WO2000072867A3 - Substantially oil-free cyclosporin compositions - Google Patents
Substantially oil-free cyclosporin compositions Download PDFInfo
- Publication number
- WO2000072867A3 WO2000072867A3 PCT/EP2000/004829 EP0004829W WO0072867A3 WO 2000072867 A3 WO2000072867 A3 WO 2000072867A3 EP 0004829 W EP0004829 W EP 0004829W WO 0072867 A3 WO0072867 A3 WO 0072867A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- substantially oil
- cyclosporin compositions
- free cyclosporin
- fatty acid
- acid ester
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK00943742T DK1181035T3 (en) | 1999-05-28 | 2000-05-26 | Practically oil-free cyclosporin preparations |
BR0011030-2A BR0011030A (en) | 1999-05-28 | 2000-05-26 | Compositions of substantially oil-free cycloporin |
AT00943742T ATE291926T1 (en) | 1999-05-28 | 2000-05-26 | ESSENTIALLY OIL-FREE CYCLOSPORINE COMPOSITIONS |
MXPA01012222A MXPA01012222A (en) | 1999-05-28 | 2000-05-26 | Pharmaceutical compositions. |
EP00943742A EP1181035B1 (en) | 1999-05-28 | 2000-05-26 | Substantially oil-free cyclosporin compositions |
CA002371247A CA2371247A1 (en) | 1999-05-28 | 2000-05-26 | Substantially oil-free cyclosporin compositions |
SI200030699T SI1181035T1 (en) | 1999-05-28 | 2000-05-26 | Substantially oil-free cyclosporin compositions |
NZ515154A NZ515154A (en) | 1999-05-28 | 2000-05-26 | Cyclosporin in a capsule comprising a polyoxyethylene sorbitan and sorbitan fatty acid esters, a reaction product of caster oil and ethylene oxide and ethanol |
AU58100/00A AU765935B2 (en) | 1999-05-28 | 2000-05-26 | Substantially oil-free cyclosporin compositions |
IL14618600A IL146186A0 (en) | 1999-05-28 | 2000-05-26 | Substantially oil-free cyclosporin compositions |
JP2000620976A JP2003500454A (en) | 1999-05-28 | 2000-05-26 | Substantially oil-free cyclosporin composition |
DE60019100T DE60019100T2 (en) | 1999-05-28 | 2000-05-26 | ESSENTIALLY OIL-FREE CYCLOSPORIN COMPOSITIONS |
DE10084671T DE10084671T1 (en) | 1999-05-28 | 2000-05-26 | Pharmaceutical compositions |
KR1020017013293A KR20010111587A (en) | 1999-05-28 | 2000-05-26 | Pharmaceutical compositions |
PL351593A PL199591B1 (en) | 1999-05-28 | 2000-05-26 | Substantially oil−free cyclosporin compositions |
SK1722-2001A SK285471B6 (en) | 1999-05-28 | 2000-05-26 | Pharmaceutical compositions containing cyclosporin |
GB0128277A GB2367004B (en) | 1999-05-28 | 2000-05-26 | A cyclosporin containing composition in the form of a capsule |
NO20015785A NO20015785L (en) | 1999-05-28 | 2001-11-27 | In its essential oil-free cyclosporin mixtures |
HK02105374.3A HK1045642B (en) | 1999-05-28 | 2002-07-19 | Substantially oil-free cyclosporin compositions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9912476.0 | 1999-05-28 | ||
GBGB9912476.0A GB9912476D0 (en) | 1999-05-28 | 1999-05-28 | Organic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000072867A2 WO2000072867A2 (en) | 2000-12-07 |
WO2000072867A3 true WO2000072867A3 (en) | 2001-04-05 |
Family
ID=10854362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2000/004829 WO2000072867A2 (en) | 1999-05-28 | 2000-05-26 | Substantially oil-free cyclosporin compositions |
Country Status (26)
Country | Link |
---|---|
US (2) | US6432445B1 (en) |
EP (1) | EP1181035B1 (en) |
