WO2001034677A8 - Swelling and deswelling polymer blends - Google Patents

Swelling and deswelling polymer blends

Info

Publication number
WO2001034677A8
WO2001034677A8 PCT/US2000/030908 US0030908W WO0134677A8 WO 2001034677 A8 WO2001034677 A8 WO 2001034677A8 US 0030908 W US0030908 W US 0030908W WO 0134677 A8 WO0134677 A8 WO 0134677A8
Authority
WO
WIPO (PCT)
Prior art keywords
polymer
environment
blend
polymer blend
polymer blends
Prior art date
Application number
PCT/US2000/030908
Other languages
French (fr)
Other versions
WO2001034677A1 (en
Inventor
Gaylen M Zentner
Jong-Seok Bark
Feng Liu
Original Assignee
Macromed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/710,403 external-priority patent/US6537584B1/en
Application filed by Macromed Inc filed Critical Macromed Inc
Priority to AU17605/01A priority Critical patent/AU775527B2/en
Priority to CA2389251A priority patent/CA2389251C/en
Priority to EP00980328A priority patent/EP1240230B1/en
Priority to JP2001537386A priority patent/JP4768945B2/en
Priority to MXPA02004583A priority patent/MXPA02004583A/en
Priority to BRPI0015521-7A priority patent/BR0015521B1/en
Priority to DE60026357T priority patent/DE60026357T2/en
Publication of WO2001034677A1 publication Critical patent/WO2001034677A1/en
Publication of WO2001034677A8 publication Critical patent/WO2001034677A8/en
Priority to HK03104609.2A priority patent/HK1052713B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/10—Esters of organic acids, i.e. acylates
    • C08L1/12—Cellulose acetate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/005—Processes for mixing polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/02—Dextran; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A polymer blend is prepared by dissolving chitosan and a second polymer in an acidic aqueous solution to form an aqueous polymer blend, dehydrating said aqueous polymer blend, and recovering said polymer blend. The second polymer may be selected from the group consisting of polyether glycols including polyethylene glycols; cellulose esters including cellulose acetate; poloxamers; polysaccharides including dextran and guar; polyvinylpyrrolidones; polyvinyl alcohols; and mixtures or copolymers thereof. These polymer blends swell in an acidic environment and deswell in a more neutral or basic environment. This technology is valuable for the dispensing of biologically active material or drugs into a surrounding environment, especially the environment as is found in the gastrointestinal tract. Since the various polymer blends of the present invention are not covalently or ionically crosslinked, but are physically combined, each polymer in the physical blend maintains its original chemical structure, and therefore, is safe for oral or other routes of administration.
PCT/US2000/030908 1999-11-12 2000-11-10 Swelling and deswelling polymer blends WO2001034677A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU17605/01A AU775527B2 (en) 1999-11-12 2000-11-10 Swelling and deswelling polymer blends
CA2389251A CA2389251C (en) 1999-11-12 2000-11-10 Swelling and deswelling polymer blends
EP00980328A EP1240230B1 (en) 1999-11-12 2000-11-10 Swelling and deswelling polymer blends
JP2001537386A JP4768945B2 (en) 1999-11-12 2000-11-10 Polymer blends that swell and de-swell
MXPA02004583A MXPA02004583A (en) 1999-11-12 2000-11-10 Swelling and deswelling polymer blends.
BRPI0015521-7A BR0015521B1 (en) 1999-11-12 2000-11-10 polymeric mixture that swells and flakes off depending on the environment and composition containing said polymeric mixture.
DE60026357T DE60026357T2 (en) 1999-11-12 2000-11-10 ADDING AND WEIGHING POLYMER MIXTURES
HK03104609.2A HK1052713B (en) 1999-11-12 2003-06-27 Swelling and deswelling polymer blends

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US43888499A 1999-11-12 1999-11-12
US09/438,884 1999-11-12
US09/710,403 2000-11-09
US09/710,403 US6537584B1 (en) 1999-11-12 2000-11-09 Polymer blends that swell in an acidic environment and deswell in a basic environment

Publications (2)

Publication Number Publication Date
WO2001034677A1 WO2001034677A1 (en) 2001-05-17
WO2001034677A8 true WO2001034677A8 (en) 2001-10-11

Family

ID=27031834

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/030908 WO2001034677A1 (en) 1999-11-12 2000-11-10 Swelling and deswelling polymer blends

Country Status (12)

