WO2000063006A1 - Rotary type powder compression molding machine - Google Patents
Rotary type powder compression molding machine Download PDFInfo
- Publication number
- WO2000063006A1 WO2000063006A1 PCT/JP2000/002507 JP0002507W WO0063006A1 WO 2000063006 A1 WO2000063006 A1 WO 2000063006A1 JP 0002507 W JP0002507 W JP 0002507W WO 0063006 A1 WO0063006 A1 WO 0063006A1
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- WO
- WIPO (PCT)
- Prior art keywords
- liquid lubricant
- punch
- compression molding
- molding machine
- spray
- Prior art date
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
- B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/0005—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses
- B30B15/0011—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses lubricating means
Definitions
- the present invention relates to a rotary powder compression molding machine for compressing powder to form a molded product mainly produced by compression molding, including pharmaceutical tablets, foods, and products.
- a disintegrating agent, an excipient, a binder, and a lubricant are blended and mixed in addition to the drug prescription component, that is, the main drug, and the raw material powder is mixed.
- the lubricant is used as the raw material for the tablet only with the active ingredient, it may cause problems such as so-called sticking, such as sticking of the raw material powder of the tablet or the tablet to the punch and die. Therefore, they are mixed to prevent this kind of obstacle.
- the lubricant magnesium stearate, calcium stearate, talc and the like are generally used.
- the lubricant does not need to be mixed with the base drug, etc., so it may be used at places where sticking occurs, such as the surface of a punch. It has been studied to produce tablets using a raw material powder that is not mixed with a lubricant by spraying only a lubricant. In the case of manufacturing tablets by applying such a lubricant only to the required area, for example, spray a powdery lubricant onto the upper punch 5, lower punch, and die hole before tableting. It is conceivable that the lubricant is compressed before or after tableting, and the lubricant is coated on the upper punch, lower punch, and mortar.
- the present invention sprays a minimum amount of a small amount of a liquid lubricant to be adhered substantially uniformly to at least the lower end surface of the upper punch and the upper end surface of the lower punch every time before tableting.
- the amount of lubricant mixed into tablets is greatly reduced, and a rotary powder compression molding machine that does not cause contamination problems or complicates the equipment is provided. It is.
- a rotary disk is rotatably disposed in a frame via a vertical shaft, and a rotary die having a die is provided.
- the upper punch and the lower punch are held vertically slidably above and below the mortar, and the upper and lower punches are moved and pressed toward each other with the tip of the punch inserted into the mortar hole. Therefore, in a rotary powder compression molding machine in which the powder filled in the die hole is compression-molded between the lower end surface of the upper punch and the upper end surface of the lower punch, the upper punch is formed before the compression molding is performed. It is characterized by having a micro liquid spraying device that sprays a small amount of liquid lubricant that adheres almost uniformly to the lower end surface, the lower punch upper end surface, and the inner peripheral surface of the die hole.
- the lubricant is sprayed and adhered, it is possible to prevent the raw material powder from adhering to the upper and lower punches due to excess liquid lubricant, and to eliminate the lubricant. Sticking can be prevented without having to mix the raw material powder in advance.
- the compression-molded tablet since lubricant is not mixed into the raw material powder, when the raw material powder is a drug, the compression-molded tablet has sufficient hardness and can shorten the disintegration time As a result, a product that can be easily eluted can be produced.
- the apparatus comprises a measuring section for measuring with a measured spray amount and a spraying section for spraying the measured liquid lubricant.
- the amount of spray can be measured according to the rotation speed of the turntable.
- the micro-liquid spraying device may further include a control unit that sends the liquid lubricant measured by the measuring unit to the spraying unit at a set predetermined amount. With such a configuration, the liquid lubricant can be sprayed with high accuracy every time.
- the metering section of such a small amount liquid sprayer is equipped with a flow controller that measures the spray amount based on the temperature difference between the two points where the liquid lubricant sent from the storage tank has passed.
- the spraying section consists of a spray pipe that vaporizes the liquid lubricant sent from the flow controller by pressurization, and pressurized air for pressurizing the spray pipe. And an air compression device 5 for supplying air. According to such a configuration, a small amount of the liquid lubricant can be accurately measured, and a vaporizer is not required, so that the liquid lubricant is small and efficient. Can be vaporized and sprayed.
