WO2001038581A3 - Vigilance nucleic acids and related diagnostic, screening and therapeutic methods - Google Patents

Vigilance nucleic acids and related diagnostic, screening and therapeutic methods Download PDF

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Publication number
WO2001038581A3
WO2001038581A3 PCT/US2000/032180 US0032180W WO0138581A3 WO 2001038581 A3 WO2001038581 A3 WO 2001038581A3 US 0032180 W US0032180 W US 0032180W WO 0138581 A3 WO0138581 A3 WO 0138581A3
Authority
WO
WIPO (PCT)
Prior art keywords
vigilance
screening
nucleic acids
therapeutic methods
invertebrate
Prior art date
Application number
PCT/US2000/032180
Other languages
French (fr)
Other versions
WO2001038581A2 (en
Inventor
Giulio Tononi
Chiara Cirelli
Paul J Shaw
Ralph J Greenspan
Original Assignee
Neurosciences Res Found
Giulio Tononi
Chiara Cirelli
Paul J Shaw
Ralph J Greenspan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosciences Res Found, Giulio Tononi, Chiara Cirelli, Paul J Shaw, Ralph J Greenspan filed Critical Neurosciences Res Found
Priority to EP00980726A priority Critical patent/EP1234059A2/en
Priority to CA2391305A priority patent/CA2391305C/en
Priority to AU17949/01A priority patent/AU785308B2/en
Publication of WO2001038581A2 publication Critical patent/WO2001038581A2/en
Publication of WO2001038581A3 publication Critical patent/WO2001038581A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection

Abstract

The invention provides methods of identifying compounds that alters vigilance, by contacting an invertebrate with a candidate compound, evaluating a vigilance property in the contacted invertebrate, and determining if the candidate compound alters the vigilance property in the contacted invertebrate. Also provided are isolated vigilance nucleic acid molecules. Methods for diagnosing and treating vigilance disorders, for determining and altering vigilance levels, and for screening for therapeutic compounds useful for treating vigilance disorders and altering vigilance level, are also provided.
PCT/US2000/032180 1999-11-24 2000-11-22 Vigilance nucleic acids and related diagnostic, screening and therapeutic methods WO2001038581A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00980726A EP1234059A2 (en) 1999-11-24 2000-11-22 Vigilance nucleic acids and related diagnostic, screening and therapeutic methods
CA2391305A CA2391305C (en) 1999-11-24 2000-11-22 Vigilance nucleic acids and related diagnostic, screening and therapeutic methods
AU17949/01A AU785308B2 (en) 1999-11-24 2000-11-22 Vigilance nucleic acids and related diagnostic, screening and therapeutic methods

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US44917599A 1999-11-24 1999-11-24
US09/449,175 1999-11-24
US45678599A 1999-12-08 1999-12-08
US09/456,785 1999-12-08

Publications (2)

Publication Number Publication Date
WO2001038581A2 WO2001038581A2 (en) 2001-05-31
WO2001038581A3 true WO2001038581A3 (en) 2002-03-14

Family

ID=27035630

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/032180 WO2001038581A2 (en) 1999-11-24 2000-11-22 Vigilance nucleic acids and related diagnostic, screening and therapeutic methods

Country Status (4)

Country Link
EP (1) EP1234059A2 (en)
AU (1) AU785308B2 (en)
CA (1) CA2391305C (en)
WO (1) WO2001038581A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030166213A1 (en) * 2000-12-15 2003-09-04 Greenspan Ralph J. Methods for identifying compounds that modulate disorders related to nitric oxide/ cGMP-dependent protein kinase signaling
US20050166269A1 (en) * 2003-12-15 2005-07-28 Giulio Tononi Sleep genes in Drosophila and their use for the screening, diagnosis and therapy of sleep disorders
US8010189B2 (en) 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
US9675796B2 (en) 2013-11-10 2017-06-13 Brainsgate Ltd. Implant and delivery system for neural stimulator
EP3093043B1 (en) 2015-05-13 2018-11-14 Brainsgate Ltd. Implant and delivery system for neural stimulator

Citations (5)

* Cited by examiner, † Cited by third party
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US5885831A (en) * 1995-03-20 1999-03-23 The Rockefeller University Nuclear localization factor associated with circadian rhythms
WO1999024610A1 (en) * 1997-11-06 1999-05-20 Millennium Pharmaceuticals, Inc. Novel genes encoding transporter-like molecules
US5968817A (en) * 1993-03-15 1999-10-19 The Scripps Research Institute DNA encoding serotonin receptors
WO1999057137A1 (en) * 1998-05-07 1999-11-11 The President & Fellows Of Harvard College Compositions and methods involving regulation of mammalian circadian rhythms

Patent Citations (5)

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US5968817A (en) * 1993-03-15 1999-10-19 The Scripps Research Institute DNA encoding serotonin receptors
US5885831A (en) * 1995-03-20 1999-03-23 The Rockefeller University Nuclear localization factor associated with circadian rhythms
EP0890578A2 (en) * 1997-07-08 1999-01-13 Smithkline Beecham Plc Polynucleotides encoding human clock gene and their use
WO1999024610A1 (en) * 1997-11-06 1999-05-20 Millennium Pharmaceuticals, Inc. Novel genes encoding transporter-like molecules
WO1999057137A1 (en) * 1998-05-07 1999-11-11 The President & Fellows Of Harvard College Compositions and methods involving regulation of mammalian circadian rhythms

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation

Also Published As

Publication number Publication date
AU785308B2 (en) 2007-01-11
CA2391305C (en) 2011-09-27
AU1794901A (en) 2001-06-04
EP1234059A2 (en) 2002-08-28
CA2391305A1 (en) 2001-05-31
WO2001038581A2 (en) 2001-05-31

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