WO2001027099A3 - Bicyclic compounds composition and method for stabilizing the same - Google Patents

Bicyclic compounds composition and method for stabilizing the same Download PDF

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Publication number
WO2001027099A3
WO2001027099A3 PCT/JP2000/007109 JP0007109W WO0127099A3 WO 2001027099 A3 WO2001027099 A3 WO 2001027099A3 JP 0007109 W JP0007109 W JP 0007109W WO 0127099 A3 WO0127099 A3 WO 0127099A3
Authority
WO
WIPO (PCT)
Prior art keywords
same
stabilizing
bicyclic compounds
compounds composition
glyceride
Prior art date
Application number
PCT/JP2000/007109
Other languages
French (fr)
Other versions
WO2001027099A2 (en
Inventor
Ryuji Ueno
Tsuyoshi Habe
Original Assignee
Sucampo Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22573018&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2001027099(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to IL14880300A priority Critical patent/IL148803A0/en
Priority to MXPA02003756A priority patent/MXPA02003756A/en
Priority to JP2001530318A priority patent/JP4332316B2/en
Priority to AT00966462T priority patent/ATE267189T1/en
Priority to AU76856/00A priority patent/AU780342B2/en
Priority to DK04005836T priority patent/DK1426361T4/en
Priority to HU1300369A priority patent/HU230484B1/en
Priority to RU2002112984A priority patent/RU2695274C3/en
Priority to DE60010913T priority patent/DE60010913T2/en
Application filed by Sucampo Ag filed Critical Sucampo Ag
Priority to CA002385732A priority patent/CA2385732C/en
Priority to NZ518020A priority patent/NZ518020A/en
Priority to BRPI0014869A priority patent/BRPI0014869B8/en
Priority to HU0203746A priority patent/HU229547B1/en
Priority to EP00966462A priority patent/EP1220849B1/en
Publication of WO2001027099A2 publication Critical patent/WO2001027099A2/en
Publication of WO2001027099A3 publication Critical patent/WO2001027099A3/en
Priority to IL148803A priority patent/IL148803A/en
Priority to NO20021736A priority patent/NO330258B1/en
Priority to HK02107337.5A priority patent/HK1045693B/en
Priority to AU2004242503A priority patent/AU2004242503B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

Abstract

Disclosed is a novel composition comprising a novel bi-cyclic compound, which is expected to be pharmaceutically active, and a glyceride. The stability of the bi-cyclic compound can be improved significantly by dissolving the same in a glyceride.
PCT/JP2000/007109 1999-10-15 2000-10-13 Bicyclic compounds composition and method for stabilizing the same WO2001027099A2 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
EP00966462A EP1220849B1 (en) 1999-10-15 2000-10-13 Bicyclic compounds composition and method for stabilizing the same
NZ518020A NZ518020A (en) 1999-10-15 2000-10-13 Novel composition and method for stabilizing the same
CA002385732A CA2385732C (en) 1999-10-15 2000-10-13 Bicyclic compounds composition and method for stabilizing the same
BRPI0014869A BRPI0014869B8 (en) 1999-10-15 2000-10-13 bicyclic prostaglandins, their stabilized compositions, as well as a process for their stabilization
MXPA02003756A MXPA02003756A (en) 1999-10-15 2000-10-13 Bicyclic compounds composition and method for stabilizing the same.
DK04005836T DK1426361T4 (en) 1999-10-15 2000-10-13 Novel compounds containing a bi-cyclic compound and a glyceride
HU1300369A HU230484B1 (en) 1999-10-15 2000-10-13 Novel composition containing a bi-cyclic compound and a glyceride
RU2002112984A RU2695274C3 (en) 1999-10-15 2000-10-13 NEW COMPOSITIONS AND METHODS FOR THEIR STABILIZATION
DE60010913T DE60010913T2 (en) 1999-10-15 2000-10-13 Bizyclic compounds, composition and process for their stabilization
IL14880300A IL148803A0 (en) 1999-10-15 2000-10-13 Novel composition and method for stabilizing the same
JP2001530318A JP4332316B2 (en) 1999-10-15 2000-10-13 Bicyclic compound composition and method for stabilizing the same
AU76856/00A AU780342B2 (en) 1999-10-15 2000-10-13 Novel composition and method for stabilizing the same
AT00966462T ATE267189T1 (en) 1999-10-15 2000-10-13 BIZYCLIC COMPOUNDS COMPOSITION AND METHOD FOR STABILIZING THEM
HU0203746A HU229547B1 (en) 1999-10-15 2000-10-13 Novel composition and method for stabilizing the same
IL148803A IL148803A (en) 1999-10-15 2002-03-21 Composition and method for stabilizing the same
NO20021736A NO330258B1 (en) 1999-10-15 2002-04-12 Pharmaceutical preparations, bicyclic compounds and use of a glyceride for stabilizing a pharmaceutical preparation
HK02107337.5A HK1045693B (en) 1999-10-15 2002-10-07 Bicyclic compounds composition and method for stabilizing the same
AU2004242503A AU2004242503B2 (en) 1999-10-15 2004-12-24 Novel composition and method for stabilizing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15954999P 1999-10-15 1999-10-15
US60/159,549 1999-10-15

Publications (2)

Publication Number Publication Date
WO2001027099A2 WO2001027099A2 (en) 2001-04-19
WO2001027099A3 true WO2001027099A3 (en) 2001-10-25

Family

ID=22573018

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2000/007109 WO2001027099A2 (en) 1999-10-15 2000-10-13 Bicyclic compounds composition and method for stabilizing the same