- the inside of the mortar is filled with powder from an empty state, and the upper punch is inserted into the mortar.
- Liquid lubricants are substances in which a substance having a lubricating effect is dissolved in a liquid, those in which the substance is dispersed, those in which the substance is emulsified, and those having a lubricating effect themselves. Are liquids. Specifically, the liquid lubricants include silicone emulsions. In this way, if the product contains silicone, a small amount
- silicones include KF966 (trade name; manufactured by Shin-Etsu Chemical Co., Ltd.) made of dimethylpolysiloxane and Dowcourt.
- Silicone oil such as Medical Fluid (trade name; manufactured by Dow Corning Co., Ltd.) may be used.
- silicone oil emulsions include KM787, KM740 (trade names; manufactured by Shin-Etsu Chemical Co., Ltd.) and Dowkoging 365, 35% dimethicone NF. 0 Marjion (trade name; manufactured by Dow Corning Co., Ltd.).
- KS66, KS69, KM72, KM72F product name as a viscous liquid or paste-like silicone resin that is a mixture of dimethylpolysiloxane and silicon dioxide Shin-Etsu Chemical Co., Ltd. 5 It is preferable that the spray tube be disposed with its tip positioned at least 13 mm in height from the upper surface of the turntable.
- the liquid lubricant sprayed from the spray pipe will have the lower end face of the upper punch, the upper end face of the lower punch and Upon reaching the mortar hole, it spreads so as to be almost evenly attached to the lower end surface of the upper punch, the upper end surface of the lower punch and the mortar hole. Therefore, the liquid lubricant can be sprayed efficiently, and the scattering of the excess liquid lubricant can be minimized.
- the height position of the spray tube is adjusted according to the diameter of the molded product to be compression molded. Specifically, for example, the height is set to about 13.3 mm for a piece with a diameter of 11 mm, and about 18.1 mm for a piece with a diameter of 15 mm. Is set to.
- the liquid lubricant is sprayed at a spray angle of about 45 degrees.
- the liquid lubricant is sprayed at such an injection angle, when the sprayed liquid lubricant reaches the lower surface of the upper punch, the upper surface of the lower punch and the die hole, the lower surface of the upper punch and It will diffuse into a circular area with a diameter approximately equal to the 0 outer diameter of the upper surface of the lower punch and the inner diameter of the die hole. Therefore, the liquid lubricant can be efficiently sprayed, and the scattering of the excess liquid lubricant can be minimized.
- Such a recovery device includes a spray case for covering a portion for spraying a liquid lubricant, and a suction device for sucking a 73 ⁇ 4 excess liquid lubricant in the spray case.
- FIG. 1 is an overall front sectional view of a rotary powder compression molding machine showing one embodiment of the present invention.
- FIG. 2 is a schematic plan view showing the turntable of the embodiment.
- FIG. 3 is an exploded front sectional view of the turntable of the embodiment.
- FIG. 4 is a block diagram showing the configuration of the trace liquid spraying device of the embodiment.
- FIG. 5 is a block diagram showing a schematic configuration of the mass flow sensor of the embodiment.
- FIG. 6 is a sectional view of a spray tube according to the embodiment.
- FIG. 7 is a sectional view of a spray tube according to another embodiment of the present invention.
- FIG. 8 is an enlarged view of the lubricant spray part of the other example.
- FIG. 9 is an end view taken along line VIII-VIII in FIG. 8. BEST MODE FOR CARRYING OUT THE INVENTION
- FIG. 1 shows an entire configuration of a rotary powder compression molding machine of the present invention.
- This rotary powder compression molding machine is equipped with a micro liquid spraying device LS for spraying a liquid lubricant L, and a rotary disk 3 is horizontally rotated through a vertical shaft 2 in a frame 1.
- a plurality of dies 4 are provided on the rotating disk 3 with a predetermined pitch, and an upper punch 5 and a lower punch 6 are held above and below each of the dies 4 so as to be vertically slidable. is there.
- an upright shaft 2 supported by a bearing 21 is disposed substantially at the center of the frame 1, and a worm wheel is provided near the lower end of the upright shaft 2.
- the rotational drive force of the motor 25 is transmitted to the worm wheel 22 via the worm 23 and the belt 24. .
- a turntable 3 divided into two functional parts is fixed.
