WO2001015727A3 - Compositions of immunostimulatory polymers and saponin adjuvants and uses thereof - Google Patents

Compositions of immunostimulatory polymers and saponin adjuvants and uses thereof Download PDF

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Publication number
WO2001015727A3
WO2001015727A3 PCT/US2000/023688 US0023688W WO0115727A3 WO 2001015727 A3 WO2001015727 A3 WO 2001015727A3 US 0023688 W US0023688 W US 0023688W WO 0115727 A3 WO0115727 A3 WO 0115727A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
saponin adjuvants
immunostimulatory
immunostimulatory polymers
phosphazenes
Prior art date
Application number
PCT/US2000/023688
Other languages
French (fr)
Other versions
WO2001015727A2 (en
Inventor
Charlotte A Kensil
Sharon A Jenkins
Original Assignee
Aquila Biopharm Inc
Charlotte A Kensil
Sharon A Jenkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aquila Biopharm Inc, Charlotte A Kensil, Sharon A Jenkins filed Critical Aquila Biopharm Inc
Priority to AU70854/00A priority Critical patent/AU7085400A/en
Publication of WO2001015727A2 publication Critical patent/WO2001015727A2/en
Publication of WO2001015727A3 publication Critical patent/WO2001015727A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Abstract

Vaccine compositions of immunostimulatory phosphazenes and saponin adjuvants and antigens and the use thereof for stimulating immunity are disclosed. Also described are immune adjuvant compositions comprising immunostimulatory phosphazenes and saponin adjuvants. The immune adjuvant compositions may be used to enhance cell-mediated immune response and to enhance antibody production. Also described is a method of stimulating immunity to an antigen.
PCT/US2000/023688 1999-09-02 2000-08-29 Compositions of immunostimulatory polymers and saponin adjuvants and uses thereof WO2001015727A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU70854/00A AU7085400A (en) 1999-09-02 2000-08-29 Compositions of immunostimulatory polymers and saponin adjuvants and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15217499P 1999-09-02 1999-09-02
US60/152,174 1999-09-02

Publications (2)

Publication Number Publication Date
WO2001015727A2 WO2001015727A2 (en) 2001-03-08
WO2001015727A3 true WO2001015727A3 (en) 2001-09-07

Family

ID=22541802

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/023688 WO2001015727A2 (en) 1999-09-02 2000-08-29 Compositions of immunostimulatory polymers and saponin adjuvants and uses thereof

Country Status (2)

Country Link
AU (1) AU7085400A (en)
WO (1) WO2001015727A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2204186B1 (en) 1999-02-17 2016-04-06 CSL Limited Immunogenic complexes and methods relating thereto
CA2471092A1 (en) 2001-12-21 2003-07-10 Antigenics Inc. Compositions comprising immunoreactive reagents and saponins, and methods of use thereof
AU2008275743A1 (en) * 2007-07-09 2009-01-15 Apogee Technology, Inc. Immunostimulating polyphosphazene compounds for intradermal immunization
NZ601345A (en) 2008-10-16 2014-05-30 Univ Dalhousie Combination adjuvant formulation
WO2017079582A1 (en) 2015-11-06 2017-05-11 Adjuvance Technologies, Inc. Triterpene saponin analogues
SG11201909311TA (en) * 2017-04-13 2019-11-28 Adjuvance Technologies Inc Triterpene saponin synthesis, intermediates and adjuvant combinations
CA3075822A1 (en) 2017-10-16 2019-04-25 Adjuvance Technologies, Inc. Triterpene saponin analogues

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494673A (en) * 1993-07-12 1996-02-27 Virus Research Institute Phosphazene polyelectrolytes as immunoadjuvants
US5583112A (en) * 1987-05-29 1996-12-10 Cambridge Biotech Corporation Saponin-antigen conjugates and the use thereof
WO1998052573A1 (en) * 1997-05-20 1998-11-26 Galenica Pharmaceuticals, Inc. Triterpene saponin analogs having adjuvant and immunostimulatory activity
WO1999027959A1 (en) * 1997-11-28 1999-06-10 Commonwealth Scientific And Industrial Research Organisation Saponin adjuvant composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583112A (en) * 1987-05-29 1996-12-10 Cambridge Biotech Corporation Saponin-antigen conjugates and the use thereof
US5494673A (en) * 1993-07-12 1996-02-27 Virus Research Institute Phosphazene polyelectrolytes as immunoadjuvants
WO1998052573A1 (en) * 1997-05-20 1998-11-26 Galenica Pharmaceuticals, Inc. Triterpene saponin analogs having adjuvant and immunostimulatory activity
WO1999027959A1 (en) * 1997-11-28 1999-06-10 Commonwealth Scientific And Industrial Research Organisation Saponin adjuvant composition

Also Published As

Publication number Publication date
AU7085400A (en) 2001-03-26
WO2001015727A2 (en) 2001-03-08

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