JP (1) | JP2003500454A (en) |
KR (1) | KR20010111587A (en) |
CN (1) | CN1353613A (en) |
AT (1) | ATE291926T1 (en) |
AU (1) | AU765935B2 (en) |
BR (1) | BR0011030A (en) |
CA (1) | CA2371247A1 (en) |
CZ (1) | CZ20014214A3 (en) |
DE (2) | DE10084671T1 (en) |
ES (1) | ES2239605T3 (en) |
GB (2) | GB9912476D0 (en) |
HK (1) | HK1045642B (en) |
HU (1) | HUP0201372A3 (en) |
IL (1) | IL146186A0 (en) |
MX (1) | MXPA01012222A (en) |
NO (1) | NO20015785L (en) |
NZ (1) | NZ515154A (en) |
PL (1) | PL199591B1 (en) |
PT (1) | PT1181035E (en) |
RU (1) | RU2249461C2 (en) |
SK (1) | SK285471B6 (en) |
TR (1) | TR200103276T2 (en) |
WO (1) | WO2000072867A2 (en) |
ZA (1) | ZA200109658B (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE29824679U1 (en) * | 1997-01-30 | 2002-03-28 | Novartis Ag | Pharmaceutical compositions |
GB9912476D0 (en) * | 1999-05-28 | 1999-07-28 | Novartis Ag | Organic compounds |
AR033711A1 (en) * | 2001-05-09 | 2004-01-07 | Novartis Ag | PHARMACEUTICAL COMPOSITIONS |
EP1455753A1 (en) * | 2001-12-20 | 2004-09-15 | Bernard Charles Sherman | Pharmaceutical compositions comprising a cyclosporin, a hydrophilic surfactant and a lipophilic surfactant |
US20040115287A1 (en) * | 2002-12-17 | 2004-06-17 | Lipocine, Inc. | Hydrophobic active agent compositions and methods |
WO2004082629A2 (en) * | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
JP2005255677A (en) * | 2004-02-12 | 2005-09-22 | Nof Corp | Cyclosporine preparation |
US20060014677A1 (en) * | 2004-07-19 | 2006-01-19 | Isotechnika International Inc. | Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds |
EP1809656A4 (en) * | 2004-09-29 | 2009-03-25 | Amr Technology Inc | Cyclosporin alkyne analogues and their pharmaceutical uses |
US7511013B2 (en) * | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
WO2006041631A2 (en) * | 2004-10-06 | 2006-04-20 | Amr Technology, Inc. | Novel cyclosporin alkynes and their utility as pharmaceutical agents |
CN101171000A (en) * | 2005-04-12 | 2008-04-30 | 依兰药物国际有限公司 | Nanoparticulate and controlled release compositions comprising cyclosporine |
WO2006114776A1 (en) * | 2005-04-27 | 2006-11-02 | Kingspan Holdings (Irl) Limited | Surfactant for phenolic foam |
US7696165B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
MY158809A (en) * | 2010-09-22 | 2016-11-15 | Craun Res Sdn Bhd | Pharmaceutical compositions for calanolides, their derivatives and analogues, and process for producing the same |
US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
WO2016033549A2 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
JP2020503269A (en) | 2016-11-28 | 2020-01-30 | リポカイン インコーポレーテッド | Oral testosterone undecanoate therapy |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998033512A1 (en) * | 1997-01-30 | 1998-08-06 | Novartis Ag | Oil-free pharmaceutical compositions containing cyclosporin a |
WO1998040094A1 (en) * | 1997-03-12 | 1998-09-17 | Abbott Laboratories | Hydrophilic binary systems for the administration of cyclosporine |
WO2000040219A1 (en) * | 1998-12-30 | 2000-07-13 | Dexcel Ltd. | Dispersible concentrate for the delivery of cyclosporin |
Family Cites Families (40)
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NL7012460A (en) | 1970-08-22 | 1972-02-24 | ||
