WO2001028498A2 - Retro-anandamides, high affinity and stability cannabinoid receptor ligands - Google Patents
Retro-anandamides, high affinity and stability cannabinoid receptor ligands Download PDFInfo
- Publication number
- WO2001028498A2 WO2001028498A2 PCT/US2000/041248 US0041248W WO0128498A2 WO 2001028498 A2 WO2001028498 A2 WO 2001028498A2 US 0041248 W US0041248 W US 0041248W WO 0128498 A2 WO0128498 A2 WO 0128498A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- cannabinoid
- receptor
- anandamide
- analogs
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU19692/01A AU1969201A (en) | 1999-10-18 | 2000-10-18 | Retro-anandamides, high affinity and stability cannabinoid receptor ligands |
JP2001531094A JP2003511478A (en) | 1999-10-18 | 2000-10-18 | Retro-anandamide, a high affinity and stable cannabinoid receptor ligand |
EP00982697A EP1226112A4 (en) | 1999-10-18 | 2000-10-18 | Retro-anandamides, high affinity and stability cannabinoid receptor ligands |
CA002387846A CA2387846A1 (en) | 1999-10-18 | 2000-10-18 | Retro-anandamides, high affinity and stability cannabinoid receptor ligands |
MXPA02005102A MXPA02005102A (en) | 1999-10-18 | 2000-10-18 | Retro anandamides, high affinity and stability cannabinoid receptor ligands. |
US10/110,862 US7276613B1 (en) | 1998-11-24 | 2000-10-18 | Retro-anandamides, high affinity and stability cannabinoid receptor ligands |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16003399P | 1999-10-18 | 1999-10-18 | |
US60/160,033 | 1999-10-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001028498A2 true WO2001028498A2 (en) | 2001-04-26 |
WO2001028498A3 WO2001028498A3 (en) | 2001-09-13 |
Family
ID=22575216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/041248 WO2001028498A2 (en) | 1998-11-24 | 2000-10-18 | Retro-anandamides, high affinity and stability cannabinoid receptor ligands |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1226112A4 (en) |
JP (1) | JP2003511478A (en) |
AU (1) | AU1969201A (en) |
CA (1) | CA2387846A1 (en) |
MX (1) | MXPA02005102A (en) |
WO (1) | WO2001028498A2 (en) |
ZA (1) | ZA200203910B (en) |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002012167A1 (en) * | 2000-07-28 | 2002-02-14 | Universidad Complutense De Madrid | Novel araquidonic acid derivatives with affinity toward the anandamide transporter |
ES2181601A1 (en) * | 2001-07-27 | 2003-02-16 | Univ Madrid Complutense | New heterocyclic-substituted arachidonic acid derivatives, are endocannabinoid transporter inhibitors useful for treating neurodegenerative diseases or tumors |
US6900236B1 (en) | 1999-10-18 | 2005-05-31 | University Of Connecticut | Cannabimimetic indole derivatives |
US6927219B2 (en) | 2001-11-12 | 2005-08-09 | Pfizer Inc. | N-alkyl-adamantyl triazinyl benzamide derivatives |
US6939977B2 (en) | 1998-05-04 | 2005-09-06 | The University Of Connecticut | Analgesic and immunomodulatory cannabinoids |
US6943266B1 (en) | 1999-10-18 | 2005-09-13 | University Of Connecticut | Bicyclic cannabinoid agonists for the cannabinoid receptor |
US6995187B1 (en) | 1999-10-18 | 2006-02-07 | University Of Connecticut | Peripheral cannabinoid receptor (CB2) selective ligands |
EP1632236A1 (en) * | 2004-07-26 | 2006-03-08 | University of Connecticut | Inhibitors of the anandamide transporter |
US7057051B2 (en) | 2001-07-20 | 2006-06-06 | Merck & Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
US7057076B2 (en) | 2001-07-13 | 2006-06-06 | University Of Connecticut | Bicyclic and tricyclic cannabinoids |
US7071223B1 (en) | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
US7176202B2 (en) | 2002-12-31 | 2007-02-13 | Pfizer Inc. | Benzamide inhibitors of the P2X7 receptor |
US7183313B2 (en) | 2002-08-23 | 2007-02-27 | University Of Connecticut | Keto cannabinoids with therapeutic indications |
US7214677B2 (en) | 2001-11-12 | 2007-05-08 | Pfizer Inc. | Benzamide, heteroarylamide and reverse amides |
US7235657B2 (en) | 2004-06-29 | 2007-06-26 | Pfizer Inc. | Methods for preparing P2X7 inhibitors |
EP2020850A1 (en) * | 2006-05-01 | 2009-02-11 | Eastern Virginia Medical School | Novel cannabinoids and methods of use |
US7897598B2 (en) | 1998-06-09 | 2011-03-01 | Alexandros Makriyannis | Inhibitors of the anandamide transporter |
WO2012104793A1 (en) * | 2011-02-02 | 2012-08-09 | Indian Council Of Medical Research | An antibacterial and antiviral compound |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2885364B1 (en) * | 2005-05-03 | 2007-06-29 | Sanofi Aventis Sa | ALKYL-, ALKENYL- AND ALKYNYLCARBAMATES DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4812457A (en) * | 1984-11-21 | 1989-03-14 | Research Development Corporation | Prostaglandin derivatives |
