WO2001036380A3 - Transesterification method for making cyanoacrylates - Google Patents

Transesterification method for making cyanoacrylates Download PDF

Info

Publication number
WO2001036380A3
WO2001036380A3 PCT/US2000/041513 US0041513W WO0136380A3 WO 2001036380 A3 WO2001036380 A3 WO 2001036380A3 US 0041513 W US0041513 W US 0041513W WO 0136380 A3 WO0136380 A3 WO 0136380A3
Authority
WO
WIPO (PCT)
Prior art keywords
cyanoacrylates
making
transesterification method
polymer
cyanoacrylate
Prior art date
Application number
PCT/US2000/041513
Other languages
French (fr)
Other versions
WO2001036380A2 (en
Inventor
Bernard Malofsky
Ibraheem T Badejo
Original Assignee
Closure Medical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Closure Medical Corp filed Critical Closure Medical Corp
Priority to EP00988494A priority Critical patent/EP1265851A2/en
Priority to AU24699/01A priority patent/AU2469901A/en
Priority to JP2001538872A priority patent/JP2003514796A/en
Publication of WO2001036380A2 publication Critical patent/WO2001036380A2/en
Publication of WO2001036380A3 publication Critical patent/WO2001036380A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups

Abstract

An α-cyanoacrylate may be formed by first condensing a cyanoacetate with paraformaldehyde or formaldehyde; reacting the polymer formed with an alcohol to transesterify the polymer; and depolymerizing the polymer to form α-cyanoacrylate monomers.
PCT/US2000/041513 1999-11-19 2000-10-26 Transesterification method for making cyanoacrylates WO2001036380A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00988494A EP1265851A2 (en) 1999-11-19 2000-10-26 Transesterification method for making cyanoacrylates
AU24699/01A AU2469901A (en) 1999-11-19 2000-10-26 Transesterification method for making cyanoacrylates
JP2001538872A JP2003514796A (en) 1999-11-19 2000-10-26 Transesterification process for producing cyanoacrylate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/443,298 US6245933B1 (en) 1999-11-19 1999-11-19 Transesterification method for making cyanoacrylates
US09/443,298 1999-11-19

Publications (2)

Publication Number Publication Date
WO2001036380A2 WO2001036380A2 (en) 2001-05-25
WO2001036380A3 true WO2001036380A3 (en) 2001-12-13

Family

ID=23760244

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/041513 WO2001036380A2 (en) 1999-11-19 2000-10-26 Transesterification method for making cyanoacrylates

Country Status (6)