- the turntable 3 is provided at an upper portion thereof and holds an upper punch 5 so that the upper punch 5 is slidable vertically, and is provided at a lower portion thereof and holds a lower punch 6 so as to be vertically slidable.
- the mortar 4 is attached and detached at the position facing the upper punch holder 32.
- the mortar 4 has a mortar hole 41 for vertically inserting a punch tip of an upper punch 5 and a lower punch 6.
- the rotary powder compression molding machine includes a powder filling section 7, a powder sliding section 8, a compression molding section 95, a product removal section 10 and a lubrication section.
- a spraying section K is provided sequentially along the rotation direction of the turntable 3.
- the lower punch 6 is lowered by the lowering device 7 1 so that the powder supplied on the turntable 3 is introduced into the mill 4 by the feed shaft 72.
- the powder is supplied to the turntable 3 by a powder supply mechanism 73.
- the powder sliding section 8 raises the lower punch 6 to a predetermined position by the dispensing rail 82, and also slides the powder overflowing from the mortar 4 by the raising of the lower punch 6 into a sliding plate 8 3 Thus, the mortar 4 is removed from the mortar 4.
- Compression molded part 9 descends upper punch 5 and descends along the slope
- the upper punch lowering cam 91 for inserting the punch tip into the mill 4 and the upper punch 5 and lower punch 6 with the punch tip inserted into the mill 4 are restrained from above and below to
- the powder is preliminarily compressed, and the lower pre-compression rolls 9 2, 9 3, and the upper punch 5 and the lower punch 6 are restrained from above and below to compress the powder in the die 4 in earnest.
- the lower compression rolls 94 and 95 are provided.
- the product take-out section 10 lifts the upper punch 5 along the inclined surface and lifts the upper punch 5 to remove the tip of the punch from the die 4. 0 0, the lower punch 6 is urged upward to push the product Q in the mortar 4 completely out of the mortar 4, and the push-up rail 1 06, and the extruded product Q is guided to the side A guide plate 105 leading to the shot 104 is provided.
- the lubricant spraying section K is formed by extending a spray pipe SP constituting the spraying section S of the trace liquid spraying device L S to above the turntable 5.
- the micro-volume liquid spray device LS is used to measure the liquid lubricant L, for example, in a pressurized state, in a storage tank P, and the liquid lubricant L sent out from the storage tank P at a set spray amount. It has zero part C and a spray part S for spraying the measured liquid lubricant L.
- the storage tank P, the measuring section C, and the spraying section S are connected by a liquid line F.
- the micro-liquid spraying device LS sprays the liquid lubricant L at a constant flow rate, depending on the rotation speed (rotation speed) of the turntable 3 or the amount of powder to be processed. A constant flow rate is set accordingly.
- the trace liquid spray device LS reduces the amount of spray.
- the liquid lubricant L may be ejected intermittently according to the rotation of the turntable 3, that is, for each of the upper punch 5, the lower punch 6, and the mill 4.
- silicone emulsion emulsion
- KM787 trade name: Shin-Etsu Chemical Co., Ltd.
- the liquid lubricant L is not limited to this, but may be a solution obtained by diluting silicone as it is, or diluted with an appropriate solvent, or emulsion. May be.
- the storage tank P has a structure in which the stored liquid lubricant L is sent out from the bottom. That is, in the storage tank P, in a state where the liquid lubricant L is stored, the upper side from the liquid surface is kept airtight, and a predetermined air pressure is applied to the liquid surface, so that the bottom surface 5 Even those with relatively high viscosity can be sent out from the provided outlet.
- the air pressure applied to the storage tank P is set based on the viscosity of the liquid lubricant L and the spray amount.
- the measuring section C measures the liquid lubricant L sent out of the storage tank P, and the measurement is performed based on the temperature difference of the liquid lubricant L being zero. That is, the measuring section C includes a flow rate controller F C that measures the spray amount based on a temperature difference between two points at which the liquid lubricant L sent from the storage tank P has passed.
- the flow controller FC has a mass flow sensor 5 MF, a control valve CV, and an EEPROM. It basically has a micro-computer CPU, A / D converter AD, DA converter DA and valve driver VD. A preset input device PI and a zero adjustment input device ZI for setting the injection amount are connected to the micro computer CPU.
