WO2001019337A3 - Dosage forms and methods for providing effective reboxetine therapy with once-a-day dosing - Google Patents

Dosage forms and methods for providing effective reboxetine therapy with once-a-day dosing Download PDF

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Publication number
WO2001019337A3
WO2001019337A3 PCT/US2000/025333 US0025333W WO0119337A3 WO 2001019337 A3 WO2001019337 A3 WO 2001019337A3 US 0025333 W US0025333 W US 0025333W WO 0119337 A3 WO0119337 A3 WO 0119337A3
Authority
WO
WIPO (PCT)
Prior art keywords
reboxetine
dosage forms
methods
once
day dosing
Prior art date
Application number
PCT/US2000/025333
Other languages
French (fr)
Other versions
WO2001019337A2 (en
Inventor
Sylvia Seroff
Noymi Yam
Atul D Ayer
Padmanabh Bhatt
Michael A Desjardin
Andrew C Lam
David E Edgren
Phillip R Nixon
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Priority to JP2001522972A priority Critical patent/JP2003509354A/en
Priority to AU74907/00A priority patent/AU7490700A/en
Priority to DE60033947T priority patent/DE60033947T2/en
Priority to CA002384624A priority patent/CA2384624C/en
Priority to EP00963500A priority patent/EP1216031B1/en
Publication of WO2001019337A2 publication Critical patent/WO2001019337A2/en
Publication of WO2001019337A3 publication Critical patent/WO2001019337A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Dosage forms and methods for providing sustained release of reboxetine are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma reboxetine concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma reboxetine concentration occurrence in each 24 hour period. In addition, the peak plasma reboxetine concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma reboxetine concentration that occurs following administration of reboxetine in an immediate-release dosage form.
PCT/US2000/025333 1999-09-15 2000-09-15 Dosage forms and methods for providing effective reboxetine therapy with once-a-day dosing WO2001019337A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2001522972A JP2003509354A (en) 1999-09-15 2000-09-15 Formulation and method for providing effective reboxetine treatment once a day
AU74907/00A AU7490700A (en) 1999-09-15 2000-09-15 Dosage forms and methods for providing effective reboxetine therapy with once-a-day dosing
DE60033947T DE60033947T2 (en) 1999-09-15 2000-09-15 DOSAGE FORM AND COMPOSITION FOR THE CONTINUOUS DELIVERANCE OF REBOXETIN ONCE DAILY ADMINISTRATION FOR EFFECTIVE THERAPY
CA002384624A CA2384624C (en) 1999-09-15 2000-09-15 Dosage forms and methods for providing effective reboxetine therapy with once-a-day dosing
EP00963500A EP1216031B1 (en) 1999-09-15 2000-09-15 Dosage forms and methods for providing effective reboxetine therapy with once-a-day dosing

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15399799P 1999-09-15 1999-09-15
US60/153,997 1999-09-15

Publications (2)

Publication Number Publication Date
WO2001019337A2 WO2001019337A2 (en) 2001-03-22
WO2001019337A3 true WO2001019337A3 (en) 2001-08-09

Family

ID=22549601

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/025333 WO2001019337A2 (en) 1999-09-15 2000-09-15 Dosage forms and methods for providing effective reboxetine therapy with once-a-day dosing

Country Status (13)

Country Link
US (2) US6387403B1 (en)
EP (1) EP1216031B1 (en)
JP (1) JP2003509354A (en)
KR (2) KR100831181B1 (en)
AR (1) AR031978A1 (en)
AT (1) ATE356619T1 (en)
AU (1) AU7490700A (en)
CA (1) CA2384624C (en)
CO (1) CO5210862A1 (en)
DE (1) DE60033947T2 (en)
PE (1) PE20010625A1 (en)
TW (1) TWI233809B (en)
WO (1) WO2001019337A2 (en)

