WO2001004118A3 - Quinuclidine derivatives and their use as muscarinic m3 receptor ligands - Google Patents

Quinuclidine derivatives and their use as muscarinic m3 receptor ligands Download PDF

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Publication number
WO2001004118A3
WO2001004118A3 PCT/EP2000/006469 EP0006469W WO0104118A3 WO 2001004118 A3 WO2001004118 A3 WO 2001004118A3 EP 0006469 W EP0006469 W EP 0006469W WO 0104118 A3 WO0104118 A3 WO 0104118A3
Authority
WO
WIPO (PCT)
Prior art keywords
muscarinic
receptor ligands
quinuclidine derivatives
quinuclidine
derivatives
Prior art date
Application number
PCT/EP2000/006469
Other languages
French (fr)
Other versions
WO2001004118A2 (en
Inventor
Forner Dolors Fernandez
Quinones Maria Prat
Albero Maria Antonia Buil
Original Assignee
Almirall Prodesfarma Sa
Forner Dolors Fernandez
Quinones Maria Prat
Albero Maria Antonia Buil
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8309225&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2001004118(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to UA2002010323A priority Critical patent/UA73509C2/en
Application filed by Almirall Prodesfarma Sa, Forner Dolors Fernandez, Quinones Maria Prat, Albero Maria Antonia Buil filed Critical Almirall Prodesfarma Sa
Priority to JP2001509727A priority patent/JP4030040B2/en
Priority to SK43-2002A priority patent/SK287480B6/en
Priority to EP00951361.5A priority patent/EP1200431B3/en
Priority to BRPI0012434A priority patent/BRPI0012434B8/en
Priority to AU64330/00A priority patent/AU779881C/en
Priority to HU0202100A priority patent/HU228594B1/en
Priority to EEP200200017A priority patent/EE04915B3/en
Priority to ES951361T priority patent/ES2193098T7/en
Priority to SI200030108T priority patent/SI1200431T1/en
Priority to CA2381165A priority patent/CA2381165C/en
Priority to AT00951361T priority patent/ATE235492T1/en
Priority to IL14753300A priority patent/IL147533A0/en
Priority to DK00951361.5T priority patent/DK1200431T6/en
Priority to DE60001840A priority patent/DE60001840D1/en
Priority to PL357160A priority patent/PL204024B1/en
Priority to DE60001840.7T priority patent/DE60001840T4/en
Publication of WO2001004118A2 publication Critical patent/WO2001004118A2/en
Publication of WO2001004118A3 publication Critical patent/WO2001004118A3/en
Priority to NO20020180A priority patent/NO329484B3/en
Priority to US10/047,464 priority patent/US6750226B2/en
Priority to HK02103992A priority patent/HK1042487B/en
Priority to US10/740,264 priority patent/US7109210B2/en
Priority to US11/116,777 priority patent/US7078412B2/en
Priority to AU2005202144A priority patent/AU2005202144B2/en
Priority to US11/325,059 priority patent/US7196098B2/en
Priority to US11/324,919 priority patent/US7214687B2/en
Priority to US11/636,181 priority patent/US7358260B2/en
Priority to US12/074,929 priority patent/US7750023B2/en
Priority to US12/787,772 priority patent/US7897617B2/en
Priority to US13/011,131 priority patent/US8129405B2/en
Priority to US13/354,873 priority patent/US8513279B2/en
Priority to CY2013001C priority patent/CY2013001I2/en
Priority to FR13C0001C priority patent/FR13C0001I2/en
Priority to NO2013002C priority patent/NO2013002I2/en
Priority to US13/939,742 priority patent/US8802699B2/en
Priority to US14/311,102 priority patent/US9056100B2/en
Priority to US14/712,866 priority patent/US9333195B2/en
Priority to US15/019,009 priority patent/USRE46417E1/en
Priority to US15/095,036 priority patent/US9687478B2/en
Priority to US15/599,646 priority patent/US10034867B2/en
Priority to US16/045,333 priority patent/US10588895B2/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A compound according to formula (I) wherein z© is a phenyl ring, a C4 to C9 heteroaromatic compound containing one or more heteroatoms, or a naphthalenyl, 5,6,7,8-tetrahydronaphthalenyl or biphenyl group; which shows high affinity for muscarinic M3 receptors (Hm3).
PCT/EP2000/006469 1999-07-14 2000-07-07 Quinuclidine derivatives and their use as muscarinic m3 receptor ligands WO2001004118A2 (en)