DE3225706C2 (en) | 1982-07-09 | 1984-04-26 | A. Nattermann & Cie GmbH, 5000 Köln | Liquid active ingredient formulations in the form of concentrates for microemulsions |
DE3315805A1 (en) | 1983-04-30 | 1984-11-08 | Bayer Ag, 5090 Leverkusen | Active substance compositions |
US5639724A (en) | 1984-07-24 | 1997-06-17 | Sandoz Ltd. | Cyclosporin galenic forms |
GB8903804D0 (en) | 1989-02-20 | 1989-04-05 | Sandoz Ltd | Improvements in or relating to organic compounds |
FR2609631A1 (en) | 1987-01-15 | 1988-07-22 | Sanofi Sa | Stable liquid compositions based on biothionol |
KR0148748B1 (en) | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | A multiphase cyclosporin composition |
US5342625A (en) | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
US6007840A (en) | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
DE3908047A1 (en) | 1989-03-13 | 1990-09-20 | Desitin Arzneimittel Gmbh | HIGH DISPERSES PHARMACEUTICAL COMPOSITION |
US5266590A (en) | 1989-12-11 | 1993-11-30 | Isp Investments Inc. | Cold stabilization of aqueous microemulsions of a water-insoluble agriculturally active compound |
US5283229A (en) | 1989-12-11 | 1994-02-01 | Isp Investments Inc. | Delivery system for agricultural chemicals |
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US6022853A (en) * | 1991-08-30 | 2000-02-08 | Creative Biomolecules, Inc. | Morphogen-enriched dietary composition |
GB9225540D0 (en) | 1992-12-07 | 1993-01-27 | Ici Plc | Cleaning compositions |
JPH06293633A (en) | 1993-04-05 | 1994-10-21 | Shin Etsu Chem Co Ltd | Production of aqueous enteric emulsion |
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DE4337041A1 (en) | 1993-10-29 | 1995-05-04 | Henkel Kgaa | Process for the preparation in oil-in-water emulsions |
WO1995022343A1 (en) | 1994-02-17 | 1995-08-24 | Shiseido Company, Ltd. | Cyclosporin-containing emulsion composition |
MY129435A (en) | 1994-10-26 | 2007-04-30 | Novartis Ag | Pharmaceutical microemulsion preconcentrates |
US5691289A (en) | 1994-11-17 | 1997-11-25 | Kay Chemical Company | Cleaning compositions and methods of using the same |
HU215966B (en) | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Oral multiple emulsion-preconcentrate containing cyclosporin |
CA2221145A1 (en) | 1995-05-19 | 1996-11-21 | Abbott Laboratories | Self-emulsifying formulations of lipophilic drugs |
SE9503143D0 (en) | 1995-09-12 | 1995-09-12 | Astra Ab | New preparation |
DE19537836A1 (en) | 1995-10-11 | 1997-04-17 | Henkel Kgaa | Preparation of oil-in-water aerosol emulsion using emulsifier |
KR970064620A (en) | 1996-03-05 | 1997-10-13 | 임성기 | Cyclosporin-containing external-use pharmaceutical composition |
DE19615271A1 (en) | 1996-04-18 | 1997-10-23 | Huels Chemische Werke Ag | Detergent containing detergents in the form of a microemulsion |
KR980008239A (en) | 1996-07-26 | 1998-04-30 | 김충환 | Cyclosporin-containing pharmaceutical composition |
WO1998040051A1 (en) | 1997-03-12 | 1998-09-17 | Abbott Laboratories | Lipophilic binary systems for the administration of lipophilic compounds |
AU1509799A (en) | 1997-12-05 | 1999-06-28 | Chong Kun Dang Corporation | Pharmaceutical composition containing cyclosporin |
US6063762A (en) | 1997-12-05 | 2000-05-16 | Chong Kun Dang Corp. | Cyclosporin-containing microemulsion preconcentrate composition |
