WO2001005427A8 - Psca: prostate stem cell antigen and uses thereof - Google Patents

Psca: prostate stem cell antigen and uses thereof

Info

Publication number
WO2001005427A8
WO2001005427A8 PCT/US2000/019967 US0019967W WO0105427A8 WO 2001005427 A8 WO2001005427 A8 WO 2001005427A8 US 0019967 W US0019967 W US 0019967W WO 0105427 A8 WO0105427 A8 WO 0105427A8
Authority
WO
WIPO (PCT)
Prior art keywords
psca
stem cell
cell antigen
prostate stem
prostate
Prior art date
Application number
PCT/US2000/019967
Other languages
French (fr)
Other versions
WO2001005427A9 (en
WO2001005427B1 (en
WO2001005427A1 (en
Inventor
Robert Reiter
Owen Witte
Douglas C Saffran
Aya Jakobovits
Original Assignee
Univ California
Urogenesys
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Urogenesys filed Critical Univ California
Priority to EP00950546A priority Critical patent/EP1200125A1/en
Priority to CA2378946A priority patent/CA2378946C/en
Priority to AU63641/00A priority patent/AU776716B2/en
Priority to JP2001510481A priority patent/JP3895988B2/en
Publication of WO2001005427A1 publication Critical patent/WO2001005427A1/en
Publication of WO2001005427B1 publication Critical patent/WO2001005427B1/en
Publication of WO2001005427A9 publication Critical patent/WO2001005427A9/en
Publication of WO2001005427A8 publication Critical patent/WO2001005427A8/en

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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07—ORGANIC CHEMISTRY
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

Abstract

The invention provides a novel prostate cell-surface antigen, designated Prostae Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.
PCT/US2000/019967 1999-07-20 2000-07-20 Psca: prostate stem cell antigen and uses thereof WO2001005427A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00950546A EP1200125A1 (en) 1999-07-20 2000-07-20 Psca: prostate stem cell antigen and uses thereof
CA2378946A CA2378946C (en) 1999-07-20 2000-07-20 Psca: prostate stem cell antigen and uses thereof
AU63641/00A AU776716B2 (en) 1999-07-20 2000-07-20 PSCA: prostate stem cell antigen and uses thereof
JP2001510481A JP3895988B2 (en) 1999-07-20 2000-07-20 PSCA: Prostate stem cell antigen and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35932699A 1999-07-20 1999-07-20
US09/359,326 1999-07-20
US09/564,329 2000-05-03
US09/564,329 US6541212B2 (en) 1997-03-10 2000-05-03 Methods for detecting prostate stem cell antigen protein

Publications (4)

Publication Number Publication Date
WO2001005427A1 WO2001005427A1 (en) 2001-01-25
WO2001005427B1 WO2001005427B1 (en) 2001-05-17
WO2001005427A9 WO2001005427A9 (en) 2002-08-29
WO2001005427A8 true WO2001005427A8 (en) 2003-10-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/019967 WO2001005427A1 (en) 1999-07-20 2000-07-20 Psca: prostate stem cell antigen and uses thereof

Country Status (6)

Country Link
US (18) US6541212B2 (en)
EP (1) EP1200125A1 (en)
JP (2) JP3895988B2 (en)
AU (1) AU776716B2 (en)
CA (1) CA2378946C (en)
WO (1) WO2001005427A1 (en)

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US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US6541212B2 (en) * 1997-03-10 2003-04-01 The Regents Of The University Of California Methods for detecting prostate stem cell antigen protein
US20080318254A9 (en) * 1997-03-10 2008-12-25 The Regents Of The University Of California PSCA antibodies and hybridomas producing them
US6960443B2 (en) * 1997-03-10 2005-11-01 The Regents Of The University Of California Methods of detecting prostate stem cell antigen in cancer
US7361336B1 (en) * 1997-09-18 2008-04-22 Ivan Bergstein Methods of cancer therapy targeted against a cancer stem line
DK1226177T3 (en) * 1999-10-29 2008-10-06 Genentech Inc Antibody Compositions for Anti-Prostate Stem Cell Antigen (PSCA) and Applications thereof
US6824780B1 (en) 1999-10-29 2004-11-30 Genentech, Inc. Anti-tumor antibody compositions and methods of use
JP2001195491A (en) * 1999-11-02 2001-07-19 Matsushita Electric Works Ltd Selling support method for commodity associated with living space, method and system for charging the same and recording medium
AU2001288436A1 (en) 2000-09-01 2002-03-22 International Bioimmune Systems, Inc The identification and development of specific monoclonal antibodies to squamous cell carcinoma
SE0100595D0 (en) * 2001-02-22 2001-02-22 Lena Carlsson Immunological detection of prostate diseases and prostatic-related diseases
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