Priority Applications (40)

Application Number Priority Date Filing Date Title
DE60001840.7T DE60001840T4 (en) 1999-07-14 2000-07-07 CHINUCLIDIN DERIVATIVES AND THEIR USE AS MUSCARIN M3 RECEPTOR LIGANDS
CA2381165A CA2381165C (en) 1999-07-14 2000-07-07 Novel quinuclidine derivatives and medicinal compositions containing the same
JP2001509727A JP4030040B2 (en) 1999-07-14 2000-07-07 Quinuclidine derivatives and their use as muscarinic M3 receptor ligands
SK43-2002A SK287480B6 (en) 1999-07-14 2000-07-07 Quinuclidine derivatives, a method for producing them, medicinal compositions containing the same and the use of them
EP00951361.5A EP1200431B3 (en) 1999-07-14 2000-07-07 Quinuclidine derivatives and their use as muscarinic m3 receptors ligands
BRPI0012434A BRPI0012434B8 (en) 1999-07-14 2000-07-07 quinuclidine ester compounds useful as muscarinic m3 receptor antagonists
AU64330/00A AU779881C (en) 1999-07-14 2000-07-07 Quinuclidine derivates and their use as muscarinic M3 receptor ligands
HU0202100A HU228594B1 (en) 1999-07-14 2000-07-07 Novel quinuclidine derivatives, process for their preparation and medicinal compositions containing the same
EEP200200017A EE04915B3 (en) 1999-07-14 2000-07-07 Quinuclidine derivatives, a method for preparing thereof, intermediates, a pharmaceutical composition, and use thereof
ES951361T ES2193098T7 (en) 1999-07-14 2000-07-07 Quinuclidine derivatives and their use as ligands for M3 muscarinic receptors
SI200030108T SI1200431T1 (en) 1999-07-14 2000-07-07 Quinuclidine derivatives and their use as muscarinic m3 receptors ligands
UA2002010323A UA73509C2 (en) 1999-07-14 2000-07-07 Quinuclidine derivatives and use thereof as ligands of muscarinic м3-receptor
DK00951361.5T DK1200431T6 (en) 1999-07-14 2000-07-07 Quinuclidine derivatives and their use as muscarinic M3 receptor ligands
IL14753300A IL147533A0 (en) 1999-07-14 2000-07-07 Novel quinuclidine derivatives and medicinal compositions containing the same
AT00951361T ATE235492T1 (en) 1999-07-14 2000-07-07 QUINUCLIDINE DERIVATIVES AND THEIR USE AS MUSCARIN M3 RECEPTOR LIGANDS
DE60001840A DE60001840D1 (en) 1999-07-14 2000-07-07 CHINUCLIDIN DERIVATIVES AND THEIR USE AS MUSCARIN M3 RECEPTOR LIGANDS
PL357160A PL204024B1 (en) 1999-07-14 2000-07-07 Quinuclidine derivatives and their use as muscarinic m3 receptor ligands
US10/047,464 US6750226B2 (en) 1999-07-14 2002-01-14 Quinuclidine derivatives and their use as muscarinic M3 receptor ligands
NO20020180A NO329484B3 (en) 1999-07-14 2002-01-14 New quinuclidine derivatives and medicinal compositions containing the same, and their use for the manufacture of medicaments
HK02103992A HK1042487B (en) 1999-07-14 2002-05-29 Quinuclidine derivatives and their use as muscarinic m3 receptors ligands
US10/740,264 US7109210B2 (en) 1999-07-14 2003-12-17 Quinuclidine derivatives and medicinal compositions containing the same
US11/116,777 US7078412B2 (en) 1999-07-14 2005-04-28 Quinuclidine derivatives and medicinal compositions containing the same
AU2005202144A AU2005202144B2 (en) 1999-07-14 2005-05-18 Quinuclidine derivatives and their use as muscarinic M3 receptor ligands
US11/324,919 US7214687B2 (en) 1999-07-14 2006-01-03 Quinuclidine derivatives and medicinal compositions containing the same