Country Link
US (1) US6245933B1 (en)
EP (1) EP1265851A2 (en)
JP (1) JP2003514796A (en)
CN (1) CN1391552A (en)
AU (1) AU2469901A (en)
WO (1) WO2001036380A2 (en)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420590B1 (en) * 2000-10-31 2002-07-16 Closure Medical Corporation Continuous processes and apparatus for forming cyanoacetate and cyanoacrylate
US6849082B2 (en) 2001-10-19 2005-02-01 Spartan Products Inc. Method for curing cyanoacrylate adhesives
EP1476170B1 (en) * 2002-02-20 2008-03-26 Spartan Products Inc. Method for curing cyanoacrylate adhesives
US20030158579A1 (en) 2002-02-20 2003-08-21 Max Azevedo Method for curing cyanoacrylate adhesives
JP2004043357A (en) * 2002-07-11 2004-02-12 Otsuka Chemical Co Ltd Method for producing acylacetonitrile compound
US7659423B1 (en) * 2006-04-18 2010-02-09 Loctite (R&D) Limited Method of preparing electron deficient olefins in polar solvents
US20080003196A1 (en) * 2006-06-30 2008-01-03 Jonn Jerry Y Absorbable cyanoacrylate compositions
US8603138B2 (en) * 2006-10-04 2013-12-10 Ethicon Endo-Surgery, Inc. Use of an adhesive to treat intraluminal bleeding
US7914511B2 (en) * 2006-10-18 2011-03-29 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive as bulking agent
US7441973B2 (en) * 2006-10-20 2008-10-28 Ethicon Endo-Surgery, Inc. Adhesive applicator
US7749235B2 (en) * 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US7569719B1 (en) 2006-10-25 2009-08-04 Loctite (R&D) Limited Method of preparing electron deficient olefins
JP5382801B2 (en) * 2006-10-25 2014-01-08 ヘンケル アイルランド リミテッド Novel iminium salt and method for producing electron-deficient olefin using the same
US7658305B2 (en) * 2006-10-25 2010-02-09 Ethicon Endo-Surgery, Inc. Adhesive applier with articulating tip
US7892250B2 (en) 2006-11-01 2011-02-22 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive on inflatable device for gastric restriction
US8876844B2 (en) * 2006-11-01 2014-11-04 Ethicon Endo-Surgery, Inc. Anastomosis reinforcement using biosurgical adhesive and device
WO2008056516A1 (en) * 2006-11-07 2008-05-15 Terumo Kabushiki Kaisha 2-cyanoacrylate-based adhesive for living organism
US7833216B2 (en) * 2006-11-08 2010-11-16 Ethicon Endo-Surgery, Inc. Fluid plunger adhesive dispenser
US7718821B1 (en) 2006-12-19 2010-05-18 Loctite (R&D) Limited Method of preparing electron deficient olefins
US8729121B2 (en) * 2007-06-25 2014-05-20 Adhezion Biomedical, Llc Curing accelerator and method of making
ES2662644T3 (en) * 2007-10-24 2018-04-09 Henkel IP & Holding GmbH Methylene reagents
US7973119B1 (en) 2007-10-24 2011-07-05 Loctite (R&D) Limited Adhesive systems using imines and salts thereof and precursurs to electron deficient olefins
US8053589B1 (en) 2007-10-24 2011-11-08 Henkel Ireland Limited Imines and methods of preparing electron deficient olefins using such novel imines
ES2634631T3 (en) * 2007-10-24 2017-09-28 Henkel IP & Holding GmbH Electron deficient olefins
EP2211727B1 (en) 2007-11-14 2014-03-12 Adhezion Biomedical, LLC Cyanoacrylate tissue adhesives
US8198344B2 (en) 2008-06-20 2012-06-12 Adhezion Biomedical, Llc Method of preparing adhesive compositions for medical use: single additive as both the thickening agent and the accelerator
US8293838B2 (en) * 2008-06-20 2012-10-23 Adhezion Biomedical, Llc Stable and sterile tissue adhesive composition with a controlled high viscosity
US20110117047A1 (en) 2008-06-23 2011-05-19 Adhezion Biomedical, Llc Cyanoacrylate tissue adhesives with desirable permeability and tensile strength
US10196471B1 (en) 2008-10-24 2019-02-05 Henkel IP & Holding GmbH Curable composition having an electron deficient olefin
US8399698B1 (en) 2008-10-24 2013-03-19 Henkel Ireland Limited Substituted activated methylene reagents and methods of using such reagents to form electron deficient olefins
US8609128B2 (en) * 2008-10-31 2013-12-17 Adhezion Biomedical, Llc Cyanoacrylate-based liquid microbial sealant drape
US9254133B2 (en) 2008-10-31 2016-02-09 Adhezion Biomedical, Llc Sterilized liquid compositions of cyanoacrylate monomer mixtures
US8652510B2 (en) 2008-10-31 2014-02-18 Adhezion Biomedical, Llc Sterilized liquid compositions of cyanoacrylate monomer mixtures
DE102009000861A1 (en) * 2009-02-13 2010-08-19 Henkel Ag & Co. Kgaa Process for the preparation of cyanoacrylates
DE102009027545A1 (en) * 2009-07-08 2011-02-03 Henkel Ag & Co. Kgaa Process for the preparation of cyanoacrylates in the presence of transition metal catalysts
US8608642B2 (en) * 2010-02-25 2013-12-17 Ethicon Endo-Surgery, Inc. Methods and devices for treating morbid obesity using hydrogel
US9309019B2 (en) 2010-05-21 2016-04-12 Adhezion Biomedical, Llc Low dose gamma sterilization of liquid adhesives
CN102101833A (en) * 2010-09-14 2011-06-22 抚顺哥俩好化学有限公司 Preparation method of alpha-cyanoacrylate
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
KR20140092225A (en) 2010-10-20 2014-07-23 바이오포믹스, 인크. Synthesis of methylene malonates substantially free of impurities