Country Status (26)

Country Link
US (5) US6583174B1 (en)
EP (2) EP1220849B1 (en)
JP (2) JP4332316B2 (en)
KR (1) KR100830061B1 (en)
CN (1) CN1268623C (en)
AR (3) AR026046A1 (en)
AT (2) ATE267189T1 (en)
AU (2) AU780342B2 (en)
BR (1) BRPI0014869B8 (en)
CA (1) CA2385732C (en)
CZ (1) CZ303625B6 (en)
DE (2) DE60010913T2 (en)
DK (2) DK1220849T3 (en)
ES (2) ES2309410T5 (en)
HK (2) HK1066792A1 (en)
HU (2) HU230484B1 (en)
IL (2) IL148803A0 (en)
MX (1) MXPA02003756A (en)
NO (1) NO330258B1 (en)
NZ (1) NZ518020A (en)
PT (2) PT1220849E (en)
RU (1) RU2695274C3 (en)
TR (1) TR200201032T2 (en)
TW (1) TWI281918B (en)
WO (1) WO2001027099A2 (en)
ZA (1) ZA200202312B (en)

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AR037524A1 (en) 2001-11-14 2004-11-17 Sucampo Ag DOSAGE UNIT INCLUDING A PROSTAGLANDINE ANALOG FOR THE CONSTIPATION TREATMENT
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EP1562604B1 (en) * 2002-10-23 2012-01-04 Sucampo AG Prostaglandin compounds for the treatment of obesity
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TWI387454B (en) 2004-09-02 2013-03-01 Sucampo Ag Method and composition for treating gastrointestinal disorder
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JP5265369B2 (en) 2006-01-24 2013-08-14 株式会社アールテック・ウエノ Pharmaceutical composition comprising a bicyclic compound and method for stabilizing the bicyclic compound
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US8969324B2 (en) * 2007-07-19 2015-03-03 R-Tech Ueno, Ltd. Pharmaceutical composition comprising 11-deoxy-prostaglandin compound and method for stabilizing the compound
US20090082442A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched lubiprostone
CN101318948B (en) 2008-04-01 2011-04-27 上海天伟生物制药有限公司 Lubiprostone1 crystal, preparation method and uses thereof
US8569279B2 (en) * 2009-05-27 2013-10-29 Sucampo Ag Method for modulating claudin mediated functions
US20110034424A1 (en) * 2009-06-30 2011-02-10 Sucampo Ag Method for the long term nsaid use
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US8940790B2 (en) 2009-11-03 2015-01-27 Bernard Charles Sherman Stable pharmaceutical formulations comprising lubiprostone
WO2012102357A1 (en) 2011-01-27 2012-08-02 小野薬品工業株式会社 Bicyclic compound and use thereof for medical purposes
WO2012102355A1 (en) * 2011-01-27 2012-08-02 小野薬品工業株式会社 Bicyclic compound and use thereof for medical purposes
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US10736871B2 (en) 2015-04-01 2020-08-11 Cedars-Sinai Medical Center Anti-methanogenic lovastatin analogs or derivatives and uses thereof
JP6954282B2 (en) 2016-06-30 2021-10-27 小野薬品工業株式会社 Method for producing bicyclic compound
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Publication number Publication date
HUP0203746A2 (en) 2003-03-28
RU2695274C3 (en) 2020-11-09
KR20020068521A (en) 2002-08-27
PT1220849E (en) 2004-10-29
TWI281918B (en) 2007-06-01
EP1426361A1 (en) 2004-06-09
HUP1300369A2 (en) 2003-03-28
AU2004242503B2 (en) 2007-06-21
BRPI0014869B8 (en) 2021-05-25
DE60039727D1 (en) 2008-09-11
WO2001027099A2 (en) 2001-04-19
AR109354A2 (en) 2018-11-21
EP1220849A2 (en) 2002-07-10
HUP0203746A3 (en) 2005-02-28
BRPI0014869B1 (en) 2017-06-13
AU2004242503A1 (en) 2005-01-27
IL148803A0 (en) 2002-09-12
NZ518020A (en) 2004-02-27
DE60010913D1 (en) 2004-06-24
HK1045693A1 (en) 2002-12-06
ATE267189T1 (en) 2004-06-15
DE60010913T2 (en) 2005-06-09
EP1426361B1 (en) 2008-07-30
CN1268623C (en) 2006-08-09
RU2002112984A (en) 2004-01-20
KR100830061B1 (en) 2008-05-16
AR089848A2 (en) 2014-09-24
CZ20021037A3 (en) 2002-09-11
IL148803A (en) 2006-07-05
US7417067B2 (en) 2008-08-26
EP1220849B1 (en) 2004-05-19
DK1426361T4 (en) 2015-03-16
US20040235885A1 (en) 2004-11-25
US6583174B1 (en) 2003-06-24
NO330258B1 (en) 2011-03-14
HU230484B1 (en) 2016-07-28
DK1220849T3 (en) 2004-09-27
HK1045693B (en) 2005-01-21
CA2385732C (en) 2009-02-10
HK1066792A1 (en) 2005-04-01
NO20021736L (en) 2002-04-12
JP2003511445A (en) 2003-03-25
AU2004242503C1 (en) 2005-01-27
RU2695274C9 (en) 2020-01-22
CN1379769A (en) 2002-11-13
EP1426361B2 (en) 2015-02-25
RU2695274C2 (en) 2019-07-22
ATE402925T2 (en) 2008-08-15
CZ303625B6 (en) 2013-01-16
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