Country Link
US (2) US6730327B2 (en)
EP (1) EP1240230B1 (en)
CN (1) CN1181816C (en)
AT (1) ATE318846T1 (en)
AU (1) AU775527B2 (en)
BR (1) BR0015521B1 (en)
CA (1) CA2389251C (en)
DE (1) DE60026357T2 (en)
ES (1) ES2259618T3 (en)
HK (1) HK1052713B (en)
MX (1) MXPA02004583A (en)
WO (1) WO2001034677A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1181816C (en) * 1999-11-12 2004-12-29 麦克罗梅德公司 Swelling and deswelling polymer blends
JP2002044663A (en) * 2000-07-24 2002-02-08 Canon Inc Image encoder and encoding method, image display and displaying method, image processing system and imaging device
US6696618B2 (en) 2001-12-12 2004-02-24 Kimberly-Clark Worldwide, Inc. Absorbent composites exhibiting swelling/deswelling properties
GB0130518D0 (en) * 2001-12-21 2002-02-06 Univ Gent Pulsed bio-agent delivery systems based on degradable polymer solutions or hydrogels
CN100413919C (en) * 2002-12-13 2008-08-27 上海爱普食品工业有限公司 Method for preparing composite comestible shell polysaccharide membrane
US20050112151A1 (en) * 2003-11-20 2005-05-26 Horng Liou L. Skin adherent hydrogels
GB0329907D0 (en) * 2003-12-23 2004-01-28 Innomed Ltd Compositions
WO2006130117A1 (en) * 2005-06-03 2006-12-07 National University Of Singapore Novel polymer blends and applications for their use in hollow polymer fibers
CA2617802A1 (en) * 2005-08-04 2007-02-08 Universite Laval Gelation of undenatured proteins with polysaccharides
KR100715815B1 (en) 2005-11-08 2007-05-08 부경대학교 산학협력단 Method for preparing a chitosan-poloxamer composite
CN101528830A (en) 2006-07-10 2009-09-09 麦德医像公司 Super elastic epoxy hydrogel
US8707964B2 (en) * 2007-10-31 2014-04-29 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US20090105561A1 (en) * 2007-10-17 2009-04-23 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US8303573B2 (en) 2007-10-17 2012-11-06 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8789536B2 (en) 2007-10-17 2014-07-29 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8808276B2 (en) * 2007-10-23 2014-08-19 The Invention Science Fund I, Llc Adaptive dispensation in a digestive tract
US8109920B2 (en) * 2007-10-31 2012-02-07 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US20090163894A1 (en) * 2007-10-31 2009-06-25 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US8808271B2 (en) * 2007-10-31 2014-08-19 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8333754B2 (en) * 2007-10-31 2012-12-18 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US20090137866A1 (en) * 2007-11-28 2009-05-28 Searete Llc, A Limited Liability Corporation Of The State Delaware Medical or veterinary digestive tract utilization systems and methods
US20090139710A1 (en) * 2007-11-30 2009-06-04 Schlumberger Technology Corporation Swellable compositions and methods and devices for controlling them
US9995295B2 (en) 2007-12-03 2018-06-12 Medipacs, Inc. Fluid metering device
WO2009086067A2 (en) * 2007-12-28 2009-07-09 Boston Scientific Scimed, Inc. Particles for injection and processes fo forming the same
US9649331B2 (en) * 2009-08-27 2017-05-16 Ara Medical Llc Sprayable polymers as adhesion barriers
US9238102B2 (en) 2009-09-10 2016-01-19 Medipacs, Inc. Low profile actuator and improved method of caregiver controlled administration of therapeutics
CA2785860A1 (en) * 2009-12-29 2011-07-28 Impax Laboratories, Inc. Gastroretentive solid oral dosage forms with swellable hydrophilic polymer
US9500186B2 (en) 2010-02-01 2016-11-22 Medipacs, Inc. High surface area polymer actuator with gas mitigating components
CN101942098B (en) * 2010-03-19 2012-05-30 中科院广州化学有限公司 Amphipathic chitosan with chemical crosslinking characteristic and preparation method thereof
WO2012061556A1 (en) 2010-11-03 2012-05-10 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
US10000605B2 (en) 2012-03-14 2018-06-19 Medipacs, Inc. Smart polymer materials with excess reactive molecules
CA2962540A1 (en) * 2014-09-25 2016-03-31 Manu Chaudhary Stealth, targeted nanoparticles (stn) for oral drug delivery
US20170362543A1 (en) * 2016-06-17 2017-12-21 The Procter & Gamble Company Delayed-Release Particles
GB202215227D0 (en) * 2022-10-14 2022-11-30 Univ Of Newcastle Composite material

