WO2001018172A3 - Fibroblast growth factor-like polypeptides - Google Patents

Fibroblast growth factor-like polypeptides Download PDF

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Publication number
WO2001018172A3
WO2001018172A3 PCT/US2000/024373 US0024373W WO0118172A3 WO 2001018172 A3 WO2001018172 A3 WO 2001018172A3 US 0024373 W US0024373 W US 0024373W WO 0118172 A3 WO0118172 A3 WO 0118172A3
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WO
WIPO (PCT)
Prior art keywords
polypeptides
growth factor
fibroblast growth
fgf
methods
Prior art date
Application number
PCT/US2000/024373
Other languages
French (fr)
Other versions
WO2001018172A2 (en
Inventor
Arlen Read Thomason
Benxian Liu
Dimitri Michael Danilenko
Original Assignee
Amgen Inc
Arlen Read Thomason
Benxian Liu
Dimitri Michael Danilenko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/391,861 external-priority patent/US7408047B1/en
Application filed by Amgen Inc, Arlen Read Thomason, Benxian Liu, Dimitri Michael Danilenko filed Critical Amgen Inc
Priority to MXPA02002384A priority Critical patent/MXPA02002384A/en
Priority to AU73500/00A priority patent/AU7350000A/en
Priority to JP2001522384A priority patent/JP4793836B2/en
Priority to CA2383774A priority patent/CA2383774C/en
Priority to DK00961560T priority patent/DK1218509T3/en
Priority to DE60042122T priority patent/DE60042122D1/en
Priority to AT00961560T priority patent/ATE430197T1/en
Priority to EP00961560A priority patent/EP1218509B9/en
Publication of WO2001018172A2 publication Critical patent/WO2001018172A2/en
Publication of WO2001018172A3 publication Critical patent/WO2001018172A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factors [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/50—Fibroblast growth factors [FGF]

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Abstract

The present invention provides Fibroblast Growth Factor-like (FGF-like) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing FGF-like polypeptides. Also provided for are methods for the diagnosis and treatment of diseases associated with FGF-like polypeptides.
PCT/US2000/024373 1999-09-07 2000-09-05 Fibroblast growth factor-like polypeptides WO2001018172A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
MXPA02002384A MXPA02002384A (en) 1999-09-07 2000-09-05 Fibroblast growth factor like polypeptides.
AU73500/00A AU7350000A (en) 1999-09-07 2000-09-05 Fibroblast growth factor-like polypeptides
JP2001522384A JP4793836B2 (en) 1999-09-07 2000-09-05 Fibroblast growth factor-like polypeptide
CA2383774A CA2383774C (en) 1999-09-07 2000-09-05 Fibroblast growth factor-like polypeptides
DK00961560T DK1218509T3 (en) 1999-09-07 2000-09-05 Fibroblast growth factor-like polypeptides
DE60042122T DE60042122D1 (en) 1999-09-07 2000-09-05 FIBROBLASTES GROWTH FACTOR-SIMILAR POLYPEPTIDES
AT00961560T ATE430197T1 (en) 1999-09-07 2000-09-05 FIBROBLAST GROWTH FACTOR-LIKE POLYPEPTIDES
EP00961560A EP1218509B9 (en) 1999-09-07 2000-09-05 Fibroblast growth factor-like polypeptides

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/391,861 US7408047B1 (en) 1999-09-07 1999-09-07 Fibroblast growth factor-like polypeptides
US09/391,861 1999-09-07
US09/644,052 2000-08-23
US09/644,052 US7459540B1 (en) 1999-09-07 2000-08-23 Fibroblast growth factor-like polypeptides

Publications (2)

Publication Number Publication Date
WO2001018172A2 WO2001018172A2 (en) 2001-03-15
WO2001018172A3 true WO2001018172A3 (en) 2002-05-02

Family

ID=27013655

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/024373 WO2001018172A2 (en) 1999-09-07 2000-09-05 Fibroblast growth factor-like polypeptides

Country Status (13)

