems

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382207A2 (en) * 1989-02-09 1990-08-16 Fuji Photo Film Co., Ltd. Analytical element for whole blood
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
WO1996015576A1 (en) * 1994-11-10 1996-05-23 David Sarnoff Research Center, Inc. Liquid distribution system
WO1996014933A1 (en) * 1994-11-14 1996-05-23 Trustees Of The University Of Pennsylvania Mesoscale devices for analysis of motile cells
WO1998022811A1 (en) * 1996-11-19 1998-05-28 Caliper Technologies Corporation Improved microfluidic systems

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WOOLLEY ADAM T ET AL: "Ultra-high-speed DNA fragment separations using microfabricated capillary array electrophoresis chips.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 91, no. 24, 1994, 1994, pages 11348 - 11352, XP002155992, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
GB9907665D0 (en) 1999-05-26
WO2000060352A2 (en) 2000-10-12
AU3569700A (en) 2000-10-23
EP1166109A2 (en) 2002-01-02

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