US9249265B1 (en) 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
US9279022B1 (en) 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
KR101175135B1 (en) * 2010-11-02 2012-08-20 (주)인튜이티브메디코프 Suture produced by using polyoctylcyanoacrylate and the method for preparing thereof
CN102178978B (en) * 2011-03-18 2013-12-11 广州白云医用胶有限公司 Medical adhesive and preparation method of medical adhesive
CA2853073A1 (en) 2011-10-19 2013-04-25 Bioformix Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
CA2861411A1 (en) 2012-01-28 2013-08-01 Optmed, Inc. Improved methylidene malonate process
IN2014DN07106A (en) 2012-01-28 2015-04-24 Optmed Inc
CA2869115A1 (en) 2012-03-30 2013-10-03 Bioformix Inc. Ink and coating formulations and polymerizable systems for producing the same
CA2869108A1 (en) 2012-03-30 2013-10-03 Bioformix Inc. Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby
EP3153530B1 (en) 2012-03-30 2021-02-24 Sirrus, Inc. Composite and laminate articles and polymerizable systems for producing the same
WO2013181600A2 (en) 2012-06-01 2013-12-05 Bioformix Inc. Optical material and articles formed therefrom
CN105008438B (en) 2012-11-16 2019-10-22 拜奥福米克斯公司 Plastics bonding system and method
EP2926368B1 (en) 2012-11-30 2020-04-08 Sirrus, Inc. Electronic assembly
CN110204441A (en) 2013-01-11 2019-09-06 瑟拉斯公司 The method for obtaining methylene malonate by the approach of bis- (methylol) malonates
CN103232366A (en) * 2013-04-25 2013-08-07 华南理工大学 Preparation method of alpha-cyano propenoic acid-2-methoxy ethyl ester
CN103319369A (en) * 2013-06-06 2013-09-25 常熟市江南粘合剂有限公司 Alpha-ethyl cyanoacrylate production process
EP2927209A1 (en) 2014-03-31 2015-10-07 Afinitica Technologies, S. L. Process for preparing 1,1-disubstituted ethylenic monomers
US9421297B2 (en) 2014-04-02 2016-08-23 Adhezion Biomedical, Llc Sterilized compositions of cyanoacrylate monomers and naphthoquinone 2,3-oxides
CN103922964B (en) * 2014-04-23 2016-03-02 广州白云医用胶有限公司 Alpha-cyanoacrylate butyl ester derivative and preparation method thereof
CN104159284B (en) * 2014-08-12 2017-12-08 福建三元达科技有限公司 A kind of control method and system of LTE system ascending power
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
EP2995664B1 (en) 2014-09-12 2019-08-28 Afinitica Technologies, S. L. Fast and universal adhesive
EP2995663A1 (en) 2014-09-12 2016-03-16 Afinitica Technologies, S. L. Fast and elastic adhesive
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
EP3124509A1 (en) 2015-07-31 2017-02-01 Afinitica Technologies, S. L. Fast light curing cyanoacrylate compositions
CN105541664B (en) * 2016-03-09 2018-01-30 潍坊同业化学有限公司 A kind of method for synthesizing cyanoacrylate
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US10428177B2 (en) 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US9617377B1 (en) 2016-06-03 2017-04-11 Sirrus, Inc. Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10196481B2 (en) 2016-06-03 2019-02-05 Sirrus, Inc. Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
GB2558264B (en) 2016-12-23 2019-11-20 Henkel IP & Holding GmbH Process for preparing electron deficient olefins
GB2558262B (en) 2016-12-23 2019-05-15 Henkel IP & Holding GmbH Process for preparing electron deficient olefins
GB2558253B (en) 2016-12-23 2019-12-11 Henkel IP & Holding GmbH Process for preparing electron deficient olefins
GB2558260B (en) 2016-12-23 2019-11-20 Henkel IP & Holding GmbH Process for preparing electron deficient olefin precursors
GB2558256B (en) 2016-12-23 2019-12-18 Henkel IP & Holding GmbH Process for preparing electron deficient olefin precursors
WO2018138546A1 (en) 2017-01-25 2018-08-02 Afinitica Technologies, S. L. Article comprising a batteryless light source and a photocurable composition
EP3573805B1 (en) 2017-01-25 2022-12-07 Afinitica Technologies, S.L. Set comprising a plug connectable led and a photocurable composition
KR102571880B1 (en) 2017-06-02 2023-08-28 아르끄마 프랑스 Curable Compositions and Uses Thereof
CN109748819A (en) * 2019-02-28 2019-05-14 秦皇岛市科峰医疗器械有限公司 The preparation method and its method of purification of α-cyanoacrylatealkyl monomer, application
GB2583145B (en) 2019-04-18 2021-08-11 Henkel IP & Holding GmbH Process for preparing cyanoacetates
GB2583146B (en) 2019-04-18 2021-08-11 Henkel IP & Holding GmbH Process for preparing cyanoacetates
GB2583135B (en) 2019-04-18 2022-07-06 Henkel IP & Holding GmbH Process for preparing cyanoacetates
EP3999607A2 (en) 2019-07-19 2022-05-25 Arkema France Curable compositions useful for obtaining non-sensitizing cured products
GB2589910B (en) 2019-12-12 2021-12-01 Henkel IP & Holding GmbH Process for preparing cyanoacetates
CN113248405A (en) * 2021-03-26 2021-08-13 湖南浩森胶业有限公司 Modified medical adhesive and preparation method thereof
EP4209484A1 (en) 2022-07-11 2023-07-12 Aleardis Ltd. Process for preparing electron-deficient olefin monomers