- the flow rate of the liquid lubricant L is measured based on the temperature of the liquid lubricant L, and is opened and closed by driving the control valve CV on and off in a very short cycle. When the liquid lubricant L flows, the difference between the temperatures of the liquid lubricant L at two positions separated by a unit distance is calculated, and measurement is performed based on the calculation result.
- the temperature of the liquid lubricant L is measured at two positions separated by a unit distance by five. After the measured temperature at each position is converted to digital data by the A / D converter AD, the temperature difference is calculated by the micro computer CPU, and the temperature difference is calculated from the temperature difference. The flow rate of liquid lubricant L is measured.
- the micro-computer CPU opens and closes the control valve CV via the DZA converter overnight DA so that the flow rate is set, for example, by the combi-0 computer CC. The flow rate of the liquid lubricant L is controlled.
- the control unit is configured by the micro computer CPU, the DA converter DA, and the control valve CV.
- the flow rate of the liquid lubricant L is, for example, about 0.5 cc per minute. Since this flow rate varies depending on the concentration of the liquid lubricant L, it is not limited to the above-mentioned numerical value, but is appropriately set according to the rotation speed of the turntable 3, the number of the dies 4, and the like. Things.
- the liquid lubricant L may be cooled instead of heated in order to measure its flow rate.
- the metered liquid lubricant L is sent from the control valve CV to the injection section S via the liquid line F.
- the spray unit 0 S is a spray pipe SP for vaporizing the liquid lubricant L sent from the flow rate controller FC by pressurization, and air for supplying pressurized air to the spray pipe SP for pressurization. It has a compression device AP and.
- the air compression device AP compresses air to a predetermined pressure and constantly sends out 5 pressurized air maintained at the predetermined pressure. In this way, by pressurizing the liquid lubricant L by the air compression device AP, the liquid lubricant L can be sprayed without pulsation.
- the spray tube SP has a liquid reservoir SP1, a spray inner tube SP2 projecting from the liquid reservoir SP1 and flowing the liquid lubricant L, and a spray tube SP2.
- the spray outer pipe SP3 which is provided so as to cover the outer circumference of the inner pipe SP2, and through which the pressurized air from the air compressor AP flows through a gap formed between the inner pipe SP2 and the spray inner pipe SP2.
- the liquid lubricant L from the inner spray tube 5 SP 2 is communicated with the inner spray tube SP 2 and the outer spray tube SP 3, respectively.
- an injection nozzle SP4 that is drawn out in a reduced pressure state by pressurized air.
- the injection nozzle SP4 has a discharge hole SP41 for the liquid lubricant L at the center thereof, and the injection nozzle SP4 is connected to the spray nozzle SP3 so as to surround the discharge hole SP41.
- a plurality of air blowing holes SP42 for blowing compressed air is provided.
- the air blown out from the air outlet SP 42 forms a spiral airflow in the vicinity of the outlet SP 41, and forms a space having a low atmospheric pressure in the vicinity of the outlet SP 41. Therefore, when the liquid lubricant L is discharged into the space having a low atmospheric pressure, the liquid lubricant L is instantaneously decompressed, vaporized and sprayed.
- the spray tube SP is arranged between the product take-out section 10 and the powder filling section 7, that is, in the lubricant spray section K.
- the spray pipe SP for spraying the liquid lubricant L onto the upper punch 5 is disposed in the lubricant spraying section K with the spout 5 outlet SP 41 facing upward, followed by the lower punch 6 and the mill hole 4.
- the spray tube SP for 1 is arranged with the outlet SP 41 facing down.
- the spray tube SP for the lower punch 6 is disposed closer to the powder filling portion 7 than the spray tube SP of the upper punch 5, that is, on the traveling side in the rotation direction of the turntable 3.
- the five positions of such a spray pipe SP are the lower surface 5a of the upper punch, the upper surface 6a of the lower punch and the inner periphery of the die hole. This is to ensure a sufficient drying time so that the liquid lubricant L sprayed and adhered to the surface 41a is dried before the powder is filled.
- the center of each of the ejection holes SP 41 coincides with the locus of the center of the upper punch 5 and the lower punch 6.
- reference symbols T0 to T5 indicate phases.
- the upper punch 5 and the lower punch 6 at the stage of passing through the product take-out section 10 are held at the highest position (TO).
- the upper punch 5 and the lower punch 6 are moved to the lubricant spraying section K by the rotation of the turntable 3 while the upper punch 5 and the lower punch 6 are held at the highest position (T 1 ).