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034756A (en) 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US4320759A (en) 1980-04-28 1982-03-23 Alza Corporation Dispenser with diffuser
US4713249A (en) 1981-11-12 1987-12-15 Schroeder Ulf Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof
US4783337A (en) 1983-05-11 1988-11-08 Alza Corporation Osmotic system comprising plurality of members for dispensing drug
US4503030A (en) 1983-06-06 1985-03-05 Alza Corporation Device for delivering drug to certain pH environments
US4627850A (en) 1983-11-02 1986-12-09 Alza Corporation Osmotic capsule
US4717566A (en) 1984-03-19 1988-01-05 Alza Corporation Dosage system and method of using same
US4814180A (en) 1984-03-21 1989-03-21 Alza Corporation Agent dispenser comprising a semipermeable wall surrounding single-piece or two-piece container
ES8505250A3 (en) 1984-04-04 1985-05-16 Ulf Schroder A procedure for producing a sphere or particles of carbohydrates
US4743247A (en) 1984-08-13 1988-05-10 Alza Corporation Process for manufacturing dosage form
US4871544A (en) 1985-08-16 1989-10-03 Alza Corporation Ruminant dispensing device
US4966767A (en) 1985-08-16 1990-10-30 Alza Corporation Ruminant dispensing device comprising agent displacement member
US4883667A (en) 1985-08-16 1989-11-28 Alza Corporation Process for forming dispensing device
US4865598A (en) 1985-08-16 1989-09-12 Alza Corporation Dispensing system for administering beneficial agent
US4948592A (en) 1986-05-09 1990-08-14 Alza Corporation Pulsed drug delivery
US4837111A (en) 1988-03-21 1989-06-06 Alza Corporation Dosage form for dispensing drug for human therapy
US5226902A (en) 1991-07-30 1993-07-13 University Of Utah Pulsatile drug delivery device using stimuli sensitive hydrogel
US5420197A (en) * 1994-01-13 1995-05-30 Hydromer, Inc. Gels formed by the interaction of polyvinylpyrrolidone with chitosan derivatives
US5620706A (en) * 1995-04-10 1997-04-15 Universite De Sherbrooke Polyionic insoluble hydrogels comprising xanthan and chitosan
TW389694B (en) 1995-08-17 2000-05-11 Novartis Ag Compositions including o-carboxyalkyl chitosan and methods of use in ophthalmics
US5770712A (en) * 1997-03-14 1998-06-23 Virginia Tech Intellectual Properties, Inc. Crosslinked hydrogel beads from chitosan
US5904927A (en) * 1997-03-14 1999-05-18 Northeastern University Drug delivery using pH-sensitive semi-interpenetrating network hydrogels
US5864025A (en) * 1997-06-30 1999-01-26 Virginia Tech Intellectual Properties, Inc. Method of making magnetic, crosslinked chitosan support materials and products thereof
US6365185B1 (en) * 1998-03-26 2002-04-02 University Of Cincinnati Self-destructing, controlled release peroral drug delivery system
US6537584B1 (en) * 1999-11-12 2003-03-25 Macromed, Inc. Polymer blends that swell in an acidic environment and deswell in a basic environment
CN1181816C (en) * 1999-11-12 2004-12-29 麦克罗梅德公司 Swelling and deswelling polymer blends

Also Published As

Publication number Publication date
BR0015521B1 (en) 2013-04-02
US20030124189A1 (en) 2003-07-03
ES2259618T3 (en) 2006-10-16
HK1052713A1 (en) 2003-09-26
US20030139495A1 (en) 2003-07-24
EP1240230B1 (en) 2006-03-01
US7182957B2 (en) 2007-02-27
DE60026357T2 (en) 2006-10-19
CA2389251C (en) 2010-03-23
EP1240230A1 (en) 2002-09-18
AU1760501A (en) 2001-06-06
CN1181816C (en) 2004-12-29
WO2001034677A1 (en) 2001-05-17
DE60026357D1 (en) 2006-04-27
MXPA02004583A (en) 2002-09-02
CA2389251A1 (en) 2001-05-17
BR0015521A (en) 2002-11-19
CN1399655A (en) 2003-02-26
AU775527B2 (en) 2004-08-05
ATE318846T1 (en) 2006-03-15
US6730327B2 (en) 2004-05-04
HK1052713B (en) 2005-08-19
EP1240230A4 (en) 2004-12-01

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