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364876A (en) * 1980-03-27 1982-12-21 Toagosei Chemical Industry Co., Ltd. Novel 2-cyanoacrylate, process for producing same and curable composition comprising same
US5047571A (en) * 1989-04-29 1991-09-10 Basf Aktiengesellschaft Process for the preparation of 2-cyano-3,3-diarylacrylates
US5698730A (en) * 1993-12-20 1997-12-16 Nitto Chemical Industry Co., Ltd. Method for preparing cyanoacetic acid higher ester

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2721858A (en) 1954-03-10 1955-10-25 Eastman Kodak Co Method of making alpha-cyanoacrylates
US2756251A (en) 1954-03-23 1956-07-24 Eastman Kodak Co Preparation of monomeric alpha-cyanoacrylates
US2763677A (en) 1954-12-20 1956-09-18 Eastman Kodak Co Process for making monomeric alpha-cyanoacrylates
US3759264A (en) 1966-04-07 1973-09-18 Eastman Kodak Co Surgical method
US3559652A (en) 1968-08-05 1971-02-02 Minnesota Mining & Mfg Method of adhesively repairing body tissue with alkoxyalkyl 2-cyanoacrylate
US3975422A (en) 1972-11-21 1976-08-17 Johnson & Johnson Preparation of bis (2-cyanoacrylate)monomers
US4012402A (en) 1974-10-04 1977-03-15 Johnson & Johnson Modified cyanoacrylate monomers and methods for preparation
SU726086A1 (en) 1977-07-25 1980-04-05 Ордена Ленина Институт Элементоорганических Соединений Ан Ссср Method of preparing cyanacrylic acid esters
JPS5853676B2 (en) 1979-12-24 1983-11-30 東亞合成株式会社 adhesive composition
CA2019669A1 (en) 1989-11-21 1991-05-21 John Woods Anionically polymerizable monomers, polymers thereof, and use of such polymers in photoresists
JPH0491069A (en) 1990-08-07 1992-03-24 Three Bond Co Ltd New alpha-cyanoacrylate and adhesive composition
US5328687A (en) 1993-03-31 1994-07-12 Tri-Point Medical L.P. Biocompatible monomer and polymer compositions
US5624669A (en) 1993-03-31 1997-04-29 Tri-Point Medical Corporation Method of hemostatic sealing of blood vessels and internal organs
ATE182328T1 (en) 1994-06-06 1999-08-15 Henkel Kgaa METHOD FOR PRODUCING BISCYANOACRYLATES
US5703267A (en) 1995-03-27 1997-12-30 Toagosei Co., Ltd. Process for producing 2-cyanoacrylic acid
US5504252A (en) 1995-05-05 1996-04-02 Loctite Corporation Synthesis of cyanoacrylate esters by oxidation of aromatic selenyl cyanopropionates
ATE263142T1 (en) * 1997-08-07 2004-04-15 Cancel Richard HIGHLY PURE ALKYL-2-CYANOACRYLATES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364876A (en) * 1980-03-27 1982-12-21 Toagosei Chemical Industry Co., Ltd. Novel 2-cyanoacrylate, process for producing same and curable composition comprising same
US5047571A (en) * 1989-04-29 1991-09-10 Basf Aktiengesellschaft Process for the preparation of 2-cyano-3,3-diarylacrylates
US5698730A (en) * 1993-12-20 1997-12-16 Nitto Chemical Industry Co., Ltd. Method for preparing cyanoacetic acid higher ester