- the micropowder L S sprays the liquid lubricant L onto the upper punch 5.
- the turntable 3 rotates, the lower punch 6 descends at the start end of the lowering device 751 by an amount corresponding to the thickness of the product Q.
- the fine liquid spraying device L S sprays the liquid lubricant L onto the lower punch 6 and the mill 4 (T 2). Therefore, the liquid lubricant L adheres to the inner peripheral surface of the lower punch upper end surface 6a and the inner peripheral surface of the die hole 41 at a depth corresponding to the thickness of the product, so that zero can be obtained.
- the liquid lubricant L is sprayed, so that the liquid lubricant L sprayed from the spray pipe SP is supplied to the lower end surface of the upper punch. 5 Attaches to a. Thereafter, the lower punch 6 paired with the upper punch 5 passes under the spray pipe SP while being held at the position 5 described above. Therefore, the liquid lubricant L sprayed from the spray pipe SP adheres to the lower punch 6 and the inner peripheral surface 4 la of the die hole.
- the amount of the liquid lubricant L to be sprayed was measured at the measuring section C, so that the liquid lubricant L was sprayed on the lower end face 5a of the upper punch, the upper end face 6a of the lower punch and the mortar. 41 Each of them is almost uniformly attached to almost the entire inner peripheral surface of the predetermined depth. After the liquid lubricant L adheres to the upper punch 5, the lower punch 6, and the die 4, the solvent partially volatilizes until the powder is filled, and the lower end surface 5a of the upper punch 5, the lower punch The upper surface 6 a of 6 and the inner peripheral surface 4 1 a0 of the mortar hole 4 1 dry. For this reason, even if the liquid lubricant L is sprayed, the powder to be filled does not adhere to each surface because the respective surfaces are not wetted by the liquid lubricant L.
- the lower punch 6 is first lowered to the middle position by the guiding action of the first half 5 of the lowering device 7 1 and the second half. It is lowered to a lower position by the guiding action of the part (T 3). On the way, the powder supplied from the powder supply mechanism 73 onto the turntable 3 is evenly introduced by the powder guiding action of the feeder 72. Thereafter, the lower punch 6 is lifted by a small amount to reach a predetermined height position by the lower punch 6 riding on the dispensing rail 82, and the die 4 is filled with the set amount of powder. It will be.
- the upper punch 5 is lowered by the guide action of the upper punch lowering cam 91 (T 4), and the tip of the punch is inserted into the die 4.
- the upper punch 5 and the lower punch 6 pass between the upper and lower pre-compression rollers 92 and 93 and between the upper and lower main compression rollers 94 and 95, and thereby the powder in the die 4 is removed. Is compression molded (T 5).
- the upper punch 5 is first lifted by the guide action of the upper punch raising cam 100 at the product take-out section 10 to remove the punch tip 0 from the die 4, and then the lower punch 6 is removed.
- the product Q in the die 4 is pushed up by the push-up 106 and pushed out onto the turntable 3.
- the product Q is guided onto the shutter 104 by the guiding action of the guide plate 105, and is led out of the compression molding machine A.
- the upper punch 5 is guided by the upper punch raising cam 1500 and further rises.
- the predetermined product Q can be manufactured by repeatedly and continuously compressing and molding the powder.
- the rotary powder compression molding machine of the present embodiment configured as described above, when the powder is compressed, the portion that comes into contact with the powder, that is, 0, that is, the lower surface 5a of the upper punch, the upper surface 6a of the lower punch, Before the powder is compressed, the liquid lubricant L adheres to the inner peripheral surface 4 1a in a substantially uniform state each time before the powder is compressed.Therefore, the powder lubricant should be mixed into the powder in advance. Therefore, the status king can be prevented. In addition, the amount of the liquid lubricant L sprayed is the minimum necessary to prevent stateing.
- Liquid lubricant L which is finely divided by spraying and the solvent is volatilized and dried, so that even if the liquid lubricant L adheres, the liquid lubricant L This can prevent the problem that the powder adheres to the upper punch 5, the lower punch 6, or the die hole 41. Therefore, it is possible to produce tablets with sufficient hardness by using powder not mixed with a lubricant. In addition, since a small amount is sprayed near the end surfaces of the upper punch 5 and the lower punch 6, not only the contamination problem can be prevented, but also the liquid lubricant L can be easily attached uniformly. It becomes 0.