US6028067A (en) | 1997-12-05 | 2000-02-22 | Chong Kun Dang Corp. | Cyclosporin-containing microemulsion preconcentrate composition |
KR100587551B1 (en) | 1997-12-10 | 2006-06-08 | 싸이클로스포린 테라퓨틱스 리미티드 | Pharmaceutical compositions containing an omega-3 fatty acid oil |
NZ329929A (en) * | 1998-03-09 | 1999-10-28 | Bernard Charles Sherman | Pharmaceutical emulsion preconcentrate containing cyclosporin in a solvent system containing glycerides, propylene or polyethylene glycol, a surfactant and a co-surfactant |
GB9912476D0 (en) | 1999-05-28 | 1999-07-28 | Novartis Ag | Organic compounds |
-
1999
- 1999-05-28 GB GBGB9912476.0A patent/GB9912476D0/en not_active Ceased
-
2000
- 2000-05-26 US US09/579,372 patent/US6432445B1/en not_active Expired - Fee Related
- 2000-05-26 SK SK1722-2001A patent/SK285471B6/en not_active IP Right Cessation
- 2000-05-26 MX MXPA01012222A patent/MXPA01012222A/en active IP Right Grant
- 2000-05-26 WO PCT/EP2000/004829 patent/WO2000072867A2/en not_active Application Discontinuation
- 2000-05-26 PT PT00943742T patent/PT1181035E/en unknown
- 2000-05-26 AT AT00943742T patent/ATE291926T1/en not_active IP Right Cessation
- 2000-05-26 DE DE10084671T patent/DE10084671T1/en not_active Withdrawn
- 2000-05-26 NZ NZ515154A patent/NZ515154A/en unknown
- 2000-05-26 BR BR0011030-2A patent/BR0011030A/en not_active Application Discontinuation
- 2000-05-26 JP JP2000620976A patent/JP2003500454A/en active Pending
- 2000-05-26 ES ES00943742T patent/ES2239605T3/en not_active Expired - Lifetime
- 2000-05-26 AU AU58100/00A patent/AU765935B2/en not_active Ceased
- 2000-05-26 CZ CZ20014214A patent/CZ20014214A3/en unknown
- 2000-05-26 RU RU2001133455/15A patent/RU2249461C2/en not_active IP Right Cessation
- 2000-05-26 HU HU0201372A patent/HUP0201372A3/en unknown
- 2000-05-26 CN CN00808183A patent/CN1353613A/en active Pending
- 2000-05-26 DE DE60019100T patent/DE60019100T2/en not_active Expired - Fee Related
- 2000-05-26 EP EP00943742A patent/EP1181035B1/en not_active Expired - Lifetime
- 2000-05-26 TR TR2001/03276T patent/TR200103276T2/en unknown
- 2000-05-26 CA CA002371247A patent/CA2371247A1/en not_active Abandoned
- 2000-05-26 GB GB0128277A patent/GB2367004B/en not_active Expired - Fee Related
- 2000-05-26 IL IL14618600A patent/IL146186A0/en unknown
- 2000-05-26 PL PL351593A patent/PL199591B1/en not_active IP Right Cessation
- 2000-05-26 KR KR1020017013293A patent/KR20010111587A/en not_active Application Discontinuation
-
2001
- 2001-11-23 ZA ZA200109658A patent/ZA200109658B/en unknown
- 2001-11-27 NO NO20015785A patent/NO20015785L/en not_active Application Discontinuation
-
2002
- 2002-07-19 HK HK02105374.3A patent/HK1045642B/en not_active IP Right Cessation
- 2002-08-13 US US10/217,732 patent/US6767555B2/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998033512A1 (en) * | 1997-01-30 | 1998-08-06 | Novartis Ag | Oil-free pharmaceutical compositions containing cyclosporin a |
WO1998040094A1 (en) * | 1997-03-12 | 1998-09-17 | Abbott Laboratories | Hydrophilic binary systems for the administration of cyclosporine |
WO2000040219A1 (en) * | 1998-12-30 | 2000-07-13 | Dexcel Ltd. | Dispersible concentrate for the delivery of cyclosporin |
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