Country Link
US (10) US7459540B1 (en)
EP (4) EP2284189A3 (en)
JP (4) JP4793836B2 (en)
AT (1) ATE430197T1 (en)
AU (1) AU7350000A (en)
CA (1) CA2383774C (en)
CY (1) CY1109166T1 (en)
DE (1) DE60042122D1 (en)
DK (1) DK1218509T3 (en)
ES (1) ES2326407T3 (en)
MX (1) MXPA02002384A (en)
PT (1) PT1218509E (en)
WO (1) WO2001018172A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9284378B2 (en) 2009-12-07 2016-03-15 Shaw-Fen Sylvia Hu Human antigen binding proteins that bind β-Klotho, FGF receptors and complexes thereof
US9434778B2 (en) 2014-10-24 2016-09-06 Bristol-Myers Squibb Company Modified FGF-21 polypeptides comprising an internal deletion and uses thereof

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7459540B1 (en) 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
US6716626B1 (en) 1999-11-18 2004-04-06 Chiron Corporation Human FGF-21 nucleic acids
JP2003516731A (en) * 1999-11-18 2003-05-20 カイロン コーポレイション Human FGF-21 gene and gene expression product
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
US20050152836A1 (en) * 2003-05-22 2005-07-14 Euan Ashley Diagnostic markers and pharmacological targets in heart failure and related reagents and methods of use thereof
KR20060135648A (en) 2003-12-10 2006-12-29 일라이 릴리 앤드 캄파니 Muteins of fibroblast growth factor 21
DK1751184T3 (en) 2004-05-13 2009-11-23 Lilly Co Eli FGF-21 fusion proteins
KR20130019457A (en) 2004-07-26 2013-02-26 다우 글로벌 테크놀로지스 엘엘씨 Process for improved protein expression by strain engineering
US7622445B2 (en) 2004-09-02 2009-11-24 Eli Lilly And Company Muteins of fibroblast growth factor 21
KR100854198B1 (en) 2004-09-02 2008-08-26 일라이 릴리 앤드 캄파니 21 muteins of fibroblast growth factor 21
JP2008522617A (en) 2004-12-14 2008-07-03 イーライ リリー アンド カンパニー Fibroblast growth factor 21 mutein
US20080261875A1 (en) * 2005-01-21 2008-10-23 Eli Lilly And Company Method For Treating Cardiovascular Disease
JP2006246823A (en) * 2005-03-11 2006-09-21 Kyoto Univ Use of fgf21 as hematopoietic factor
AU2007254005B2 (en) 2006-02-10 2012-11-29 Genentech, Inc. Anti-FGF19 antibodies and methods using same
AU2012268895B2 (en) * 2007-03-30 2015-07-16 Ambrx, Inc. Modified FGF-21 polypeptides and their uses
CN101663046B (en) * 2007-03-30 2017-07-28 Ambrx公司 Through modifying the polypeptides of FGF 21 and its purposes
ATE554785T1 (en) 2007-03-30 2012-05-15 Ambrx Inc MODIFIED FGF-21 POLYPEPTIDES AND THEIR USE
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
CN101688213A (en) 2007-04-27 2010-03-31 陶氏环球技术公司 Be used for rapidly screening microbial hosts to identify some method at the bacterial strain of output that has improvement aspect the expressing heterologous protein and/or quality
JOP20190083A1 (en) 2008-06-04 2017-06-16 Amgen Inc Fgf21 mutant fusion polypeptides and uses thereof
EA032727B1 (en) 2008-10-10 2019-07-31 Амген Инк. Fgf21 mutant proteolysis-resistant polypeptide and use thereof
US20120052069A1 (en) 2009-05-05 2012-03-01 Amgen Inc Fgf21 mutants and uses thereof
HRP20240135T1 (en) 2009-05-05 2024-04-12 Amgen Inc. Fgf21 mutants and uses thereof
WO2010148142A1 (en) 2009-06-17 2010-12-23 Amgen Inc. Chimeric fgf19 polypeptides and uses thereof
JP2013512672A (en) 2009-12-02 2013-04-18 アムジエン・インコーポレーテツド Human FGFR1c, human β-croto-, and binding proteins that bind to both human FGFR1c and human β-croto-
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EP2189475A3 (en) 2010-11-17
JP2007044044A (en) 2007-02-22
US20080071065A1 (en) 2008-03-20
ATE430197T1 (en) 2009-05-15

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