- this rotary powder compression molding machine is similar to the existing one, except that the lowering device 71 in the lubricant spraying section K is changed and the spray pipe SP is arranged at a predetermined position. It can be configured only by making very simple changes such as adding a storage tank P, a flow controller FC, an air compressor A5P, and a liquid pipeline F to the apparatus. Therefore, a complicated compression mechanism or the like is required, as in the case where only the lubricant is compressed with a dummy before tableting, which leads to an increase in the size and complexity of the device and a decrease in tableting performance. There are no shortcomings.
- the liquid lubricant L, silicone emulsion type release agent KM—7 8 7 (trade name: Shin-Etsu Chemical Co., Ltd., Type 5 Company) is stored in the storage tank P at 500 m.
- the flow rate is controlled by a flow controller FC including a mass flow sensor MF and a control valve CV composed of a control valve (CV-110: LINTEC Co., Ltd.).
- the powder containing Neusilin composition Neusilin 2 0%, Avicel 40%, lactose 0 40%
- upper punch 5 at the lower end face 5a, which has a concave surface with a diameter of 8 mm (six engraved radially), and lower face of the upper punch
- a lower punch 6 (12 engraved radially) with a concave shape of 6a shape, rotation speed 30 rpm
- tableting pressure Tableting was performed at 5.9 kN / cm 2 .
- the scattered powder due to the spraying of the liquid 5-body lubricant L was collected by a dust collector (not shown).
- the liquid lubricant L (silicone) was sprayed at a rate of 0.15 g Z to the lower surface 5 a of the upper punch and 0.3 O g Z to the upper surface 6 a of the lower punch and the die hole 41. After continuous spraying of nemulsion), tableting was performed, and no tablet was observed, and no adhesion of Neusilin-containing powder on the lower surface of the upper punch 5a and the upper surface 6a of the lower punch was observed. .
- the liquid powder lubricant L was not sprayed by the micro-liquid spraying device LS, but the rotary powder compression molding machine of the above-mentioned embodiment was equipped with the upper punch 5 and the lower punch 6 having the same shape as the above-mentioned embodiment 11 without spraying.
- neurinin-containing powder composition Neusilin 20%, Avicel 40%, lactose 40%
- the tablet was compressed at 2 . In this case, 5 tablets of the tablet are immediately generated, and the Adhesion of Neusilin-containing powder was observed.
- the spray tube may have a discharge hole in the vertical direction at the tip. That is, as shown in FIG. 7, the spray tube SPB has a liquid reservoir SPB 1 and a spray through which the liquid lubricant L is projected from the liquid reservoir SPB 1, as in the above embodiment. Pressurized air from the air compressor AP flows into the gap formed between the inner pipe SPB2 and the spray 0 inner pipe SPB2 provided so as to cover the outer periphery of the spray inner pipe SPB2.
- the outer spray tube SPB3 has an upper discharge hole SPB41a and a lower discharge hole SPBb at the tip of the spray outer tube SPB3, from which the liquid lubricant L is ejected.
- the tip of the spray tube SPB is located at least 13 mm above the upper surface of the rotary press 3, for example.
- the tip of the spray tube SPB is, for example, for a molded tablet having a diameter of 11 mm, the height from the upper surface of the turntable 3 is about 13.3 mm.
- the distal end of the spray outer tube SPB 3 is closed by a plug member SPB 3a.
- the inner diameters of the upper and lower discharge holes SPB41a and S5PB41b are set to, for example, 0.7 mm. Ma
- the liquid lubricant L sprayed from the upper and lower discharge holes SPB41a and SPB41 is, for example, approximately from the center of the upper and lower discharge holes SPB41a and SPB41b. Sprayed radially at an angle of 45 °.
- the measuring section C does not need to include two flow controllers FC, but connects one spray controller SP to the spray pipe SPB. Accordingly, only one air compressor AP is required.
- the liquid lubricant L which has been sprayed and becomes excessive, is lubricated so as not to be widely scattered inside the rotary powder compression molding machine.
- the lubricant spray section 5K is covered with a spray case JC formed so as to surround the spray pipe SPB.
- a dust collector V D for collecting the excess liquid lubricant L scattered inside.