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US8637512B2 (en) * 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
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US8293799B2 (en) * 2003-12-29 2012-10-23 Osmotica Keresleedelmo és Szolgáltató KFT Osmotic device containing a venlafaxine salt and a salt having an ion in common
DE602004015246D1 (en) * 2003-02-11 2008-09-04 Alza Corp METHOD AND DOSAGE FORMS WITH MODIFIED LAYERING GEOMETRY
MXPA05009886A (en) * 2003-03-14 2006-05-04 Nirmal Mulye A process for preparing sustained release tablets.
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ATE454138T1 (en) * 2003-08-08 2010-01-15 Biovail Lab Int Srl MODIFIED RELEASE TABLET OF BUPROPION HYDROCHLORIDE
US20050131028A1 (en) * 2003-09-11 2005-06-16 Pharmacia Corporation Methods and compositions for the extended duration treatment of pain, inflammation and inflammation-related disorders
AU2004275835B2 (en) * 2003-09-26 2011-06-23 Alza Corporation Controlled release formulations exhibiting an ascending rate of release
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US20050182122A1 (en) * 2003-11-20 2005-08-18 Bello Carlo L. Method of treating abnormal cell growth using indolinone compounds
US20050265955A1 (en) * 2004-05-28 2005-12-01 Mallinckrodt Inc. Sustained release preparations
RS51527B2 (en) 2004-08-13 2018-02-28 Boehringer Ingelheim Int Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
AR053986A1 (en) 2004-12-03 2007-05-30 Osmotica Pharmaceutical Argent OSMOTIC DEVICE CONTAINING AMANTADINE AND AN OSMOTIC SALT
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WO2007044234A1 (en) * 2005-10-07 2007-04-19 Alza Corporation Osmotic dosage form with controlled release and fast release aspects
BRPI0618918B8 (en) 2005-11-22 2021-05-25 Nalpropion Pharmaceuticals Llc use of a first compound and a second compound to treat a blood glucose condition
WO2007089318A2 (en) * 2005-11-23 2007-08-09 Orexigen Therapeutics, Inc. Compositions and methods for reducing food cravings
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US8088786B2 (en) * 2006-11-09 2012-01-03 Orexigen Therapeutics, Inc. Layered pharmaceutical formulations
US7714201B2 (en) * 2006-12-22 2010-05-11 Monsanto Technology Llc Cotton variety 781000G
US7419684B2 (en) * 2006-12-22 2008-09-02 Reliant Pharmaceuticals, Inc. System and method for manufacturing oral osmotic drug delivery devices, and methods of administering same
EP2303025A4 (en) 2008-05-30 2012-07-04 Orexigen Therapeutics Inc Methods for treating visceral fat conditions
US20100069389A1 (en) * 2008-09-06 2010-03-18 Bionevia Pharmaceuticals, Inc. Novel forms of reboxetine
US10485770B2 (en) * 2009-12-21 2019-11-26 Aptapharma, Inc. Functionally-coated multilayer tablets
ES2762113T3 (en) 2010-01-11 2020-05-22 Nalpropion Pharmaceuticals Inc Methods of providing weight loss therapy in patients with major depression
CN105853445A (en) * 2011-06-06 2016-08-17 橡冠科学研究院 Drug delivery device employing wicking release window
EP4104824A1 (en) 2012-06-06 2022-12-21 Nalpropion Pharmaceuticals LLC Composition for use in a method of treating overweight and obesity in patients with high cardiovascular risk
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Also Published As

Publication number Publication date
DE60033947D1 (en) 2007-04-26
KR20070007215A (en) 2007-01-12
CO5210862A1 (en) 2002-10-30
DE60033947T2 (en) 2007-11-29
KR100831181B1 (en) 2008-05-21
AR031978A1 (en) 2003-10-22
US6387403B1 (en) 2002-05-14
US6630165B2 (en) 2003-10-07
CA2384624A1 (en) 2001-03-22
EP1216031B1 (en) 2007-03-14
TWI233809B (en) 2005-06-11
WO2001019337A2 (en) 2001-03-22
KR100723850B1 (en) 2007-05-31
CA2384624C (en) 2009-12-29
AU7490700A (en) 2001-04-17
KR20020031424A (en) 2002-05-01
PE20010625A1 (en) 2001-06-04
US20020146453A1 (en) 2002-10-10
JP2003509354A (en) 2003-03-11
EP1216031A2 (en) 2002-06-26
ATE356619T1 (en) 2007-04-15

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