US11/325,059 US7196098B2 (en) 1999-07-14 2006-01-03 Quinuclidine derivatives and medicinal compositions containing the same
US11/636,181 US7358260B2 (en) 1999-07-14 2006-12-08 Quinuclidine derivatives and medicinal compositions containing the same
US12/074,929 US7750023B2 (en) 1999-07-14 2008-03-07 Quinuclidine derivatives and medicinal compositions containing the same
US12/787,772 US7897617B2 (en) 1999-07-14 2010-05-26 Quinuclidine derivatives and medicinal compositions containing the same
US13/011,131 US8129405B2 (en) 1999-07-14 2011-01-21 Quinuclidine derivatives and medicinal compositions containing the same
US13/354,873 US8513279B2 (en) 1999-07-14 2012-01-20 Quinuclidine derivatives and medicinal compositions containing the same
CY2013001C CY2013001I2 (en) 1999-07-14 2013-01-07 NEW QUINUCLIDINE DERIVATIVES AND MEDICINAL PREPARATION COMPRISING THEM
FR13C0001C FR13C0001I2 (en) 1999-07-14 2013-01-08 QUINUCLIDINE DERIVATIVES AND THEIR USE AS M3 MUSCARINIC RECEPTOR LIGANDS
NO2013002C NO2013002I2 (en) 1999-07-14 2013-01-18 Aclidinium salt with a pharmaceutically acceptable anion of a mono- or polyhydric acid, especially aclidinium bromide
US13/939,742 US8802699B2 (en) 1999-07-14 2013-07-11 Quinuclidine derivatives and medicinal compositions containing the same
US14/311,102 US9056100B2 (en) 1999-07-14 2014-06-20 Quinuclidine derivatives and medicinal compositions containing the same
US14/712,866 US9333195B2 (en) 1999-07-14 2015-05-14 Quinuclidine derivatives and medicinal compositions containing the same
US15/019,009 USRE46417E1 (en) 1999-07-14 2016-02-09 Quinuclidine derivatives and their use as muscarinic M3 receptor ligands
US15/095,036 US9687478B2 (en) 1999-07-14 2016-04-09 Quinuclidine derivatives and medicinal compositions containing the same
US15/599,646 US10034867B2 (en) 1999-07-14 2017-05-19 Quinuclidine derivatives and medicinal compositions containing the same
US16/045,333 US10588895B2 (en) 1999-07-14 2018-07-25 Quinuclidine derivatives and medicinal compositions containing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009901580A ES2165768B1 (en) 1999-07-14 1999-07-14 NEW DERIVATIVES OF QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
ESP9901580 1999-07-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/047,464 Continuation US6750226B2 (en) 1999-07-14 2002-01-14 Quinuclidine derivatives and their use as muscarinic M3 receptor ligands

Publications (2)

Publication Number Publication Date
WO2001004118A2 WO2001004118A2 (en) 2001-01-18
WO2001004118A3 true WO2001004118A3 (en) 2001-07-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/006469 WO2001004118A2 (en) 1999-07-14 2000-07-07 Quinuclidine derivatives and their use as muscarinic m3 receptor ligands

Country Status (39)

Country Link
US (16) US6750226B2 (en)
EP (1) EP1200431B3 (en)
JP (2) JP4030040B2 (en)
KR (3) KR100854321B1 (en)
CN (2) CN1272334C (en)
AR (1) AR029760A1 (en)
AT (1) ATE235492T1 (en)
AU (1) AU2005202144B2 (en)
BE (1) BE2013C001I2 (en)
BG (1) BG65565B1 (en)
BR (1) BRPI0012434B8 (en)
CA (1) CA2381165C (en)
CO (1) CO5200759A1 (en)
CY (1) CY2013001I2 (en)
CZ (1) CZ304292B6 (en)
DE (2) DE60001840T4 (en)
DK (1) DK1200431T6 (en)
EE (1) EE04915B3 (en)
EG (1) EG24066A (en)
ES (2) ES2165768B1 (en)
FR (1) FR13C0001I2 (en)
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