- the lower surface of the spray case JC is kept airtight with the turntable 3 by a seal member SL.
- a collection device is formed by the spray case JC and the dust collector VD.
- the spray case JC is attached to the guide plate 105, and has a storage space JVa for storing the spray pipe SPB, and an excess of five liquids sprayed in communication with the storage space JVa. With a recovery space JV b filled with the lubricant L I have. On the upper surface of the storage space JVa, a through hole TH is provided on the line connecting the upper discharge hole SPB4 1a of the spray pipe SPB and the upper punch 5, and the rise of the sprayed liquid lubricant L An air outlet ACa for the air curtain for forming an air curtain AC for preventing air is provided at a position facing the recovery space JVb.
- the air curtain AC is formed above the lower surface 5a of the upper punch, and does not prevent the liquid lubricant L from adhering to the lower surface 5a of the upper punch.
- the connected collection duct RD is connected.
- the air curtain AC is formed above the lower end surface 5a of the upper punch, so that the air curtain AC prevents the liquid lubricant L that is going to rise above the lower end surface 5a of the upper punch. It can be prevented from adhering to the upper punch 5 and its surroundings.
- the bellows BL made of a flexible material are used so that the liquid lubricant L does not adhere to the trunk at the lower end of the upper punch 5. Coated.
- the spray tube SPB is used when the liquid lubricant L is in a state where the powder can be filled into the mortar hole 41 after the lower punch 6 discharges the product from the mortar 4, that is, Lower 5 Lower punch 6 just before lower punch 6 is lowered by lower unit 7 1 It is attached so that it is sprayed on the end face 5a, the upper face 6a of the lower punch and the die hole 41.
- the liquid lubricant L can be simultaneously sprayed on the lower end face 5a of the upper punch, the upper end face 6a of the lower punch, and the die hole 41.
- the number of flow controllers FC can be reduced to one, and the device configuration can be simplified.
- the spray case JC is used to suppress and collect the liquid lubricant L, so that excess liquid lubricant L can be removed from the upper punch 5 and the rotating disk 3. It can be effectively prevented from adhering to the like, and maintenance can be facilitated.
- spray case J C can be applied to the embodiment having two spray tubes SP described above.
- covering the lower trunk portion of the upper punch with the bellows B L can be applied to the above embodiment.
- configuration of each section is not limited to the illustrated example, and can be modified without departing from the spirit of the present invention.
- the rotary powder compression molding machine according to the present invention is suitably used in the case of producing molded articles produced by compression molding, including pharmaceuticals, foods, and toiletry.
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Abstract
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Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002367406A CA2367406A1 (en) | 1999-04-19 | 2000-04-17 | Rotary type powder compression molding machine |
AU38388/00A AU3838800A (en) | 1999-04-19 | 2000-04-17 | Rotary type powder compression molding machine |
EP00917335A EP1179414A4 (en) | 1999-04-19 | 2000-04-17 | Rotary type powder compression molding machine |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11060799 | 1999-04-19 | ||
JP11/110607 | 1999-04-19 |
Publications (1)
Publication Number | Publication Date |
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WO2000063006A1 true WO2000063006A1 (en) | 2000-10-26 |
Family
ID=14540132
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/JP2000/002507 WO2000063006A1 (en) | 1999-04-19 | 2000-04-17 | Rotary type powder compression molding machine |
Country Status (4)
Country | Link |
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EP (1) | EP1179414A4 (en) |
AU (1) | AU3838800A (en) |
CA (1) | CA2367406A1 (en) |
WO (1) | WO2000063006A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006334515A (en) * | 2005-06-02 | 2006-12-14 | Hata Tekkosho:Kk | Powdery lubricant spray apparatus and rotary powder compacting machine |
