WO2001007583A8 - Cell/tissue analysis via controlled electroporation - Google Patents

Cell/tissue analysis via controlled electroporation

Info

Publication number
WO2001007583A8
WO2001007583A8 PCT/US2000/019971 US0019971W WO0107583A8 WO 2001007583 A8 WO2001007583 A8 WO 2001007583A8 US 0019971 W US0019971 W US 0019971W WO 0107583 A8 WO0107583 A8 WO 0107583A8
Authority
WO
WIPO (PCT)
Prior art keywords
cell
analysis via
tissue analysis
via controlled
current
Prior art date
Application number
PCT/US2000/019971
Other languages
French (fr)
Other versions
WO2001007583A1 (en
Inventor
Boris Rubinsky
Yong Huang
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Priority to AU63642/00A priority Critical patent/AU6364200A/en
Priority to CA002378110A priority patent/CA2378110A1/en
Priority to EP00950548A priority patent/EP1196550A4/en
Priority to JP2001512853A priority patent/JP2003505072A/en
Publication of WO2001007583A1 publication Critical patent/WO2001007583A1/en
Publication of WO2001007583A8 publication Critical patent/WO2001007583A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Abstract

An electrical current is created across an electrically conductive medium comprising a cell which may be part of a tissue of a living organism. A first electrical parameter which may be current, voltage, or electrical impedance is measured. A second electrical parameter which may be current, voltage or a combination of both is then adjusted and/or analyzed. Adjustments are carried out to facilitate analysis and/or obtain a desired degree of electroporation. Analysis is carried out to determine characteristics of the cell membrane and/or tissue.
PCT/US2000/019971 1999-07-21 2000-07-20 Cell/tissue analysis via controlled electroporation WO2001007583A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU63642/00A AU6364200A (en) 1999-07-21 2000-07-20 Cell/tissue analysis via controlled electroporation
CA002378110A CA2378110A1 (en) 1999-07-21 2000-07-20 Cell/tissue analysis via controlled electroporation
EP00950548A EP1196550A4 (en) 1999-07-21 2000-07-20 Cell/tissue analysis via controlled electroporation
JP2001512853A JP2003505072A (en) 1999-07-21 2000-07-20 Cell / tissue analysis by controlled electroporation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/358,510 1999-07-21
US09/358,510 US6300108B1 (en) 1999-07-21 1999-07-21 Controlled electroporation and mass transfer across cell membranes
US09/618,951 2000-07-19
US09/618,951 US6482619B1 (en) 1999-07-21 2000-07-19 Cell/tissue analysis via controlled electroporation

Publications (2)

Publication Number Publication Date
WO2001007583A1 WO2001007583A1 (en) 2001-02-01
WO2001007583A8 true WO2001007583A8 (en) 2001-08-16

Family

ID=23409957

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/019971 WO2001007583A1 (en) 1999-07-21 2000-07-20 Cell/tissue analysis via controlled electroporation

Country Status (6)

Country Link
US (8) US6300108B1 (en)
EP (1) EP1196550A4 (en)
JP (1) JP2003505072A (en)
AU (3) AU6364200A (en)
CA (1) CA2378110A1 (en)
WO (1) WO2001007583A1 (en)

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US9598691B2 (en) 2008-04-29 2017-03-21 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds

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US8926606B2 (en) 2009-04-09 2015-01-06 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation

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US20010051366A1 (en) 2001-12-13
US20030194808A1 (en) 2003-10-16
US7955827B2 (en) 2011-06-07
AU6365000A (en) 2001-02-13
US20030166181A1 (en) 2003-09-04
EP1196550A4 (en) 2006-06-07
EP1196550A2 (en) 2002-04-17
JP2003505072A (en) 2003-02-12
AU6231400A (en) 2001-02-13
US6562604B2 (en) 2003-05-13
US20060121610A1 (en) 2006-06-08
US20100196984A1 (en) 2010-08-05
US7718409B2 (en) 2010-05-18
CA2378110A1 (en) 2001-02-01
US6482619B1 (en) 2002-11-19
US20010046706A1 (en) 2001-11-29
US6300108B1 (en) 2001-10-09
WO2001007583A1 (en) 2001-02-01
AU6364200A (en) 2001-02-13

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