WO2001018235A3 - Lateral flow device with metal oxide indicator and assay method employing same - Google Patents

Lateral flow device with metal oxide indicator and assay method employing same Download PDF

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Publication number
WO2001018235A3
WO2001018235A3 PCT/US2000/040859 US0040859W WO0118235A3 WO 2001018235 A3 WO2001018235 A3 WO 2001018235A3 US 0040859 W US0040859 W US 0040859W WO 0118235 A3 WO0118235 A3 WO 0118235A3
Authority
WO
WIPO (PCT)
Prior art keywords
metal oxide
assay
analyte
analyzing
indicator
Prior art date
Application number
PCT/US2000/040859
Other languages
French (fr)
Other versions
WO2001018235A8 (en
WO2001018235A2 (en
Inventor
L Allen Ross
Raymond L Miller
Timothy J Barder
Original Assignee
Eichrom Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eichrom Technologies Inc filed Critical Eichrom Technologies Inc
Priority to AU12510/01A priority Critical patent/AU1251001A/en
Publication of WO2001018235A2 publication Critical patent/WO2001018235A2/en
Publication of WO2001018235A8 publication Critical patent/WO2001018235A8/en
Publication of WO2001018235A3 publication Critical patent/WO2001018235A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/10—Magnetic particle immunoreagent carriers the magnetic material being used to coat a pre-existing polymer particle but not being present in the particle core

Abstract

A lateral flow device with an indicator comprising a metal oxide label grafted to an analyzing moiety and assay method employing same are disclosed. The invention employs a plurality of metal oxide particles or metal oxide-coated non-porous silica particles as labels grafted to analyzing moieties that selectively bind the analyte, and identify the analyte to which the assay is directed. In a contemplated assay, after a sample is introduced, the analyzing moiety selectively binds the analyte, if present, to form an indicator-analyte complex. The complex flows through the device via capillary action to the receptor region where a second, capture, moiety that is affixed to the assay medium binds the complex thereby causing metal oxide indicators to accumulate. The assay can then be interpreted by a characteristic property of metal oxide label such as color at the receptor region.
PCT/US2000/040859 1999-09-09 2000-09-08 Lateral flow device with metal oxide indicator and assay method employing same WO2001018235A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU12510/01A AU1251001A (en) 1999-09-09 2000-09-08 Lateral flow device with metal oxide indicator and assay method employing same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15297399P 1999-09-09 1999-09-09
US60/152,973 1999-09-09
US65723300A 2000-09-07 2000-09-07
US09/657,233 2000-09-07

Publications (3)

Publication Number Publication Date
WO2001018235A2 WO2001018235A2 (en) 2001-03-15
WO2001018235A8 WO2001018235A8 (en) 2001-08-09
WO2001018235A3 true WO2001018235A3 (en) 2002-09-12

Family

ID=26850051

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/040859 WO2001018235A2 (en) 1999-09-09 2000-09-08 Lateral flow device with metal oxide indicator and assay method employing same

Country Status (1)

Country Link
WO (1) WO2001018235A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2721064C (en) * 2008-04-09 2016-11-01 Kristin Weidemaier Sensitive immunoassays using coated nanoparticles
CN108267575B (en) * 2018-01-23 2020-07-07 闽江学院 Preparation of protein molecular imprinting membrane with controllable thickness by using CuO labeling technology

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424193A (en) * 1993-02-25 1995-06-13 Quidel Corporation Assays employing dyed microorganism labels
US5445970A (en) * 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
US5736188A (en) * 1994-08-08 1998-04-07 Alcock; Susan Printed fluid transport devices
US5998224A (en) * 1997-05-16 1999-12-07 Abbott Laboratories Magnetically assisted binding assays utilizing a magnetically responsive reagent
US6136610A (en) * 1998-11-23 2000-10-24 Praxsys Biosystems, Inc. Method and apparatus for performing a lateral flow assay
US6140136A (en) * 1998-09-18 2000-10-31 Syntron Bioresearch, Inc. Analytical test device and method of use

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5445970A (en) * 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
US5424193A (en) * 1993-02-25 1995-06-13 Quidel Corporation Assays employing dyed microorganism labels
US5736188A (en) * 1994-08-08 1998-04-07 Alcock; Susan Printed fluid transport devices
US5998224A (en) * 1997-05-16 1999-12-07 Abbott Laboratories Magnetically assisted binding assays utilizing a magnetically responsive reagent
US6140136A (en) * 1998-09-18 2000-10-31 Syntron Bioresearch, Inc. Analytical test device and method of use
US6136610A (en) * 1998-11-23 2000-10-24 Praxsys Biosystems, Inc. Method and apparatus for performing a lateral flow assay

Also Published As

Publication number Publication date
WO2001018235A8 (en) 2001-08-09
WO2001018235A2 (en) 2001-03-15

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