JP2008301876A (en) * | 2007-06-05 | 2008-12-18 | Nikkiso Co Ltd | Method of preparing solidified dialysis agent |
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DE10212959A1 (en) * | 2002-03-22 | 2003-10-16 | Wolfram Minke | Machine, in particular, in the form of a tablet press comprises a die table which, in addition to a first circle of dies, is provided with a second circle of dies together with their respective top and bottom punches |
EP2095806B1 (en) * | 2006-12-22 | 2014-07-02 | Kikusui Seisakusho Ltd. | Nozzle mechanism |
DE102008002311B4 (en) * | 2007-10-22 | 2012-06-06 | Korsch Ag | Apparatus and method for dusting upper and lower punches of a powder press with a lubricant and / or release agent and powder press |
CN105193623B (en) * | 2015-09-29 | 2019-03-26 | 武汉轻工大学 | A kind of hand-held moxibustion piece pelleting press |
DE102016123279B4 (en) | 2016-12-01 | 2019-02-21 | Fette Compacting Gmbh | Method and system for feeding a lubricant or release agent to press tools of a tablet press |
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US4373888A (en) * | 1979-07-13 | 1983-02-15 | Takeda Chemical Industries, Ltd. | Apparatus for mass-producing medical tablets |
US4388343A (en) * | 1978-11-04 | 1983-06-14 | Boehringer Ingelheim Gmbh | Method and apparatus for lubricating molding tools |
JPS6220322U (en) * | 1985-07-19 | 1987-02-06 | ||
US4707309A (en) * | 1983-04-08 | 1987-11-17 | Dr. Karl Thomae Gmbh | Dotting of molding tools with droplets |
JPS6393500A (en) * | 1986-10-03 | 1988-04-23 | ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Method and device for controlling discharge of lubricant |
JPH0791998A (en) * | 1993-09-24 | 1995-04-07 | Sekisui Plastics Co Ltd | Flow rate sensor |
EP0650826A1 (en) * | 1993-11-01 | 1995-05-03 | Kyowa Hakko Kogyo Co., Ltd. | Rotary-type tabletting machine with lubricant spraying means |
JPH10317007A (en) * | 1997-05-16 | 1998-12-02 | Kozo Ishizaki | Method for compacting green compact |
Family Cites Families (1)
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DD136026A5 (en) * | 1977-04-20 | 1979-06-13 | Thomae Gmbh Dr K | METHOD FOR BESPRESSING THE COMPRESSION TOOLS WITH LUBRICANTS |
-
2000
- 2000-04-17 AU AU38388/00A patent/AU3838800A/en not_active Abandoned
- 2000-04-17 CA CA002367406A patent/CA2367406A1/en not_active Abandoned
- 2000-04-17 EP EP00917335A patent/EP1179414A4/en not_active Withdrawn
- 2000-04-17 WO PCT/JP2000/002507 patent/WO2000063006A1/en not_active Application Discontinuation
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4388343A (en) * | 1978-11-04 | 1983-06-14 | Boehringer Ingelheim Gmbh | Method and apparatus for lubricating molding tools |
US4373888A (en) * | 1979-07-13 | 1983-02-15 | Takeda Chemical Industries, Ltd. | Apparatus for mass-producing medical tablets |
US4707309A (en) * | 1983-04-08 | 1987-11-17 | Dr. Karl Thomae Gmbh | Dotting of molding tools with droplets |
JPS6220322U (en) * | 1985-07-19 | 1987-02-06 | ||
JPS6393500A (en) * | 1986-10-03 | 1988-04-23 | ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Method and device for controlling discharge of lubricant |
JPH0791998A (en) * | 1993-09-24 | 1995-04-07 | Sekisui Plastics Co Ltd | Flow rate sensor |
EP0650826A1 (en) * | 1993-11-01 | 1995-05-03 | Kyowa Hakko Kogyo Co., Ltd. | Rotary-type tabletting machine with lubricant spraying means |
JPH10317007A (en) * | 1997-05-16 | 1998-12-02 | Kozo Ishizaki | Method for compacting green compact |
Non-Patent Citations (1)
Title |
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See also references of EP1179414A4 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006334515A (en) * | 2005-06-02 | 2006-12-14 | Hata Tekkosho:Kk | Powdery lubricant spray apparatus and rotary powder compacting machine |
JP4624859B2 (en) * | 2005-06-02 | 2011-02-02 | 株式会社畑鉄工所 | Powder lubricant injection device and rotary powder compression molding machine |
JP2008301876A (en) * | 2007-06-05 | 2008-12-18 | Nikkiso Co Ltd | Method of preparing solidified dialysis agent |
Also Published As
Publication number | Publication date |
---|---|
EP1179414A1 (en) | 2002-02-13 |
CA2367406A1 (en) | 2000-10-26 |
AU3838800A (en) | 2000-11-02 |
EP1179414A4 (en) | 2005-07-13 |
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