Also Published As

Publication number Publication date
US6245933B1 (en) 2001-06-12
AU2469901A (en) 2001-05-30
CN1391552A (en) 2003-01-15
EP1265851A2 (en) 2002-12-18
WO2001036380A2 (en) 2001-05-25
JP2003514796A (en) 2003-04-22

Similar Documents

Publication Publication Date Title
WO2001036380A3 (en) Transesterification method for making cyanoacrylates
WO2001000699A3 (en) Phenol/formaldehyde and polyacrylic acid co-binder and low emissions process for making the same
WO2002016458A3 (en) Controlled release urea-formaldehyde liquid fertilizer resins
EP1186644A3 (en) Pressure-sensitive adhesive composition and pressure-sensitive tape or sheet
AU2002217766A1 (en) Flange with cut for wind tower
WO2003049637A3 (en) In situ bonds
WO2006078456A3 (en) Low viscosity unsaturated polyester resin with reduced voc emission levels
WO2001004144A3 (en) Fabrication of beta-pleated sheet proteins with specific binding properties
EP1156042A4 (en) Process for the preparation of glycerol carbonate
WO2002022737A3 (en) Methods for slowing the degradation rate of biodegradable polymer and biodegradable polymer compositions and compositions thereof
AU2001247346A1 (en) Phosphate based biodegradable polymers
MY116224A (en) Cross - catalyzed phenol- resorcinol adhesive for lignocellulosic bonding and method of manufacture
EP1116748A4 (en) Composition for molding biodegradable plastic, biodegradable plastic obtained therefrom, method of molding the same, and use of biodegradable plastic
EP1191068A3 (en) Biodegradable composition and method of producing the same
WO2002022700A3 (en) Radiation curable dendritic oligomer of polymer
EP1057857A3 (en) Curing accelerator and resin composition
CA2463636A1 (en) Method of gluing wood based materials
AU2001263300A1 (en) Post-added alpha-sulfofatty acid ester compositions and methods of making and using the same
AU2001283048A1 (en) Process for improving polymer to metal adhesion
AU6117100A (en) Ethylene acid copolymer with enhanced adhesion
WO1999016602A3 (en) Improved internal release agents for producing polyurethane moulded bodies
WO2005010104A3 (en) Covalently compatible in-mold coating compositions for use with epoxy
EP1046691A3 (en) Use of high hydroxyl compounds for water sensitive hot melt adhesives
EP1535980A4 (en) Photochromic composition
EP1403321A4 (en) Form made from recycled resin

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 538872

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 008159025

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 2000988494

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2000988494

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2000988494

Country of ref document: EP