US5618955A (en) * | 1992-11-30 | 1997-04-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Fatty acid derivatives and pharmaceutical compositions containing same |
US5688825A (en) * | 1996-05-31 | 1997-11-18 | University Of Connecticut | Anandamide amidase inhibitors as analgesic agents |
US5925628A (en) * | 1997-03-31 | 1999-07-20 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
-
2000
- 2000-10-18 AU AU19692/01A patent/AU1969201A/en not_active Abandoned
- 2000-10-18 JP JP2001531094A patent/JP2003511478A/en active Pending
- 2000-10-18 CA CA002387846A patent/CA2387846A1/en not_active Abandoned
- 2000-10-18 EP EP00982697A patent/EP1226112A4/en not_active Withdrawn
- 2000-10-18 MX MXPA02005102A patent/MXPA02005102A/en unknown
- 2000-10-18 WO PCT/US2000/041248 patent/WO2001028498A2/en not_active Application Discontinuation
-
2002
- 2002-05-16 ZA ZA200203910A patent/ZA200203910B/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4812457A (en) * | 1984-11-21 | 1989-03-14 | Research Development Corporation | Prostaglandin derivatives |
US5618955A (en) * | 1992-11-30 | 1997-04-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Fatty acid derivatives and pharmaceutical compositions containing same |
US5688825A (en) * | 1996-05-31 | 1997-11-18 | University Of Connecticut | Anandamide amidase inhibitors as analgesic agents |
US5874459A (en) * | 1996-05-31 | 1999-02-23 | University Of Connecticut | Anandamide amidase inhibitors as analgesic agents |
US5925628A (en) * | 1997-03-31 | 1999-07-20 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
Non-Patent Citations (1)
Title |
---|
See also references of EP1226112A2 * |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6939977B2 (en) | 1998-05-04 | 2005-09-06 | The University Of Connecticut | Analgesic and immunomodulatory cannabinoids |
US7897598B2 (en) | 1998-06-09 | 2011-03-01 | Alexandros Makriyannis | Inhibitors of the anandamide transporter |
US6995187B1 (en) | 1999-10-18 | 2006-02-07 | University Of Connecticut | Peripheral cannabinoid receptor (CB2) selective ligands |
US6900236B1 (en) | 1999-10-18 | 2005-05-31 | University Of Connecticut | Cannabimimetic indole derivatives |
US6943266B1 (en) | 1999-10-18 | 2005-09-13 | University Of Connecticut | Bicyclic cannabinoid agonists for the cannabinoid receptor |
WO2002012167A1 (en) * | 2000-07-28 | 2002-02-14 | Universidad Complutense De Madrid | Novel araquidonic acid derivatives with affinity toward the anandamide transporter |
US7057076B2 (en) | 2001-07-13 | 2006-06-06 | University Of Connecticut | Bicyclic and tricyclic cannabinoids |
US7057051B2 (en) | 2001-07-20 | 2006-06-06 | Merck & Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
US7572785B2 (en) | 2001-07-20 | 2009-08-11 | Merck & Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
ES2181601A1 (en) * | 2001-07-27 | 2003-02-16 | Univ Madrid Complutense | New heterocyclic-substituted arachidonic acid derivatives, are endocannabinoid transporter inhibitors useful for treating neurodegenerative diseases or tumors |
US6927219B2 (en) | 2001-11-12 | 2005-08-09 | Pfizer Inc. | N-alkyl-adamantyl triazinyl benzamide derivatives |
US7235549B2 (en) | 2001-11-12 | 2007-06-26 | Pfizer Inc. | Benzamide, heteroarylamide and reverse amides |
US7214677B2 (en) | 2001-11-12 | 2007-05-08 | Pfizer Inc. | Benzamide, heteroarylamide and reverse amides |
US7183313B2 (en) | 2002-08-23 | 2007-02-27 | University Of Connecticut | Keto cannabinoids with therapeutic indications |
US7071223B1 (en) | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
US7407956B2 (en) | 2002-12-31 | 2008-08-05 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
US7176202B2 (en) | 2002-12-31 | 2007-02-13 | Pfizer Inc. | Benzamide inhibitors of the P2X7 receptor |
US7235657B2 (en) | 2004-06-29 | 2007-06-26 | Pfizer Inc. | Methods for preparing P2X7 inhibitors |
EP1632236A1 (en) * | 2004-07-26 | 2006-03-08 | University of Connecticut | Inhibitors of the anandamide transporter |
EP2020850A1 (en) * | 2006-05-01 | 2009-02-11 | Eastern Virginia Medical School | Novel cannabinoids and methods of use |
EP2020850A4 (en) * | 2006-05-01 | 2010-10-13 | Eastern Virginia Med School | Novel cannabinoids and methods of use |
WO2012104793A1 (en) * | 2011-02-02 | 2012-08-09 | Indian Council Of Medical Research | An antibacterial and antiviral compound |
Also Published As
Publication number | Publication date |
---|---|
WO2001028498A3 (en) | 2001-09-13 |
MXPA02005102A (en) | 2003-09-25 |
EP1226112A2 (en) | 2002-07-31 |
EP1226112A4 (en) | 2004-10-13 |
ZA200203910B (en) | 2004-01-26 |
AU1969201A (en) | 2001-04-30 |
CA2387846A1 (en) | 2001-04-26 |
JP2003511478A (en) | 2003-03-25 |
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