WO2000071169A3 - Magnetic resonance tracking of magnetically labeled cells - Google Patents

Magnetic resonance tracking of magnetically labeled cells Download PDF

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Publication number
WO2000071169A3
WO2000071169A3 PCT/US2000/013826 US0013826W WO0071169A3 WO 2000071169 A3 WO2000071169 A3 WO 2000071169A3 US 0013826 W US0013826 W US 0013826W WO 0071169 A3 WO0071169 A3 WO 0071169A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
magnetic resonance
sensitive
mri
agents
Prior art date
Application number
PCT/US2000/013826
Other languages
French (fr)
Other versions
WO2000071169A2 (en
Inventor
Jeff W Bulte
Ian D Duncan
Joseph A Frank
Original Assignee
Us Gov Health & Human Serv
Jeff W Bulte
Ian D Duncan
Joseph A Frank
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Jeff W Bulte, Ian D Duncan, Joseph A Frank filed Critical Us Gov Health & Human Serv
Priority to AU51463/00A priority Critical patent/AU5146300A/en
Publication of WO2000071169A2 publication Critical patent/WO2000071169A2/en
Publication of WO2000071169A3 publication Critical patent/WO2000071169A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1896—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes not provided for elsewhere, e.g. cells, viruses, ghosts, red blood cells, virus capsides

Abstract

The method of the present invention is to label living cells so as to render them detectable in MRI. The invention relates to the use of magnetic resonance (MR) sensitive agents to render treated living cells identifiable and distinguishable in MR Imaging (MRI). MR sensitive agents can be bound to a targeting compound such as a protein or antibody. The targeting compound reacts with living cells in a way that the MR sensitive agent is incorporated into the or onto the cell surface. The MR sensitive agents can also be coated with agents that render the magnetic resonance sensitive agent able to bind to or be internalized by cells. The treated cells of the invention can be applied to patient for any therapeutic, diagnostic, or experimental purpose. The invention also encompasses imaging the host with MRI to locate MR labeled cells, to track their migration or bio-distribution non-invasively, and to establish to survival characteristics of such cells.
PCT/US2000/013826 1999-05-21 2000-05-19 Magnetic resonance tracking of magnetically labeled cells WO2000071169A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU51463/00A AU5146300A (en) 1999-05-21 2000-05-19 Magnetic resonance tracking of magnetically labeled cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13542899P 1999-05-21 1999-05-21
US60/135,428 1999-05-21

Publications (2)

Publication Number Publication Date
WO2000071169A2 WO2000071169A2 (en) 2000-11-30
WO2000071169A3 true WO2000071169A3 (en) 2001-08-02

Family

ID=22468067

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/013826 WO2000071169A2 (en) 1999-05-21 2000-05-19 Magnetic resonance tracking of magnetically labeled cells

Country Status (2)

Country Link
AU (1) AU5146300A (en)
WO (1) WO2000071169A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9265577B2 (en) 2007-05-18 2016-02-23 The Johns Hopkins University Methods and systems for providing planning and dispensation of research and/or treatment for brain disease

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US6986942B1 (en) 1996-11-16 2006-01-17 Nanomagnetics Limited Microwave absorbing structure
US6815063B1 (en) 1996-11-16 2004-11-09 Nanomagnetics, Ltd. Magnetic fluid
GB2319253A (en) 1996-11-16 1998-05-20 Eric Leigh Mayes Composition, for use in a device, comprising a magnetic layer of domain-separated magnetic particles
US6713173B2 (en) 1996-11-16 2004-03-30 Nanomagnetics Limited Magnetizable device
EP1376443A1 (en) * 2002-06-19 2004-01-02 BrainLAB AG Method and device for determining the migration ways of cells
US8249813B2 (en) 2003-05-22 2012-08-21 Brainlab Ag System and process for metabolic guidance of introduced cellular material
ATE491781T1 (en) * 2003-06-30 2011-01-15 Eisai R&D Man Co Ltd MAGNETIC CELL AND METHOD OF USE THEREOF
US7848543B2 (en) 2004-02-05 2010-12-07 Brainlab Ag Method and system for prediction and management of material and information transport in an organism
WO2005095621A1 (en) * 2004-03-31 2005-10-13 Genomidea Inc. Method of regulating gene introduction with use of artificial magnetic material and system therefor
DE102004052533A1 (en) † 2004-10-15 2006-05-04 Mykhaylyk, Olga, Dr. Particles for use in diagnosis and therapy, especially for binding therapeutic agent for treating e.g. tumors and bacterial, rheumatic, neurologic and thrombotic diseases, have nanocrystalline magnetic core and envelope enclosing core
US8580230B2 (en) 2009-02-23 2013-11-12 Kent State University Materials and methods for MRI contrast agents and drug delivery
DE102009060317B4 (en) * 2009-12-23 2013-04-04 Siemens Aktiengesellschaft A contrast agent for use in an imaging method for diagnosing a metastatic tumor disease and a method for imaging a metastatic tumor tissue
US20120052014A1 (en) * 2010-05-11 2012-03-01 Sufi Oasim Raja Ferritin biosensor and methods of using the same
CN113648426A (en) * 2021-08-18 2021-11-16 浙江大学 Construction method and application of magnetic nanoparticles capable of being connected in two directions

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BULTE J W M ET AL: "DEXTRAN-MAGNETITE PARTICLES: CONTRAST-ENHANCED MRI OF BLOOD-BRAIN BARRIER DISRUPTION IN A RAT MODEL*", MAGNETIC RESONANCE IN MEDICINE,US,ACADEMIC PRESS, DULUTH, MN, vol. 23, no. 2, 1 February 1992 (1992-02-01), pages 215 - 223, XP000261759, ISSN: 0740-3194 *
BULTE J W M ET AL: "Preparation, relaxometry, and biokinetics of PEGylated magnetoliposomes as MR contrast agent", JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 194, no. 1-3, April 1999 (1999-04-01), pages 204 - 209, XP004166667, ISSN: 0304-8853 *
BULTE J W M ET AL: "Specific MR imaging of human lymphocytes by monoclonal antibody-guided dextran - magnetite particles", MAGNETIC RESONANCE IN MEDICINE,US,ACADEMIC PRESS, DULUTH, MN, vol. 25, no. 1, 1992, pages 148 - 157, XP002112218, ISSN: 0740-3194 *
BULTE J.W.M. ET AL: "Short-vs. long-circulating magnetoliposomes as bone marrow-seeking MR contrast agents", J. MAGNETIC RESONANCE IMAGING, vol. 9, February 1999 (1999-02-01), pages 329 - 335, XP000986439 *
BULTE J.W.M. ET AL: "Tagging of T cells with superparamagnetic iron oxide: Uptake kinetics and relaxometry", ACAD RADIOL., vol. 3, 3 August 1996 (1996-08-03), pages s301 - s303, XP000986426 *
BULTE, J. W. M. ET AL: "Neurotransplantation of magnetically labeled oligodendrocyte progenitors: Magnetic resonance tracking of cell migration and myelination", PNAS, vol. 96, no. 26, 21 December 1999 (1999-12-21), pages 15256 - 15261, XP000982063 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9265577B2 (en) 2007-05-18 2016-02-23 The Johns Hopkins University Methods and systems for providing planning and dispensation of research and/or treatment for brain disease

Also Published As

Publication number Publication date
AU5146300A (en) 2000-12-12
WO2000071169A2 (en) 2000-11-30

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